Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?

References

• Liu J, Cui L, Losic D. Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater. 2013;9(12):9243–9257. doi:10.1016/j.actbio.2013.08.01623958782
   PubMed Web of Science ®Google Scholar
• Li Z, Fan J, Tong C, et al. A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy. Nanomedicine. 2019;14(15):2011–2025. doi:10.2217/nnm-2018-037831355696
   PubMed Web of Science ®Google Scholar
• Novoselov KS, Geim A. The rise of graphene. Nat Mater. 2007;6(3):183–191. doi:10.1038/nmat184917330084
   PubMed Web of Science ®Google Scholar
• Pinto AM, Goncalves IC, Magalhães FD. Graphene-based materials biocompatibility: a review. Colloids Surf B Biointerfaces. 2013;111:188–202. doi:10.1016/j.colsurfb.2013.05.02223810824
   PubMed Web of Science ®Google Scholar
• Zangabad PS, Mirkiani S, Shahsavari S, et al. Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications. Nanotechnol Rev. 2018;7(1):95–122.29404233
   PubMed Web of Science ®Google Scholar
• Farjadian F, Ghasemi A, Gohari O, Roointan A, Karimi M, Hamblin MR. Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities. Nanomedicine. 2019;14(1):93–126. doi:10.2217/nnm-2018-012030451076
   PubMed Web of Science ®Google Scholar
• Farjadian F, Roointan A, Mohammadi-Samani S, Hosseini M. Mesoporous silica nanoparticles: synthesis, pharmaceutical applications, biodistribution, and biosafety assessment. Chem Eng J. 2019;359:684–705. doi:10.1016/j.cej.2018.11.156
   Web of Science ®Google Scholar
• Entezar-Almahdi E, Mohammadi-Samani S, Tayebi L, Farjadian F. Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer. Int J Nanomedicine. 2020;15:5445. doi:10.2147/IJN.S25770032801699
   PubMed Web of Science ®Google Scholar
• Karimi M, Ghasemi A, Mirkiani S, Basri SMM, Hamblin MR. Carbon Nanotubes in Drug and Gene Delivery. San Rafael, CA: Morgan & Claypool Publishers; 2017.
   Google Scholar
• Fatemeh Farjadian SA, Sadatlu MAA, Mirkiani S, et al. Recent developments in graphene and graphene oxide: properties, synthesis, and modifications: a review chemistryselect. ChemistrySelect. 2020;5(33):10200–10219. doi:10.1002/slct.202002501
   Web of Science ®Google Scholar
• А F, Prischepa S, Fedotova J, et al. Electrical conductivity and magnetoresistance in twisted graphene electrochemically decorated with Co particles. Physica E Low Dimens Syst Nanostruct. 2020;117:113790. doi:10.1016/j.physe.2019.113790
   Web of Science ®Google Scholar
• Jiang J-H, Pi J, Jin H, Cai J-Y. Functional graphene oxide as cancer-targeted drug delivery system to selectively induce oesophageal cancer cell apoptosis. Arti Cells Nanomed Biotechnol. 2018;46(sup3):S297–S307. doi:10.1080/21691401.2018.1492418
   PubMed Web of Science ®Google Scholar
• Muñoz R, Singh DP, Kumar R, Matsuda A. Graphene oxide for drug delivery and cancer therapy In: Swain SK, Jawaid M, editors. Nanostructured Polymer Composites for Biomedical Applications.. Elsevier; 2019:447–488.
   Google Scholar
• Liu Z, Robinson JT, Sun X, Dai H. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc. 2008;130(33):10876–10877. doi:10.1021/ja803688x18661992
   PubMed Web of Science ®Google Scholar
• Campbell E, Hasan MT, Pho C, Callaghan K, Akkaraju G, Naumov A. Graphene oxide as a multifunctional platform for intracellular delivery, imaging, and cancer sensing. Sci Rep. 2019;9(1):1–9. doi:10.1038/s41598-018-36617-430626917
   PubMed Web of Science ®Google Scholar
• McCallion C, Burthem J, Rees-Unwin K, Golovanov A, Pluen A. Graphene in therapeutics delivery: problems, solutions and future opportunities. Eur J Pharm Biopharm. 2016;104:235–250. doi:10.1016/j.ejpb.2016.04.01527113141
   PubMed Web of Science ®Google Scholar
• Singh N, Kushwaha P, Gupta A, Prakash O. Recent advances of novel therapeutic agents from botanicals for prevention and therapy of breast cancer: an updated review. Curr Cancer Ther Rev. 2020;16(1):5–18. doi:10.2174/1573394715666181129101502
   Web of Science ®Google Scholar
• Choi J-S, Joo SH. Recent trends in cyclic peptides as therapeutic agents and biochemical tools. Biomol Ther (Seoul). 2020;28(1):18. doi:10.4062/biomolther.2019.08231597413
   PubMed Web of Science ®Google Scholar
• Kovalchuk O, Kovalchuk I. Cannabinoids as anticancer therapeutic agents. Cell Cycle. 2020;19(9):961–989. doi:10.1080/15384101.2020.174295232249682
   PubMed Web of Science ®Google Scholar
• Hosseini M, Farjadian F, Makhlouf ASH. Smart stimuli-responsive nano-sized hosts for drug delivery In: Hosseini, Makhlouf M, Hamdy AS, editors. Industrial Applications for Intelligent Polymers and Coatings.. Springer; 2016:1–26.
   Google Scholar
• Abdelhamid HN, Khan MS, Wu H-F. Graphene oxide as a nanocarrier for gramicidin (GOGD) for high antibacterial performance. RSC Adv. 2014;4(91):50035–50046. doi:10.1039/C4RA07250B
   Web of Science ®Google Scholar
• Sun X, Liu Z, Welsher K, et al. Nano-graphene oxide for cellular imaging and drug delivery. Nano Res. 2008;1(3):203–212. doi:10.1007/s12274-008-8021-820216934
   PubMed Web of Science ®Google Scholar
• Goenka S, Sant V, Sant S. Graphene-based nanomaterials for drug delivery and tissue engineering. J Controlled Release. 2014;173:75–88. doi:10.1016/j.jconrel.2013.10.017
   PubMed Web of Science ®Google Scholar
• Lu CH, Yang HH, Zhu CL, Chen X, Chen GN. A graphene platform for sensing biomolecules. Angewandte Chemie. 2009;121(26):4879–4881. doi:10.1002/ange.200901479
   Google Scholar
• Ahmadi S, Rabiee N, Bagherzadeh M, et al. Stimulus-responsive sequential release systems for drug and gene delivery. Nano Today. 2020;34:100914. doi:10.1016/j.nantod.2020.10091432788923
   PubMed Web of Science ®Google Scholar
• Robinson JT, Tabakman SM, Liang Y, et al. Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J Am Chem Soc. 2011;133(17):6825–6831. doi:10.1021/ja201017521476500
   PubMed Web of Science ®Google Scholar
• Yang K, Wan J, Zhang S, Tian B, Zhang Y, Liu Z. The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power. Biomaterials. 2012;33(7):2206–2214. doi:10.1016/j.biomaterials.2011.11.06422169821
   PubMed Web of Science ®Google Scholar
• Wang A, Long L, Zhao W, et al. Increased optical nonlinearities of graphene nanohybrids covalently functionalized by axially-coordinated porphyrins. Carbon. 2013;53:327–338. doi:10.1016/j.carbon.2012.11.019
   Web of Science ®Google Scholar
• Chen Y-W, Chen P-J, Hu S-H, Chen IW, S-Y C. NIR-triggered synergic photo-chemothermal therapy delivered by reduced graphene oxide/carbon/mesoporous silica nanocookies. Adv Funct Mater. 2014;24(4):451–459.
   Web of Science ®Google Scholar
• Tang Y, Hu H, Zhang MG, et al. An aptamer-targeting photoresponsive drug delivery system using “off-on” graphene oxide wrapped mesoporous silica nanoparticles. Nanoscale. 2015;7(14):6304–6310. doi:10.1039/C4NR07493A25782595
   PubMed Web of Science ®Google Scholar
• Yang K, Feng L, Liu Z. Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy. Adv Drug Deliv Rev. 2016;105(Part):B:228–241. doi:10.1016/j.addr.2016.05.015
   PubMedGoogle Scholar
• Yang Y, Zhang YM, Chen Y, Zhao D, Chen JT, Liu Y. Construction of a graphene oxide based noncovalent multiple nanosupramolecular assembly as a scaffold for drug delivery. Chem Eur J. 2012;18(14):4208–4215. doi:10.1002/chem.20110344522374621
   PubMed Web of Science ®Google Scholar
• Wu J, Y-S W, X-Y Y, et al. Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology. 2012;23(35):355101. doi:10.1088/0957-4484/23/35/35510122875697
   PubMed Web of Science ®Google Scholar
• Fan X, Jiao G, Gao L, Jin P, Li X. The preparation and drug delivery of a graphene–carbon nanotube–Fe 3 O 4 nanoparticle hybrid. J Mater Chem B. 2013;1(20):2658–2664. doi:10.1039/c3tb00493g32260953
   PubMed Web of Science ®Google Scholar
• Zhang L, Lu Z, Zhao Q, Huang J, Shen H, Zhang Z. Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI‐grafted graphene oxide. Small. 2011;7(4):460–464. doi:10.1002/smll.20100152221360803
   PubMed Web of Science ®Google Scholar
• Shen H, Liu M, He H, et al. PEGylated graphene oxide-mediated protein delivery for cell function regulation. ACS Appl Mater Interfaces. 2012;4(11):6317–6323. doi:10.1021/am301936723106794
   PubMed Web of Science ®Google Scholar
• La WG, Park S, Yoon HH, et al. Delivery of a therapeutic protein for bone regeneration from a substrate coated with graphene oxide. Small. 2013;9(23):4051–4060. doi:10.1002/smll.20130057123839958
   PubMed Web of Science ®Google Scholar
• Zhang L, Xia J, Zhao Q, Liu L, Zhang Z. Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small. 2010;6(4):537–544. doi:10.1002/smll.20090168020033930
   PubMed Web of Science ®Google Scholar
• Öztürk-Atar K, Eroğlu H, Çalış S. Novel advances in targeted drug delivery. J Drug Target. 2018;26(8):633–642. doi:10.1080/1061186X.2017.140107629096554
   PubMed Web of Science ®Google Scholar
• Zhang M, Wu F, Wang W, Shen J, Zhou N, Wu C. Multifunctional nanocomposites for targeted, photothermal, and chemotherapy. Chemi Mater. 2019;31(6):1847–1859. doi:10.1021/acs.chemmater.8b00934
   Web of Science ®Google Scholar
• De S, Patra K, Ghosh D, et al. Tailoring the efficacy of multifunctional biopolymeric graphene oxide quantum dot-based nanomaterial as nanocargo in cancer therapeutic application. ACS Biomater Sci Eng. 2018;4(2):514–531.33418741
   PubMed Web of Science ®Google Scholar
• Li D, Deng M, Yu Z, et al. Biocompatible and stable GO-coated Fe3O4 nanocomposite: a robust drug delivery carrier for simultaneous tumor MR imaging and targeted therapy. ACS Biomater Sci Eng. 2018;4(6):2143–2154. doi:10.1021/acsbiomaterials.8b0002933435038
   PubMed Web of Science ®Google Scholar
• Chowdhury AD, Ganganboina AB, Y-C T, H-C C, R-A D. Multifunctional GQDs-Concanavalin A@ Fe3O4 nanocomposites for cancer cells detection and targeted drug delivery. Anal Chim Acta. 2018;1027:109–120. doi:10.1016/j.aca.2018.04.02929866260
   PubMed Web of Science ®Google Scholar
• Hussien NA, Işıklan N, Türk M. Aptamer-functionalized magnetic graphene oxide nanocarrier for targeted drug delivery of paclitaxel. Mater Chem Phys. 2018;211:479–488. doi:10.1016/j.matchemphys.2018.03.015
   Web of Science ®Google Scholar
• Gong P, Ji S, Wang J, et al. Fluorescence-switchable ultrasmall fluorinated graphene oxide with high near-infrared absorption for controlled and targeted drug delivery. Chem Eng J. 2018;348:438–446. doi:10.1016/j.cej.2018.04.193
   Web of Science ®Google Scholar
• Ratajczak K, Stobiecka M. Ternary interactions and energy transfer between fluorescein isothiocyanate, adenosine triphosphate, and graphene oxide nanocarriers. J Phys Chem B. 2017;121(28):6822–6830. doi:10.1021/acs.jpcb.7b0429528650635
   PubMed Web of Science ®Google Scholar
• Itatahine A, Mehdi YA, Fizir M, Qi M, Dramou P, He H. Multifunctional carbon nanomateriels for camptothecine low-water soluble anticancer drug delivery. N J Chem. 2018;42(2):1326–1336. doi:10.1039/C7NJ04609J
   Web of Science ®Google Scholar
• Deb A, Andrews NG, Raghavan V. Natural polymer functionalized graphene oxide for co-delivery of anticancer drugs: in-vitro and in-vivo. Int J Biol Macromol. 2018;113:515–525. doi:10.1016/j.ijbiomac.2018.02.15329496437
   PubMed Web of Science ®Google Scholar
• Zare-Zardini H, Taheri-Kafrani A, Amiri A, Bordbar AK. New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity. Sci Rep. 2018;8(1):1–15. doi:10.1038/s41598-017-18938-y29311619
   PubMedGoogle Scholar
• Javanbakht S, Namazi H. Doxorubicin loaded carboxymethyl cellulose/graphene quantum dot nanocomposite hydrogel films as a potential anticancer drug delivery system. Mater Sci Eng C. 2018;87:50–59. doi:10.1016/j.msec.2018.02.010
   PubMed Web of Science ®Google Scholar
• Li Y, Gao X, Yu Z, et al. Reversing multidrug resistance by multiplexed gene silencing for enhanced breast cancer chemotherapy. ACS Appl Mater Interfaces. 2018;10(18):15461–15466. doi:10.1021/acsami.8b0280029663807
   PubMed Web of Science ®Google Scholar
• Xie M, Zhang F, Liu L, et al. Surface modification of graphene oxide nanosheets by protamine sulfate/sodium alginate for anti-cancer drug delivery application. Appl Surf Sci. 2018;440:853–860. doi:10.1016/j.apsusc.2018.01.175
   Web of Science ®Google Scholar
• Puvirajesinghe TM, Zhi Z, Craster R, Guenneau S. Tailoring drug release rates in hydrogel-based therapeutic delivery applications using graphene oxide. J R Soc Interface. 2018;15(139):20170949. doi:10.1098/rsif.2017.094929445040
   PubMed Web of Science ®Google Scholar
• Rao Z, Ge H, Liu L, et al. Carboxymethyl cellulose modified graphene oxide as pH-sensitive drug delivery system. Int J Biol Macromol. 2018;107:1184–1192. doi:10.1016/j.ijbiomac.2017.09.09628951302
   PubMed Web of Science ®Google Scholar
• Deb A, Vimala R. Camptothecin loaded graphene oxide nanoparticle functionalized with polyethylene glycol and folic acid for anticancer drug delivery. J Drug Deliv Sci Technol. 2018;43(October2017):333–342. doi:10.1016/j.jddst.2017.10.025
   Google Scholar
• de Sousa M, Visani de Luna LA, Fonseca LC, Giorgio S, Alves OL. Folic-acid-functionalized graphene oxide nanocarrier: synthetic approaches, characterization, drug delivery study, and antitumor screening. ACS Appl Nano Mater. 2018;1(2):922–932. doi:10.1021/acsanm.7b00324
   Web of Science ®Google Scholar
• Karimi M, Eslami M, Sahandi‐Zangabad P, et al. pH‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016;8(5):696–716.26762467
   PubMed Web of Science ®Google Scholar
• Roointan A, Farzanfar J, Mohammadi-Samani S, Behzad-Behbahani A, Farjadian F. Smart pH responsive drug delivery system based on poly (HEMA-co-DMAEMA) nanohydrogel. Int J Pharm. 2018;552(1–2):301–311. doi:10.1016/j.ijpharm.2018.10.00130291961
   PubMedGoogle Scholar
• Mozafari N, Farjadian F, Samani SM, Azadi S, Azadi A. Simvastatin-chitosan-citicoline conjugates nanoparticles as the co-delivery system in Alzheimer susceptible patients. Int J Biol Macromol. 2020;156:1396–1407. doi:10.1016/j.ijbiomac.2019.11.18031760027
   PubMed Web of Science ®Google Scholar
• Kavitha T, Abdi SIH, Park S-Y. pH-sensitive nanocargo based on smart polymer functionalized graphene oxide for site-specific drug delivery. Phys Chem Chem Phys. 2013;15(14):5176–5185. doi:10.1039/c3cp00008g23454895
   PubMed Web of Science ®Google Scholar
• Wang C, Chen B, Zou M, Cheng G. Cyclic RGD-modified chitosan/graphene oxide polymers for drug delivery and cellular imaging. Colloids Surf B Biointerfaces. 2014;122:332–340. doi:10.1016/j.colsurfb.2014.07.01825064484
   PubMed Web of Science ®Google Scholar
• Feng L, Li K, Shi X, Gao M, Liu J, Liu Z. Smart pH‐responsive nanocarriers based on nano‐graphene oxide for combined chemo‐and photothermal therapy overcoming drug resistance. Adv Healthcare Mater. 2014;3(8):1261–1271. doi:10.1002/adhm.201300549
   Web of Science ®Google Scholar
• Jiang T, Sun W, Zhu Q, et al. Furin‐mediated sequential delivery of anticancer cytokine and small‐molecule drug shuttled by graphene. Adv Mater. 2015;27(6):1021–1028. doi:10.1002/adma.20140449825504623
   PubMed Web of Science ®Google Scholar
• Lv O, Tao Y, Qin Y, et al. Highly fluorescent and morphology-controllable graphene quantum dots-chitosan hybrid xerogels for in vivo imaging and pH-sensitive drug carrier. Mater Sci Eng C. 2016;67:478–485. doi:10.1016/j.msec.2016.05.031
   PubMed Web of Science ®Google Scholar
• Qiu J, Zhang R, Li J, et al. Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems. Int J Nanomedicine. 2015;10:6709.26604747
   PubMed Web of Science ®Google Scholar
• Huang Y-S, Lu Y-J, Chen J-P. Magnetic graphene oxide as a carrier for targeted delivery of chemotherapy drugs in cancer therapy. J Magn Magn Mater. 2016.
   Web of Science ®Google Scholar
• Tyagi N, Attia NF, Geckeler KE. Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity. J Colloid Interface Sci. 2017;498:364–377. doi:10.1016/j.jcis.2017.03.05728343134
   PubMed Web of Science ®Google Scholar
• Javanbakht S, Shaabani A. Encapsulation of graphene quantum dot-crosslinked chitosan by carboxymethylcellulose hydrogel beads as a pH-responsive bio-nanocomposite for the oral delivery agent. Int J Biol Macromol. 2019;123:389–397. doi:10.1016/j.ijbiomac.2018.11.11830445077
   PubMed Web of Science ®Google Scholar
• Dong J, Wang K, Sun L, et al. Application of graphene quantum dots for simultaneous fluorescence imaging and tumor-targeted drug delivery. Sens Actuators B Chem. 2018;256:616–623. doi:10.1016/j.snb.2017.09.200
   Web of Science ®Google Scholar
• Sumathra M, Sadasivuni KK, Kumar SS, Rajan M. Cisplatin-Loaded graphene oxide/chitosan/hydroxyapatite composite as a promising tool for osteosarcoma-affected bone regeneration. ACS Omega. 2018;3(11):14620–14633. doi:10.1021/acsomega.8b0209030555982
   PubMed Web of Science ®Google Scholar
• Vinothini K, Rajendran NK, Rajan M, Ramu A, Marraiki N, Elgorban AM. A magnetic nanoparticle functionalized reduced graphene oxide-based drug carrier system for a chemo-photodynamic cancer therapy. N J Chem. 2020;44(14):5265–5277. doi:10.1039/D0NJ00049C
   Web of Science ®Google Scholar
• Vinothini K, Rajendran NK, Ramu A, Elumalai N, Rajan M. Folate receptor targeted delivery of paclitaxel to breast cancer cells via folic acid conjugated graphene oxide grafted methyl acrylate nanocarrier. Biomedicine Pharmacother. 2019;110:906–917. doi:10.1016/j.biopha.2018.12.008
   PubMed Web of Science ®Google Scholar
• Vinothini K, Rajendran NK, Munusamy MA, Alarfaj AA, Rajan M. Development of biotin molecule targeted cancer cell drug delivery of doxorubicin loaded κ-carrageenan grafted graphene oxide nanocarrier. Mater Sci Eng C. 2019;100:676–687. doi:10.1016/j.msec.2019.03.011
   PubMed Web of Science ®Google Scholar
• Prabakaran S, Jeyaraj M, Nagaraj A, Sadasivuni KK, Rajan M. Polymethyl methacrylate–ovalbumin@ graphene oxide drug carrier system for high anti-proliferative cancer drug delivery. Applied Nanosci. 2019;9(7):1487–1500. doi:10.1007/s13204-019-00950-5
   Web of Science ®Google Scholar
• Luo Y, Tang Y, Liu T, et al. Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics. Chem Commun. 2019;55(13):1963–1966. doi:10.1039/C8CC09185D
   PubMed Web of Science ®Google Scholar
• Kazempour M, Namazi H, Akbarzadeh A, Kabiri R. Synthesis and characterization of PEG-functionalized graphene oxide as an effective pH-sensitive drug carrier. Artif Cells Nanomed Biotechnol. 2019;47(1):90–94. doi:10.1080/21691401.2018.154319630663418
   PubMed Web of Science ®Google Scholar
• Kundu A, Nandi S, Das P, Nandi AK. Fluorescent graphene oxide via polymer grafting: an efficient nanocarrier for both hydrophilic and hydrophobic drugs. ACS Appl Mater Interfaces. 2015;7(6):3512–3523. doi:10.1021/am507110r25612470
   PubMed Web of Science ®Google Scholar
• Onuki Y, Bhardwaj U, Papadimitrakopoulos F, Burgess DJ. A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response. SAGE Publications; 2008.
   Google Scholar
• Romberg B, Hennink WE, Storm G. Sheddable coatings for long-circulating nanoparticles. Pharm Res. 2008;25(1):55–71. doi:10.1007/s11095-007-9348-717551809
   PubMed Web of Science ®Google Scholar
• Meng F, Hennink WE, Zhong Z. Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials. 2009;30(12):2180–2198. doi:10.1016/j.biomaterials.2009.01.02619200596
   PubMed Web of Science ®Google Scholar
• Wen H, Dong C, Dong H, et al. Engineered redox‐responsive PEG detachment mechanism in PEGylated nano‐graphene oxide for intracellular drug delivery. Small. 2012;8(5):760–769. doi:10.1002/smll.20110161322228696
   PubMed Web of Science ®Google Scholar
• Chen H, Wang Z, Zong S, et al. SERS-fluorescence monitored drug release of a redox-responsive nanocarrier based on graphene oxide in tumor cells. ACS Appl Mater Interfaces. 2014;6(20):17526–17533. doi:10.1021/am505160v25272041
   PubMed Web of Science ®Google Scholar
• Zhao X, Yang L, Li X, et al. Functionalized graphene oxide nanoparticles for cancer cell-specific delivery of antitumor drug. Bioconjug Chem. 2015;26(1):128–136. doi:10.1021/bc500513725525819
   PubMed Web of Science ®Google Scholar
• Al-Nahain A, Lee SY, In I, Lee KD, Park SY. Triggered pH/redox responsive release of doxorubicin from prepared highly stable graphene with thiol grafted pluronic. Int J Pharm. 2013;450(1):208–217. doi:10.1016/j.ijpharm.2013.04.05323624082
   PubMedGoogle Scholar
• Cho Y, Choi Y. Graphene oxide–photosensitizer conjugate as a redox-responsive theranostic agent. Chem Commun. 2012;48(79):9912–9914. doi:10.1039/c2cc35197h
   PubMed Web of Science ®Google Scholar
• Yin T, Liu J, Zhao Z, et al. Redox sensitive hyaluronic acid-decorated graphene oxide for photothermally controlled tumor-cytoplasm-selective rapid drug delivery. Adv Funct Mater. 2017;27(14):1604620. doi:10.1002/adfm.201604620
   Web of Science ®Google Scholar
• Kim DJ, Kim J, Lee HL, et al. Redox-responsive nanocomposites composed of graphene oxide and chlorin e6 for photodynamic treatment of cholangiocarcinoma. Bull Korean Chem Soc. 2018;39(9):1073–1082. doi:10.1002/bkcs.11552
   Web of Science ®Google Scholar
• Liu J, Zhang D, Lian S, et al. Redox-responsive hyaluronic acid-functionalized graphene oxide nanosheets for targeted delivery of water-insoluble cancer drugs. Int J Nanomedicine. 2018;13:7457. doi:10.2147/IJN.S17388930532533
   PubMed Web of Science ®Google Scholar
• Ma N, Song A, Li Z, Luan Y. Redox-sensitive prodrug molecules meet graphene oxide: an efficient graphene oxide-based nanovehicle toward cancer therapy. ACS Biomater Sci Eng. 2019;5(3):1384–1391. doi:10.1021/acsbiomaterials.9b0011433405614
   PubMed Web of Science ®Google Scholar
• Farjadian F, Rezaeifard S, Naeimi M, et al. Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam). Int J Nanomedicine. 2019;14:6901. doi:10.2147/IJN.S21446731564860
   PubMed Web of Science ®Google Scholar
• Farjadian F, Ghasemi S, Andami Z, Tamami B. Thermo-responsive nanocarrier based on poly (N-isopropylacrylamide) serving as a smart doxorubicin delivery system. Iranian Polymer J. 2020;29(3):197–207. doi:10.1007/s13726-020-00785-w
   Web of Science ®Google Scholar
• Zhu S, Li J, Chen Y, et al. Grafting of graphene oxide with stimuli-responsive polymers by using ATRP for drug release. J Nanoparticle Res. 2012;14(9):1–11. doi:10.1007/s11051-012-1132-x
   PubMed Web of Science ®Google Scholar
• Wang H, Sun D, Zhao N, et al. Thermo-sensitive graphene oxide–polymer nanoparticle hybrids: synthesis, characterization, biocompatibility and drug delivery. J Mater Chem B. 2014;2(10):1362–1370.32261451
   PubMed Web of Science ®Google Scholar
• Pan Y, Bao H, Sahoo NG, Wu T, Water‐Soluble Poly LL. (N‐isopropylacrylamide)–graphene sheets synthesized via click chemistry for drug delivery. Adv Funct Mater. 2011;21(14):2754–2763. doi:10.1002/adfm.201100078
   Web of Science ®Google Scholar
• Bardajee GR, Hooshyar Z, Farsi M, Mobini A, Sang G. Synthesis of a novel thermo/pH sensitive nanogel based on salep modified graphene oxide for drug release. Mater Sci Eng C. 2016.
   PubMedGoogle Scholar
• Wang C, Mallela J, Garapati USet al., A chitosan-modified graphene nanogel for noninvasive controlled drug release. Nanomedicine. 2013;9(7):903–911. doi:10.1016/j.nano.2013.01.00323352802
   PubMed Web of Science ®Google Scholar
• Wang P, Chen S, Cao Z, Wang G, Light- NIR. Temperature-, pH-, and redox-responsive polymer-modified reduced graphene oxide/mesoporous silica sandwich-like nanocomposites for controlled release. ACS Appl Mater Interfaces. 2017;9(34):29055–29062. doi:10.1021/acsami.7b0746828795557
   PubMed Web of Science ®Google Scholar
• Khoee S, Karimi MR. Dual-drug loaded Janus graphene oxide-based thermoresponsive nanoparticles for targeted therapy. Polymer. 2018;142:80–98. doi:10.1016/j.polymer.2018.03.022
   Web of Science ®Google Scholar
• Havanur S, Batish I, Cheruku SP, Gourishetti K, Kumar PEJ. N. Poly(N,N-diethyl acrylamide)/functionalized graphene quantum dots hydrogels loaded with doxorubicin as a nano-drug carrier for metastatic lung cancer in mice. Mater Sci Eng C. 2019;105:110094. doi:10.1016/j.msec.2019.110094
   PubMed Web of Science ®Google Scholar
• Farjadian F, Ghasemi S, Mohammadi-Samani S. Hydroxyl-modified magnetite nanoparticles as novel carrier for delivery of methotrexate. Int J Pharm. 2016;504(1–2):110–116. doi:10.1016/j.ijpharm.2016.03.02226994523
   PubMedGoogle Scholar
• Yang X, Wang Y, Huang X, et al. Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity. J Mater Chem. 2011;21(10):3448–3454. doi:10.1039/C0JM02494E
   Web of Science ®Google Scholar
• Wang Z, Zhou C, Xia J, et al. Fabrication and characterization of a triple functionalization of graphene oxide with Fe 3 O 4, folic acid and doxorubicin as dual-targeted drug nanocarrier. Colloids Surf B Biointerfaces. 2013;106:60–65. doi:10.1016/j.colsurfb.2013.01.03223434692
   PubMed Web of Science ®Google Scholar
• Swain AK, Pradhan L, Bahadur D. Polymer stabilized Fe3O4-graphene as an amphiphilic drug carrier for thermo-chemotherapy of cancer. ACS Appl Mater Interfaces. 2015;7(15):8013–8022. doi:10.1021/acsami.5b0253625821899
   PubMed Web of Science ®Google Scholar
• Ma X, Tao H, Yang K, et al. A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging. Nano Res. 2012;5(3):199–212. doi:10.1007/s12274-012-0200-y
   Web of Science ®Google Scholar
• Wang C, Ravi S, Garapati USet al., Multifunctional chitosan magnetic-graphene (CMG) nanoparticles: a theranostic platform for tumor-targeted co-delivery of drugs, genes and MRI contrast agents. J Mater Chem B. 2013;1(35):4396–4405. doi:10.1039/c3tb20452a24883188
   PubMed Web of Science ®Google Scholar
• Guo L, Shi H, Wu H, et al. Prostate cancer targeted multifunctionalized graphene oxide for magnetic resonance imaging and drug delivery. Carbon. 2016;107:87–99. doi:10.1016/j.carbon.2016.05.054
   Web of Science ®Google Scholar
• Wang C, Li B, Niu W, et al. β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs. RSC Adv. 2015;5(108):89299–89308. doi:10.1039/C5RA13082D
   Web of Science ®Google Scholar
• Xie M, Zhang F, Peng H, et al. Layer-by-layer modification of magnetic graphene oxide by chitosan and sodium alginate with enhanced dispersibility for targeted drug delivery and photothermal therapy. Colloids Surf B Biointerfaces. 2019;176:462–470. doi:10.1016/j.colsurfb.2019.01.02830682619
   PubMed Web of Science ®Google Scholar
• Bardajee GR, Hooshyar Z. Thermo/pH/magnetic-triple sensitive poly(N-isopropylacrylamide-co-2-dimethylaminoethyl) methacrylate)/sodium alginate modified magnetic graphene oxide nanogel for anticancer drug delivery. Polymer Bull. 2018;75(12):5403–5419. doi:10.1007/s00289-018-2329-7
   Web of Science ®Google Scholar
• Shirvalilou S, Khoei S, Khoee S, Raoufi NJ, Karimi MR, Shakeri-Zadeh A. Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: in vitro and in vivo evaluations. Chem Biol Interact. 2018;295:97–108. doi:10.1016/j.cbi.2018.08.02730170108
   PubMed Web of Science ®Google Scholar
• Gupta J, Prakash A, Jaiswal MK, Agarrwal A, Bahadur D. Superparamagnetic iron oxide-reduced graphene oxide nanohybrid-a vehicle for targeted drug delivery and hyperthermia treatment of cancer. J Magn Magn Mater. 2018;448:332–338. doi:10.1016/j.jmmm.2017.05.084
   Web of Science ®Google Scholar
• Bao Z, Liu X, Liu Y, Liu H, Zhao K. Near-infrared light-responsive inorganic nanomaterials for photothermal therapy. Asian J Pharm Sci. 2016;11(3):349–364. doi:10.1016/j.ajps.2015.11.123
   Web of Science ®Google Scholar
• Tian B, Wang C, Zhang S, Feng L, Liu Z. Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. ACS Nano. 2011;5(9):7000–7009. doi:10.1021/nn201560b21815655
   PubMed Web of Science ®Google Scholar
• Zhou L, Jiang H, Wei S, Ge X, Zhou J, Shen J. High-efficiency loading of hypocrellin B on graphene oxide for photodynamic therapy. Carbon. 2012;50(15):5594–5604. doi:10.1016/j.carbon.2012.08.013
   Web of Science ®Google Scholar
• Wang Y, Wang H, Liu D, Song S, Wang X, Zhang H. Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy. Biomaterials. 2013;34(31):7715–7724. doi:10.1016/j.biomaterials.2013.06.04523859660
   PubMed Web of Science ®Google Scholar
• Tran TH, Nguyen HT, Pham TT, et al. Development of a graphene oxide nanocarrier for dual-drug chemo-phototherapy to overcome drug resistance in cancer. ACS Appl Mater Interfaces. 2015;7(51):28647–28655. doi:10.1021/acsami.5b1042626641922
   PubMed Web of Science ®Google Scholar
• Shi J, Wang L, Zhang J, et al. A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@ Ag nanoparticles for chemo-photothermal therapy and X-ray imaging. Biomaterials. 2014;35(22):5847–5861. doi:10.1016/j.biomaterials.2014.03.04224746963
   PubMed Web of Science ®Google Scholar
• Chen J, Liu H, Zhao C, et al. One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery. Biomaterials. 2014;35(18):4986–4995. doi:10.1016/j.biomaterials.2014.02.03224656608
   PubMed Web of Science ®Google Scholar
• Song J, Yang X, Jacobson O, et al. Sequential drug release and enhanced photothermal and photoacoustic effect of hybrid reduced graphene oxide-loaded ultrasmall gold nanorod vesicles for cancer therapy. ACS Nano. 2015;9(9):9199–9209. doi:10.1021/acsnano.5b0380426308265
   PubMed Web of Science ®Google Scholar
• Chen L, Zhong X, Yi X, et al. Radionuclide 131 I labeled reduced graphene oxide for nuclear imaging guided combined radio-and photothermal therapy of cancer. Biomaterials. 2015;66:21–28. doi:10.1016/j.biomaterials.2015.06.04326188609
   PubMed Web of Science ®Google Scholar
• Feng L, Yang X, Shi X, et al. Polyethylene glycol and polyethylenimine dual‐functionalized nano‐graphene oxide for photothermally enhanced gene delivery. Small. 2013;9(11):1989–1997. doi:10.1002/smll.20120253823292791
   PubMed Web of Science ®Google Scholar
• Liu W, Zhang X, Zhou L, Shang L, Su Z. Reduced graphene oxide (rGO) hybridized hydrogel as a near-infrared (NIR)/pH dual-responsive platform for combined chemo-photothermal therapy. J Colloid Interface Sci. 2019;536:160–170. doi:10.1016/j.jcis.2018.10.05030366181
   PubMed Web of Science ®Google Scholar
• Huang C, Hu X, Hou Z, Ji J, Li Z, Luan Y. Tailored graphene oxide-doxorubicin nanovehicles via near-infrared dye-lactobionic acid conjugates for chemo-photothermal therapy. J Colloid Interface Sci. 2019;545:172–183. doi:10.1016/j.jcis.2019.03.01930878783
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang H, Wang Z, Jin Y. pH-Sensitive graphene oxide conjugate purpurin-18 methyl ester photosensitizer nanocomplex in photodynamic therapy. N J Chem. 2018;42(16):13272–13284. doi:10.1039/C8NJ00439K
   Web of Science ®Google Scholar
• Du B, Liu J, Ding Get al., Positively charged graphene/Fe3O4/polyethylenimine with enhanced drug loading and cellular uptake for magnetic resonance imaging and magnet-responsive cancer therapy. Nano Res. 2017;10(7):2280–2295. doi:10.1007/s12274-016-1418-x
   Web of Science ®Google Scholar
• Chang G, Li S, Huang F, Zhang X, Shen Y, Xie A. Multifunctional reduced graphene oxide hydrogel as drug carrier for localized and synergic photothermal/photodynamics/chemo therapy. J Mater Sci Technol. 2016;32(8):753–762. doi:10.1016/j.jmst.2016.06.014
   Web of Science ®Google Scholar
• Sahu A, Choi WI, Lee JH, Tae G. Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy. Biomaterials. 2013;34(26):6239–6248. doi:10.1016/j.biomaterials.2013.04.06623706688
   PubMed Web of Science ®Google Scholar
• Wei Y, Zhou F, Zhang D, Chen Q, Xing D. A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy. Nanoscale. 2016;8(6):3530–3538. doi:10.1039/C5NR07785K26799192
   PubMed Web of Science ®Google Scholar
• Li Y, Wu Z, Du D, Dong H, Shi D, Li Y. A graphene quantum dot (GQD) nanosystem with redox-triggered cleavable PEG shell facilitating selective activation of the photosensitiser for photodynamic therapy. RSC Adv. 2016;6(8):6516–6522. doi:10.1039/C5RA23622C
   Web of Science ®Google Scholar
• Lee JS, Kim S, Na HK, Min DH. MicroRNA‐responsive drug release system for selective fluorescence imaging and photodynamic therapy in vivo. Adv Healthcare Mater. 2016;5(18):2386–2395. doi:10.1002/adhm.201600328
   Web of Science ®Google Scholar
• Su T, Cheng F, Yan J, et al. Hierarchical nanocomposites of graphene oxide and PEGylated protoporphyrin as carriers to load doxorubicin hydrochloride for trimodal synergistic therapy. J Mater Chem B. 2018;6(28):4687–4696. doi:10.1039/C8TB00733K32254413
   PubMed Web of Science ®Google Scholar
• Ju J, Regmi S, Fu A, Lim S, Liu Q. Graphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapy. J Biophoton. 2019;12(6):e201800367. doi:10.1002/jbio.201800367
   PubMed Web of Science ®Google Scholar
• Pack DW, Hoffman AS, Pun S, Stayton PS. Design and development of polymers for gene delivery. Nat Rev Drug Discov. 2005;4(7):581. doi:10.1038/nrd177516052241
   PubMed Web of Science ®Google Scholar
• Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev. 2003;55(3):329–347. doi:10.1016/S0169-409X(02)00228-412628320
   PubMed Web of Science ®Google Scholar
• Xiang Y, Oo NNL, Lee JP, Li Z, Loh XJ. Recent development of synthetic nonviral systems for sustained gene delivery. Drug Discov Today. 2017;22(9):1318–1335. doi:10.1016/j.drudis.2017.04.00128428056
   PubMed Web of Science ®Google Scholar
• Midoux P, Pichon C, Yaouanc JJ, Jaffrès PA. Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol. 2009;157(2):166–178. doi:10.1111/j.1476-5381.2009.00288.x19459843
   PubMed Web of Science ®Google Scholar
• Farjadian F, Moghoofei M, Mirkiani S, et al. Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: set the bugs to work? Biotechnol Adv. 2018;36(4):968–985. doi:10.1016/j.biotechadv.2018.02.01629499341
   PubMed Web of Science ®Google Scholar
• Wong JK, Mohseni R, Hamidieh AA, MacLaren RE, Habib N, Seifalian AM. Will nanotechnology bring new hope for gene delivery? Trends Biotechnol. 2017;35(5):434–451. doi:10.1016/j.tibtech.2016.12.00928108036
   PubMed Web of Science ®Google Scholar
• Karimi M, Solati N, Ghasemi A, et al. Carbon nanotubes part II: a remarkable carrier for drug and gene delivery. Expert Opin Drug Deliv. 2015;12(7):1089–1105. doi:10.1517/17425247.2015.100430925613837
   PubMed Web of Science ®Google Scholar
• Chandrasekhar P. Medical and pharmaceutical applications of graphene In: Dalton, editor. Conducting Polymers, Fundamentals and Applications. Springer; 2018:149–150.
   Google Scholar
• Zhi F, Dong H, Jia X, et al. Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS One. 2013;8(3):e60034. doi:10.1371/journal.pone.006003423527297
   PubMed Web of Science ®Google Scholar
• Goncalves G, Marques P, Vila M. Graphene-Based Materials in Health and Environment. Springer; 2017.
   Google Scholar
• Jian H-J, Wu R-S, Lin T-Y, et al. Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis. ACS Nano. 2017;11(7):6703–6716. doi:10.1021/acsnano.7b0102328677399
   PubMed Web of Science ®Google Scholar
• Lam P-L, Wong W-Y, Bian Z, Chui C-H GR. Recent advances in green nanoparticulate systems for drug delivery: efficient delivery and safety concern. Nanomedicine. 2017;12(4):357–385. doi:10.2217/nnm-2016-030528078952
   PubMed Web of Science ®Google Scholar
• Teimouri M, Nia AH, Abnous K, Eshghi H, Ramezani M. Graphene oxide–cationic polymer conjugates: synthesis and application as gene delivery vectors. Plasmid. 2016;84:51–60. doi:10.1016/j.plasmid.2016.03.00227072918
   PubMed Web of Science ®Google Scholar
• Zhou X, Laroche F, Lamers GE, et al. Ultra-small graphene oxide functionalized with polyethylenimine (PEI) for very efficient gene delivery in cell and zebrafish embryos. Nano Res. 2012;5(10):703–709. doi:10.1007/s12274-012-0254-x
   Web of Science ®Google Scholar
• Hu H, Tang C, Yin C. Folate conjugated trimethyl chitosan/graphene oxide nanocomplexes as potential carriers for drug and gene delivery. Mater Lett. 2014;125:82–85. doi:10.1016/j.matlet.2014.03.133
   Web of Science ®Google Scholar
• Zhu X, Zhang Y, Huang H, Zhang H, Hou L, Zhang Z. Functionalized graphene oxide-based thermosensitive hydrogel for near-infrared chemo-photothermal therapy on tumor. J Biomater Appl. 2016;30(8):1230–1241. doi:10.1177/088532821561958326759390
   PubMed Web of Science ®Google Scholar
• Bao H, Pan Y, Ping Yet al., Chitosan‐functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small. 2011;7(11):1569–1578. doi:10.1002/smll.20110019121538871
   PubMed Web of Science ®Google Scholar
• Liu X, Ma D, Tang H, et al. Polyamidoamine dendrimer and oleic acid-functionalized graphene as biocompatible and efficient gene delivery vectors. ACS Appl Mater Interfaces. 2014;6(11):8173–8183. doi:10.1021/am500812h24836601
   PubMed Web of Science ®Google Scholar
• Kou Z, Wang X, Yuan R, et al. A promising gene delivery system developed from PEGylated MoS 2 nanosheets for gene therapy. Nanoscale Res Lett. 2014;9(1):587. doi:10.1186/1556-276X-9-58725386104
   PubMedGoogle Scholar
• Feng L, Zhang S, Liu Z. Graphene based gene transfection. Nanoscale. 2011;3(3):1252–1257. doi:10.1039/c0nr00680g21270989
   PubMed Web of Science ®Google Scholar
• Cao X, Zheng S, Zhang S, et al. Functionalized graphene oxide with hepatocyte targeting as anti-tumor drug and gene intracellular transporters. J Nanosci Nanotechnol. 2015;15(3):2052–2059. doi:10.1166/jnn.2015.914526413620
   PubMed Web of Science ®Google Scholar
• Fan Z, Fu PP, Yu H, Ray PC. Theranostic nanomedicine for cancer detection and treatment. J Food Drug Anal. 2014;22(1):3–17. doi:10.1016/j.jfda.2014.01.00124673900
   PubMed Web of Science ®Google Scholar
• Fan Z, Senapati D, Singh AK, Ray PC. Theranostic magnetic core-plasmonic shell star shape nanoparticle for the isolation of targeted rare tumor cells from whole blood, fluorescence imaging, and photothermal destruction of cancer. Mol Pharm. 2013;10(3):857–866. doi:10.1021/mp300468q23110457
   PubMedGoogle Scholar
• Li J, Lyv Z, Li Y, et al. A theranostic prodrug delivery system based on Pt (IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug. Biomaterials. 2015;51:12–21. doi:10.1016/j.biomaterials.2015.01.07425770993
   PubMed Web of Science ®Google Scholar
• Gorgizadeh M, Azarpira N, Sattarahmady N. In vitro and in vivo tumor annihilation by near-infrared photothermal effect of a NiFe2O4/C nanocomposite. Colloids Surf B Biointerfaces. 2018;170:393–400.29945051
   PubMed Web of Science ®Google Scholar
• Luo Y, Li Z, Zhu C, et al. Graphene-like metal-free 2D nanosheets for cancer imaging and theranostics. Trends Biotechnol. 2018;36(11):1145–1156. doi:10.1016/j.tibtech.2018.05.01229954613
   PubMed Web of Science ®Google Scholar
• Chen H, Liu F, Lei Z, Ma L, Wang Z. Fe2O3@Au core@shell nanoparticle–graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy. RSC Adv. 2015;5(103):84980–84987. doi:10.1039/C5RA17143A
   Web of Science ®Google Scholar
• Bahreyni A, Yazdian-Robati R, Hashemitabar S, et al. A new chemotherapy agent-free theranostic system composed of graphene oxide nano-complex and aptamers for treatment of cancer cells. Int J Pharm. 2017;526(1–2):391–399. doi:10.1016/j.ijpharm.2017.05.01428495579
   PubMedGoogle Scholar
• Yang K, Hu L, Ma X, et al. Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Adv Mater. 2012;24(14):1868–1872. doi:10.1002/adma.20110496422378564
   PubMed Web of Science ®Google Scholar
• Lamb J, Fischer E, Rosillo-Lopez M, Salzmann CG, Holland JP. Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles. Chem Sci. 2019;10(38):8880–8888. doi:10.1039/C9SC03736E32874485
   PubMed Web of Science ®Google Scholar
• Karki N, Rana A, Tiwari H, Negi P, Sahoo NG. Theranostics application of graphene-based materials in cancer imaging, targeting and treatment In: Lasfar A, Cohen-Solal K, editors. Tumor Progression and Metastasis. IntechOpen; 2020.
   Google Scholar
• Janib SM, Moses AS, MacKay JA. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev. 2010;62(11):1052–1063. doi:10.1016/j.addr.2010.08.00420709124
   PubMed Web of Science ®Google Scholar
• Bao X, Yuan Y, Chen J, et al. In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration. Light. 2018;7(1):1–11. doi:10.1038/s41377-018-0090-1
   Google Scholar
• Pramanik A, Chavva SR, Fan Z, Sinha SS, Nellore BPV, Ray PC. Extremely high two-photon absorbing graphene oxide for imaging of tumor cells in the second biological window. J Phys Chem Lett. 2014;5(12):2150–2154. doi:10.1021/jz500985626270507
   PubMed Web of Science ®Google Scholar
• Yang Y, Wang S, Wang C, Tian C, Shen Y, Zhu M. Engineered targeted hyaluronic acid–glutathione‐stabilized gold nanoclusters/graphene oxide–5‐fluorouracil as a smart theranostic platform for stimulus‐controlled fluorescence imaging‐assisted synergetic chemo/phototherapy. Chem Asian J. 2019;14(9):1418–1423. doi:10.1002/asia.20190015330829452
   PubMed Web of Science ®Google Scholar
• Prasad R, Yadav AS, Gorain M, et al. Graphene oxide supported liposomes as red emissive theranostics for phototriggered tissue visualization and tumor regression. ACS Appl Bio Mater. 2019;2(8):3312–3320. doi:10.1021/acsabm.9b00335
   PubMedGoogle Scholar
• Kumawat MK, Thakur M, Bahadur R, et al. Preparation of graphene oxide-graphene quantum dots hybrid and its application in cancer theranostics. Mater Sci Eng C. 2019;103:109774. doi:10.1016/j.msec.2019.109774
   PubMed Web of Science ®Google Scholar
• Lui CH, Mak KF, Shan J, Heinz TF. Ultrafast photoluminescence from graphene. Phys Rev Lett. 2010;105(12):127404. doi:10.1103/PhysRevLett.105.12740420867672
   PubMed Web of Science ®Google Scholar
• Xu X, Liu C, Sun Z, et al. Interfacial engineering in graphene bandgap. Chem Soc Rev. 2018;47(9):3059–3099.29513306
   PubMed Web of Science ®Google Scholar
• Xiong J, Yang Q, Li J, Zhou S. Effects of MDM2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer. Angiogenesis. 2014;17(1):37–50. doi:10.1007/s10456-013-9376-323907365
   PubMed Web of Science ®Google Scholar
• Khurana R, Simons M, Martin JF, Zachary IC. Role of angiogenesis in cardiovascular disease: a critical appraisal. Circulation. 2005;112(12):1813–1824. doi:10.1161/CIRCULATIONAHA.105.53529416172288
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. nature. 2000;407(6801):249–257. doi:10.1038/3502522011001068
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Sriram P, Barui AK, et al. Graphene oxides show angiogenic properties. Adv Healthcare Mater. 2015;4(11):1722–1732. doi:10.1002/adhm.201500155
   Web of Science ®Google Scholar
• Qian Y, Song J, Zhao X, et al. 3D fabrication with integration molding of a graphene oxide/polycaprolactone nanoscaffold for neurite regeneration and angiogenesis. Advan Sci. 2018;5(4):1700499. doi:10.1002/advs.201700499
   Web of Science ®Google Scholar
• Sun Z, Huang P, Tong G, et al. VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle. Nanoscale. 2013;5(15):6857–6866. doi:10.1039/c3nr01573d23770832
   PubMed Web of Science ®Google Scholar
• Paul A, Hasan A, Kindi HA, et al. Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano. 2014;8(8):8050–8062. doi:10.1021/nn502078724988275
   PubMed Web of Science ®Google Scholar
• Xue D, Chen E, Zhong H, et al. Immunomodulatory properties of graphene oxide for osteogenesis and angiogenesis. Int J Nanomedicine. 2018;13:5799. doi:10.2147/IJN.S17030530310282
   PubMed Web of Science ®Google Scholar
• Ur Rehman SR, Augustine R, Zahid AA, et al. Reduced graphene oxide incorporated GelMA hydrogel promotes angiogenesis for wound healing applications. Int J Nanomedicine. 2019;14(9603):9603–9617. doi:10.2147/IJN.S21812031824154
   PubMedGoogle Scholar
• Shim G, Kim J-Y, Han J, et al. Reduced graphene oxide nanosheets coated with an anti-angiogenic anticancer low-molecular-weight heparin derivative for delivery of anticancer drugs. J Controlled Release. 2014;189:80–89. doi:10.1016/j.jconrel.2014.06.026
   PubMed Web of Science ®Google Scholar
• Lai P-X, Chen C-W, Wei S-C, et al. Ultrastrong trapping of VEGF by graphene oxide: anti-angiogenesis application. Biomaterials. 2016;109:12–22. doi:10.1016/j.biomaterials.2016.09.00527639528
   PubMed Web of Science ®Google Scholar
• Cibecchini G, Veronesi M, Catelani T, Bandiera T, Guarnieri D, Pompa PP. Antiangiogenic effect of graphene oxide in primary human endothelial cells. ACS Appl Mater Interfaces. 2020;12(20):22507–22518.32255338
   PubMed Web of Science ®Google Scholar
• Wierzbicki M, Sawosz E, Strojny B, Jaworski S, Grodzik M, Chwalibog A. NF-κB-related decrease of glioma angiogenic potential by graphite nanoparticles and graphene oxide nanoplatelets. Sci Rep. 2018;8(1):1–9. doi:10.1038/s41598-018-33179-329311619
   PubMedGoogle Scholar
• Li J, Ge X, Cui C, et al. Preparation and characterization of functionalized graphene oxide carrier for siRNA delivery. Int J Mol Sci. 2018;19(10):3202. doi:10.3390/ijms19103202
   PubMed Web of Science ®Google Scholar
• Stone V, Johnston H, Schins RPF. Development of in vitro systems for nanotoxicology: methodological considerations. Crit Rev Toxicol. 2009;39(7):613–626. doi:10.1080/1040844090312097519650720
   PubMed Web of Science ®Google Scholar
• Liu K, Zhang -J-J, Cheng -F-F, Zheng -T-T, Wang C, Zhu -J-J. Green and facile synthesis of highly biocompatible graphene nanosheets and its application for cellular imaging and drug delivery. J Mater Chem. 2011;21(32):12034–12040. doi:10.1039/c1jm10749f
   Web of Science ®Google Scholar
• Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009;1(5):511–529.20049814
   PubMed Web of Science ®Google Scholar
• Dreyer DR, Park S, Bielawski CW, Ruoff RS. The chemistry of graphene oxide. Chem Soc Rev. 2010;39(1):228–240. doi:10.1039/B917103G20023850
   PubMed Web of Science ®Google Scholar
• Muthoosamy K, Abubakar IB, Bai RG, Loh H-S, Manickam S. Exceedingly higher co-loading of curcumin and paclitaxel onto polymer-functionalized reduced graphene oxide for highly potent synergistic anticancer treatment. Sci Rep. 2016;6:32808. doi:10.1038/srep3280827597657
   PubMed Web of Science ®Google Scholar
• Cho YC, Pak PJ, Joo YH, Lee H-S CN. In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127. Sci Rep. 2016;6:38884. doi:10.1038/srep3888427941848
   PubMed Web of Science ®Google Scholar
• Zhao M-L, Liu X-Q, Cao Y, et al. Enhancement of interaction of L-929 cells with functionalized graphene via COOH+ ion implantation vs. chemical method. Sci Rep. 2016;6:37112. doi:10.1038/srep3711227845420
   PubMed Web of Science ®Google Scholar
• Vuppaladadium SSR, Agarwal T, Kulanthaivel S, et al. Silanization improves biocompatibility of graphene oxide. Mater Sci Eng C. 2020;110:110647. doi:10.1016/j.msec.2020.110647
   PubMed Web of Science ®Google Scholar
• Sydlik SA, Jhunjhunwala S, Webber MJ, Anderson DG, Langer R. In vivo compatibility of graphene oxide with differing oxidation states. ACS Nano. 2015;9(4):3866–3874. doi:10.1021/acsnano.5b0129025849074
   PubMed Web of Science ®Google Scholar
• Zhang X, Yin J, Peng C, et al. Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration. carbon. 2011;49(3):986–995. doi:10.1016/j.carbon.2010.11.005
   Web of Science ®Google Scholar
• Nurunnabi M, Khatun Z, Huh KM, et al. In vivo biodistribution and toxicology of carboxylated graphene quantum dots. ACS Nano. 2013;7(8):6858–6867. doi:10.1021/nn402043c23829293
   PubMed Web of Science ®Google Scholar
• Yang K, Zhang S, Zhang G, Sun X, Lee S-T LZ. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2010;10(9):3318–3323. doi:10.1021/nl100996u20684528
   PubMed Web of Science ®Google Scholar
• Reina G, González-Domínguez JM, Criado A, Vázquez E, Bianco A, Prato M. Promises, facts and challenges for graphene in biomedical applications. Chem Soc Rev. 2017;46(15):4400–4416. doi:10.1039/C7CS00363C28722038
   PubMed Web of Science ®Google Scholar
• Bianco A. Graphene: safe or toxic? The two faces of the medal. Angewandte Chemie Int Ed. 2013;52(19):4986–4997. doi:10.1002/anie.201209099
   PubMed Web of Science ®Google Scholar
• Zhang Y, Ali SF, Dervishi E, et al. Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano. 2010;4(6):3181–3186. doi:10.1021/nn100717620481456
   PubMed Web of Science ®Google Scholar