The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation

References

• Neurath MF. Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol. 2019;20(8):970–979. doi:10.1038/s41590-019-0415-0
   PubMed Web of Science ®Google Scholar
• Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. Science. 2017;356(6342):1026–1030. doi:10.1126/science.aam7928
   PubMed Web of Science ®Google Scholar
• Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159–175. doi:10.1038/nri3399
   PubMed Web of Science ®Google Scholar
• Soehnlein O, Libby P. Targeting inflammation in atherosclerosis - from experimental insights to the clinic. Nat Rev Drug Discov. 2021;20:589–610.
   PubMed Web of Science ®Google Scholar
• Jaillon S, Ponzetta A, Di Mitri D, Santoni A, Bonecchi R, Mantovani A. Neutrophil diversity and plasticity in tumour progression and therapy. Nat Rev Cancer. 2020;20(9):485–503. doi:10.1038/s41568-020-0281-y
   PubMed Web of Science ®Google Scholar
• Qin J, Chen DW, Hu HY, Cui Q, Qiao MX, Chen BY. Surface modification of RGD-Liposomes for selective drug delivery to monocytes/neutrophils in brain. Chem Pharm Bull. 2007;55(8):1192–1197. doi:10.1248/cpb.55.1192
   PubMedGoogle Scholar
• Gu XY, Gao YZ, Wang P, et al. Nano-delivery systems focused on tumor microenvironment regulation and biomimetic strategies for treatment of breast cancer metastasis. J Control Release. 2021;333:374–390. doi:10.1016/j.jconrel.2021.03.039
   PubMed Web of Science ®Google Scholar
• Liu YH, Zhou JY, Li Q, et al. Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma q. Adv Drug Deliver Rev. 2021;172:80–103. doi:10.1016/j.addr.2021.02.019
   PubMedGoogle Scholar
• Din FU, Aman W, Ullah I, et al. Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomed. 2017;12:7291–7309. doi:10.2147/IJN.S146315
   PubMed Web of Science ®Google Scholar
• van der Meel R, Sulheim E, Shi Y, Kiessling F, Mulder WJM, Lammers T. Smart cancer nanomedicine. Nat Nanotechnol. 2019;14(11):1007–1017. doi:10.1038/s41565-019-0567-y
   PubMed Web of Science ®Google Scholar
• Choi KY, Han HS, Lee ES, et al. Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery. Adv Mater. 2019;31(34):1803549. doi:10.1002/adma.201803549
   PubMed Web of Science ®Google Scholar
• Stuart MAC, Huck WTS, Genzer J, et al. Emerging applications of stimuli-responsive polymer materials. Nat Mater. 2010;9(2):101–113. doi:10.1038/nmat2614
   PubMed Web of Science ®Google Scholar
• Sun QH, Zhou ZX, Qiu NS, Shen YQ. Rational design of cancer nanomedicine: nanoproperty integration and synchronization. Adv Mater. 2017;29(14):1606628. doi:10.1002/adma.201606628
   Web of Science ®Google Scholar
• Stirland DL, Nichols JW, Miura S, Bae YH. Mind the gap: a survey of how cancer drug carriers are susceptible to the gap between research and practice. J Control Release. 2013;172(3):1045–1064. doi:10.1016/j.jconrel.2013.09.026
   PubMed Web of Science ®Google Scholar
• Gewin V, Giordani S. Designing nano-sized chemotherapy. Nature. 2021;593(7859):470. doi:10.1038/d41586-021-01322-2
   PubMedGoogle Scholar
• Bourzac K. News feature: cancer nanomedicine, reengineered. Proc Natl Acad Sci USA. 2016;113(45):12600–12603. doi:10.1073/pnas.1616895113
   PubMedGoogle Scholar
• Peng CQ, Huang YY, Zheng J. Renal clearable nanocarriers: overcoming the physiological barriers for precise drug delivery and clearance. J Control Release. 2020;322:64–80. doi:10.1016/j.jconrel.2020.03.020
   PubMed Web of Science ®Google Scholar
• He JY, Li CC, Ding L, et al. Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment. Adv Mater. 2019;31(40):1902409. doi:10.1002/adma.201902409
   PubMed Web of Science ®Google Scholar
• Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33(9):941–951. doi:10.1038/nbt.3330
   PubMed Web of Science ®Google Scholar
• Mo R, Jiang TY, DiSanto R, Tai WY, Gu Z. ATP-triggered anticancer drug delivery. Nat Commun. 2014;5(1):3364. doi:10.1038/ncomms4364
   PubMedGoogle Scholar
• Yuan P, Dou G, Liu T, et al. On-demand manipulation of tumorigenic microenvironments by nano-modulator for synergistic tumor therapy. Biomaterials. 2021;275:120956. doi:10.1016/j.biomaterials.2021.120956
   PubMed Web of Science ®Google Scholar
• Ma Z, Pi JX, Zhang Y, et al. Enhanced anticancer efficacy of dual drug-loaded self-assembled nanostructured lipid carriers mediated by pH-responsive folic acid and human-derived cell penetrating peptide dNP2. Pharmaceutics. 2021;13(5):600. doi:10.3390/pharmaceutics13050600
   PubMedGoogle Scholar
• Yu LX, Tang P, Nie CX, Hou Y, Haag R. Well-defined nanostructured biointerfaces: strengthened cellular interaction for circulating tumor cells isolation. Adv Healthc Mater. 2021;10(11):2002202. doi:10.1002/adhm.202002202
   Google Scholar
• Song J, Ju Y, Amarasena TH, et al. Influence of poly(ethylene glycol) molecular architecture on particle assembly and ex vivo particle-immune cell interactions in human blood. ACS Nano. 2021;15(6):10025–10038. doi:10.1021/acsnano.1c01642
   PubMedGoogle Scholar
• Gregory AD, Houghton AM. Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res. 2011;71(7):2411–2416. doi:10.1158/0008-5472.CAN-10-2583
   PubMed Web of Science ®Google Scholar
• Bi YH, Duan WX, Chen J, et al. Neutrophil decoys with anti-inflammatory and anti-oxidative properties reduce secondary spinal cord injury and improve neurological functional recovery. Adv Funct Mater. 2021;31(34):2102912. doi:10.1002/adfm.202102912
   Google Scholar
• Li J, Long Y, Guo R, et al. Shield and sword nano-soldiers ameliorate rheumatoid arthritis by multi-stage manipulation of neutrophils. J Control Release. 2021;335:38–48. doi:10.1016/j.jconrel.2021.05.008
   PubMed Web of Science ®Google Scholar
• Han Y, Zhao RB, Xu F. Neutrophil-based delivery systems for nanotherapeutics. Small. 2018;14(42):e1801674. doi:10.1002/smll.201801674
   PubMed Web of Science ®Google Scholar
• Gustafson HH, Holt-Casper D, Grainger DW, Ghandehari H. Nanoparticle uptake: the phagocyte problem. Nano Today. 2015;10(4):487–510. doi:10.1016/j.nantod.2015.06.006
   PubMed Web of Science ®Google Scholar
• Wu H, Wang MD, Liang L, et al. Nanotechnology for hepatocellular carcinoma: from surveillance, diagnosis to management. Small. 2021;17(6):e2005236. doi:10.1002/smll.202005236
   PubMed Web of Science ®Google Scholar
• Zhang WZ, Wang MZ, Tang W, et al. Nanoparticle-laden macrophages for tumor-tropic drug delivery. Adv Mater. 2018;30(50):1805557. doi:10.1002/adma.201805557
   PubMed Web of Science ®Google Scholar
• Ahamad N, Kar A, Mehta S, et al. Immunomodulatory nanosystems for treating inflammatory diseases. Biomaterials. 2021;274:120875. doi:10.1016/j.biomaterials.2021.120875
   PubMed Web of Science ®Google Scholar
• Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limon P. The polarization of immune cells in the tumour environment by TGF beta. Nat Rev Immunol. 2010;10(8):554–567. doi:10.1038/nri2808
   PubMed Web of Science ®Google Scholar
• Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils. Nat Rev Immunol. 2019;19(4):255–265. doi:10.1038/s41577-019-0141-8
   PubMed Web of Science ®Google Scholar
• Fang RH, Jiang Y, Fang JC, Zhang LF. Cell membrane-derived nanomaterials for biomedical applications. Biomaterials. 2017;128:69–83.
   PubMed Web of Science ®Google Scholar
• Dehaini D, Wei XL, Fang RH, et al. Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization. Adv Mater. 2017;29(16):1606209. doi:10.1002/adma.201606209
   Web of Science ®Google Scholar
• Liu WC, Yan QW, Xia C, et al. Recent advances in cell membrane coated metal-organic frameworks (MOFs) for tumor therapy. J Mater Chem B. 2021;9(22):4459–4474. doi:10.1039/D1TB00453K
   PubMed Web of Science ®Google Scholar
• Hu CMJ, Zhang L, Aryal S, Cheung C, Fang RH, Zhang LF. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc Natl Acad Sci USA. 2011;108(27):10980–10985. doi:10.1073/pnas.1106634108
   PubMed Web of Science ®Google Scholar
• Li LY, Zuo XX, Xiao YZ, Liu D, Luo H, Zhu HL. Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells. Biochem Biophys Res Commun. 2020;526(2):334–340. doi:10.1016/j.bbrc.2020.03.088
   PubMedGoogle Scholar
• Nauseef WM, Borregaard N. Neutrophils at work. Nat Immunol. 2014;15(7):602–611. doi:10.1038/ni.2921
   PubMed Web of Science ®Google Scholar
• Xue YA, Wu Y, Wang QQ, Xue LJ, Su ZG, Zhang C. Cellular vehicles based on neutrophils enable targeting of atherosclerosis. Mol Pharmaceut. 2019;16(7):3109–3120. doi:10.1021/acs.molpharmaceut.9b00342
   PubMedGoogle Scholar
• Batrakova EV, Gendelman HE, Kabanov AV. Cell-mediated drug delivery. Expert Opin Drug Deliv. 2011;8(4):415–433. doi:10.1517/17425247.2011.559457
   PubMed Web of Science ®Google Scholar
• Pierige F, Serafini S, Rossi L, Magnani A. Cell-based drug delivery. Adv Drug Deliver Rev. 2008;60(2):286–295. doi:10.1016/j.addr.2007.08.029
   PubMed Web of Science ®Google Scholar
• Xue JW, Zhao ZK, Zhang L, et al. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nat Nanotechnol. 2017;12(7):692–700. doi:10.1038/nnano.2017.54
   PubMed Web of Science ®Google Scholar
• Wang HJ, Liu Y, He RQ, et al. Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery. Biomater Sci. 2020;8(2):552–568. doi:10.1039/C9BM01392J
   PubMed Web of Science ®Google Scholar
• Wang M, Xin YF, Cao H, et al. Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery. Biomater Sci. 2021;9(4):1088–1103. doi:10.1039/D0BM01164A
   PubMed Web of Science ®Google Scholar
• Wang KY, Lei YT, Xia DL, et al. Neutrophil membranes coated, antibiotic agent loaded nanoparticles targeting to the lung inflammation. Colloids Surf B Biointerfaces. 2020;188:110755. doi:10.1016/j.colsurfb.2019.110755
   PubMed Web of Science ®Google Scholar
• Zhao Q, Jiang D, Sun X, et al. Biomimetic nanotherapy: core-shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma. J Nanobiotechnol. 2021;19(1):179. doi:10.1186/s12951-021-00922-4
   PubMedGoogle Scholar
• Zhang QZ, Dehaini D, Zhang Y, et al. Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis. Nat Nanotechnol. 2018;13(12):1182–1190. doi:10.1038/s41565-018-0254-4
   PubMed Web of Science ®Google Scholar
• Kang T, Zhu QQ, Wei D, et al. Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis. ACS Nano. 2017;11(2):1397–1411. doi:10.1021/acsnano.6b06477
   PubMed Web of Science ®Google Scholar
• Cully M. Exosome-based candidates move into the clinic. Nat Rev Drug Discov. 2021;20(1):6–7. doi:10.1038/d41573-020-00220-y
   PubMed Web of Science ®Google Scholar
• Agrawal M, Saraf S, Saraf S, et al. Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting. J Control Release. 2020;321:372–415.
   PubMed Web of Science ®Google Scholar
• Zheng MB, Yue CX, Ma YF, et al. Single-step assembly of DOX/ICG loaded lipid-polymer nanoparticles for highly effective chemo-photothermal combination therapy. ACS Nano. 2013;7(3):2056–2067. doi:10.1021/nn400334y
   PubMed Web of Science ®Google Scholar
• Zhang YM, Liu YH, Liu Y. Cyclodextrin-based multistimuli-responsive supramolecular assemblies and their biological functions. Adv Mater. 2020;32(3):e1806158. doi:10.1002/adma.201806158
   PubMedGoogle Scholar
• Li YT, Tang JL, He LC, et al. Core-shell upconversion nanoparticle@metal-organic framework nanoprobes for luminescent/magnetic dual-mode targeted imaging. Adv Mater. 2015;27(27):4075–4080. doi:10.1002/adma.201501779
   PubMed Web of Science ®Google Scholar
• Zhang X, Machuki JO, Pan WZ, et al. Carbon nitride hollow theranostic nanoregulators executing laser-activatable water splitting for enhanced ultrasound/fluorescence imaging and cooperative phototherapy. ACS Nano. 2020;14(4):4045–4060. doi:10.1021/acsnano.9b08737
   PubMed Web of Science ®Google Scholar
• Yang M, Xu ZX, Yan HL, et al. PD-L1 cellular nanovesicles carrying rapamycin inhibit alloimmune responses in transplantation. Biomater Sci. 2021;9(4):1246–1255. doi:10.1039/D0BM01798A
   PubMedGoogle Scholar
• Chen FF, Wang GK, Griffin JI, et al. Complement proteins bind to nanoparticle protein Corona and undergo dynamic exchange in vivo. Nat Nanotechnol. 2017;12(4):387–393. doi:10.1038/nnano.2016.269
   PubMed Web of Science ®Google Scholar
• Zou YJ, Ito S, Yoshino F, Suzuki Y, Zhao L, Komatsu N. Polyglycerol grafting shields nanoparticles from protein corona formation to avoid macrophage uptake. ACS Nano. 2020;14(6):7216–7226.
   PubMed Web of Science ®Google Scholar
• Cabral H, Matsumoto Y, Mizuno K, et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol. 2011;6(12):815–823. doi:10.1038/nnano.2011.166
   PubMed Web of Science ®Google Scholar
• Yang GB, Phua SZF, Lim WQ, et al. A hypoxia-responsive albumin-based nanosystem for deep tumor penetration and excellent therapeutic efficacy. Adv Mater. 2019;31(25):1901513. doi:10.1002/adma.201901513
   PubMed Web of Science ®Google Scholar
• Gao A, Chen BF, Gao J, et al. Sheddable prodrug vesicles combating adaptive immune resistance for improved photodynamic immunotherapy of cancer. Nano Lett. 2020;20(1):353–362. doi:10.1021/acs.nanolett.9b04012
   PubMedGoogle Scholar
• Hayat SMG, Bianconi V, Pirro M, Jaafari MR, Hatamipour M, Sahebkar A. CD47: role in the immune system and application to cancer therapy. Cell Oncol. 2020;43(1):19–30. doi:10.1007/s13402-019-00469-5
   Web of Science ®Google Scholar
• Oroojalian F, Beygi M, Baradaran B, Mokhtarzadeh A, Shahbazi MA. Immune cell membrane-coated biomimetic nanoparticles for targeted cancer therapy. Small. 2021;17(12):e2006484. doi:10.1002/smll.202006484
   PubMed Web of Science ®Google Scholar
• Hu Q, Zhang XL, Jia LL, et al. Engineering biomimetic graphene nanodecoys camouflaged with the EGFR/HEK293 cell membrane for targeted capture of drug leads. Biomater Sci. 2020;8(20):5690–5697. doi:10.1039/D0BM00841A
   PubMedGoogle Scholar
• Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Ionizable lipid nanoparticle-mediated mRNA delivery for human CAR T cell engineering. Nano Lett. 2020;20(3):1578–1589. doi:10.1021/acs.nanolett.9b04246
   PubMed Web of Science ®Google Scholar
• Chen Q, Wang C, Zhang X, et al. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat Nanotechnol. 2019;14(1):89–97. doi:10.1038/s41565-018-0319-4
   PubMed Web of Science ®Google Scholar
• Nemeth T, Sperandio M, Mocsai A. Neutrophils as emerging therapeutic targets. Nat Rev Drug Discov. 2020;19(4):253–275.
   PubMed Web of Science ®Google Scholar
• Zhen X, Cheng PH, Pu KY. Recent advances in cell membrane-camouflaged nanoparticles for cancer phototherapy. Small. 2019;15(1):e1804105. doi:10.1002/smll.201804105
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhang Y, Xue YN, et al. Transforming weakness into strength: photothermal-therapy-induced inflammation enhanced cytopharmaceutical chemotherapy as a combination anticancer treatment. Adv Mater. 2019;31:1805936.
   Google Scholar
• Dong HQ, Li Y, Liu YQ, et al. A nano-immunotraining strategy to enhance the tumor targeting of neutrophils via in vivo pathogen-mimicking stimulation. Biomater Sci. 2019;7(12):5238–5246. doi:10.1039/C9BM01278H
   PubMedGoogle Scholar
• Ye B, Zhao B, Wang K, et al. Neutrophils mediated multistage nanoparticle delivery for prompting tumor photothermal therapy. J Nanobiotechnol. 2020;18(1):138. doi:10.1186/s12951-020-00682-7
   PubMedGoogle Scholar
• Li M, Li SY, Zhou H, et al. Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy. Nat Commun. 2020;11(1):1126. doi:10.1038/s41467-020-14963-0
   PubMed Web of Science ®Google Scholar
• Chu DF, Zhao Q, Yu J, Zhang FY, Zhang H, Wang ZJ. Nanoparticle targeting of neutrophils for improved cancer immunotherapy. Adv Healthc Mater. 2016;5(9):1088–1093. doi:10.1002/adhm.201500998
   PubMed Web of Science ®Google Scholar
• Luo X, Liu MQ, Hu L, et al. Targeted delivery of pixantrone to neutrophils by poly(sialic acid)-p-octadecylamine conjugate modified liposomes with improved antitumor activity. Int J Pharmaceut. 2018;547(1–2):315–329.
   PubMedGoogle Scholar
• Li S, Li M, Huo S, et al. Voluntary-opsonization-enabled precision nanomedicines for inflammation treatment. Adv Mater. 2020;33(3):e2006160. doi:10.1002/adma.202006160
   PubMedGoogle Scholar
• Su YJ, Wang TT, Su YN, et al. A neutrophil membrane-functionalized black phosphorus riding inflammatory signal for positive feedback and multimode cancer therapy. Mater Horiz. 2020;7(2):574–585. doi:10.1039/C9MH01068H
   Google Scholar
• Cao X, Hu Y, Luo S, et al. Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma. Acta Pharmacol Sin B. 2019;9(3):575–589. doi:10.1016/j.apsb.2018.12.009
   PubMed Web of Science ®Google Scholar
• Wang JS, Gu XM, Ouyang YQ, et al. Engineering of neutrophil membrane camouflaging nanoparticles realizes targeted drug delivery for amplified antitumor therapy. Int J Nanomed. 2021;16:1175–1187. doi:10.2147/IJN.S288636
   PubMed Web of Science ®Google Scholar
• Zhang C, Zhang L, Wu W, et al. Artificial super neutrophils for inflammation targeting and HClO generation against tumors and infections. Adv Mater. 2019;31(19):e1901179. doi:10.1002/adma.201901179
   PubMed Web of Science ®Google Scholar
• Wang J, Tang W, Yang M, et al. Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy. Biomaterials. 2021;273:120784. doi:10.1016/j.biomaterials.2021.120784
   PubMed Web of Science ®Google Scholar
• Zhang P, Zhao Q, Shi MS, et al. Fe3O4@TiO2-laden neutrophils activate innate immunity via photosensitive reactive oxygen species release. Nano Lett. 2020;20(1):261–271. doi:10.1021/acs.nanolett.9b03777
   PubMed Web of Science ®Google Scholar
• Zhang CY, Dong XY, Gao J, Lin WJ, Liu Z, Wang ZJ. Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke. Sci Adv. 2019;5(11):eaax7964. doi:10.1126/sciadv.aax7964
   PubMed Web of Science ®Google Scholar
• Tang CM, Wang C, Zhang Y, et al. Recognition, intervention, and monitoring of neutrophils in acute ischemic stroke. Nano Lett. 2019;19(7):4470–4477. doi:10.1021/acs.nanolett.9b01282
   PubMed Web of Science ®Google Scholar
• Zhou X, Cao X, Tu H, Zhang ZR, Deng L. Inflammation-targeted delivery of celastrol via neutrophil membrane-coated nanoparticles in the management of acute pancreatitis. Mol Pharmaceut. 2019;16(3):1397–1405. doi:10.1021/acs.molpharmaceut.8b01342
   PubMed Web of Science ®Google Scholar
• Zhang L, Cheng Q, Li C, Zeng X, Zhang XZ. Near infrared light-triggered metal ion and photodynamic therapy based on AgNPs/porphyrinic MOFs for tumors and pathogens elimination. Biomaterials. 2020;248:120029. doi:10.1016/j.biomaterials.2020.120029
   PubMed Web of Science ®Google Scholar
• Tang C, Wang Q, Li K, et al. A neutrophil-mimetic magnetic nanoprobe for molecular magnetic resonance imaging of stroke-induced neuroinflammation. Biomater Sci. 2021;9(15):5247–5258. doi:10.1039/D1BM00566A
   PubMedGoogle Scholar
• Gao J, Wang S, Dong X, Leanse LG, Dai T, Wang Z. Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice. Commun Biol. 2020;3(1):680. doi:10.1038/s42003-020-01410-5
   PubMed Web of Science ®Google Scholar
• Gao J, Dong XY, Su YJ, Wang ZJ. Human neutrophil membrane-derived nanovesicles as a drug delivery platform for improved therapy of infectious diseases. Acta Biomater. 2021;123:354–363. doi:10.1016/j.actbio.2021.01.020
   PubMed Web of Science ®Google Scholar
• Dong XY, Gao J, Zhang CY, Hayworth C, Frank M, Wang ZJ. Neutrophil membrane-derived nanovesicles alleviate inflammation to protect mouse brain injury from ischemic stroke. ACS Nano. 2019;13(2):1272–1283.
   PubMed Web of Science ®Google Scholar