Role of Circulating Exosomal miRNA-3976 in Early Diabetic Retinopathy

References

• Saeedi P, Petersohn I, Salpea P, et al. Committee, Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2019;157:107843. doi:10.1016/j.diabres.2019.107843
   PubMed Web of Science ®Google Scholar
• Leasher JL, Bourne RR, Flaxman SR, et al. Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010. Diabetes Care. 2016;39(9):1643–1649. doi:10.2337/dc15-2171
   PubMed Web of Science ®Google Scholar
• Teo ZL, Tham YC, Yan Yu MC, et al. Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology. 2021;128(11):1580–1591.
   PubMed Web of Science ®Google Scholar
• Tang L, Zhang C, Yang Q, et al. Melatonin maintains inner blood-retinal barrier via inhibition of p38/TXNIP/NF-κB pathway in diabetic retinopathy. J Cell Physiol. 2021;236(8):5848–5864. doi:10.1002/jcp.30269
   PubMed Web of Science ®Google Scholar
• Zhu SH, Liu BQ, Hao MJ, et al. Paeoniflorin suppressed high glucose-induced retinal microglia MMP-9 expression and inflammatory response via inhibition of TLR4/NF-κB pathway through upregulation of SOCS3 in diabetic retinopathy. Inflammation. 2017;40:1475–1486. doi:10.1007/s10753-017-0571-z
   PubMed Web of Science ®Google Scholar
• Vujosevic S, Aldington SJ, Silva P, et al. Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol. 2020;8(4):337–347. doi:10.1016/S2213-8587(19)30411-5
   PubMed Web of Science ®Google Scholar
• Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478). doi:10.1126/science.aau6977
   PubMed Web of Science ®Google Scholar
• Mahbubfam S, Rezaie J, Nejati V. Crosstalk between exosomes signaling pathway and autophagy flux in senescent human endothelial cells. Tissue Cell. 2022;76:101803. doi:10.1016/j.tice.2022.101803
   PubMed Web of Science ®Google Scholar
• Feghhi M, Rezaie J, Akbari A, et al. Effect of multi-functional polyhydroxylated polyhedral oligomeric silsesquioxane (POSS) nanoparticles on the angiogenesis and exosome biogenesis in human umbilical vein endothelial cells (HUVECs). Mater Des. 2021;197:109227. doi:10.1016/j.matdes.2020.109227
   Web of Science ®Google Scholar
• Shaban SA, Rezaie JA-O, Nejati VA-O. Exosomes derived from senescent endothelial cells contain distinct pro-angiogenic miRNAs and proteins. Cardiovasc Toxicol. 2022;22(6):592–601. doi:10.1007/s12012-022-09740-y
   PubMed Web of Science ®Google Scholar
• Huang X, Yuan T, Tschannen M, et al. Characterization of human plasma-derivedexosomal RNAs by deep sequencing. BMC Genomics. 2013;14(319). doi:10.1186/1471-2164-14-319
   Google Scholar
• Rezaie J, Feghhi M, Etemadi T. A review on exosomes application in clinical trials: perspective, questions, and challenges. Cell Commun Signal. 2022;20(1):145. doi:10.1186/s12964-022-00959-4
   PubMed Web of Science ®Google Scholar
• Rezaie J, Etemadi T, Feghhi M. The distinct roles of exosomes in innate immune responses and therapeutic applications in cancer. Eur J Pharmacol. 2022;933:175292. doi:10.1016/j.ejphar.2022.175292
   PubMed Web of Science ®Google Scholar
• Nemati M, Singh B, Mir RA, et al. Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges. Cell Commun Signal. 2022;20. doi:10.1186/s12964-022-00889-1
   PubMed Web of Science ®Google Scholar
• Faramin Lashkarian M, Hashemipour N, Niaraki N, et al. MicroRNA-122 in human cancers: from mechanistic to clinical perspectives. Cancer Cell Int. 2023;23. doi:10.1186/s12935-023-02868-z
   PubMed Web of Science ®Google Scholar
• Shirvani H, Ghanavi J, Aliabadi A, et al. MiR-211 plays a dual role in cancer development: from tumor suppressor to tumor enhancer. Cell Signal. 2023;101:110504. doi:10.1016/j.cellsig.2022.110504
   PubMed Web of Science ®Google Scholar
• Xiong Y, Chen L, Yan C, et al. Circulating exosomal miR-20b-5p inhibition restores Wnt9b signaling and reverses diabetes-associated impaired wound healing. Small. 2020;16(3):e1904044. doi:10.1002/smll.201904044
   PubMed Web of Science ®Google Scholar
• Katayama M, Wiklander OPB, Fritz T, et al. Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle. Diabetes. 2019;68(3):515–526. doi:10.2337/db18-0470
   PubMed Web of Science ®Google Scholar
• Martins B, Amorim M, Reis F, Ambrosio AF, Fernandes R. Extracellular Vesicles and MicroRNA: putative role in diagnosis and treatment of diabetic retinopathy. Antioxidants. 2020;9:8.
   Web of Science ®Google Scholar
• Liu J, Jiang F, Jiang Y, et al. Roles of exosomes in ocular diseases. Int J Nanomedicine. 2020;15:10519–10538. doi:10.2147/IJN.S277190
   PubMed Web of Science ®Google Scholar
• Gu S, Liu Y, Zou J, et al. Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy. Exp Eye Res. 2020;201:108271. doi:10.1016/j.exer.2020.108271
   PubMed Web of Science ®Google Scholar
• Dehghan M, Ghorbani F, Najafi S, et al. Progress toward molecular therapy for diabetes mellitus: a focus on targeting inflammatory factors. Diabetes Res Clin Pract. 2022;189:109945. doi:10.1016/j.diabres.2022.109945
   PubMed Web of Science ®Google Scholar
• Jiang L, Cao H, Deng T, et al. Serum exosomal miR-377-3p inhibits retinal pigment epithelium proliferation and offers a biomarker for diabetic macular edema. J Int Med Res. 2021;49(4):3000605211002975. doi:10.1177/03000605211002975
   Web of Science ®Google Scholar
• Chang W, Wang J. Exosomes and their noncoding RNA cargo are emerging as new modulators for diabetes mellitus. Cells. 2019;8(8):853. doi:10.3390/cells8080853
   PubMed Web of Science ®Google Scholar
• Hiratsuka I, Yamada H, Munetsuna E, Hashimoto S, Itoh M. Circulating MicroRNAs in graves’ disease in relation to clinical activity. Thyroid. 2016;26(10):1431–1440. doi:10.1089/thy.2016.0062
   PubMed Web of Science ®Google Scholar
• Xiong L, Chen L, Wu L, et al. Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction. Diabetologia. 2022;65(1):188–205. doi:10.1007/s00125-021-05591-4
   PubMed Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–1207. doi:10.1016/j.jaci.2017.08.034
   PubMed Web of Science ®Google Scholar
• Guay C, Regazzi R. Exosomes as new players in metabolic organ cross-talk. Diabetes Obes Metab. 2017;19:137–146. doi:10.1111/dom.13027
   PubMed Web of Science ®Google Scholar
• Mathieu M, Martin-Jaular L, Lavieu G, Thery C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9–17. doi:10.1038/s41556-018-0250-9
   PubMed Web of Science ®Google Scholar
• Antonetti DA, Klein R, Bronson SK. Diabetic retinopathy. N Engl J Med. 2012;366(13):1227–1239. doi:10.1056/NEJMra1005073
   PubMed Web of Science ®Google Scholar
• Simo R, Stitt AW, Gardner TW. Neurodegeneration in diabetic retinopathy: does it really matter? Diabetologia. 2018;61(9):1902–1912. doi:10.1007/s00125-018-4692-1
   PubMed Web of Science ®Google Scholar
• Naslund TI, Paquin-Proulx D, Paredes PT, Vallhov H, Sandberg JK, Gabrielsson S. Exosomes from breast milk inhibit HIV-1 infection of dendritic cells and subsequent viral transfer to CD4+ T cells. AIDS. 2014;28(2):171–180. doi:10.1097/QAD.0000000000000159
   PubMed Web of Science ®Google Scholar
• Liang WJ, Yang HW, Liu HN, Qian W, Chen XL. HMGB1 upregulates NF-kB by inhibiting IKB-alpha and associates with diabetic retinopathy. Life Sci. 2020;241:117146. doi:10.1016/j.lfs.2019.117146
   PubMed Web of Science ®Google Scholar
• Li W, Jin L, Cui Y, Nie A, Xie N, Liang G. Bone marrow mesenchymal stem cells-induced exosomal microRNA-486-3p protects against diabetic retinopathy through TLR4/NF-kappaB axis repression. J Endocrinol Invest. 2021;44(6):1193–1207. doi:10.1007/s40618-020-01405-3
   PubMed Web of Science ®Google Scholar
• Alomar SY, B MB, Eldosoky M, et al. Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity. Int Immunopharmacol. 2021;90:107193. doi:10.1016/j.intimp.2020.107193
   PubMed Web of Science ®Google Scholar
• Zhang Q, Lenardo MJ, Baltimore D. 30 Years of NF-kappaB: a blossoming of relevance to human pathobiology. Cell. 2017;168(1–2):37–57. doi:10.1016/j.cell.2016.12.012
   PubMed Web of Science ®Google Scholar
• Nikfarjam S, Rezaie J, Zolbanin NM, Jafari RA-O. Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine. J Transl Med. 2020;18. doi:10.1186/s12967-020-02622-3
   PubMed Web of Science ®Google Scholar
• Vahabi A, Rezaie J, Hassanpour M, et al. Tumor Cells-derived exosomal CircRNAs: novel cancer drivers, molecular mechanisms, and clinical opportunities. Biochem Pharmacol. 2022;200:115038. doi:10.1016/j.bcp.2022.115038
   PubMed Web of Science ®Google Scholar
• Joo HS, Suh JH, Lee JM, Bang ES, Lee JM. Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent. Int J Mol Sci. 2020;21(3):727. doi:10.3390/ijms21030727
   PubMed Web of Science ®Google Scholar
• Rezaie J, Ahmadi M, Ravanbakhsh R, et al. Tumor-derived extracellular vesicles: the metastatic organotropism drivers. Life Sci. 2022;289:120216. doi:10.1016/j.lfs.2021.120216
   PubMed Web of Science ®Google Scholar
• Almohammai A, Rahbarghazi R, Keyhanmanesh R, Rezaie J, Ahmadi M. Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues. J Inflamm. 2021;18. doi:10.1186/s12950-021-00275-7
   Google Scholar
• Rahbarghazi R, Jabbari N, Sani NA, et al. Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications. Cell Commun Signal. 2019;17. doi:10.1186/s12964-019-0390-y
   Web of Science ®Google Scholar
• Tian Y, Zhang F, Qiu Y, et al. Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells. Nat Biomed Eng. 2021;5:968–982. doi:10.1038/s41551-021-00764-3
   PubMed Web of Science ®Google Scholar
• Aghaei-Zarch SM, Alipourfard I, Rasoulzadeh H, et al. Non-coding RNAs: an emerging player in particulate matter 2.5-mediated toxicity. Int J Biol Macromol. 2023;235:123790. doi:10.1016/j.ijbiomac.2023.123790
   PubMed Web of Science ®Google Scholar
• Bahari Khasraghi L, Nouri M, Vazirzadeh M, et al. MicroRNA-206 in human cancer: mechanistic and clinical perspectives. Cell Signal. 2023;101:110525. doi:10.1016/j.cellsig.2022.110525
   PubMed Web of Science ®Google Scholar
• Mori MA, Ludwig RG, Garcia-Martin R, Brandao BB, Kahn CR. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–673. doi:10.1016/j.cmet.2019.07.011
   PubMed Web of Science ®Google Scholar
• Cao X, Xue LD, Di Y, Li T, Tian YJ, Song Y. MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis. Life Sci. 2021;272:119232. doi:10.1016/j.lfs.2021.119232
   PubMed Web of Science ®Google Scholar
• Wong TY, Cheung CM, Larsen M, Sharma S, Simo R. Diabetic retinopathy. Nat Rev Dis Primers. 2016;2:16012. doi:10.1038/nrdp.2016.12
   PubMed Web of Science ®Google Scholar
• American Diabetes. 11. Microvascular complications and foot care: standards of medical care in diabetes-2020. Diabetes Care. 2020;43(Suppl 1):S135–S151. doi:10.2337/dc20-S011
   PubMedGoogle Scholar
• McKeage K, Keating GM. Fenofibrate: a review of its use in dyslipidaemia. Drugs. 2011;71(14):1917–1946. doi:10.2165/11208090-000000000-00000
   PubMed Web of Science ®Google Scholar
• Madhavan B, Yue S, Galli U, et al. Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity. Int J Cancer. 2015;136(11):2616–2627. doi:10.1002/ijc.29324
   PubMed Web of Science ®Google Scholar
• Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet. 2011;378(9791):607–620. doi:10.1016/S0140-6736(10)62307-0
   PubMed Web of Science ®Google Scholar