Study on the Local Anti-Osteoporosis Effect of Polaprezinc-Loaded Antioxidant Electrospun Membrane

References

• Henslee AM, Spicer PP, Yoon DM, et al. Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in segmental long bone defects. Acta Biomater. 2011;7(10):3627–3637. doi:10.1016/j.actbio.2011.06.043
   PubMed Web of Science ®Google Scholar
• Omar O, Elgali I, Dahlin C, Thomsen P. Barrier membranes: more than the barrier effect? J Clin Periodontol. 2019;46 Suppl 21:103–123. doi:10.1111/jcpe.13068
   PubMed Web of Science ®Google Scholar
• Elgali I, Omar O, Dahlin C, Thomsen P. Guided bone regeneration: materials and biological mechanisms revisited. Eur J Oral Sci. 2017;125(5):315–337. doi:10.1111/eos.12364
   PubMed Web of Science ®Google Scholar
• Santos DM. Advances in functional polymer nanofibers from spinning fabrication techniques to recent biomedical applications. ACS Appl Mater Interfaces. 2020;12(41):45673–45701. doi:10.1021/acsami.0c12410
   PubMed Web of Science ®Google Scholar
• Shitole AA, Raut P, Giram P, et al. Poly (vinylpyrrolidone)-iodine engineered poly (ε-caprolactone) nanofibers as potential wound dressing materials. Mater Sci Eng C Mater Biol Appl. 2020;110:110731. doi:10.1016/j.msec.2020.110731
   PubMed Web of Science ®Google Scholar
• Lan X. Multidrug-loaded electrospun micronanofibrous membranes Fabrication strategies, release behaviors and applications in regenerative medicine. J Controlled Release. 2020;330:1264–1287. doi:10.1016/j.jconrel.2020.11.036
   PubMed Web of Science ®Google Scholar
• Ajmal G, Bonde GV, Mittal P, et al. Biomimetic PCL-gelatin based nanofibers loaded with ciprofloxacin hydrochloride and quercetin: a potential antibacterial and anti-oxidant dressing material for accelerated healing of a full thickness wound. Int J Pharm. 2019;567:118480. doi:10.1016/j.ijpharm.2019.118480
   PubMed Web of Science ®Google Scholar
• Chen W, Wang C, Gao Y, et al. Incorporating chitin derived glucosamine sulfate into nanofibers via coaxial electrospinning for cartilage regeneration. Carbohydr Polym. 2020;229:115544. doi:10.1016/j.carbpol.2019.115544
   PubMed Web of Science ®Google Scholar
• Luo J, Zhu J, Wang L, Kang J, Wang X, Xiong J. Co-electrospun nano-/microfibrous composite scaffolds with structural and chemical gradients for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2021;119:111622. doi:10.1016/j.msec.2020.111622
   PubMed Web of Science ®Google Scholar
• Ghitescu RE, Popa AM, Popa VI, Rossi RM, Fortunato G. Encapsulation of polyphenols into pHEMA e-spun fibers and determination of their antioxidant activities. Int J Pharm. 2015;494(1):278–287. doi:10.1016/j.ijpharm.2015.08.020
   PubMed Web of Science ®Google Scholar
• Kim K, Luu YK, Chang C, et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release. 2004;98(1):47–56. doi:10.1016/j.jconrel.2004.04.009
   PubMed Web of Science ®Google Scholar
• Song JH, Kim HE, Kim HW. Production of electrospun gelatin nanofiber by water-based co-solvent approach. J Mater Sci Mater Med. 2008;19(1):95–102. doi:10.1007/s10856-007-3169-4
   PubMed Web of Science ®Google Scholar
• Izquierdo R, Garcia-Giralt N, Rodriguez MT, et al. Biodegradable PCL scaffolds with an interconnected spherical pore network for tissue engineering. J Biomed Mater Res A. 2008;85(1):25–35. doi:10.1002/jbm.a.31396
   PubMed Web of Science ®Google Scholar
• Chong EJ, Phan TT, Lim IJ, et al. Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution. Acta Biomater. 2007;3(3):321–330. doi:10.1016/j.actbio.2007.01.002
   PubMed Web of Science ®Google Scholar
• You P, Liu Y, Wang X, Li B, Wu W, Tang L. Acellular pericardium: a naturally hierarchical, osteoconductive, and osteoinductive biomaterial for guided bone regeneration. J Biomed Mater Res A. 2021;109(2):132–145. doi:10.1002/jbm.a.37011
   PubMed Web of Science ®Google Scholar
• Calciolari E, Mardas N, Dereka X, Anagnostopoulos AK, Tsangaris GT, Donos N. The effect of experimental osteoporosis on bone regeneration: part 2, proteomics results. Clin Oral Implants Res. 2017;28(9):e135–e145. doi:10.1111/clr.12950
   PubMed Web of Science ®Google Scholar
• Calciolari E, Mardas N, Dereka X, Kostomitsopoulos N, Petrie A, Donos N. The effect of experimental osteoporosis on bone regeneration: part 1, histology findings. Clin Oral Implants Res. 2017;28(9):e101–e110. doi:10.1111/clr.12936
   PubMed Web of Science ®Google Scholar
• Segredo-Morales E, García-García P, Reyes R, Pérez-Herrero E, Delgado A, Évora C. Bone regeneration in osteoporosis by delivery BMP-2 and PRGF from tetronic-alginate composite thermogel. Int J Pharm. 2018;543(1–2):160–168. doi:10.1016/j.ijpharm.2018.03.034
   PubMed Web of Science ®Google Scholar
• Segredo-Morales E, Reyes R, Arnau MR, Delgado A, Évora C. In situ gel-forming system for dual BMP-2 and 17β-estradiol controlled release for bone regeneration in osteoporotic rats. Drug Deliv Transl Res. 2018;8(5):1103–1113. doi:10.1007/s13346-018-0574-9
   PubMed Web of Science ®Google Scholar
• Chen K, Qiu P, Yuan Y, et al. Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species. Theranostics. 2019;9(6):1634–1650. doi:10.7150/thno.30206
   PubMed Web of Science ®Google Scholar
• Arioka M, Zhang X, Li Z, et al. Osteoporotic changes in the periodontium impair alveolar bone healing. J Dent Res. 2019;98(4):450–458. doi:10.1177/0022034518818456
   PubMed Web of Science ®Google Scholar
• Domazetovic V, Marcucci G, Iantomasi T, Brandi ML, Vincenzini MT. Oxidative stress in bone remodeling: role of antioxidants. Clin Cases Miner Bone Metab. 2017;14(2):209–216. doi:10.11138/ccmbm/2017.14.1.209
   PubMedGoogle Scholar
• Zhao F, Guo L, Wang X, Zhang Y. Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis. Arch Osteoporos. 2021;16(1):4. doi:10.1007/s11657-020-00854-w
   PubMed Web of Science ®Google Scholar
• Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 2004;266(1–2):37–56. doi:10.1023/b:mcbi.0000049134.69131.89
   PubMed Web of Science ®Google Scholar
• Huang Y, Du Z, Wei P, et al. Biodegradable microspheres made of conductive polyorganophosphazene showing antioxidant capacity for improved bone regeneration. Chem Eng J. 2020:397. doi:10.1016/j.cej.2020.125352
   Web of Science ®Google Scholar
• Pinna A, Torki Baghbaderani M, Vigil Hernandez V, et al. Nanoceria provides antioxidant and osteogenic properties to mesoporous silica nanoparticles for osteoporosis treatment. Acta Biomater. 2021;122:365–376. doi:10.1016/j.actbio.2020.12.029
   PubMed Web of Science ®Google Scholar
• Yoshikawa T, Naito Y, Tanigawa T, Yoneta T, Kondo M. The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L-histidinato zinc. Biochim Biophys Acta. 1991;1115(1):15–22. doi:10.1016/0304-4165(91)90005-2
   PubMed Web of Science ®Google Scholar
• Ueki S, Seiki M, Yoneta T, et al. Effect of Z-103 on compound 48/80-induced gastric lesions in rats. Scand J Gastroenterol Suppl. 1989;162:202–205. doi:10.3109/00365528909091161
   PubMedGoogle Scholar
• Maywald M, Wessels I, Rink L. Zinc Signals and Immunity. Int J Mol Sci. 2017;18(10):2222. doi:10.3390/ijms18102222
   PubMed Web of Science ®Google Scholar
• Pormohammad A, Monych NK, Turner RJ. Zinc and SARS-CoV-2: a molecular modeling study of Zn interactions with RNA-dependent RNA-polymerase and 3C-like proteinase enzymes. Int J Mol Med. 2021;47(1):326–334. doi:10.3892/ijmm.2020.4790
   PubMed Web of Science ®Google Scholar
• Beyersmann D, Haase H. Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals. 2001;14(3–4):331–341. doi:10.1023/a:1012905406548
   PubMed Web of Science ®Google Scholar
• Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. Zinc and Oxidative Stress: current Mechanisms. Antioxidants. 2017;6(2). doi:10.3390/antiox6020024
   Web of Science ®Google Scholar
• Su Y. Zinc-Based Biomaterials for Regeneration and Therapy. Trends Biotechnol. 2019;37(4):428–441. doi:10.1016/j.tibtech.2018.10.009
   PubMed Web of Science ®Google Scholar
• Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev. 2013;93(4):1803–1845. doi:10.1152/physrev.00039.2012
   PubMed Web of Science ®Google Scholar
• Smith E. The buffering of muscle in rigor; protein, phosphate and carnosine. J Physiol. 1938;92(3):336–343. doi:10.1113/jphysiol.1938.sp003605
   PubMedGoogle Scholar
• Boldyrev A. Carnosine as a modulator of endogenous Zn(2+) effects. Trends Pharmacol Sci. 2001;22(3):112–113. doi:10.1016/s0165-6147(00)01648-5
   PubMed Web of Science ®Google Scholar
• Hiraishi H, Sasai T, Oinuma T, Shimada T, Sugaya H, Terano A. Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacol Ther. 1999;13(2):261–269. doi:10.1046/j.1365-2036.1999.00458.x
   PubMed Web of Science ®Google Scholar
• Kitagawa J, Kobayashi R, Nagata Y, et al. Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: a multi-institutional randomized controlled trial. Int J Cancer. 2021;148(6):1462–1469. doi:10.1002/ijc.33316
   PubMed Web of Science ®Google Scholar
• Sakagami M, Ikeda M, Tomita H, et al. A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study. Acta Otolaryngol. 2009;129(10):1115–1120. doi:10.1080/00016480802552550
   PubMed Web of Science ®Google Scholar
• Sakae K, Suka M, Yanagisawa H. Polaprezinc (Zinc-L-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions A Pilot Study. J Clin Psychopharmacol. 2020;40(6):599–606. doi:10.1097/JCP.0000000000001284
   PubMed Web of Science ®Google Scholar
• Sakae K, Yanagisawa H. Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial. Biol Trace Elem Res. 2014;158(3):280–288. doi:10.1007/s12011-014-9943-5
   PubMed Web of Science ®Google Scholar
• Hewlings S, Kalman D. A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders. Nutrients. 2020;12(3):665. doi:10.3390/nu12030665
   PubMed Web of Science ®Google Scholar
• Ren K, Wang Y, Sun T, Yue W, Zhang H. Electrospun PCL/gelatin composite nanofiber structures for effective guided bone regeneration membranes. Materials Sci Eng. 2017;78:324–332. doi:10.1016/j.msec.2017.04.084
   PubMed Web of Science ®Google Scholar
• Pavliňáková V, Fohlerová Z, Pavliňák D, Viera Khunová VL. Potential of Chrysin-loaded PCL-gelatin nanofibers for modulation of macrophage functional polarity towards anti-inflammatory pro-regenerative phenotype. Mater Sci Eng C Mater Biol Appl. 2018;91:94–102. doi:10.1016/j.msec.2018.05.033
   PubMed Web of Science ®Google Scholar
• Rajzer I, Menaszek E, Kwiatkowski R, Planell JA, Castano O. Electrospun gelatin/poly(ε-caprolactone) fibrous scaffold modified with calcium phosphate for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2014;44:183–190. doi:10.1016/j.msec.2014.08.017
   PubMed Web of Science ®Google Scholar
• Unalan I, Endlein SJ, Slavik B, et al. Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing. Pharmaceutics. 2019;11(11):570. doi:10.3390/pharmaceutics11110570
   PubMed Web of Science ®Google Scholar
• Castelletto V, Cheng G, Greenland BW, Hamley IW, Harris PJ. Tuning the self-assembly of the bioactive dipeptide L-carnosine by incorporation of a bulky aromatic substituent. Langmuir. 2011;27(6):2980–2988. doi:10.1021/la104495g
   PubMed Web of Science ®Google Scholar
• Binulal NS, Natarajan A, Menon D, Bhaskaran VK, Mony U, Nair SV. PCL-gelatin composite nanofibers electrospun using diluted acetic acid-ethyl acetate solvent system for stem cell-based bone tissue engineering. J Biomater Sci Polym Ed. 2014;25(4):325–340. doi:10.1080/09205063.2013.859872
   PubMed Web of Science ®Google Scholar
• Bolgen N, Menceloglu YZ, Acatay K, Vargel I, Piskin E. In vitro and in vivo degradation of non-woven materials made of poly(epsilon-caprolactone) nanofibers prepared by electrospinning under different conditions. J Biomater Sci Polym Ed. 2005;16(12):1537–1555. doi:10.1163/156856205774576655
   PubMed Web of Science ®Google Scholar
• Zandi N, Lotfi R, Tamjid E, Shokrgozar MA, Simchi A. Core-sheath gelatin based electrospun nanofibers for dual delivery release of biomolecules and therapeutics. Mater Sci Eng C Mater Biol Appl. 2020;108:110432. doi:10.1016/j.msec.2019.110432
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang X, Liu T, Liu S, Jing X. Antitumor activity of electrospun polylactide nanofibers loaded with 5-fluorouracil and oxaliplatin against colorectal cancer. Drug Deliv. 2016;23(3):794–800. doi:10.3109/10717544.2014.916768
   PubMed Web of Science ®Google Scholar
• Liu W, Walker G, Price S, Yang X, Li J, Bunt C. Electrospun membranes as a porous barrier for molecular transport: membrane characterization and release assessment. Pharmaceutics. 2021;13(6):916. doi:10.3390/pharmaceutics13060916
   PubMed Web of Science ®Google Scholar
• Sharif R, Thomas P, Zalewski P, Graham RD, Fenech M. The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line. Mutat Res. 2011;720(1–2):22–33. doi:10.1016/j.mrgentox.2010.12.004
   PubMed Web of Science ®Google Scholar
• Ooi TC, Chan KM, Sharif R. Antioxidant, Anti-inflammatory, and Genomic Stability Enhancement Effects of Zinc l-carnosine A Potential Cancer Chemopreventive Agent. Nutr Cancer. 2017;69(2):201–210. doi:10.1080/01635581.2017.1265132
   PubMed Web of Science ®Google Scholar
• Jessica RC, Priestley KE, Casati MC, Endres BT, Geurts AM, Lombard JH. Casati, Bradley T. The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. Am J Physiol Heart Circ Physiol. 2016;310:H478–H487. doi:10.1152/ajpheart.00586.2015
   PubMed Web of Science ®Google Scholar
• Ooi TC, Chan KM, Sharif R. Zinc L-Carnosine Protects CCD-18co Cells from L-Buthionine Sulfoximine-Induced Oxidative Stress via the Induction of Metallothionein and Superoxide Dismutase 1 Expression. Biol Trace Elem Res. 2020;198(2):464–471. doi:10.1007/s12011-020-02108-9
   PubMed Web of Science ®Google Scholar
• Ooi TC, Chan KM, Sharif R. Zinc L-carnosine suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 murine macrophages cell line via activation of Nrf2/HO-1 signaling pathway. Immunopharmacol Immunotoxicol. 2017;39(5):259–267. doi:10.1080/08923973.2017.1344987
   PubMed Web of Science ®Google Scholar
• Liu AL, Zhang ZM, Zhu BF, Liao ZH, Liu Z. Metallothionein protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. Cell Biol Int. 2004;28(12):905–911. doi:10.1016/j.cellbi.2004.09.004
   PubMed Web of Science ®Google Scholar
• Bai XC, Lu D, Bai J, et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004;314(1):197–207. doi:10.1016/j.bbrc.2003.12.073
   PubMed Web of Science ®Google Scholar
• Arai M, Shibata Y, Pugdee K, Abiko Y, Ogata Y. Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life. 2007;59(1):27–33. doi:10.1080/15216540601156188
   PubMed Web of Science ®Google Scholar
• Hinoi E, Fujimori S, Wang L, Hojo H, Uno K, Yoneda Y. Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation. J Biol Chem. 2006;281(26):18015–18024. doi:10.1074/jbc.M600603200
   PubMed Web of Science ®Google Scholar
• Zhao Z, Li G, Ruan H, et al. Capturing Magnesium Ions via Microfluidic Hydrogel Microspheres for Promoting Cancellous Bone Regeneration. ACS Nano. 2021;15(8):13041–13054. doi:10.1021/acsnano.1c02147
   PubMed Web of Science ®Google Scholar