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Original Research

Co-Delivery of Dexamethasone and Captopril by α8 Integrin Antibodies Modified Liposome-PLGA Nanoparticle Hybrids for Targeted Anti-Inflammatory/Anti-Fibrosis Therapy of Glomerulonephritis

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Pages 1531-1547 | Published online: 30 Mar 2022

References

  • Yuan J, Zou XR, Han SP, et al. Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE). BMC Nephrol. 2017;18(1):23.
  • Lousa I, Reis F, Beirão I, Rui A, Santos-SilVa A. New Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literature. Int J Mol Sci. 2020;22(1):43.
  • Gao JR, Jiang NN, Jiang H, et al. Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis. Drug Des Devel Ther. 2019;13(1):1901–1913.
  • Infante BRM, Leo S, Troise D, et al. Recurrent Glomerulonephritis after Renal Transplantation: the Clinical Problem. Int J Mol Sci. 2020;21(17):5954.
  • Li W, Qu W, Zhou H. Assessment of Bailing Capsule in the Treatment of Chronic Glomerulonephritis: a Meta-analysis. Indian J Pharm Sci. 2020;82(1):59–63.
  • Wójcicka G, Bełtowski J. [Oxidative stress in glomerulonephritis]. Postpy Higieny I Medycyny Dowiadczalnej. 2001;55(6):855–869. Spanish.
  • Curran CS, Kopp JB. PD-1 immunobiology in glomerulonephritis and renal cell carcinoma. BMC Nephrol. 2021;22(1):1–19.
  • Zwiech R. Macrophage migration inhibitory factor urinary excretion revisited–MIF a potent predictor of the immunosuppressive treatment outcomes in patients with proliferative primary glomerulonephritis. BMC Immunol. 2015;16(1):1–9.
  • Klinkhammer BM, Goldschmeding R, Floege J, Boor P. Treatment of renal fibrosis—turning challenges into opportunities. Adv Chronic Kidney Dis. 2017;24(2):117–129.
  • Tumlin JA, Madaio MP, Hennigar R. Idiopathic IgA nephropathy: pathogenesis, histopathology, and therapeutic options. Clin J Am Soc Nephrol. 2007;2(5):1054–1061.
  • Liu CP, Hu Y, Lin JC, Fu HL, Lim LY, YZ X. Targeting strategies for drug delivery to the kidney: from renal glomeruli to tubules. Med Res Rev. 2019;39(2):561–578.
  • Yuan ZX, Shang ZH, Gu J, He LL. Renal targeting delivery systems. Future Med Chem. 2019;11(17):2237–2240.
  • Qin X, Xu Y, Zhou X, et al. An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis. Acta Pharmaceutica Sinica B. 2021;11(3):835–847.
  • Guo L, Luo S, Du Z, et al. Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis. Nat Commun. 2017;8(1):878.
  • Fleischmann DHM, Maslanka Figueroa S, Schlossmann J, Goepferich A. Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway. Int J Mol Sci. 2021;22(5):2557.
  • Yw A, Qw A, Jw B, et al. Co-delivery of p38α MAPK and p65 siRNA by novel liposomal glomerulus-targeting nano carriers for effective immunoglobulin a nephropathy treatment - ScienceDirect. J Controlled Release. 2020;320:457–468.
  • Yuan Z-X, Jia L, Lim LY, et al. Renal-targeted delivery of triptolide by entrapment in pegylated TRX-20-modified liposomes. Int J Nanomedicine. 2017;12(1):5673–5686.
  • Fatemeh SA. Active targeting drug delivery nanocarriers: ligands. Nano Stru Nano-Objects. 2019;23:100370.
  • Yogesh SUDPR, Harini T. Anti-alpha8 integrin immunoliposomes in glomeruli of lupus-susceptible mice: a novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosus. Arthritis Rheum. 2008;58(12):3884–3891.
  • Yuan F, Nelson RK, Tabor DE, Zhang Y, Wang D. Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects. Arthritis Rheumatol. 2014;64(12):4029–4039.
  • Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids–new mechanisms for old drugs. N Engl J Med. 2005;353(16):1711–1723.
  • Ayroldi E, Cannarile L, Migliorati G, Nocentini G, Delfino DV, Riccardi C. Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways. FASEB J. 2012;26(12):4805–4820.
  • Mizar S, Kozman MR, Abo-Saif AA, et al. Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin-induced Diabetes Mellitus. Endocrine Metab Immune Disorders Drug Targets. 2021;21(6):1096–1106.
  • Corey SJ, Jha J, Mccart EA, Rittase WB, Day RM. Captopril mitigates splenomegaly and myelofibrosis in the Gata1low murine model of myelofibrosis. J Cell Mol Med. 2018;22(9):4274–4282.
  • Shirazi M, Noorafshan A, Bahri MA, Tanideh N. Captopril Reduces Interstitial Renal Fibrosis and Preserves More Normal Renal Tubules in Neonatal Dogs with Partial Urethral Obstruction: a Preliminary Study. Urol Int. 2007;78(2):173–177.
  • Zhang MY, He JH, Zhang WL, Liu JP. Fabrication of TPGS-Stabilized Liposome-PLGA Hybrid Nanoparticle Via a New Modified Nanoprecipitation Approach: in Vitro and In Vivo Evaluation. Pharm Res. 2018;35(11):1–13.
  • Shin GH, Chung SK, Kim JT, Joung HJ, Park HJ. Preparation of Chitosan-Coated Nanoliposomes for Improving the Mucoadhesive Property of Curcumin Using the Ethanol Injection Method. J Agric Food Chem. 2013;61(46):11119–11126.
  • Petrilli R, Eloy JO, Lee RJ, Lopez RFV. Preparation of Immunoliposomes by Direct Coupling of Antibodies Based on a Thioether Bond. In: Picanço-Castro V, Swiech K, editors. Methods in Molecular Biology. New York: Humana Press; 2018:229–237.
  • Wang Y, Liu F, Wang Q, et al. A novel immunoliposome mediated by CD123 antibody targeting to acute myeloid leukemia cells. Int J Pharm. 2017;529(1):531–542.
  • Gao J, Wu L, Wang S, Chen X. Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases. Mediators Inflamm. 2020;2020(1):1–16.
  • Li Y, Wang J, Zhu X, Feng Q, Li X, Feng X. Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. BMC Nephrol. 2012;13(1):1–10.
  • Neto OV, Russo EM, Costa RS, Coimbra TM, Dantas M. Effect of the absence of interleukin-12 on mesangial proliferative glomerulonephritis induced by habu snake venom. Ren Fail. 2009;31(10):964–970.
  • Wu L, Chen X, Mei Y, et al. CXCL10 expression induced by Mxi1 inactivation induces mesangial cell apoptosis in mouse Habu nephritis. Cell Signal. 2015;27(5):943–950.
  • Kenneth JL, Thomas DS. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 2002;25:402–408.
  • PETRACHI T, GANZERLI F, CUOGHI A, et al. Assessing Biocompatibility of Face Mask Materials during COVID-19 Pandemic by a Rapid Multi-Assays Strategy. Int J Environ Res Public Health. 2021;18(10):5387.
  • Sun Y, Davis E. Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: a Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms. Nanomaterials. 2021;11(3):746.
  • Jan N, Jonathan B, Julian BA, Renfrow MB. Aberrant Glycosylation of the IgA1 Molecule in IgA Nephropathy. Semin Nephrol. 2018;38(5):461–476.
  • Zhang M, Gao S, Yang D, Fang Y, Shi K. Influencing factors and strategies of enhancing nanoparticles into tumors in vivo. Acta Pharmaceutica Sinica B. 2021;11(8):2265–2285.
  • Nikolay T, Chames K, Philippe C, Siem VDL, Dana H, Domenico M. PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage. Nucleic Acids Res. 2014;42(6):3692–3706.
  • Strzalka W, Ziemienowicz A. Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann Bot. 2011;107(7):1127–1140.
  • Kanemitsu N, Kiyonaga F, Mizukami K, Maeno K, Ito H. Chronic treatment with the (iso-)glutaminyl cyclase inhibitor PQ529 is a novel and effective approach for glomerulonephritis in chronic kidney disease. Naunyn Schmiedeberg Arch Pharmacol. 2020;394(5):751–761.
  • Sonja D, Peter B. Cellular and molecular mechanisms of kidney fibrosis. Mol Aspects Med. 2018;65:16–36.
  • Ihm CG. Hypertension in Chronic Glomerulonephritis. Electrolyte Blood Pressure E Bp. 2015;13(2):41–45.
  • Anton N, Benoit JP, Saulnier P. Design and production of nanoparticles formulated from nano-emulsion templates-a review. J Controlled Release. 2008;128(3):185–199.
  • Guerra-Rosas MI, Morales-Castro J, Cubero-Márquez M, Salvia-Trujillo L, Martín-Belloso O. Antimicrobial activity of nanoemulsions containing essential oils and high methoxyl pectin during long-term storage. Food Control. 2017;77:131–138.
  • Ban J, Yan Z, Xin H, Deng G, Lu Z. dexamethasone. Int J Nanomedicine. 2017;12(1):1329.
  • Krishnan V, Xu X, Barwe SP, et al. Dexamethasone-Loaded Block Copolymer Nanoparticles Induce Leukemia Cell Death and Enhance Therapeutic Efficacy: a Novel Application in Pediatric Nanomedicine. Mol Pharm. 2013;10(6):2199–2210.
  • Bing G, Yan W, Burgess DJ. In vitro and in vivo performance of dexamethasone loaded PLGA microspheres prepared using polymer blends. Int J Pharm. 2015;496(2):534–540.
  • Yu D, Hao W, Sun C, Shi F, Wang X. A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration. Int J Nanomedicine. 2015;10:3567–3579.
  • Zhang Z, Tan S, Feng -S-S. Vitamin E TPGS as a molecular biomaterial for drug delivery. Biomaterials. 2012;33(19):4889–4906.
  • Gómez-Gaete C, Tsapis N, Besnard M, Bochot A, Fattal E. nanoparticles. Int J Pharm. 2007;331(2):153–159.
  • Dawes G, Fratila-Apachitei LE, Necula BS, Apachitei I, Witkamp GJ, Duszczyk J. Release of PLGA–encapsulated dexamethasone from microsphere loaded porous surfaces. J Mater Sci Mater Med. 2010;21(1):215–221.
  • Guo Y, Terazzi E, Seemann R, Fleury JB, Baulin VA. Direct proof of spontaneous translocation of lipid-covered hydrophobic nanoparticles through a phospholipid bilayer. Sci Adv. 2016;2(11):e1600261.
  • Patsula V, Horák D, Kuka J, Macková H, Efc L. Synthesis and modification of uniform PEG-neridronate-modified magnetic nanoparticles determines prolonged blood circulation and biodistribution in a mouse preclinical model. Sci Rep. 2019;9(1):10765.
  • Zhou H, Fan Z, Li PY, Deng J, Cheng H. Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation. ACS Nano. 2018;12(10):10130–10141.
  • Bieritz B, Spessotto P, Colombatti A, Jahn A, Hartner A. Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation. Kidney Int. 2003;64(1):119–127.
  • Ray S, Li Z, Hsu C-H, et al. Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics. Theranostics. 2018;8(22):6322–6349.
  • Ma Y, Cai F, Li Y, Chen J, Lin W. A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease. Bioactive Materials. 2020;5(3):732–743.
  • Wan Y, Gu L, Suzuki K, et al. Multi-Glycoside of Tripterygium wilfordii Hook f. Ameliorates Proteinuria and Acute Mesangial Injury Induced by Anti-Thy1.1 Monoclonal Antibody. Nephron Exp Nephrol. 2005;99(4):e121–e129.
  • Geng W, Wei R, Liu S, et al. Shenhua Tablet inhibits mesangial cell proliferation in rats with chronic anti-Thy-1 nephritis. Biol Res. 2016;49(1):17.
  • Cattell V, Bradfield JWB. Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake venom. Am J Pathol. 1977;87(3):511.
  • Kashyap S, Osman M, Ferguson CM, et al. Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension. Sci Rep. 2018;8(1):8598.
  • Alvarez AM, Deocesano-Pereira C, Teixeira C, et al. IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020;9(2005):1.
  • Gillespie SR, Tedesco LJ, Wang L, Bernstein AM. The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing. J Cell Sci. 2017;130(20):3481–3495.
  • Xu Y, Niu Y, Wu B, et al. Extended-release of therapeutic microRNA via a host-guest supramolecular hydrogel to locally alleviate renal interstitial fibrosis. Biomaterials. 2021;275:120902.
  • Frangogiannis NG. Transforming growth factor–β in tissue fibrosis. J Exp Med. 2020;217(3):e20190103.
  • Tang MK, Zhang YY, Xiao J, et al. Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition. Proce National Acad Sci. 2020;117(34):201917663.
  • Alcalde-Estévez E, Asenjo-Bueno A, Sosa P, et al. Endothelin-1 induces cellular senescence and fibrosis in cultured myoblasts. A potential mechanism of aging-related sarcopenia. Aging. 2020;12(12):11200–11223.
  • Wang Y, Qi H, Liu Y, et al. The double-edged roles of ROS in cancer prevention and therapy. Theranostics. 2021;11(10):4839–4857.
  • Tian Y, Li HB, Liu PY, et al. Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans. Mediators Inflamm. 2015;2015:819232.