Silver Nanoparticles Cause Neural and Vascular Disruption by Affecting Key Neuroactive Ligand-Receptor Interaction and VEGF Signaling Pathways

References

• Bao S, Tang W, Fang T. Sex-dependent and organ-specific toxicity of silver nanoparticles in livers and intestines of adult zebrafish. Chemosphere. 2020;249:126172. doi:10.1016/j.chemosphere.2020.126172
   PubMed Web of Science ®Google Scholar
• Stevenson LM, Dickson H, Klanjscek T, et al. Environmental Feedbacks and Engineered Nanoparticles: mitigation of Silver Nanoparticle Toxicity to Chlamydomonas reinhardtii by Algal-Produced Organic Compounds. PLoS One. 2013;8(9):e74456. doi:10.1371/journal.pone.0074456
   PubMed Web of Science ®Google Scholar
• Lyon TDB, Patriarca M, Howatson G, et al. Age dependence of potentially toxic elements (Sb, Cd, Pb, Ag) in human liver tissue from paediatric subjects. J Environ Monit. 2002;4:1034–1039.
   PubMedGoogle Scholar
• Boyle D, Goss GG. Effects of silver nanoparticles in early life-stage zebrafish are associated with particle dissolution and the toxicity of soluble silver. Nanoimpact. 2018;12:1–8.
   Web of Science ®Google Scholar
• Gao J, Mahapatra CT, Mapes CD, et al. Vascular toxicity of silver nanoparticles to developing zebrafish (Danio rerio). Nanotoxicology. 2016;10:1363–1372.
   PubMed Web of Science ®Google Scholar
• Qiang L, Arabeyyat ZH, Xin Q, et al. Silver Nanoparticles in Zebrafish (Danio rerio) Embryos: uptake, Growth and Molecular Responses. Int J Mol Sci. 2020;21:1876.
   PubMed Web of Science ®Google Scholar
• Mosselhy D, He W, Li D, et al. Silver nanoparticles: in vivo toxicity in zebrafish embryos and a comparison to silver nitrate. J Nanopart Res. 2016;18:222.
   Web of Science ®Google Scholar
• McGillicuddy E, Murray I, Kavanagh S, et al. Silver nanoparticles in the environment: sources, detection and ecotoxicology. Sci Total Environ. 2017;575:231–246.
   PubMed Web of Science ®Google Scholar
• Campbell LA, Gormley PT, Bennett JC, et al. Functionalized silver nanoparticles depress aerobic metabolism in the absence of overt toxicity in brackish water killifish, Fundulus heteroclitus. Aquat Toxicol. 2019;213:105221.
   PubMed Web of Science ®Google Scholar
• Ma Y, Song L, Lei Y, et al. Sex dependent effects of silver nanoparticles on the zebrafish gut microbiota. Enciron Sci Nano. 2018;5:704.
   Web of Science ®Google Scholar
• Rajkumar KS, Kanipandian N, Thirumurugan R. Toxicity assessment on haemotology, biochemical and histopathological alterations of silver nanoparticles-exposed freshwater fish Labeo rohita. Appl Nanosci. 2016;6(1):19–29. doi:10.1007/s13204-015-0417-7
   Web of Science ®Google Scholar
• Powers CM, Slotkin TA, Seidler FJ, et al. Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition. Neurotoxicol Teratol. 2011;33(6):708–714. doi:10.1016/j.ntt.2011.02.002
   PubMed Web of Science ®Google Scholar
• Asharani PV, Wu Y, Gong Z, et al. Toxicity of silver nanoparticles in zebrafish models. Nanotechnology. 2008;19(25):255102. doi:10.1088/0957-4484/19/25/255102
   PubMed Web of Science ®Google Scholar
• Yeo MK, Yoon JW. Comparison of the Effects of Nano-silver Antibacterial Coatings and Silver Ions on Zebrafish Embryogenesis. Mol Cell Toxicol. 2009;5:23–31.
   Web of Science ®Google Scholar
• Xin Q, Rotchell JM, Cheng J, et al. Silver nanoparticles affect the neural development of zebrafish embryos. J Appl Toxicol. 2015;35(12):1481–1492. doi:10.1002/jat.3164
   PubMed Web of Science ®Google Scholar
• Jia H-R, Zhu Y-X, Xu K-F, et al. Efficient cell surface labelling of live zebrafish embryos: wash-free fluorescence imaging for cellular dynamics tracking and nanotoxicity evaluation. Chem Sci. 2019;10(14):4062–4068. doi:10.1039/C8SC04884C
   PubMed Web of Science ®Google Scholar
• Lu C, Lv Y, Kou G, et al. Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2022;243:113993. doi:10.1016/j.ecoenv.2022.113993
   PubMed Web of Science ®Google Scholar
• Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio Rerio). Eugene: University of Oregon Press; 2007.
   Google Scholar
• Zhang J, Wang G, Huang A, et al. Association between Serum Level of Multiple Trace Elements and Esophageal Squamous Cell Carcinoma Risk: a Case–Control Study in China. Cancers. 2022;14(17):4239. doi:10.3390/cancers14174239
   PubMed Web of Science ®Google Scholar
• Bu D, Luo H, Huo P, et al. KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis. Nucleic Acids Res. 2021;49:W317–W325.
   PubMed Web of Science ®Google Scholar
• Jia P, Ma Y, Lu C, et al. The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP. PLoS One. 2016;11:e0155762.
   PubMed Web of Science ®Google Scholar
• Lu CJ, Jiang XF, Junaid M, et al. Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo. Chemosphere. 2017;184:795–805.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Yang XJ, Chen GL, Yu SC, et al. TGF-beta 1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model. Int Immunopharm. 2013;15:191–198.
   PubMed Web of Science ®Google Scholar
• Liu F, Mahmood M, Xu Y, et al. Effects of silver nanoparticles on human and rat embryonic neural stem cells. Front Neurosci. 2015;9:115.
   PubMed Web of Science ®Google Scholar
• Sharma HS, Sharma A. Nanoparticles aggravate heat stress induced cognitive deficits, blood-brain barrier disruption, edema formation and brain pathology. Prog Brain Res. 2007;162:245–273.
   PubMed Web of Science ®Google Scholar
• Holland NA, Thompson LC, Vidanapathirana AK, et al. Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury. Part Fibre Toxicol. 2016;13(1):48.
   PubMedGoogle Scholar
• Cunningham B, Engstrom AM, Harper BJ, et al. Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo. Nanomaterials. 2021;11(6):1516.
   Web of Science ®Google Scholar
• Lee CY, Horng JL, Chen PY, et al. Silver nanoparticle exposure impairs ion regulation in zebrafish embryos. Aquat Toxicol. 2019;214:105263.
   PubMed Web of Science ®Google Scholar
• Cooper RJ, Spitzer N. Silver nanoparticles at sublethal concentrations disrupt cytoskeleton and neurite dynamics in cultured adult neural stem cells. Neurotoxicology. 2015;48:231–238.
   PubMed Web of Science ®Google Scholar
• Shi J, Sun X, Lin Y, et al. Endothelial cell injury and dysfunction induced by silver nanoparticles through oxidative stress via IKK/KF-κB pathways. Biomaterials. 2014;35:6657–6666.
   PubMed Web of Science ®Google Scholar
• Chen G, Wang L, Li W, et al. Nodularin induced oxidative stress contributes to developmental toxicity in zebrafish embryos. Ecotoxicol Eviiron Saf. 2020;194:110444.
   PubMed Web of Science ®Google Scholar
• Christen V, Capelle M, Fent K. Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish. Toxicol Appl Pharmacol. 2013;272:519–528.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang Z, Zhao G, et al. Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Ecotoxicol Environ Saf. 2018;163:279–288.
   PubMed Web of Science ®Google Scholar
• Huang Y, Guo L, Cao C, et al. Silver nanoparticles exposure induces developmental neurotoxicity in hiPSC-derived cerebral organoids. Sci Total Environ. 2022;845:157047.
   PubMed Web of Science ®Google Scholar
• Lee KJ, Nallathamby PD, Browning LM, et al. In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano. 2007;1:133–143.
   PubMed Web of Science ®Google Scholar
• Xiao B, Wang X, Yang J, et al. Bioaccumulation kinetics and tissue distribution of silver nanoparticles in zebrafish: the mechanisms and influence of natural organic matter. Ecotoxicol Environ Saf. 2020;194:110454.
   PubMed Web of Science ®Google Scholar
• Krishnaraj C, Harper SL, Yun SI. In vivo toxicological assessment of biologically synthesized silver nanoparticles in adult zebrafish (Danio rerio). J Hazard Mater. 2016;301:480–491.
   PubMed Web of Science ®Google Scholar
• Dan M, Wen H, Shao A, et al. Silver nanoparticle exposure induces neurotoxicity in the rat hippocampus without increasing the blood-brain barrier permeability. J Biomed Nanotechnol. 2018;14:1330–1338.
   PubMed Web of Science ®Google Scholar
• Wei J, Liu J, Liang S, et al. Low-Dose Exposure of Silica Nanoparticles Induces Neurotoxicity via Neuroactive Ligand-Receptor Interaction Signaling Pathway in Zebrafish Embryos. Int J Nanomedicine. 2020;15:4407–4415.
   PubMed Web of Science ®Google Scholar
• Papassotiropoulos A, de Quervain DJ. Failed drug discovery in psychiatry: time for human genome-guided solutions. Trends Cogn Sci. 2015;19(4):183–187.
   PubMed Web of Science ®Google Scholar
• Freed AS, Schwarz AC, Brei BK, et al. CHRNB1-associated congenital myasthenia syndrome: expanding the clinical spectrum. Am J Med Genet A. 2021;185:827–835.
   PubMed Web of Science ®Google Scholar
• Stueven AK, Kayser A, Wetz C, et al. Somatostatin analogues in the treatment of neuroendocrine tumors: past, present and future. Int J Mol Sci. 2019;20:3049.
   PubMed Web of Science ®Google Scholar
• Zhang PP, Yang XL, Zhong YM. Cellular localization of P2Y₆ receptor in rat retina. Neuroscience. 2012;220:62–69.
   PubMed Web of Science ®Google Scholar
• Sun L, Liu F, Chen H, et al. Transcriptional responses in adult zebrafish (Danio rerio) exposed to propranolol and metoprolol. Ecotoxicology. 2015;24:1352–1361.
   PubMed Web of Science ®Google Scholar
• Kurabayashi N, Tanaka A, Nguyen MD, et al. The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons. Development. 2018;145(17):dev162529.
   PubMed Web of Science ®Google Scholar
• Bächner D, Kreienkamp HJ, Richter D. MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. FEBS Lett. 2002;526:124–128.
   PubMed Web of Science ®Google Scholar
• Wang B, Cui A, Wang P, et al. Temporal expression profiles of leptin and its receptor genes during early development and ovarian maturation of Cynoglossus semilaevis. Fish Physiol Biochem. 2020;46(1):359–370.
   PubMed Web of Science ®Google Scholar
• Ohga H, Hirata D, Matsumori K, et al. Possible role of the leptin system in controlling puberty in the male chub mackerel, Scomber japonicus. Comp Biochem Physiol a Mol Integr Physiol. 2017;203:159–166.
   PubMed Web of Science ®Google Scholar
• Fang P, Yu C, Liu J, et al. Study on the potential mechanism of Semen Strychni against myasthenia gravis based on network pharmacology and molecular docking with experimental verification. Evid Based Complement Alternat Med. 2022;2022:3056802.
   PubMed Web of Science ®Google Scholar
• Sabbir MG, Speth RC, Albensi BC. Loss of cholinergic receptor muscarinic 1 (CHRM1) protein in the hippocampus and temporal cortex of a subset of individuals with Alzheimer’s disease, Parkinson’s disease, or frontotemporal dementia: implications for patient survival. J Alzheimers Dis. 2022;90:727–747.
   PubMed Web of Science ®Google Scholar
• Kalishwaralal K, Banumathi E, Pandian SRK, et al. Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells. Colloid Surf B Biointerfaces. 2009;73:51–57.
   PubMed Web of Science ®Google Scholar
• Evans I. An overview of VEGF-mediated signal transduction. Methods Mol Biol. 2015;1332:91–120.
   PubMedGoogle Scholar
• Shibuya M. Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. J Biochem. 2013;153:13–19.
   PubMed Web of Science ®Google Scholar
• Ylä-Herttuala S, Rissanen TT, Vajanto I, et al. Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol. 2007;49:1015–1026.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wang D, Kundumani-Sridharan V, et al. PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization. Blood. 2010;116:1377–1385.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wang D, Singh NK, et al. Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C γ (PKCγ) signaling axis is required for hypoxia-induced pathological retinal angiogenesis. J Biol Chem. 2011;286:22489–22498.
   PubMed Web of Science ®Google Scholar
• Wang Y, Shao Y, Zhang H, et al. Comprehensive analysis of key genes and pathways for biological and clinical implications in thyroid-associated ophthalmopathy. BMC Genomics. 2022;23(1):630.
   PubMed Web of Science ®Google Scholar
• Abrial E, Etievant A, Bétry C, et al. Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2013;43:40–48.
   PubMed Web of Science ®Google Scholar
• Tan W, Palmby TR, Gavard J, et al. An essential role for Rac1 in endothelial cell function and vascular development. FASEB J. 2008;22(6):1829–1838.
   PubMed Web of Science ®Google Scholar