Biomimetic Mineralized Hydroxyapatite Nanofiber-Incorporated Methacrylated Gelatin Hydrogel with Improved Mechanical and Osteoinductive Performances for Bone Regeneration

References

• Li Z, Du T, Ruan C, Niu X. Bioinspired mineralized collagen scaffolds for bone tissue engineering. Bioact Mater. 2021;6(5):1491–1511. doi:10.1016/j.bioactmat.2020.11.004
   PubMed Web of Science ®Google Scholar
• Ovsianikov A, Khademhosseini A, Mironov V. The synergy of scaffold-based and scaffold-free tissue engineering strategies. Trends Biotechnol. 2018;36(4):348–357. doi:10.1016/j.tibtech.2018.01.005
   PubMed Web of Science ®Google Scholar
• Du T, Niu X, Hou S, et al. Highly aligned hierarchical intrafibrillar mineralization of collagen induced by periodic fluid shear stress. J Mater Chem B. 2020;8(13):2562–2572. doi:10.1039/C9TB02643F
   PubMed Web of Science ®Google Scholar
• Zhang X, Li Z, Yang P, et al. Polyphenol scaffolds in tissue engineering. Mater Horiz. 2021;8(1):145–167. doi:10.1039/D0MH01317J
   PubMed Web of Science ®Google Scholar
• Fernandez-Yague M, Abbah S, McNamara L, et al. Biomimetic approaches in bone tissue engineering: integrating biological and physicomechanical strategies. Adv Drug Deliver Rev. 2015;84:1–29.
   PubMed Web of Science ®Google Scholar
• Wei W, Ma Y, Yao X, et al. Advanced hydrogels for the repair of cartilage defects and regeneration. Bioact Mater. 2021;6(4):998–1011. doi:10.1016/j.bioactmat.2020.09.030
   PubMed Web of Science ®Google Scholar
• Eggermont LJ, Rogers ZJ, Colombani T, Memic A, Bencherif SA. Injectable cryogels for biomedical applications. Trends Biotechnol. 2020;38(4):418–431. doi:10.1016/j.tibtech.2019.09.008
   PubMed Web of Science ®Google Scholar
• Li Y, Yang H, Lee D. Advances in biodegradable and injectable hydrogels for Biomedical applications. J Control Release. 2021;330:151–160. doi:10.1016/j.jconrel.2020.12.008
   PubMed Web of Science ®Google Scholar
• Maturavongsadit P, Bi X, Metavarayuth K, Luckanagul J, Wang Q. Influence of cross-linkers on the in vitro chondrogenesis of mesenchymal stem cells in hyaluronic acid hydrogels. ACS Appl Mater Interfaces. 2017;9(4):3318–3329. doi:10.1021/acsami.6b12437
   PubMed Web of Science ®Google Scholar
• Zhu H, Monavari M, Zheng K, et al. 3D bioprinting of multifunctional dynamic nanocomposite bioinks incorporating Cu-doped mesoporous bioactive glass nanoparticles for bone tissue engineering. Small. 2022;e2104996. doi:10.1002/smll.202104996
   PubMed Web of Science ®Google Scholar
• Lee C-S, Hwang HS, Kim S, et al. Inspired by nature: facile design of nanoclay-organic hydrogel bone sealant with multifunctional properties for robust bone regeneration. Adv Funct Mater. 2020;30(43):2003717. doi:10.1002/adfm.202003717
   PubMed Web of Science ®Google Scholar
• Yue K, Trujillo-de Santiago G, Alvarez MM, et al. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 2015;73:254–271. doi:10.1016/j.biomaterials.2015.08.045
   PubMed Web of Science ®Google Scholar
• Xu J, Feng Q, Lin S, et al. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials. 2019;210:51–61. doi:10.1016/j.biomaterials.2019.04.031
   PubMed Web of Science ®Google Scholar
• Deng Z, Guo Y, Ma P, Guo B. Rapid thermal responsive conductive hybrid cryogels with shape memory properties, photothermal properties and pressure dependent conductivity. J Colloid Interf Sci. 2018;526:281–294. doi:10.1016/j.jcis.2018.04.093
   PubMed Web of Science ®Google Scholar
• Zhu J. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials. 2010;31(17):4639–4656. doi:10.1016/j.biomaterials.2010.02.044
   PubMed Web of Science ®Google Scholar
• Chen X, Tan B, Bao Z, et al. Enhanced bone regeneration via spatiotemporal and controlled delivery of a genetically engineered BMP-2 in a composite hydrogel. Biomaterials. 2021;277:121117. doi:10.1016/j.biomaterials.2021.121117
   PubMed Web of Science ®Google Scholar
• Kurian AG, Singh RK, Patel KD, Lee J-H, Kim H-W. Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics. Bioact Mater. 2022;8:267–295. doi:10.1016/j.bioactmat.2021.06.027
   PubMed Web of Science ®Google Scholar
• Klotz BJ, Gawlitta D, Rosenberg AJ, Malda J, Melchels FPW. Gelatin-methacryloyl hydrogels: towards biofabrication-based tissue repair. Trends Biotechnol. 2016;34(5):394–407. doi:10.1016/j.tibtech.2016.01.002
   PubMed Web of Science ®Google Scholar
• Yang F, Niu X, Gu X, et al. Biodegradable magnesium-incorporated Poly(l -lactic acid) microspheres for manipulation of drug release and alleviation of inflammatory response. ACS Appl Mater Interfaces. 2019;11(26):23546–23557. doi:10.1021/acsami.9b03766
   PubMed Web of Science ®Google Scholar
• Huang B, Chen M, Tian J, et al. Oxygen-carrying and antibacterial fluorinated nano-hydroxyapatite incorporated hydrogels for enhanced bone regeneration. Adv Healthc Mater. 2022;e2102540. doi:10.1002/adhm.202102540
   PubMed Web of Science ®Google Scholar
• Shi Z, Zhong Q, Chen Y, et al. Nanohydroxyapatite, nanosilicate-reinforced injectable, and biomimetic gelatin-methacryloyl hydrogel for bone tissue engineering. Int J Nanomedicine. 2021;16:5603–5619. doi:10.2147/IJN.S321387
   PubMed Web of Science ®Google Scholar
• Xu Y, Gaillez MP, Zheng K, et al. A self-assembled matrix system for cell-bioengineering applications in different dimensions, scales, and geometries. Small. 2022;e2104758. doi:10.1002/smll.202104758
   PubMed Web of Science ®Google Scholar
• Brunello G, Sivolella S, Meneghello R, et al. Powder-based 3D printing for bone tissue engineering. Biotechnol Adv. 2016;34(5):740–753. doi:10.1016/j.biotechadv.2016.03.009
   PubMed Web of Science ®Google Scholar
• Ingavle GC, Gionet-Gonzales M, Vorwald CE, et al. Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model. Biomaterials. 2019;197:119–128. doi:10.1016/j.biomaterials.2019.01.005
   PubMed Web of Science ®Google Scholar
• Raina D, Isaksson H, Teotia A, et al. Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration. J Control Release. 2016;235:365–378. doi:10.1016/j.jconrel.2016.05.061
   PubMed Web of Science ®Google Scholar
• Thoniyot P, Tan M, Karim A, Young D, Loh X. Nanoparticle-hydrogel composites: concept, design, and applications of these promising, multi-functional materials. Adv Sci. 2015;2:1400010. doi:10.1002/advs.201400010
   Web of Science ®Google Scholar
• Sun T, Yu W, Zhu Y, et al. Porous nanocomposite comprising ultralong hydroxyapatite nanowires decorated with zinc-containing nanoparticles and chitosan: synthesis and application in bone defect repair. Chemistry. 2018;24(35):8809–8821. doi:10.1002/chem.201800425
   PubMed Web of Science ®Google Scholar
• Huang G, Yu H, Wang X, et al. Highly porous and elastic aerogel based on ultralong hydroxyapatite nanowires for high-performance bone regeneration and neovascularization. J Mater Chem B. 2021;9(5):1277–1287. doi:10.1039/D0TB02288H
   PubMed Web of Science ®Google Scholar
• Cho K, Wang G, Raju R, et al. Influence of surface treatment on the interfacial and mechanical properties of short S-glass fiber-reinforced dental composites. ACS Appl Mater Interfaces. 2019;11(35):32328–32338. doi:10.1021/acsami.9b01857
   PubMed Web of Science ®Google Scholar
• Santos A, Ferreira C, Veiga F, et al. Halloysite clay nanotubes for life sciences applications: from drug encapsulation to bioscaffold. Adv Colloid Interface Sci. 2018;257:58–70. doi:10.1016/j.cis.2018.05.007
   PubMed Web of Science ®Google Scholar
• Farokhi M, Mottaghitalab F, Samani S, et al. Silk fibroin/hydroxyapatite composites for bone tissue engineering. Biotechnol Adv. 2018;36(1):68–91. doi:10.1016/j.biotechadv.2017.10.001
   PubMed Web of Science ®Google Scholar
• Liao S, Wang W, Uo M, et al. A three-layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane for guided tissue regeneration. Biomaterials. 2005;26(36):7564–7571. doi:10.1016/j.biomaterials.2005.05.050
   PubMed Web of Science ®Google Scholar
• Kim H, Kim H, Salih V. Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds. Biomaterials. 2005;26(25):5221–5230. doi:10.1016/j.biomaterials.2005.01.047
   PubMed Web of Science ®Google Scholar
• Fleet ME, Liu X. Coupled substitution of type A and B carbonate in sodium-bearing apatite. Biomaterials. 2007;28(6):916–926. doi:10.1016/j.biomaterials.2006.11.003
   PubMed Web of Science ®Google Scholar
• Sun T, Zhu Y, Chen F. Highly flexible multifunctional biopaper comprising chitosan reinforced by ultralong hydroxyapatite nanowires. Chemistry. 2017;23(16):3850–3862. doi:10.1002/chem.201605165
   PubMed Web of Science ®Google Scholar
• Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 2006;27(15):2907–2915. doi:10.1016/j.biomaterials.2006.01.017
   PubMed Web of Science ®Google Scholar
• Xiao W, Qu X, Tan Y, et al. Synthesis of photocrosslinkable hydrogels for engineering three-dimensional vascular-like constructs by surface tension-driven assembly. Mater Sci Eng C Mater Biol Appl. 2020;116:111143. doi:10.1016/j.msec.2020.111143
   PubMed Web of Science ®Google Scholar
• Eke G, Mangir N, Hasirci N, MacNeil S, Hasirci V. Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. Biomaterials. 2017;129:188–198. doi:10.1016/j.biomaterials.2017.03.021
   PubMed Web of Science ®Google Scholar
• Nichol JW, Koshy ST, Bae H, et al. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials. 2010;31(21):5536–5544. doi:10.1016/j.biomaterials.2010.03.064
   PubMed Web of Science ®Google Scholar
• Fang J, Li P, Lu X, et al. A strong, tough, and osteoconductive hydroxyapatite mineralized polyacrylamide/dextran hydrogel for bone tissue regeneration. Acta Biomater. 2019;88:503–513. doi:10.1016/j.actbio.2019.02.019
   PubMed Web of Science ®Google Scholar
• Zhang X, Chang W, Lee P, et al. Polymer-ceramic spiral structured scaffolds for bone tissue engineering: effect of hydroxyapatite composition on human fetal osteoblasts. PLoS One. 2014;9(1):e85871. doi:10.1371/journal.pone.0085871
   PubMed Web of Science ®Google Scholar
• Barros J, Ferraz MP, Azeredo J, et al. Alginate-nanohydroxyapatite hydrogel system: optimizing the formulation for enhanced bone regeneration. Mater Sci Eng C Mater Biol Appl. 2019;105:109985. doi:10.1016/j.msec.2019.109985
   PubMed Web of Science ®Google Scholar
• Costa DO, Prowse PDH, Chrones T, et al. The differential regulation of osteoblast and osteoclast activity by surface topography of hydroxyapatite coatings. Biomaterials. 2013;34(30):7215–7226. doi:10.1016/j.biomaterials.2013.06.014
   PubMed Web of Science ®Google Scholar
• Gentile F, Tirinato L, Battista E, et al. Cells preferentially grow on rough substrates. Biomaterials. 2010;31(28):7205–7212. doi:10.1016/j.biomaterials.2010.06.016
   PubMed Web of Science ®Google Scholar
• Annabi N, Nichol JW, Zhong X, et al. Controlling the porosity and microarchitecture of hydrogels for tissue engineering. Tissue Eng Part B Rev. 2010;16(4):371–383. doi:10.1089/ten.teb.2009.0639
   PubMed Web of Science ®Google Scholar
• Yang G, Liu H, Hu X, et al. Bio-inspired hybrid nanoparticles promote vascularized bone regeneration in a morphology-dependent manner. Nanoscale. 2017;9(18):5794–5805. doi:10.1039/C7NR00347A
   PubMed Web of Science ®Google Scholar
• Gu L, Zhang J, Li L, et al. Hydroxyapatite nanowire composited gelatin cryogel with improved mechanical properties and cell migration for bone regeneration. Biomed Mater. 2019;14(4):045001. doi:10.1088/1748-605X/ab1583
   PubMed Web of Science ®Google Scholar
• Cabezas MD, Meckes B, Mirkin CA, Mrksich M. Subcellular control over focal adhesion anisotropy, independent of cell morphology, dictates stem cell fate. ACS Nano. 2019;13(10):11144–11152. doi:10.1021/acsnano.9b03937
   PubMed Web of Science ®Google Scholar
• Li YY, Choy TH, Ho FC, Chan PB. Scaffold composition affects cytoskeleton organization, cell-matrix interaction and the cellular fate of human mesenchymal stem cells upon chondrogenic differentiation. Biomaterials. 2015;52:208–220. doi:10.1016/j.biomaterials.2015.02.037
   PubMed Web of Science ®Google Scholar
• Zhao R, Xie P, Zhang K, et al. Selective effect of hydroxyapatite nanoparticles on osteoporotic and healthy bone formation correlates with intracellular calcium homeostasis regulation. Acta Biomater. 2017;59:338–350. doi:10.1016/j.actbio.2017.07.009
   PubMed Web of Science ®Google Scholar
• Lee SS, Kim JH, Jeong J, et al. Sequential growth factor releasing double cryogel system for enhanced bone regeneration. Biomaterials. 2020;257:120223. doi:10.1016/j.biomaterials.2020.120223
   PubMed Web of Science ®Google Scholar
• Yuan Z, Tao B, He Y, et al. Remote eradication of biofilm on titanium implant via near-infrared light triggered photothermal/photodynamic therapy strategy. Biomaterials. 2019;223:119479. doi:10.1016/j.biomaterials.2019.119479
   PubMed Web of Science ®Google Scholar
• Dhivya S, Saravanan S, Sastry TP, Selvamurugan N. Nanohydroxyapatite-reinforced chitosan composite hydrogel for bone tissue repair in vitro and in vivo. J NanobioTechnology. 2015;13:40. doi:10.1186/s12951-015-0099-z
   PubMed Web of Science ®Google Scholar
• Spicer PP, Kretlow JD, Young S, et al. Evaluation of bone regeneration using the rat critical size calvarial defect. Nat Protoc. 2012;7(10):1918–1929. doi:10.1038/nprot.2012.113
   PubMed Web of Science ®Google Scholar
• Lin Z, Wu J, Qiao W, et al. Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration. Biomaterials. 2018;174:1–16. doi:10.1016/j.biomaterials.2018.05.011
   PubMed Web of Science ®Google Scholar
• Han H-S, Jun I, Seok H-K, et al. Biodegradable magnesium alloys promote angio-osteogenesis to enhance bone repair. Adv Sci. 2020;7(15):2000800. doi:10.1002/advs.202000800
   Web of Science ®Google Scholar
• Chen JL, Yin Z, Shen WL, et al. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials. 2010;31(36):9438–9451. doi:10.1016/j.biomaterials.2010.08.011
   PubMed Web of Science ®Google Scholar
• Kang H, Wong DSH, Yan X, et al. Remote control of multimodal nanoscale ligand oscillations regulates stem cell adhesion and differentiation. ACS Nano. 2017;11(10):9636–9649. doi:10.1021/acsnano.7b02857
   PubMed Web of Science ®Google Scholar
• Black C, Kanczler JM, de Andrés MC, et al. Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold. Biomaterials. 2020;247:119998. doi:10.1016/j.biomaterials.2020.119998
   PubMed Web of Science ®Google Scholar
• Yu L, Sui B, Fan W, et al. Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p. J Extracell Vesicles. 2021;10(3):e12056. doi:10.1002/jev2.12056
   PubMed Web of Science ®Google Scholar
• Wang R, Shi M, Xu F, et al. Graphdiyne-modified TiO(2) nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection. Nat Commun. 2020;11(1):4465. doi:10.1038/s41467-020-18267-1
   PubMed Web of Science ®Google Scholar
• Lee N-H, Kang MS, Kim T-H, et al. Dual actions of osteoclastic-inhibition and osteogenic-stimulation through strontium-releasing bioactive nanoscale cement imply biomaterial-enabled osteoporosis therapy. Biomaterials. 2021;276:121025. doi:10.1016/j.biomaterials.2021.121025
   PubMed Web of Science ®Google Scholar
• Mota C, Camarero-Espinosa S, Baker MB, Wieringa P, Moroni L. Bioprinting: from tissue and organ development to models. Chem Rev. 2020;120(19):10547–10607. doi:10.1021/acs.chemrev.9b00789
   PubMed Web of Science ®Google Scholar
• Gu H, Guo F, Zhou X, et al. The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway. Biomaterials. 2011;32(29):7023–7033. doi:10.1016/j.biomaterials.2011.06.003
   PubMed Web of Science ®Google Scholar
• Chan G, Mooney DJ. Ca(2+) released from calcium alginate gels can promote inflammatory responses in vitro and in vivo. Acta Biomater. 2013;9(12):9281–9291. doi:10.1016/j.actbio.2013.08.002
   PubMed Web of Science ®Google Scholar