Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification

References

• Jia CY, Guo YX, Wu FG. Chemodynamic therapy via fenton and fenton-like nanomaterials: strategies and recent advances. Small. 2022;18(6):2103868. doi:10.1002/smll.202103868
   Web of Science ®Google Scholar
• Bai Y, Zhao J, Zhang L, et al. A smart near-infrared carbon dot-metal organic framework assemblies for tumor microenvironment-activated cancer imaging and chemodynamic-photothermal combined therapy. Adv Healthcare Mater;2022. e2102759–e2102759. doi:10.1002/adhm.202102759
   Web of Science ®Google Scholar
• Gao FL, Wu J, Gao HQ, et al. Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics. Biomaterials. 2020;230:119635. doi:10.1016/j.biomaterials.2019.119635
   PubMed Web of Science ®Google Scholar
• Zhang SC, Cao CY, Lv XY, et al. A H2O2 self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy. Chem Sci. 2020;11(7):1926–1934. doi:10.1039/C9SC05506A
   PubMed Web of Science ®Google Scholar
• Li Y, Jia R, Lin HM, Sun XL, Qu FY. Synthesis of MoSe2/CoSe2 nanosheets for NIR-enhanced chemodynamic therapy via synergistic in-situ H2O2 production and activation. Appl Organomet Chem. 2020;31(8):2008420.
   Google Scholar
• Lin J, He T, Yuan Y, et al. Light-triggered transformable ferrous ion delivery system for photothermal primed chemodynamic therapy. Angewandte Chemie. 2020;60(11):6047–6054.
   Google Scholar
• Jia T, Wang Z, Sun QQ, et al. Intelligent Fe-Mn layered double hydroxides nanosheets anchored with upconversion nanoparticles for oxygen-elevated synergetic therapy and bioimaging. Small. 2020;16(46):2001343. doi:10.1002/smll.202001343
   Web of Science ®Google Scholar
• Nie X, Xia L, Wang HL, et al. Photothermal therapy nanomaterials boosting transformation of Fe(III) into Fe(II) in tumor cells for highly improving chemodynamic therapy. Acs Appl Mater Inter. 2019;11(35):31735–31742. doi:10.1021/acsami.9b11291
   PubMed Web of Science ®Google Scholar
• He Z, Zhang H, Li H, et al. Preparation, biosafety, and cytotoxicity studies of a newly tumor-microenvironment-responsive biodegradable mesoporous silica nanosystem based on multimodal and synergistic treatment. Oxid Med Cell Longev. 2020;2020:7152173. doi:10.1155/2020/7152173
   PubMed Web of Science ®Google Scholar
• Li SS, Huang J, Guo Y, et al. PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy. Front Immunol. 2021;12:714244. doi:10.3389/fimmu.2021.714244
   PubMed Web of Science ®Google Scholar
• Zheng NN, Wang Q, Li CL, et al. Responsive degradable theranostic agents enable controlled selenium delivery to enhance photothermal radiotherapy and reduce side effects. Adv Healthc Mater. 2021;10(10):2002024. doi:10.1002/adhm.202002024
   Web of Science ®Google Scholar
• Tang ZM, Liu YY, He MY, Bu WB. Chemodynamic therapy: tumour microenvironment-mediated fenton and fenton-like reactions. Angewandte Chemie. 2019;58(4):946–956. doi:10.1002/anie.201805664
   Google Scholar
• Zhang HW, Lu F, Pan W, et al. A dual-catalytic nanoreactor for synergistic chemodynamic-starvation therapy toward tumor metastasis suppression. Biomater Sci-Uk. 2021;9(10):3814–3820. doi:10.1039/D1BM00240F
   PubMed Web of Science ®Google Scholar
• He YL, Jin XY, Guo SW, Zhao HX, Liu Y, Ju HX. Conjugated polymer-ferrocence nanoparticle as an NIR-II light powered nanoamplifier to enhance chemodynamic therapy. Acs Appl Mater Inter. 2021;13(27):31452–31461. doi:10.1021/acsami.1c06613
   PubMed Web of Science ®Google Scholar
• Hu CL, Wang JZ, Liu SN, et al. Urchin-shaped metal organic/hydrogen-bonded framework nanocomposite as a multifunctional nanoreactor for catalysis-enhanced synergetic therapy. Acs Appl Mater Inter. 2021;13(4):4825–4834. doi:10.1021/acsami.0c19584
   PubMed Web of Science ®Google Scholar
• Fu LH, Wan YL, Qi C, et al. Nanocatalytic theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient cancer therapy. Adv Mater. 2021;33(7):2006892. doi:10.1002/adma.202006892
   PubMed Web of Science ®Google Scholar
• He H, Yang QY, Li HM, et al. Hollow mesoporous MnO2-carbon nanodot-based nanoplatform for GSH depletion enhanced chemodynamic therapy, chemotherapy, and normal/cancer cell differentiation. Microchim Acta. 2021;188(4):141. doi:10.1007/s00604-021-04801-5
   PubMed Web of Science ®Google Scholar
• Yang GB, Ji JS, Liu Z. Multifunctional MnO2 nanoparticles for tumor microenvironment modulation and cancer therapy. Wires Nanomed Nanobi. 2021;13(6):1720. doi:10.1002/wnan.1720
   Google Scholar
• Bao YW, Hua XW, Zeng J, Wu FG. Bacterial template synthesis of multifunctional nanospindles for glutathione detection and enhanced cancer-specific chemo-chemodynamic therapy. Research-China. 2020;2020:9301215.
   PubMedGoogle Scholar
• Kang YW, Hwang KY. Effects of reaction conditions on the oxidation efficiency in the Fenton process. Water Res. 2000;34(10):2786–2790. doi:10.1016/S0043-1354(99)00388-7
   Web of Science ®Google Scholar
• Ke WD, Li JJ, Mohammed F, et al. Therapeutic polymersome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy. Acs Nano. 2019;13(2):2357–2369. doi:10.1021/acsnano.8b09082
   PubMed Web of Science ®Google Scholar
• Dong SM, Dong YS, Jia T, et al. GSH-depleted nanozymes with hyperthermia-enhanced dual enzyme-mimic activities for tumor nanocatalytic therapy. Adv Mater. 2020;32(42):2002439. doi:10.1002/adma.202002439
   Web of Science ®Google Scholar
• Zhang Y, Eltayeb O, Meng YT, et al. Tumor microenvironment responsive mesoporous silica nanoparticles for dual delivery of doxorubicin and chemodynamic therapy (CDT) agent. New J Chem. 2020;44(6):2578–2586. doi:10.1039/C9NJ05427H
   Web of Science ®Google Scholar
• Tang W, Gao HB, Ni DL, et al. Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy. J Nanobiotechnol. 2019;17:68. doi:10.1186/s12951-019-0501-3
   PubMed Web of Science ®Google Scholar
• Yang SD, Wang Y, Ren ZX, Chen MT, Chen WL, Zhang XN. Stepwise pH/reduction-responsive polymeric conjugates for enhanced drug delivery to tumor. Mat Sci Eng C-Mater. 2018;82:234–243. doi:10.1016/j.msec.2017.08.079
   Web of Science ®Google Scholar
• Li JJ, Kataoka K. Chemo-physical strategies to advance the in vivo functionality of targeted nanomedicine: the next generation. J Am Chem Soc. 2021;143(2):538–559. doi:10.1021/jacs.0c09029
   PubMed Web of Science ®Google Scholar
• Zhou H, Li XW, Niu DC, et al. Ultrasensitive chemodynamic therapy: bimetallic peroxide triggers high pH-activated, synergistic effect/H2O2 self-supply-mediated cascade fenton chemistry. Adv Healthc Mater. 2021;10(9):2002126. doi:10.1002/adhm.202002126
   Web of Science ®Google Scholar
• Naser FJ, Jackstadt MM, Fowle-Grider R, et al. Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver. Cell Metab. 2021;33(7):1493. doi:10.1016/j.cmet.2021.04.014
   PubMed Web of Science ®Google Scholar
• Butler M, van der Meer LT, Van Leeuwen FN. Amino acid depletion therapies: starving cancer cells to death. Trends Endocrin Met. 2021;32(6):367–381. doi:10.1016/j.tem.2021.03.003
   PubMed Web of Science ®Google Scholar
• Yang C, Gao M, Zhao H, et al. A dual-functional biomimetic-mineralized nanoplatform for glucose detection and therapy with cancer cells in vitro. J Mater Chem B. 2021;9(18):3885–3891. doi:10.1039/D1TB00324K
   PubMed Web of Science ®Google Scholar
• Ming J, Zhu TB, Yang WH, et al. Pd@Pt-GOx/HA as a novel enzymatic cascade nanoreactor for high-efficiency starving-enhanced chemodynamic cancer therapy. Acs Appl Mater Inter. 2020;12(46):51249–51262. doi:10.1021/acsami.0c15211
   PubMed Web of Science ®Google Scholar
• Deng FA, Fan GL, Yuan P, et al. A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy. Chem Commun. 2020;56(93):14633–14636. doi:10.1039/D0CC06483A
   PubMed Web of Science ®Google Scholar
• Yang GB, Wang DD, Phua SZF, et al. Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer. Acs Nano. 2022;16(2):2319–2329. doi:10.1021/acsnano.1c08536
   PubMed Web of Science ®Google Scholar
• Wang M, Wang DM, Chen Q, Li CX, Li ZQ, Lin J. Recent advances in glucose-oxidase-based nanocomposites for tumor therapy. Small. 2019;15(51):1903895. doi:10.1002/smll.201903895
   PubMed Web of Science ®Google Scholar
• Wang Q, Niu DG, Shi JS, Wang LL. A three-in-one ZIFs-derived CuCo(O)/GOx@PCNs hybrid cascade nanozyme for immunotherapy/enhanced starvation/photothermal therapy. Acs Appl Mater Inter. 2021;13(10):11683–11695. doi:10.1021/acsami.1c01006
   PubMed Web of Science ®Google Scholar
• Liu XP, Liu ZW, Dong K, et al. Tumor-activatable ultrasmall nanozyme generator for enhanced penetration and deep catalytic therapy. Biomaterials. 2020;258:120263. doi:10.1016/j.biomaterials.2020.120263
   PubMed Web of Science ®Google Scholar
• Fang C, Deng Z, Cao GD, et al. Co-Ferrocene MOF/Glucose oxidase as cascade nanozyme for effective tumor therapy. Adv Funct Mater. 2020;30(16):1910085. doi:10.1002/adfm.201910085
   Web of Science ®Google Scholar
• Li JJ, Li YF, Wang YH, et al. Polymer prodrug-based nanoreactors activated by tumor acidity for orchestrated oxidation/chemotherapy. Nano Lett. 2017;17(11):6983–6990. doi:10.1021/acs.nanolett.7b03531
   PubMed Web of Science ®Google Scholar
• Li JJ, Anraku Y, Kataoka K. Self-boosting catalytic nanoreactors integrated with triggerable crosslinking membrane networks for initiation of immunogenic cell death by pyroptosis. Angewandte Chemie. 2020;59(32):13526–13530. doi:10.1002/anie.202004180
   Google Scholar
• Li JJ, Dirisala A, Ge ZS, et al. Therapeutic vesicular nanoreactors with tumor-specific activation and self-destruction for synergistic tumor ablation. Angewandte Chemie. 2017;56(45):14025–14030. doi:10.1002/anie.201706964
   Google Scholar
• Yang X, Yang Y, Gao F, Wei JJ, Qian CG, Sun MJ. Biomimetic hybrid nanozymes with self-supplied H(+) and accelerated O2 generation for enhanced starvation and photodynamic therapy against hypoxic tumors. Nano Lett. 2019;19(7):4334–4342. doi:10.1021/acs.nanolett.9b00934
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang ZZ, Zhang Y, et al. Erythrocyte membrane cloaked metal-organic framework nanoparticle as biomimetic nanoreactor for starvation-activated colon cancer therapy. Acs Nano. 2018;12(10):10201–10211. doi:10.1021/acsnano.8b05200
   PubMed Web of Science ®Google Scholar
• Shao YJ, Wang ZY, Hao YT, et al. Cascade catalytic nanoplatform based on “butterfly effect” for enhanced immunotherapy. Adv Healthc Mater. 2021;10(8):2002171. doi:10.1002/adhm.202002171
   Web of Science ®Google Scholar
• Zhang YW, Hu HR, Liu WW, et al. Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity. J Immunother Cancer. 2021;9(4):e002137. doi:10.1136/jitc-2020-002137
   PubMed Web of Science ®Google Scholar
• Mazzoni A, Capone M, Ramazzotti M, et al. IL4I1 is expressed by head-neck cancer-derived mesenchymal stromal cells and contributes to suppress T cell proliferation. J Clin Med. 2021;10(10):2111. doi:10.3390/jcm10102111
   PubMed Web of Science ®Google Scholar
• Cormerais Y, Vucetic M, Pouyssegur J. Targeting amino acids transporters (SLCs) to starve cancer cells to death. Biochem Bioph Res Co. 2019;520(4):691–693. doi:10.1016/j.bbrc.2019.10.173
   PubMed Web of Science ®Google Scholar
• Zhang L, Wu WT. Isolation and characterization of ACTX-6: a cytotoxic L-amino acid oxidase from Agkistrodon acutus snake venom. Nat Prod Res. 2008;22(6):554–563. doi:10.1080/14786410701592679
   PubMed Web of Science ®Google Scholar
• Chu Q, Zhu H, Liu B, et al. Delivery of amino acid oxidase via catalytic nanocapsules to enable effective tumor inhibition. J Mater Chem B. 2020;8(37):8546–8557. doi:10.1039/D0TB01425G
   PubMed Web of Science ®Google Scholar
• Sanborn CD, Chacko JV, Digman M, Ardo S. Interfacial and nanoconfinement effects decrease the excited-state acidity of polymer-bound photoacids. Chem-Us. 2019;5(6):1648–1670. doi:10.1016/j.chempr.2019.04.022
   Web of Science ®Google Scholar
• Peretz-Soroka H, Pevzner A, Davidi G, et al. Manipulating and monitoring on-surface biological reactions by light-triggered local pH alterations. Nano Lett. 2015;15(7):4758–4768. doi:10.1021/acs.nanolett.5b01578
   PubMed Web of Science ®Google Scholar
• Liao Y. Design and applications of metastable-state photoacids. Accounts Chem Res. 2017;50(8):1956–1964.
   PubMed Web of Science ®Google Scholar
• Yan DM, Chen JR, Xiao WJ. New roles for photoexcited Eosin Y in photochemical reactions. Angewandte Chemie. 2019;58(2):378–380. doi:10.1002/anie.201811102
   Google Scholar
• Chen X, Chen Y, Wang C, et al. NIR-triggered intracellular H+ transients for lamellipodia-collapsed antimetastasis and enhanced chemodynamic therapy. Angew Chem Int Ed Engl. 2021;60(40):21905–21910. doi:10.1002/anie.202107588
   PubMed Web of Science ®Google Scholar
• McKenzie M, Liolitsa D, Akinshina N, et al. Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. J Biol Chem. 2007;282(51):36845–36852. doi:10.1074/jbc.M704158200
   PubMed Web of Science ®Google Scholar
• Park JS, Sharma LK, Li HZ, et al. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009;18(9):1578–1589. doi:10.1093/hmg/ddp069
   PubMed Web of Science ®Google Scholar
• Chen Z, Wei XY, Wang XY, et al. NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell Death Dis. 2021;12(4):377. doi:10.1038/s41419-021-03646-3
   PubMed Web of Science ®Google Scholar
• Chaube B, Malvi P, Singh SV, Mohammad N, Meena AS, Bhat MK. Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. Oncotarget. 2015;6(35):37281–37299. doi:10.18632/oncotarget.6134
   PubMedGoogle Scholar
• Heinz S, Freyberger A, Lawrenz B, Schladt L, Schmuck G, Ellinger-Ziegelbauer H. Mechanistic investigations of the mitochondrial complex i inhibitor rotenone in the context of pharmacological and safety evaluation. Sci Rep-Uk. 2017;7:45465. doi:10.1038/srep45465
   PubMed Web of Science ®Google Scholar
• Shi LN, Wang YJ, Zhang C, et al. An acidity-unlocked magnetic nanoplatform enables self-boosting ROS generation through upregulation of lactate for imaging-guided highly specific chemodynamic therapy. Angewandte Chemie. 2021;60(17):9562–9572. doi:10.1002/anie.202014415
   Google Scholar
• Ju R, Guo L, Li J, et al. Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition. Cancer Lett. 2016;370(2):232–241. doi:10.1016/j.canlet.2015.10.025
   PubMed Web of Science ®Google Scholar
• Cornelissen J, Wanders RJA, Vangennip AH, Vandenbogert C, Voute PA, Vankuilenburg ABP. Metaiodobenzylguanidine inhibits Complex-I and complex-iii of the respiratory-chain in the human cell-line Molt-4. Biochem Pharmacol. 1995;49(4):471–477. doi:10.1016/0006-2952(94)00450-Z
   PubMed Web of Science ®Google Scholar
• Tian H, Zhang M, Jin G, Jiang Y, Luan Y. Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy. J Colloid Interface Sci. 2021;587:358–366. doi:10.1016/j.jcis.2020.12.028
   PubMed Web of Science ®Google Scholar
• Xu P, Zhang Y, Ge F, Zhang F, He X, Gao X. Modulation of tumor microenvironment to enhance radiotherapy efficacy in esophageal squamous cell carcinoma by inhibiting carbonic anhydrase IX. Front Oncol. 2021;11:637252. doi:10.3389/fonc.2021.637252
   PubMed Web of Science ®Google Scholar
• Papakonstantinou E, Vlachakis D, Thireou T, Vlachoyiannopoulos PG, Eliopoulos E. A holistic evolutionary and 3D pharmacophore modelling study provides insights into the metabolism, function, and substrate selectivity of the human monocarboxylate transporter 4 (hMCT4). Int J Mol Sci. 2021;22(6):2918. doi:10.3390/ijms22062918
   PubMed Web of Science ®Google Scholar
• Hou KY, Liu J, Du JY, et al. Dihydroartemisinin prompts amplification of photodynamic therapy-induced reactive oxygen species to exhaust Na/H exchanger 1-mediated glioma cells invasion and migration. J Photoch Photobio B. 2021;219:112192. doi:10.1016/j.jphotobiol.2021.112192
   PubMed Web of Science ®Google Scholar
• Toft NJ, Axelsen TV, Pedersen HL, et al. Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival. Elife. 2021;10:e68447. doi:10.7554/eLife.68447
   PubMed Web of Science ®Google Scholar
• Bozdag M, Ferraroni M, Ward C, et al. Carbonic anhydrase inhibitors based on sorafenib scaffold: design, synthesis, crystallographic investigation and effects on primary breast cancer cells. Eur J Med Chem. 2019;182:111600. doi:10.1016/j.ejmech.2019.111600
   PubMed Web of Science ®Google Scholar
• Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011;71(13):4733.
   Web of Science ®Google Scholar
• Williams KJ, Gieling RG. Preclinical evaluation of ureidosulfamate carbonic anhydrase IX/XII inhibitors in the treatment of cancers. Int J Mol Sci. 2019;20:23. doi:10.3390/ijms20236080
   Web of Science ®Google Scholar
• Kurt BZ, Sonmez F, Ozturk D, Akdemir A, Angeli A, Supuran CT. Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies. Eur J Med Chem. 2019;183. doi:10.1016/j.ejmech.2018.11.064
   PubMed Web of Science ®Google Scholar
• Ni K, Lan G, Song Y, Hao Z, Lin W. Biomimetic nanoscale metal-organic framework harnesses hypoxia for effective cancer radiotherapy and immunotherapy. Chem Sci. 2020;11(29):7641–7653. doi:10.1039/D0SC01949F
   PubMed Web of Science ®Google Scholar
• Lou Y, McDonald PC, Oloumi A, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011;71(9):3364–3376. doi:10.1158/0008-5472.CAN-10-4261
   PubMed Web of Science ®Google Scholar
• Sarnella A, D’Avino G, Hill BS, et al. A novel inhibitor of carbonic anhydrases prevents hypoxia-induced TNBC cell plasticity. Int J Mol Sci. 2020;21(21):8405. doi:10.3390/ijms21218405
   PubMed Web of Science ®Google Scholar
• Angeli A, Pinteala M, Maier SS, et al. Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. Bioorg Med Chem Lett. 2021;45:128147. doi:10.1016/j.bmcl.2021.128147
   PubMed Web of Science ®Google Scholar
• Kugler M, Holub J, Brynda J, et al. The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzym Inhib Med Ch. 2020;35(1):1800–1810. doi:10.1080/14756366.2020.1816996
   PubMed Web of Science ®Google Scholar
• Zhang ZP, Zhong Y, Han ZB, et al. Synthesis, molecular docking analysis and biological evaluations of saccharide-modified thiadiazole sulfonamide derivatives. Int J Mol Sci. 2021;22(11). doi:10.3390/ijms222413610
   Web of Science ®Google Scholar
• Petrenko M, Guttler A, Funtan A, et al. Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells. Chem Biol Interact. 2021;4:333.
   Google Scholar
• Bua S, Lomelino C, Murray AB, et al. “A sweet combination”: developing saccharin and acesulfame K structures for selectively targeting the tumor-associated carbonic anhydrases IX and XII. J Med Chem. 2020;63(1):321–333. doi:10.1021/acs.jmedchem.9b01669
   PubMed Web of Science ®Google Scholar
• Mboge MY, Combs J, Singh S, et al. Inhibition of carbonic anhydrase using SLC-149: support for a noncatalytic function of CAIX in breast cancer. J Med Chem. 2021;64(3):1713–1724. doi:10.1021/acs.jmedchem.0c02077
   PubMed Web of Science ®Google Scholar
• D’Ascenzio M, Secci D, Carradori S, et al. 1,3-Dipolar Cycloaddition, HPLC enantioseparation, and docking studies of saccharin/isoxazole and saccharin/isoxazoline derivatives as selective carbonic anhydrase IX and XII inhibitors. J Med Chem. 2020;63(5):2470–2488. doi:10.1021/acs.jmedchem.9b01434
   PubMed Web of Science ®Google Scholar
• Grandane A, Nocentini A, Domraceva I, Zalubovskis R, Supuran CT. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020;45:200.
   Google Scholar
• Malebari AM, Ibrahim TS, Salem IM, et al. The anticancer activity for the bumetanide-based analogs via targeting the tumor-associated membrane-bound human carbonic anhydrase-IX enzyme. Pharmaceuticals-Base. 2020;13(9):e34.
   PubMed Web of Science ®Google Scholar
• Hanson DJ, Nakamura S, Amachi R, et al. Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation. Oncotarget. 2015;6(32):33568–33586. doi:10.18632/oncotarget.5598
   PubMedGoogle Scholar
• Beloueche-Babari M, Wantuch S, Galobart TC, et al. MCT1 inhibitor AZD3965 increases mitochondrial metabolism, facilitating combination therapy and noninvasive magnetic resonance spectroscopy. Cancer Res. 2017;77(21):5913–5924. doi:10.1158/0008-5472.CAN-16-2686
   PubMed Web of Science ®Google Scholar
• Guan X, Rodriguez-Cruz V, Morris ME. Cellular uptake of MCT1 inhibitors AR-C155858 and AZD3965 and their effects on MCT-mediated transport of l-lactate in murine 4T1 breast tumor cancer cells. Aaps J. 2019;21(2). doi:10.1208/s12248-018-0279-5
   PubMed Web of Science ®Google Scholar
• Liu YL, Ji XY, Tong WWL, et al. Engineering multifunctional RNAi nanomedicine to concurrently target cancer hallmarks for combinatorial therapy. Angewandte Chemie. 2018;57(6):1510–1513. doi:10.1002/anie.201710144
   Google Scholar
• Puri S, Juvale K. Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: a review with structure-activity relationship insights. Eur J Med Chem. 2020;45:199.
   Google Scholar
• Renner K, Bruss C, Schnell A, et al. Restricting glycolysis preserves T cell effector functions and augments checkpoint therapy. Cell Rep. 2019;29(1):135. doi:10.1016/j.celrep.2019.08.068
   PubMed Web of Science ®Google Scholar
• Sadeghzadeh M, Moldovan RP, Teodoro R, Brust P, Wenzel B. One-step radiosynthesis of the MCTs imaging agent F-18 FACH by aliphatic F-18-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group. Sci Rep-Uk. 2019;9:45.
   PubMed Web of Science ®Google Scholar
• Yang XK, Wang DS, Dong W, Song ZS, Dou KF. Expression and modulation of Na+/H+ exchanger 1 gene in hepatocellular carcinoma: a potential therapeutic target. J Gastroenterol Hepatol. 2011;26(2):364–370. doi:10.1111/j.1440-1746.2010.06382.x
   PubMed Web of Science ®Google Scholar
• Yang X, Wang D, Dong W, Song Z, Dou K. Suppression of Na+/H+ exchanger 1 by RNA interference or amiloride inhibits human hepatoma cell line SMMC-7721 cell invasion. Med Oncol. 2011;28(1):385–390. doi:10.1007/s12032-010-9447-x
   PubMed Web of Science ®Google Scholar
• Yang X, Wang D, Dong W, Song Z, Dou K. Inhibition of Na(+)/H(+) exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility. Cancer Lett. 2010;295(2):198–204. doi:10.1016/j.canlet.2010.03.001
   PubMed Web of Science ®Google Scholar
• Wang J, Xu H, Wang Q, et al. CIAPIN1 targets Na+/H+ exchanger 1 to mediate MDA-MB-231 cells’ metastasis through regulation of MMPs via ERK1/2 signaling pathway. Exp Cell Res. 2015;333(1):60–72. doi:10.1016/j.yexcr.2015.02.012
   PubMed Web of Science ®Google Scholar
• Guan XD, Luo LX, Begum G, et al. Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas. J Exp Clin Canc Res. 2018;37:456.
   Web of Science ®Google Scholar
• Zhu W, Carney KE, Pigott VM, et al. Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1. Carcinogenesis. 2016;37(9):839–851. doi:10.1093/carcin/bgw068
   PubMed Web of Science ®Google Scholar
• Amith SR, Wilkinson JM, Fliegel L. KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells. Biochem Pharmacol. 2016;118:31–39. doi:10.1016/j.bcp.2016.08.010
   PubMed Web of Science ®Google Scholar
• Rolver MG, Elingaard-Larsen LO, Andersen AP, Counillon L, Pedersen SF. Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1. Sci Rep-Uk. 2020;10(1):e65.
   PubMed Web of Science ®Google Scholar
• Marala RB, Brown JA, Kong JX, et al. Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur J Pharmacol. 2002;451(1):37–41. doi:10.1016/S0014-2999(02)02193-3
   PubMed Web of Science ®Google Scholar
• Wu DM, Doods H, Stassen JM. Inhibition of human pulmonary artery smooth muscle cell proliferation and migration by sabiporide, a new specific NHE-1 inhibitor. J Cardiovasc Pharm. 2006;48(2):34–40. doi:10.1097/01.fjc.0000239691.69346.6a
   PubMed Web of Science ®Google Scholar
• Wang D, Balkovetz DF, Warnock DG. Mutational analysis of transmembrane histidines in the amiloride-sensitive Na+/H+ exchanger. Am J Physiol. 1995;269(2 Pt 1):C392–402. doi:10.1152/ajpcell.1995.269.2.C392
   PubMed Web of Science ®Google Scholar
• Kim MJ, Moon CH, Kim MY, et al. KR-32570, a novel Na+/H+ exchanger-1 inhibitor, attenuates hypoxia-induced cell death through inhibition of intracellular Ca2+ overload and mitochondrial death. pathway in H9c2 cells. Eur J Pharmacol. 2005;525(1–3):1–7. doi:10.1016/j.ejphar.2005.09.043
   PubMed Web of Science ®Google Scholar
• Kawamoto T, Kimura H, Kusumoto K, et al. Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001;420(1):1–8. doi:10.1016/S0014-2999(01)00991-8
   PubMed Web of Science ®Google Scholar
• Lorrain J, Briand V, Favennec E, et al. Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger. Brit J Pharmacol. 2000;131(6):1188–1194. doi:10.1038/sj.bjp.0703671
   PubMed Web of Science ®Google Scholar
• He BY, Deng CS, Zhang M, Zou DD, Xu M. Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger. Leukemia Res. 2007;31(4):507–514. doi:10.1016/j.leukres.2006.06.015
   PubMed Web of Science ®Google Scholar
• Andersen AP, Flinck M, Oernbo EK, Pedersen NB, Viuff BM, Pedersen SF. Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment. Mol Cancer. 2016;15. doi:10.1186/s12943-016-0500-z
   PubMed Web of Science ®Google Scholar
• Lee SP, Chao SC, Huang SF, Chen YL, Tsai YT, Loh SH. Expressional and functional characterization of intracellular ph regulators and effects of ethanol in human oral epidermoid carcinoma cells. Cell Physiol Biochem. 2018;47(5):2056. doi:10.1159/000491473
   PubMedGoogle Scholar
• Giambelluca MS, Ciancio MC, Orlowski A, Gende OA, Pouliot M, Aiello EA. Characterization of the Na+/HCO3−cotransport in human neutrophils. Cell Physiol Biochem. 2014;33(4):982–990. doi:10.1159/000358669
   Google Scholar
• Orlowski A, Vargas LA, Aiello EA, Alvarez BV. Elevated carbon dioxide upregulates NBCn1 Na+/HCO3− cotransporter in human embryonic kidney cells. Am J Physiol-Renal. 2013;305(12):F1765–F1774. doi:10.1152/ajprenal.00096.2013
   Google Scholar
• Nordstrom T, Andersson LC, Akerman KEO. Regulation of intracellular pH by electrogenic Na+/HCO3−co-transporters in embryonic neural stem cell-derived radial glia-like cells. Bba-Biomembranes. 2019;1861(6):1037–1048. doi:10.1016/j.bbamem.2019.03.007
   Google Scholar
• Radvak P, Repic M, Svastova E, et al. Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncol Rep. 2013;29(3):1147–1153. doi:10.3892/or.2013.2226
   PubMed Web of Science ®Google Scholar
• Juhasz M, Chen J, Lendeckel U, et al. Expression of carbonic anhydrase IX in human pancreatic cancer. Aliment Pharm Ther. 2003;18(8):837–846. doi:10.1046/j.1365-2036.2003.01738.x
   PubMed Web of Science ®Google Scholar
• Stock C, Schwab A. Protons make tumor cells move like clockwork. Pflug Arch Eur J Phy. 2009;458(5):981–992. doi:10.1007/s00424-009-0677-8
   PubMed Web of Science ®Google Scholar
• Pastorek J, Pastorekova S, Callebaut I, et al. Cloning and characterization of Mn, a human tumor-associated protein with a domain homologous to carbonic-anhydrase and a putative helix-loop-helix DNA-binding segment. Oncogene. 1994;9(10):2877–2888.
   PubMed Web of Science ®Google Scholar
• Aldera AP, Govender D. Carbonic anhydrase IX: a regulator of pH and participant in carcinogenesis. J Clin Pathol. 2021;74(6):350–354. doi:10.1136/jclinpath-2020-207073
   Web of Science ®Google Scholar
• Zhang SY, Yang CM, Lu WQ, et al. A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging. Chem Commun. 2011;47(29):8301–8303. doi:10.1039/c1cc12386f
   PubMed Web of Science ®Google Scholar
• Chen XY, Zhang HL, Zhang M, et al. Amorphous Fe-based nanoagents for self-enhanced chemodynamic therapy by re-establishing tumor acidosis. Adv Funct Mater. 2020;30(6):1908365. doi:10.1002/adfm.201908365
   Web of Science ®Google Scholar
• Buonanno M, Langella E, Zambrano N, et al. Disclosing the interaction of carbonic anhydrase IX with cullin-associated NEDD8-dissociated protein 1 by molecular modeling and integrated binding measurements. ACS Chem Biol. 2017;12(6):1460–1465. doi:10.1021/acschembio.7b00055
   PubMed Web of Science ®Google Scholar
• Chandel V, Maru S, Kumar A, et al. Role of monocarboxylate transporters in head and neck squamous cell carcinoma. Life Sci. 2021;279:119709. doi:10.1016/j.lfs.2021.119709
   PubMed Web of Science ®Google Scholar
• Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1 alpha-dependent mechanism. J Biol Chem. 2006;281(14):9030–9037. doi:10.1074/jbc.M511397200
   PubMed Web of Science ®Google Scholar
• Kiran D, Basaraba RJ. Lactate metabolism and signaling in tuberculosis and cancer: a comparative review. Front Cell Infect Microbiol. 2021;11:624607. doi:10.3389/fcimb.2021.624607
   PubMed Web of Science ®Google Scholar
• Luo F, Zou Z, Liu X, et al. Enhanced glycolysis, regulated by HIF-1alpha via MCT-4, promotes inflammation in arsenite-induced carcinogenesis. Carcinogenesis. 2017;38(6):615–626. doi:10.1093/carcin/bgx034
   PubMed Web of Science ®Google Scholar
• Hu X, Liu Z, Duan X, et al. Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells. Mol Carcinog. 2021;60(10):702–714. doi:10.1002/mc.23336
   PubMed Web of Science ®Google Scholar
• Ruan Y, Zeng F, Cheng Z, Zhao X, Fu P, Chen H. High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncol Lett. 2017;14(5):5727–5734. doi:10.3892/ol.2017.6964
   PubMed Web of Science ®Google Scholar
• Stock C, Pedersen SF. Roles of pH and the Na+/H+ exchanger NHE1 in cancer: from cell biology and animal models to an emerging translational perspective? Semin Cancer Biol. 2017;43:5–16. doi:10.1016/j.semcancer.2016.12.001
   PubMed Web of Science ®Google Scholar
• Hendus-Altenburger R, Vogensen J, Pedersen ES, et al. The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity. Commun Biol. 2020;3(1):731. doi:10.1038/s42003-020-01455-6
   PubMed Web of Science ®Google Scholar
• Ariyoshi Y, Shiozaki A, Ichikawa D, et al. Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma. Oncotarget. 2017;8(2):2209–2223. doi:10.18632/oncotarget.13645
   PubMedGoogle Scholar
• Reshkin SJ, Cardone RA, Harguindey S. Na+-H+ exchanger, pH regulation and cancer. Recent Pat Anti-Canc. 2013;8(1):85–99.
   PubMed Web of Science ®Google Scholar
• Chiang YH, Chou CY, Hsu KF, Huang YF, Shen MR. EGF upregulates Na+/H+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness. J Cell Physiol. 2008;214(3):810–819. doi:10.1002/jcp.21277
   PubMed Web of Science ®Google Scholar
• Buckley BJ, Kumar A, Aboelela A, et al. Screening of 5-and 6-substituted amiloride libraries identifies dual-uPA/NHE1 active and single target-selective inhibitors. Int J Mol Sci. 2021;22(6):2999. doi:10.3390/ijms22062999
   PubMed Web of Science ®Google Scholar
• Andersen AP, Samsoe-Petersen J, Oernbo EK, et al. The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms. Int J Cancer. 2018;142(12):2529–2542. doi:10.1002/ijc.31276
   PubMed Web of Science ®Google Scholar
• Gorbatenko A, Olesen CW, Morup N, et al. ErbB2 upregulates the Na+,HCO3 (-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4. FASEB J. 2014;28(1):350–363. doi:10.1096/fj.13-233288
   PubMed Web of Science ®Google Scholar
• Boedtkjer E. Na+,HCO3− cotransporter NBCn1 accelerates breast carcinogenesis. Cancer Metast Rev. 2019;38(1–2):165–178. doi:10.1007/s10555-019-09784-7
   Google Scholar
• Yang HS, Cooper DS, Rajbhandari I, Park HJ, Lee S, Choi I. Inhibition of rat Na+-HCO3− cotransporter (NBCn1) function and expression by the alternative splice domain. Exp Physiol. 2009;94(11):1114–1123. doi:10.1113/expphysiol.2009.048603
   Google Scholar
• Lee S, Mele M, Vahl P, Christiansen PM, Jensen VED, Boedtkjer E. Na+,HCO3 (-)-cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane. Pflug Arch Eur J Phy. 2015;467(2):367–377. doi:10.1007/s00424-014-1524-0
   PubMed Web of Science ®Google Scholar
• Boedtkjer E, Bunch L, Pedersen SF. Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy. Curr Pharm Des. 2012;18(10):1345–1371. doi:10.2174/138161212799504830
   PubMed Web of Science ®Google Scholar
• Lee S, Axelsen TV, Andersen AP, Vahl P, Pedersen SF, Boedtkjer E. Disrupting Na+, HCO3–cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. Oncogene. 2016;35(16):2112–2122. doi:10.1038/onc.2015.273
   PubMed Web of Science ®Google Scholar
• Lee S, Axelsen TV, Jesse N, Pedersen SF, Vahi P, Boedtkjer E. Na+,HCO3–cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice. Oncogene. 2018;37(41):5569–5584. doi:10.1038/s41388-018-0353-6
   PubMed Web of Science ®Google Scholar
• Lin L, Wang S, Deng H, et al. Endogenous labile iron pool-mediated free radical generation for cancer chemodynamic therapy. J Am Chem Soc. 2020;142(36):15320–15330. doi:10.1021/jacs.0c05604
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhen WY, Wang YH, et al. One-dimensional Fe2P acts as a fenton agent in response to NIR II light and ultrasound for deep tumor synergetic theranostics. Angewandte Chemie. 2019;58(8):2407–2412. doi:10.1002/anie.201813702
   Google Scholar
• Liu X, Liu Y, Wang J, Wei T, Dai Z. Mild hyperthermia-enhanced enzyme-mediated tumor cell chemodynamic therapy. ACS Appl Mater Interfaces. 2019;11(26):23065–23071. doi:10.1021/acsami.9b08257
   PubMed Web of Science ®Google Scholar
• Wu H, Chen F, Gu D, You C, Sun B. A pH-activated autocatalytic nanoreactor for self-boosting Fenton-like chemodynamic therapy. Nanoscale. 2020;12(33):17319–17331. doi:10.1039/D0NR03135F
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang R, Yang X, et al. A honeycomb-like bismuth/manganese oxide nanoparticle with mutual reinforcement of internal and external response for triple-negative breast cancer targeted therapy. Adv Healthc Mater. 2021;10:e2100518. doi:10.1002/adhm.202100518
   PubMed Web of Science ®Google Scholar
• Su JJ, Lu S, Wei Z, et al. Biocompatible inorganic nanoagent for efficient synergistic tumor treatment with augmented antitumor immunity. Small. 2022;18(16):2200897.
   Web of Science ®Google Scholar
• Guo Y, Jia HR, Zhang X, et al. A glucose/oxygen-exhausting nanoreactor for starvation- and hypoxia-activated sustainable and cascade chemo-chemodynamic therapy. Small. 2020;16(31):e2000897. doi:10.1002/smll.202000897
   PubMed Web of Science ®Google Scholar
• Zhang L, Yang Z, He W, Ren J, Wong CY. One-pot synthesis of a self-reinforcing cascade bioreactor for combined photodynamic/chemodynamic/starvation therapy. J Colloid Interface Sci. 2021;599:543–555. doi:10.1016/j.jcis.2021.03.173
   PubMed Web of Science ®Google Scholar
• Zhao PR, Tang ZM, Chen XY, et al. Ferrous-cysteine-phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy. Mater Horiz. 2019;6(2):369–374. doi:10.1039/C8MH01176A
   Web of Science ®Google Scholar
• Zhang HL, Li JJ, Chen Y, et al. Magneto-electrically enhanced intracellular catalysis of FePt-FeC heterostructures for chemodynamic therapy. Adv Mater. 2021;33(17):2100472. doi:10.1002/adma.202100472
   Web of Science ®Google Scholar
• Meng X, Chen L, Lv R, Liu M, He N, Wang Z. A metal-phenolic network-based multifunctional nanocomposite with pH-responsive ROS generation and drug release for synergistic chemodynamic/photothermal/chemo-therapy. J Mater Chem B. 2020;8(10):2177–2188. doi:10.1039/D0TB00008F
   PubMed Web of Science ®Google Scholar
• Liu Y, Chi SY, Cao Y, Liu ZH. Glutathione-responsive biodegradable core-shell nanoparticles that self-generate H2O2 and deliver doxorubicin for chemo-chemodynamic therapy. Acs Appl Nano Mater. 2022;5(2):2592–2602. doi:10.1021/acsanm.1c04277
   Web of Science ®Google Scholar
• Wang Y, Song M. pH-responsive cascaded nanocatalyst for synergistic like-starvation and chemodynamic therapy. Colloids Surf B Biointerfaces. 2020;192:111029. doi:10.1016/j.colsurfb.2020.111029
   PubMed Web of Science ®Google Scholar
• Chen J, Wang X, Zhang Y, et al. A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy. Biomaterials. 2021;266:120457. doi:10.1016/j.biomaterials.2020.120457
   PubMed Web of Science ®Google Scholar
• Cui Y, Chen X, Cheng Y, et al. CuWO4 nanodots for NIR-induced photodynamic and chemodynamic synergistic therapy. ACS Appl Mater Interfaces. 2021;13(19):22150–22158. doi:10.1021/acsami.1c00970
   PubMed Web of Science ®Google Scholar
• Hu T, Yan L, Wang Z, et al. A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy. Chem Sci. 2021;12(7):2594–2603. doi:10.1039/D0SC06742C
   PubMed Web of Science ®Google Scholar
• Tao Q, He GH, Ye S, et al. Mn doped Prussian blue nanoparticles for T-1/T-2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor. J Nanobiotechnol. 2022;20(1). doi:10.1186/s12951-021-01235-2
   Web of Science ®Google Scholar
• Peng H, Qin YT, Feng YS, He XW, Li WY, Zhang YK. Phosphate-degradable nanoparticles based on metal-organic frameworks for chemo-starvation-chemodynamic synergistic antitumor therapy. ACS Appl Mater Interfaces. 2021;13(31):37713–37723. doi:10.1021/acsami.1c10816
   PubMed Web of Science ®Google Scholar
• Zheng RX, Cheng Y, Qi F, et al. Biodegradable copper-based nanoparticles augmented chemodynamic therapy through deep penetration and suppressing antioxidant activity in tumors. Adv Healthc Mater. 2021;10(14):2100412. doi:10.1002/adhm.202100412
   Web of Science ®Google Scholar
• Lin XH, Zhu R, Hong ZZ, et al. GSH-responsive radiosensitizers with deep penetration ability for multimodal imaging-guided synergistic radio-chemodynamic cancer therapy. Adv Funct Mater. 2021;31(24):2101278. doi:10.1002/adfm.202101278
   Web of Science ®Google Scholar
• Fu S, Yang R, Ren J, et al. Catalytically active CoFe2O4 nanoflowers for augmented sonodynamic and chemodynamic combination therapy with elicitation of robust immune response. Acs Nano. 2021;15(7):11953–11969. doi:10.1021/acsnano.1c03128
   PubMed Web of Science ®Google Scholar
• Zhang X, He C, Chen Y, et al. Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy. Biomaterials. 2021;275:120987. doi:10.1016/j.biomaterials.2021.120987
   PubMed Web of Science ®Google Scholar
• Yang BC, Liu QY, Yao XX, et al. FePt@MnO-based nanotheranostic platform with acidity-triggered dual-ions release for enhanced MR imaging-guided ferroptosis chemodynamic therapy. Acs Appl Mater Inter. 2019;11(42):38395–38404. doi:10.1021/acsami.9b11353
   PubMed Web of Science ®Google Scholar
• Wang YN, Song D, Zhang WS, Xu ZR. Enhanced chemodynamic therapy at weak acidic pH based on g-C3N4-supported hemin/Au nanoplatform and cell apoptosis monitoring during treatment. Colloid Surface B. 2021;197:111437. doi:10.1016/j.colsurfb.2020.111437
   PubMed Web of Science ®Google Scholar
• Li T, He F, Liu B, et al. In situ synthesis of FeOCl in hollow dendritic mesoporous organosilicon for ascorbic acid-enhanced and MR imaging-guided chemodynamic therapy in neutral pH conditions. ACS Appl Mater Interfaces. 2020;12(51):56886–56897. doi:10.1021/acsami.0c19330
   PubMed Web of Science ®Google Scholar
• Dong SM, Dong YS, Jia T, et al. Sequential catalytic, magnetic targeting nanoplatform for synergistic photothermal and NIR-enhanced chemodynamic therapy. Chem Mater. 2020;32(23):9868–9881. doi:10.1021/acs.chemmater.9b05170
   Web of Science ®Google Scholar