Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer

References

• Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer. 2011;11(6):393–410. doi:10.1038/nrc3064
   PubMed Web of Science ®Google Scholar
• Manoochehri Khoshinani H, Afshar S, Najafi R. Hypoxia: a double-edged sword in cancer therapy. Cancer Invest. 2016;34(10):536–545. doi:10.1080/07357907.2016.1245317
   PubMed Web of Science ®Google Scholar
• Fu J, Wu Q, Dang Y, et al. Synergistic therapy using doxorubicin-loading and nitric oxide-generating hollow Prussian blue nanoparticles with photoacoustic imaging potential against breast cancer. Int J Nanomedicine. 2021;16:6003–6016. doi:10.2147/IJN.S327598
   PubMed Web of Science ®Google Scholar
• Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review. Int J Nanomedicine. 2018;13:3921–3935. doi:10.2147/IJN.S165210
   PubMed Web of Science ®Google Scholar
• Zheng P, Fan M, Liu H, et al. Self-Propelled and Near-infrared-phototaxic photosynthetic bacteria as photothermal agents for hypoxia-targeted cancer therapy. ACS Nano. 2021;15(1):1100–1110. doi:10.1021/acsnano.0c08068
   PubMed Web of Science ®Google Scholar
• Chen F, Zang Z, Chen Z, et al. Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy. Biomaterials. 2019;214:119226. doi:10.1016/j.biomaterials.2019.119226
   PubMed Web of Science ®Google Scholar
• He W, Li X, Morsch M, et al. Brain-targeted codelivery of Bcl-2/Bcl-xl and Mcl-1 inhibitors by biomimetic nanoparticles for orthotopic glioblastoma therapy. ACS Nano. 2022;16(4):6293–6308. doi:10.1021/acsnano.2c00320
   PubMed Web of Science ®Google Scholar
• Li Y, Ma X, Yue Y, et al. Rapid surface display of mRNA antigens by bacteria-derived outer membrane vesicles for a personalized tumor vaccine. Adv Mater. 2022;34(20):e2109984. doi:10.1002/adma.202109984
   PubMed Web of Science ®Google Scholar
• Chen H, Li Y, Wang Y, et al. An engineered bacteria-hybrid microrobot with the magnetothermal bioswitch for remotely collective perception and imaging-guided cancer treatment. ACS Nano. 2022;16(4):6118–6133. doi:10.1021/acsnano.1c11601
   PubMed Web of Science ®Google Scholar
• Yang S, Gao H. Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy. Pharmacol Res. 2017;126:97–108. doi:10.1016/j.phrs.2017.05.004
   PubMed Web of Science ®Google Scholar
• Sang W, Zhang Z, Dai Y, et al. Recent advances in nanomaterial-based synergistic combination cancer immunotherapy. Chem Soc Rev. 2019;48(14):3771–3810. doi:10.1039/c8cs00896e
   PubMed Web of Science ®Google Scholar
• Xiong W, Peng L, Chen H, et al. Surface modification of MPEG-b-PCL-based nanoparticles via oxidative self-polymerization of dopamine for malignant melanoma therapy. Int J Nanomedicine. 2015;10:2985–2996. doi:10.2147/IJN.S79605
   PubMed Web of Science ®Google Scholar
• Hao Y, Chen Y, He X, et al. Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy. Bioact Mater. 2020;5(3):542–552. doi:10.1016/j.bioactmat.2020.04.002
   PubMed Web of Science ®Google Scholar
• Hu Y, He Y, Ji J, et al. Tumor targeted curcumin delivery by folate-modified MPEG-PCL self-assembly micelles for colorectal cancer therapy. Int J Nanomedicine. 2020;15:1239–1252. doi:10.2147/IJN.S232777
   PubMed Web of Science ®Google Scholar
• Danhier F. To exploit the tumor microenvironment: since the EPR effect fails in the clinic, what is the future of nanomedicine? J Control Release. 2016;244(Pt A):108–121. doi:10.1016/j.jconrel.2016.11.015
   PubMed Web of Science ®Google Scholar
• Srivastava I, Xue R, Jones J, et al. Biomimetic surface-enhanced Raman scattering nanoparticles with improved dispersibility, signal brightness, and tumor targeting functions. ACS Nano. 2022;16(5):8051–8063. doi:10.1021/acsnano.2c01062
   PubMed Web of Science ®Google Scholar
• Barua S, Mitragotri S. Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects. Nano Today. 2014;9(2):223–243. doi:10.1016/j.nantod.2014.04.008
   PubMed Web of Science ®Google Scholar
• Overchuk M, Zheng G. Overcoming obstacles in the tumor microenvironment: recent advancements in nanoparticle delivery for cancer theranostics. Biomaterials. 2018;156:217–237. doi:10.1016/j.biomaterials.2017.10.024
   PubMed Web of Science ®Google Scholar
• Charbonneau MR, Isabella VM, Li N, et al. Developing a new class of engineered live bacterial therapeutics to treat human diseases. Nat Commun. 2020;11(1):1738. doi:10.1038/s41467-020-15508-1
   PubMed Web of Science ®Google Scholar
• Zheng DW, Chen Y, Li ZH, et al. Optically-controlled bacterial metabolite for cancer therapy. Nat Commun. 2018;9(1):1680. doi:10.1038/s41467-018-03233-9
   PubMed Web of Science ®Google Scholar
• Yi X, Zhou H, Chao Y, et al. Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer. Sci Adv. 2020;6(33):eaba3546. doi:10.1126/sciadv.aba3546
   PubMed Web of Science ®Google Scholar
• Wang SB, Liu XH, Li B, et al. Bacteria-assisted selective photothermal therapy for precise tumor inhibition. Adv Funct Mater. 2019;29(35):1904093. doi:10.1002/adfm.201904093
   Web of Science ®Google Scholar
• Deng X, Yang W, Shao Z, et al. Genetically modified bacteria for targeted phototherapy of tumor. Biomaterials. 2021;272:120809. doi:10.1016/j.biomaterials.2021.120809
   PubMed Web of Science ®Google Scholar
• Liu Y, Lu Y, Ning B, et al. Intravenous delivery of living listeria monocytogenes elicits gasdmermin-dependent tumor pyroptosis and motivates anti-tumor immune response. ACS Nano. 2022;16(3):4102–4115. doi:10.1021/acsnano.1c09818
   PubMed Web of Science ®Google Scholar
• Wang L, Vuletic I, Deng D, et al. Bifidobacterium breve as a delivery vector of IL-24 gene therapy for head and neck squamous cell carcinoma in vivo. Gene Ther. 2017;24(11):699–705. doi:10.1038/gt.2017.74
   PubMed Web of Science ®Google Scholar
• Jiang BL, Gao X, Xiong J, et al. Experimental study on synergistic effect of HIFU treatment of tumors using Bifidobacterium bound with cationic phase-change nanoparticles. Eur Rev Med Pharmacol Sci. 2020;24(10):5714–5725. doi:10.26355/eurrev_202005_21363
   PubMed Web of Science ®Google Scholar
• Xiao S, Shi H, Zhang Y, et al. Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer. J Nanobiotechnol. 2022;20(1):178. doi:10.1186/s12951-022-01373-1
   PubMed Web of Science ®Google Scholar
• Li Y, Leng Q, Zhang Y, et al. Anaerobic bacteria mediated ‘smart missile’ targeting tumor hypoxic area enhances the therapeutic outcome of lung cancer. Chem Eng J. 2022;438:135566. doi:10.1016/j.cej.2022.135566
   Web of Science ®Google Scholar
• Lee H, Dellatore SM, Miller WM, et al. Mussel-inspired surface chemistry for multifunctional coatings. Science. 2007;318(5849):426–430. doi:10.1126/science.1147241
   PubMed Web of Science ®Google Scholar
• Dai G, Choi CKK, Choi CHJ, et al. Glutathione-degradable polydopamine nanoparticles as a versatile platform for fabrication of advanced photosensitisers for anticancer therapy. Biomater Sci. 2021;10(1):189–201. doi:10.1039/D1BM01482J
   PubMed Web of Science ®Google Scholar
• Zhang J, Sun X, Zhao X, et al. Watson-crick base pairing-inspired laser/GSH activatable miRNA-coordination polymer nanoplexes for combined cancer chemo-immuno-photothermal therapy. ACS Appl Mater Interface. 2022;14(18):20762–20777. doi:10.1021/acsami.2c03523
   PubMed Web of Science ®Google Scholar
• Wang Q, Li X, Mao J, et al. Biomimic binding affinity gradients triggered GSH-response of core-shell nanoparticles for cascade chemo/chemodynamic therapy. Adv Healthc Mater. 2022;11(2):e2101634. doi:10.1002/adhm.202101634
   PubMed Web of Science ®Google Scholar
• Zhou J, Schmid T, Schnitzer S, et al. Tumor hypoxia and cancer progression. Cancer Lett. 2006;237(1):10–21. doi:10.1016/j.canlet.2005.05.028
   PubMed Web of Science ®Google Scholar
• Dhani N, Fyles A, Hedley D, et al. The clinical significance of hypoxia in human cancers. Semin Nucl Med. 2015;45(2):110–121. doi:10.1053/j.semnuclmed.2014.11.002
   PubMed Web of Science ®Google Scholar
• Zeng Y, Ma J, Zhan Y, et al. Hypoxia-activated prodrugs and redox-responsive nanocarriers. Int J Nanomedicine. 2018;13:6551–6574. doi:10.2147/IJN.S173431
   PubMed Web of Science ®Google Scholar
• Wang Y, Xie Y, Li J, et al. Tumor-penetrating nanoparticles for enhanced anticancer activity of combined photodynamic and hypoxia-activated therapy. ACS Nano. 2017;11(2):2227–2238. doi:10.1021/acsnano.6b08731
   PubMed Web of Science ®Google Scholar
• Taniguchi S, Fujimori M, Sasaki T, et al. Targeting solid tumors with non-pathogenic obligate anaerobic bacteria. Cancer Sci. 2010;101(9):1925–1932. doi:10.1111/j.1349-7006.2010.01628.x
   PubMed Web of Science ®Google Scholar
• Zhao M, Yang M, Li XM, et al. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA. 2005;102(3):755–760. doi:10.1073/pnas.0408422102
   PubMed Web of Science ®Google Scholar
• Pawelek JM, Low KB, Bermudes D. Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res. 1997;57(20):4537–4544.
   PubMed Web of Science ®Google Scholar
• Tang Y, Chen C, Jiang B, et al. Bifidobacterium bifidum-mediated specific delivery of nanoparticles for Tumor Therapy. Int J Nanomedicine. 2021;16:4643–4659. doi:10.2147/IJN.S315650
   PubMed Web of Science ®Google Scholar
• Dang LH, Bettegowda C, Huso DL, et al. Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci USA. 2001;98(26):15155–15160. doi:10.1073/pnas.251543698
   PubMed Web of Science ®Google Scholar
• Jain RK, Forbes NS. Can engineered bacteria help control cancer? Proc Natl Acad Sci USA. 2001;98(26):14748–14750. doi:10.1073/pnas.261606598
   PubMed Web of Science ®Google Scholar
• Fan JX, Peng MY, Wang H, et al. Engineered bacterial bioreactor for tumor therapy via Fenton-like reaction with localized H2O2 generation. Adv Mater. 2019;31(16):e1808278. doi:10.1002/adma.201808278
   PubMed Web of Science ®Google Scholar
• Zhang W, Liu J, Li X, et al. Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes. ACS Nano. 2021;15(12):19321–19333. doi:10.1021/acsnano.1c05605
   PubMed Web of Science ®Google Scholar
• Kuo WS, Wu CM, Yang ZS, et al. Biocompatible bacteria@Au composites for application in the photothermal destruction of cancer cells. Chem Commun (Camb). 2008;37(7):4430–4432. doi:10.1039/b808871c
   Google Scholar
• Farokhi M, Mottaghitalab F, Saeb MR, et al. Functionalized theranostic nanocarriers with bio-inspired polydopamine for tumor imaging and chemo-photothermal therapy. J Control Release. 2019;309:203–219. doi:10.1016/j.jconrel.2019.07.036
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zhang J, Tian J, et al. A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1). J Nanobiotechnol. 2021;19(1):323. doi:10.1186/s12951-021-01063-4
   PubMed Web of Science ®Google Scholar
• Hao YN, Zheng AQ, Guo TT, et al. Glutathione triggered degradation of polydopamine to facilitate controlled drug release for synergic combinational cancer treatment. J Mater Chem B. 2019;7(43):6742–6750. doi:10.1039/C9TB01400D
   PubMed Web of Science ®Google Scholar
• Kennedy L, Sandhu JK, Harper ME, et al. Role of glutathione in cancer: from mechanisms to therapies. Biomolecules. 2020;10(10):1429. doi:10.3390/biom10101429
   PubMed Web of Science ®Google Scholar
• Chen W, Wang Y, Qin M, et al. Bacteria-driven hypoxia targeting for combined biotherapy and photothermal therapy. ACS Nano. 2018;12(6):5995–6005. doi:10.1021/acsnano.8b02235
   PubMed Web of Science ®Google Scholar
• Lu J, Cai L, Dai Y, et al. Polydopamine-based nanoparticles for photothermal therapy/chemotherapy and their synergistic therapy with autophagy inhibitor to promote antitumor treatment. Chem Rec. 2021;21(4):781–796. doi:10.1002/tcr.202000170
   PubMed Web of Science ®Google Scholar
• Yan S, Huang Q, Chen J, et al. Tumor-targeting photodynamic therapy based on folate-modified polydopamine nanoparticles. Int J Nanomedicine. 2019;14:6799–6812. doi:10.2147/IJN.S216194
   PubMed Web of Science ®Google Scholar