Size-Dependent Cytotoxicity and Reactive Oxygen Species of Cerium Oxide Nanoparticles in Human Retinal Pigment Epithelia Cells

References

• Celardo I, Pedersen JZ, Traversa E, Ghibelli LJN. Pharmacological potential of cerium oxide nanoparticles. Nanoscale. 2011;3(4):1411–1420. doi:10.1039/c0nr00875c
   PubMed Web of Science ®Google Scholar
• Karakoti A, Singh S, Dowding JM, Seal S, Self WT. Redox-active radical scavenging nanomaterials. Chem Soc Rev. 2010;39(11):4422–4432. doi:10.1039/b919677n
   PubMed Web of Science ®Google Scholar
• Ponnurangam S, O’Connell GD, Chernyshova IV, Wood K, Hung CT, Somasundaran P. Beneficial effects of cerium oxide nanoparticles in development of chondrocyte-seeded hydrogel constructs and cellular response to interleukin insults. Tissue Eng Part A. 2014;20(21–22):2908–2919. doi:10.1089/ten.tea.2013.0592
   PubMedGoogle Scholar
• Pezzini I, Marino A, Del Turco S, et al. Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance. Nanomed. 2017;12(4):403. doi:10.2217/nnm-2016-0342
   PubMedGoogle Scholar
• Casals E, Zeng M, Parra-Robert M, et al. Cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration. Small. 2020;16(20):e1907322. doi:10.1002/smll.201907322
   PubMed Web of Science ®Google Scholar
• Tong Y, Zhang L, Gong R, et al. A ROS-scavenging multifunctional nanoparticle for combinational therapy of diabetic nephropathy. Nanoscale. 2020;12(46):23607–23619. doi:10.1039/D0NR06098D
   PubMed Web of Science ®Google Scholar
• Kalashnikova I, Chung SJ, Nafiujjaman M, et al. Ceria-based nanotheranostic agent for rheumatoid arthritis. Theranostics. 2020;10(26):11863–11880. doi:10.7150/thno.49069
   PubMed Web of Science ®Google Scholar
• Kim CK, Kim T, Choi IY, et al. Ceria nanoparticles that can protect against ischemic stroke. Angew Chem Int Ed Engl. 2012;51(44):11039–11043. doi:10.1002/anie.201203780
   PubMed Web of Science ®Google Scholar
• Gao R, Mitra RN, Zheng M, Wang K, Dahringer JC, Han Z. Developing nanoceria-based ph-dependent cancer-directed drug delivery system for retinoblastoma. Adv Funct Mater. 2018;28(52):1806248. doi:10.1002/adfm.201806248
   PubMedGoogle Scholar
• Muhammad F, Wang A, Qi W, Zhang S, Zhu G. Intracellular antioxidants dissolve man-made antioxidant nanoparticles: using redox vulnerability of nanoceria to develop a responsive drug delivery system. ACS Appl Mater Interfaces. 2014;6(21):19424–19433. doi:10.1021/am5055367
   PubMedGoogle Scholar
• Zhang Y, Wu X, Hou C, et al. Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery. Int J Nanomed. 2018;13:2161–2173. doi:10.2147/IJN.S152002
   PubMed Web of Science ®Google Scholar
• Tisi A, Passacantando M, Lozzi L, Maccarone R. Cerium oxide nanoparticles reduce the accumulation of autofluorescent deposits in light-induced retinal degeneration: insights for age-related macular de generation. Exp Eye Res. 2020;199:108169. doi:10.1016/j.exer.2020.108169
   PubMedGoogle Scholar
• Wong LL, Pye QN, Lijuan C, Sudipta S, Mcginnis JF, Knut S. Defining the catalytic activity of nanoceria in the P23H-1 rat, a photoreceptor degeneration model. PLoS One. 2015;10(3):e0121977.
   PubMedGoogle Scholar
• Tisi A, Passacantando M, Lozzi L, Riccitelli S, Bisti S, Maccarone R. Retinal long term neuroprotection by cerium oxide nanoparticles after an acute damage induced by high intensity light exposure. Exp Eye Res. 2019;182:30–38. doi:10.1016/j.exer.2019.03.003
   PubMedGoogle Scholar
• Mittal S, Pandey AK. Cerium oxide nanoparticles induced toxicity in human lung cells: role of ROS mediated DNA damage and apoptosis. BioMed Res Int. 2014;2014:891934.
   PubMed Web of Science ®Google Scholar
• Lin W, Huang YW, Zhou XD, Ma YJ. Toxicity of cerium oxide nanoparticles in human lung cancer cells. Int J Toxicol. 2006;25(6):451–457. doi:10.1080/10915810600959543
   PubMed Web of Science ®Google Scholar
• Cheng G, Guo W, Han L, et al. Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways. Toxicol In Vitro. 2013;27(3):1082–1088. doi:10.1016/j.tiv.2013.02.005
   PubMed Web of Science ®Google Scholar
• Ngoc LTN, Bui VKH, Moon JY, Lee YC. In-vitro cytotoxicity and oxidative stress induced by cerium aminoclay and cerium oxide nanoparticles in human skin keratinocyte cells. J Nanosci Nanotechnol. 2019;19(10):6369–6375. doi:10.1166/jnn.2019.17035
   PubMedGoogle Scholar
• Fisichella M, Berenguer F, Steinmetz G, Auffan M, Rose J, Prat O. Toxicity evaluation of manufactured CeO2 nanoparticles before and after alteration: combined physicochemical and whole-genome expression analysis in Caco-2 cells. BMC Genomics. 2014;15:700. doi:10.1186/1471-2164-15-700
   PubMedGoogle Scholar
• Checa J, Aran JM. Reactive oxygen species: drivers of physiological and pathological processes. J Inflamm Res. 2020;13:1057–1073. doi:10.2147/JIR.S275595
   PubMed Web of Science ®Google Scholar
• Halliwell BJ. Oxidative stress and neurodegeneration: where are we now? J Neurochem. 2010;97(6):1634–1658.
   Google Scholar
• Markovic Z, Trajkovic VJB. Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60). Biomaterials. 2008;29(26):3561–3573. doi:10.1016/j.biomaterials.2008.05.005
   PubMedGoogle Scholar
• Caputo F, De Nicola M, Sienkiewicz A, et al. Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis. J Nanoscale. 2015;7(38):15643–15656. doi:10.1039/C5NR03767K
   PubMed Web of Science ®Google Scholar
• Logan A, Pell VR, Shaffer KJ, et al. Assessing the mitochondrial membrane potential in cells and in vivo using targeted click chemistry and mass spectrometry. Cell Metab. 2016;23(2):379–385. doi:10.1016/j.cmet.2015.11.014
   PubMed Web of Science ®Google Scholar
• Picard M, McEwen BS, Epel ES, Sandi C. An energetic view of stress: focus on mitochondria. Front Neuroendocrinol. 2018;49:72–85. doi:10.1016/j.yfrne.2018.01.001
   PubMed Web of Science ®Google Scholar
• Seppet E, Gruno M, Peetsalu A, et al. Mitochondria and energetic depression in cell pathophysiology. Int J Mol Sci. 2009;10(5):2252–2303.
   PubMedGoogle Scholar
• Zhang Z, Chen S, Mei H, et al. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Sci Rep. 2015;5:14633. doi:10.1038/srep14633
   PubMed Web of Science ®Google Scholar
• Balaji S, Mandal BK, Vinod Kumar Reddy L, Sen D. Biogenic ceria nanoparticles (CeO2 NPs) for effective photocatalytic and cytotoxic activity. Bioengineering. 2020;7(1):26. doi:10.3390/bioengineering7010026
   PubMedGoogle Scholar
• Ahamed M, Akhtar MJ, Khan MAM, Alaizeri ZM, Alhadlaq HA. Evaluation of the cytotoxicity and oxidative stress response of CeO2-RGO nanocomposites in human lung epithelial A549 Cells. Nanomaterials. 2019;9(12):1709. doi:10.3390/nano9121709
   Web of Science ®Google Scholar
• Guo X, Li Y, Yan J, et al. Size- and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays. Nanotoxicology. 2016;10(9):1373–1384. doi:10.1080/17435390.2016.1214764
   PubMed Web of Science ®Google Scholar
• Kim IY, Joachim E, Choi H, Kim K. Toxicity of silica nanoparticles depends on size, dose, and cell type. Nanomedicine. 2015;11(6):1407–1416. doi:10.1016/j.nano.2015.03.004
   PubMed Web of Science ®Google Scholar
• Das S, Dowding JM, Klump KE, McGinnis JF, Self W, Seal S. Cerium oxide nanoparticles: applications and prospects in nanomedicine. Nanomedicine. 2013;8(9):1483–1508. doi:10.2217/nnm.13.133
   PubMed Web of Science ®Google Scholar
• Wason MS, Zhao J. Cerium oxide nanoparticles: potential applications for cancer and other diseases. Am J Transl Res. 2013;5(2):126–131.
   PubMed Web of Science ®Google Scholar
• Kwon HJ, Cha MY, Kim D, et al. Mitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer’s disease. ACS Nano. 2016;10(2):2860–2870. doi:10.1021/acsnano.5b08045
   PubMed Web of Science ®Google Scholar
• Xia T, Kovochich M, Liong M, et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano. 2008;2(10):2121–2134. doi:10.1021/nn800511k
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–627. doi:10.1126/science.1114397
   PubMed Web of Science ®Google Scholar
• Zhang Z, Ren Z, Chen S, et al. ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells. Arch Toxicol. 2018;92(2):717–728. doi:10.1007/s00204-017-2084-9
   PubMedGoogle Scholar
• Li L, Wang Y, Guo R, et al. Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury. J Control Release. 2020;317:259–272. doi:10.1016/j.jconrel.2019.11.032
   PubMed Web of Science ®Google Scholar
• Guo X, Chen S, Zhang Z, et al. Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells. Chem Biol Interact. 2015;235:27–36. doi:10.1016/j.cbi.2015.04.009
   PubMedGoogle Scholar