PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers

References

• Garg P, Venuganti VVK, Roy A, Roy G. Novel drug delivery methods for the treatment of keratitis: moving away from surgical intervention. Expert Opin Drug Deliv. 2019;16(12):1381–1391. doi:10.1080/17425247.2019.169045131701781
   PubMed Web of Science ®Google Scholar
• Meng T, Kulkarni V, Simmers R, Brar V, Xu QG. Therapeutic implications of nanomedicine for ocular drug delivery. Drug Discov Today. 2019;24(8):1524–1538. doi:10.1016/j.drudis.2019.05.00631102733
   PubMed Web of Science ®Google Scholar
• Singh RRT, Tekko I, McAvoy K, McMillan H, Jones D, Donnelly RF. Minimally invasive microneedles for ocular drug delivery. Expert Opin Drug Deliv. 2017;14(4):525–537. doi:10.1080/17425247.2016.121846027485251
   PubMed Web of Science ®Google Scholar
• Aksungur P, Demirbilek M, Denkbas EB, Vandervoort J, Ludwig A, Unlu N. Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: cellular toxicity, uptake, and kinetic studies. J Control Release. 2011;151(3):286–294. doi:10.1016/j.jconrel.2011.01.01021241752
   PubMed Web of Science ®Google Scholar
• Vasconcelos A, Vega E, Perez Y, Gomara MJ, Garcia ML, Haro I. Conjugation of cell-penetrating peptides with poly(lactic-co-glycolic acid)-polyethylene glycol nanoparticles improves ocular drug delivery. Int J Nanomedicine. 2015;10:609–631. doi:10.2147/IJN.S7119825670897
   PubMedGoogle Scholar
• Li F, Wen Y, Zhang Y, et al. Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles. Artif Cells Nanomed Biotechnol. 2019;47(1):4097–4108. doi:10.1080/21691401.2019.168356731663388
   PubMed Web of Science ®Google Scholar
• Panyam J, Labhasetwar V. Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res. 2003;20(2):212–220. doi:10.1023/a:102221900355112636159
   PubMed Web of Science ®Google Scholar
• Qaddoumi MG, Ueda H, Yang J, Davda J, Labhasetwar V, Lee VH. The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers. Pharm Res. 2004;21(4):641–648. doi:10.1023/b:pham.0000022411.47059.7615139521
   PubMed Web of Science ®Google Scholar
• Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res. 1996;13(12):1838–1845. doi:10.1023/a:10160851088898987081
   PubMed Web of Science ®Google Scholar
• Tobio M, Sanchez A, Vila A, et al. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf B Biointerfaces. 2000;18(3–4):315–323. doi:10.1016/s0927-7765(99)00157-510915953
   PubMed Web of Science ®Google Scholar
• Vila A, Gill H, McCallion O, Alonso MJ. Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J Control Release. 2004;98(2):231–244. doi:10.1016/j.jconrel.2004.04.02615262415
   PubMed Web of Science ®Google Scholar
• Cabrera FJ, Wang DC, Reddy K, Acharya G, Shin CS. Challenges and opportunities for drug delivery to the posterior of the eye. Drug Discov Today. 2019;24(8):1679–1684. doi:10.1016/j.drudis.2019.05.03531175955
   PubMed Web of Science ®Google Scholar
• Arafa MG, Girgis GNS, El-Dahan MS. Chitosan-coated PLGA nanoparticles for enhanced ocular anti-inflammatory efficacy of atorvastatin calcium. Int J Nanomedicine. 2020;15:1335–1347. doi:10.2147/IJN.S23731432184589
   PubMed Web of Science ®Google Scholar
• Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev. 2005;57(11):1556–1568. doi:10.1016/j.addr.2005.07.00116198441
   PubMed Web of Science ®Google Scholar
• Junga T, Kamm W, Breitenbacha A, Kaiserlingc E, Xiaoc JX, Kissel T. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur J Pharm Biopharm. 2000;50(1):147–160. doi:10.1016/S0939-6411(00)00084-910840198
   PubMed Web of Science ®Google Scholar
• Mathiowitz E, Jacob JS, Jong YS, et al. Biologically erodable microsphere as potential oral drug delivery system. Nature. 1997;386(6623):410–414. doi:10.1038/386410a09121559
   PubMed Web of Science ®Google Scholar
• Sayed S, Elsayed I, Ismail MM. Optimization of beta-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug. Int J Pharm. 2018;549(1–2):249–260. doi:10.1016/j.ijpharm.2018.08.00130077759
   PubMedGoogle Scholar
• Li J, Tan G, Cheng B, Liu D, Pan W. Transport mechanism of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin-6 loaded nanostructured lipid carriers across the rabbit ocular. Eur J Pharm Biopharm. 2017;120:89–97. doi:10.1016/j.ejpb.2017.08.01328867370
   PubMed Web of Science ®Google Scholar
• Ding D, Zhu Q. Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics. Mater Sci Eng C Mater Biol Appl. 2018;92:1041–1060. doi:10.1016/j.msec.2017.12.03630184728
   PubMed Web of Science ®Google Scholar
• Chen SH, Jia HH, Cui XH, et al. Characterization of stimuli-responsive and cross-linked nanohydrogels for applications in ophthalmiatrics therapy. Appl Nanosci. 2020. doi:10.1007/s13204-020-01450-7
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang Y, Yang J, Zhang H, Gan L. Cationized hyaluronic acid coated spanlastics for cyclosporine A ocular delivery: prolonged ocular retention, enhanced corneal permeation and improved tear production. Int J Pharm. 2019;565:133–142. doi:10.1016/j.ijpharm.2019.05.01831075435
   PubMedGoogle Scholar
• Tipnis NP, Shen J, Jackson D, Leblanc D, Burgess DJ. Flow-through cell-based in vitro release method for triamcinolone acetonide poly (lactic-co-glycolic) acid microspheres. Int J Pharm. 2020;579:119130. doi:10.1016/j.ijpharm.2020.11913032070759
   PubMedGoogle Scholar
• Song X, Zhao Y, Wu W, et al. PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency. Int J Pharm. 2008;350(1–2):320–329. doi:10.1016/j.ijpharm.2007.08.03417913411
   PubMedGoogle Scholar
• Yu M, Yuan W, Li D, Schwendeman A, Schwendeman SP. Predicting drug release kinetics from nanocarriers inside dialysis bags. J Control Release. 2019;315:23–30. doi:10.1016/j.jconrel.2019.09.01631629038
   PubMed Web of Science ®Google Scholar
• Wen Y, Ban J, Mo Z, et al. A potential nanoparticle-loaded in situ gel for enhanced and sustained ophthalmic delivery of dexamethasone. Nanotechnology. 2018;29(42):425101. doi:10.1088/1361-6528/aad7da30074486
   PubMed Web of Science ®Google Scholar
• Hahne M, Zorn-Kruppa M, Guzman G, et al. Prevalidation of a human cornea construct as an alternative to animal corneas for in vitro drug absorption studies. J Pharm Sci Us. 2012;101(8):2976–2988. doi:10.1002/jps.23190
   PubMed Web of Science ®Google Scholar
• Juretic M, Cetina-Cizmek B, Filipovic-Grcic J, Hafner A, Lovric J, Pepic I. Biopharmaceutical evaluation of surface active ophthalmic excipients using in vitro and ex vivo corneal models. Eur J Pharm Sci. 2018;120:133–141. doi:10.1016/j.ejps.2018.04.03229702232
   PubMed Web of Science ®Google Scholar
• Wang JL, Zhao F, Liu R, et al. Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. Int J Nanomed. 2017;12:8115–8127. doi:10.2147/Ijn.S139436
   PubMed Web of Science ®Google Scholar
• Zhang WJ, Li XD, Ye TT, et al. Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions. Int J Nanomed. 2014;9:4305–4315. doi:10.2147/Ijn.S63414
   PubMed Web of Science ®Google Scholar
• Kohno M, Andhariya JV, Wan B, et al. The effect of PLGA molecular weight differences on risperidone release from microspheres. Int J Pharmaceut. 2020;582:119339. doi:10.1016/j.ijpharm.2020.119339
   PubMed Web of Science ®Google Scholar
• Song XR, Zhao Y, Hou SX, et al. Dual agents loaded PLGA nanoparticles: systematic study of particle size and drug entrapment efficiency. Eur J Pharm Biopharm. 2008;69(2):445–453. doi:10.1016/j.ejpb.2008.01.01318374554
   PubMed Web of Science ®Google Scholar
• Mylonaki I, Allemann E, Delie F, Jordan O. Imaging the porous structure in the core of degrading PLGA microparticles: the effect of molecular weight. J Control Release. 2018;286:231–239. doi:10.1016/j.jconrel.2018.07.04430071251
   PubMed Web of Science ®Google Scholar
• Fredenberg S, Wahlgren M, Reslow M, Axelsson A. The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-a review. Int J Pharm. 2011;415(1–2):34–52. doi:10.1016/j.ijpharm.2011.05.04921640806
   PubMed Web of Science ®Google Scholar
• Mir M, Ahmed N, Rehman AU. Recent applications of PLGA based nanostructures in drug delivery. Colloids Surf B Biointerfaces. 2017;159:217–231. doi:10.1016/j.colsurfb.2017.07.03828797972
   PubMed Web of Science ®Google Scholar
• Mittal G, Sahana DK, Bhardwaj V, Kumar MNVR. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release. 2007;119(1):77–85. doi:10.1016/j.jconrel.2007.01.01617349712
   PubMed Web of Science ®Google Scholar
• Abou-ElNour M, Ishak RAH, Tiboni M, et al. Triamcinolone acetonide-loaded PLA/PEG-PDL microparticles for effective intra-articular delivery: synthesis, optimization, in vitro and in vivo evaluation. J Control Release. 2019;309:125–144. doi:10.1016/j.jconrel.2019.07.03031344425
   PubMed Web of Science ®Google Scholar
• Nirbhavane P, Sharma G, Singh B, et al. Triamcinolone acetonide loaded-cationic nano-lipoidal formulation for uveitis: evidences of improved biopharmaceutical performance and anti-inflammatory activity. Colloids Surf B Biointerfaces. 2020;190:110902. doi:10.1016/j.colsurfb.2020.11090232143010
   PubMed Web of Science ®Google Scholar
• Meng Y, Sun S, Li J, et al. Sustained release of triamcinolone acetonide from an episcleral plaque of multilayered poly-epsilon-caprolactone matrix. Acta Biomater. 2014;10(1):126–133. doi:10.1016/j.actbio.2013.09.02224076072
   PubMed Web of Science ®Google Scholar
• Gonzalez-Pizarro R, Carvajal-Vidal P, Halbault Bellowa L, Calpena AC, Espina M, Garcia ML. In-situ forming gels containing fluorometholone-loaded polymeric nanoparticles for ocular inflammatory conditions. Colloids Surf B Biointerfaces. 2019;175:365–374. doi:10.1016/j.colsurfb.2018.11.06530554015
   PubMed Web of Science ®Google Scholar
• Ridolfo R, Tavakoli S, Junnuthula V, Williams DS, Urtti A, van Hest JCM. Exploring the impact of morphology on the properties of biodegradable nanoparticles and their diffusion in complex biological medium. Biomacromolecules. Epub 2020 Jun 8. doi:10.1021/acs.biomac.0c00726.
   Web of Science ®Google Scholar
• Zhang W, Liu CP, Chen SQ, et al. Poloxamer modified florfenicol instant microparticles for improved oral bioavailability. Colloids Surf B Biointerfaces. 2020;193:111078. doi:10.1016/j.colsurfb.2020.11107832422561
   PubMed Web of Science ®Google Scholar
• Agrahari V, Burnouf PA, Burnouf T, Agrahari V. Nanoformulation properties, characterization, and behavior in complex biological matrices: challenges and opportunities for brain-targeted drug updates delivery applications and enhanced translational potential. Adv Drug Deliver Rev. 2019;148:146–180. doi:10.1016/j.addr.2019.02.008
   PubMed Web of Science ®Google Scholar
• Mura P. Advantages of the combined use of cyclodextrins and nanocarriers in drug delivery: A review. Int J Pharmaceut. 2020;579:119181. doi:10.1016/j.ijpharm.2020.119181
   PubMed Web of Science ®Google Scholar
• Janagam DR, Wu LF, Lowe TL. Nanoparticles for drug delivery to the anterior segment of the eye. Adv Drug Deliver Rev. 2017;122:31–64. doi:10.1016/j.addr.2017.04.001
   PubMed Web of Science ®Google Scholar
• Hammoud Z, Khreich N, Auezova L, Fourmentin S, Elaissari A, Greige-Gerges H. Cyclodextrin-membrane interaction in drug delivery and membrane structure maintenance. Int J Pharmaceut. 2019;564:59–76. doi:10.1016/j.ijpharm.2019.03.063
   PubMed Web of Science ®Google Scholar
• Costa P, Manuel J, Lobo S. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13(2):123–133. doi:10.1016/S0928-0987(01)00095-111297896
   PubMed Web of Science ®Google Scholar
• Siepmann J, Siepmann F. Mathematical modeling of drug delivery. Int J Pharm. 2008;364(2):328–343. doi:10.1016/j.ijpharm.2008.09.00418822362
   PubMed Web of Science ®Google Scholar
• Jumelle C, Gholizadeh S, Annabi N, Dana R. Advances and limitations of drug delivery systems formulated as eye drops. J Control Release. 2020;321:1–22. doi:10.1016/j.jconrel.2020.01.05732027938
   PubMed Web of Science ®Google Scholar