Long-Circulating Lipid Nanospheres Loaded with Flurbiprofen Axetil for Targeted Rheumatoid Arthritis Treatment

References

• Ptacek J, Hawtin RE, Sun D, et al. Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity. PLoS One. 2021;16:1. doi:10.1371/journal.pone.0244187
   Web of Science ®Google Scholar
• Tanaka Y, Hoshino-Negishi K, Kuboi Y, et al. Emerging role of fractalkine in the treatment of rheumatic diseases. Immunotargets Ther. 2020;9:241–253. doi:10.2147/itt.S277991
   PubMed Web of Science ®Google Scholar
• Ye Z, Shen Y, Jin K, et al. Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation. Nat Commun. 2021;12(1):907. doi:10.1038/s41467-021-21242-z
   PubMed Web of Science ®Google Scholar
• Yang M, Feng X, Ding J, et al. Nanotherapeutics relieve rheumatoid arthritis. J Control Release. 2017;252:108–124. doi:10.1016/j.jconrel.2017.02.032
   PubMed Web of Science ®Google Scholar
• Gunasekera WM, Kirwan JR. Rheumatoid arthritis: previously untreated early disease. BMJ Clin Evid. 2016;2016:1.
   Google Scholar
• Wei W, Lu W, Chen X, et al. Use of network pharmacology to investigate the mechanism of the compound xuanju capsule in the treatment of rheumatoid arthritis. Biomed Res Int. 2021;2021:1–14. doi:10.1155/2021/5568791
   PubMed Web of Science ®Google Scholar
• Feldmann M, Maini RN. Perspectives from masters in rheumatology and autoimmunity: can we get closer to a cure for rheumatoid arthritis? Arthritis Rheumatol. 2015;67(9):2283–2291. doi:10.1002/art.39269
   PubMed Web of Science ®Google Scholar
• Arfè A, Scotti L, Varas-Lorenzo C, et al. Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study. BMJ. 2016;354. doi:10.1136/bmj.i4857
   PubMedGoogle Scholar
• Qiu S, Wu X, Li Z, et al. A smart nanoreactor based on an O2-economized dual energy inhibition strategy armed with dual multi-stimuli-responsive “Doorkeepers” for Enhanced CDT/PTT of rheumatoid arthritis. ACS Nano. 2022;16(10):17062–17079. doi:10.1021/acsnano.2c07338
   PubMed Web of Science ®Google Scholar
• Qiu S, Wu X, Geng D, et al. H2O2/NIR-sensitive “two-step” nano theranostic system based hollow mesoporous copper sulfide/hyaluronic acid/JWH133 as an optimally designed delivery system for multidimensional treatment of RA. Int J Biol Macromol. 2023;225:298–309. doi:10.1016/j.ijbiomac.2022.11.019
   PubMed Web of Science ®Google Scholar
• Yuan F, Quan LD, Cui L, et al. Development of macromolecular prodrug for rheumatoid arthritis. Adv Drug Deliv Rev. 2012;64(12):1205–1219. doi:10.1016/j.addr.2012.03.006
   PubMed Web of Science ®Google Scholar
• Zhao M, Liu M. New avenues for nanoparticle-related therapies. Nanoscale Res Lett. 2018;13(1):136. doi:10.1186/s11671-018-2548-8
   PubMedGoogle Scholar
• Zhou M, Hou J, Zhong Z, et al. Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy. Drug Deliv. 2018;25(1):716–722. doi:10.1080/10717544.2018.1447050
   PubMed Web of Science ®Google Scholar
• Liu S. Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging. Mol Pharm. 2006;3(5):472–487. doi:10.1021/mp060049x
   PubMed Web of Science ®Google Scholar
• Wilder RL. Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann Rheum Dis. 2002;61(2):96ii–99. doi:10.1136/ard.61.suppl_2.ii96
   Google Scholar
• Liu W, Zhang Y, Zhu W, et al. Sinomenine inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte/macrophage subsets. Front Immunol. 2018;9:2228. doi:10.3389/fimmu.2018.02228
   PubMed Web of Science ®Google Scholar
• Emam SH, Sonousi A, Osman EO, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021;107:104630. doi:10.1016/j.bioorg.2021.104630
   PubMed Web of Science ®Google Scholar
• Matsumoto T, Takahashi N, Kojima T, et al. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages. Arthritis Res Ther. 2016;18(1):133. doi:10.1186/s13075-016-1035-9
   PubMedGoogle Scholar
• Fu S, Xu X, Ma Y, et al. RGD peptide-based non-viral gene delivery vectors targeting integrin α v β 3 for cancer therapy. J Drug Target. 2019;27(1):1–11. doi:10.1080/1061186x.2018.1455841
   PubMed Web of Science ®Google Scholar
• Lomen PL, Lamborn KR, Porter GH, et al. Treatment of osteoarthritis of the knee. A comparison of flurbiprofen and aspirin. Am J Med. 1986;80(3a):97–102. doi:10.1016/0002-9343(86)90122-1
   PubMed Web of Science ®Google Scholar
• Zhao X, Ji L. Flurbiprofen axetil: analgesic effect and adverse reaction. Pak J Pharm Sci. 2018;31:1163–1167.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang H, Zhao L, Gu J, Feng Y, An H. Erratum: population pharmacokinetic modeling of flurbiprofen, the active metabolite of flurbiprofen Axetil, in Chinese Patients with Postoperative Pain. J Pain Res. 2020;13:553. doi:10.2147/jpr.S251590
   PubMed Web of Science ®Google Scholar
• Tyagi P, Santos JL. Macromolecule nanotherapeutics: approaches and challenges. Drug Discov Today. 2018;23(5):1053–1061. doi:10.1016/j.drudis.2018.01.017
   PubMed Web of Science ®Google Scholar
• Er Y, Barnes TJ, Fornasiero D, et al. The encapsulation and release of guanosine from PEGylated liposomes. J Liposome Res. 2009;19(1):29–36. doi:10.1080/08982100802673940
   PubMed Web of Science ®Google Scholar
• Saneja A, Kumar R, Singh A, et al. Development and evaluation of long-circulating nanoparticles loaded with betulinic acid for improved anti-tumor efficacy. Int J Pharm. 2017;531(1):153–166. doi:10.1016/j.ijpharm.2017.08.076
   PubMedGoogle Scholar
• Usta A, Man KP, Strong N, et al. Investigating MTX-Loaded magnetic nanocomposite particles for treatment of rheumatoid arthritis. J Magn Magn Mater. 2020;499:166171. doi:10.1016/j.jmmm.2019.166171
   Web of Science ®Google Scholar
• Wu H, Su S, Wu Y, et al. Nanoparticle-facilitated delivery of BAFF-R siRNA for B cell intervention and rheumatoid arthritis therapy. Int Immunopharmacol. 2020;88:106933. doi:10.1016/j.intimp.2020.106933
   PubMed Web of Science ®Google Scholar
• Guo Y, Ye Q, Yang S, et al. Therapeutic effects of polysaccharides from Anoectochilus roxburghii on type II collagen-induced arthritis in rats. Int J Biol Macromol. 2019;122:882–892. doi:10.1016/j.ijbiomac.2018.11.015
   PubMed Web of Science ®Google Scholar
• Ma YX, Song YX, Ma F, et al. a potential polymeric nanogel system for effective delivery of chlorogenic acid to target collagen-induced arthritis. J Inorg Organomet Polym Mater. 2020;30(7):2356–2365. doi:10.1007/s10904-019-01421-8
   Web of Science ®Google Scholar
• Liang X, Chen X, Zhao G, et al. Preparation, characterization, and pharmacokinetic evaluation of imperatorin lipid microspheres and their effect on the proliferation of MDA-MB-231 Cells. Pharmaceutics. 2018;10(4):236. doi:10.3390/pharmaceutics10040236
   PubMed Web of Science ®Google Scholar
• Chen Z, Luo Z, Lyu J, et al. Preparation and formulation optimization of methotrexate-loaded human serum albumin nanoparticles modified by mannose. Curr Med Chem. 2021;28(24):5016–5029. doi:10.2174/0929867328666210118112640
   PubMed Web of Science ®Google Scholar
• Aktan B, Chambre L, Sanyal R, et al. “Clickable” nanogels via thermally driven self-assembly of polymers: facile access to targeted imaging platforms using thiol-maleimide conjugation. Biomacromolecules. 2017;18(2):490–497. doi:10.1021/acs.biomac.6b01576
   PubMed Web of Science ®Google Scholar
• Liu XY, Ruan LM, Mao WW, et al. Preparation of RGD-modified long circulating liposome loading matrine, and its in vitro anti-cancer effects. Int J Med Sci. 2010;7(4):197–208. doi:10.7150/ijms.7.197
   PubMed Web of Science ®Google Scholar
• Tizro P, Choi C, Khanlou N. sample preparation for transmission electron microscopy. Methods Mol Biol. 2019;1897:417–424. doi:10.1007/978-1-4939-8935-5_33
   PubMedGoogle Scholar
• Huang X, Li Y, Fu M, Xin HB. Polarizing macrophages in vitro. Methods Mol Biol. 2018;1784:119–126. doi:10.1007/978-1-4939-7837-3_12
   PubMedGoogle Scholar
• Hinz B, Brune K, Rau T, et al. Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages. Pharm Res. 2001;18(2):151–156. doi:10.1023/a:1011020132140
   PubMed Web of Science ®Google Scholar
• Boutet MA, Najm A, Bart G, et al. IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Ann Rheum Dis. 2017;76(7):1304–1312. doi:10.1136/annrheumdis-2016-210630
   PubMed Web of Science ®Google Scholar
• Wu J, Fan KJ, Wang QS, et al. DMY protects the knee joints of rats with collagen-induced arthritis by inhibition of NF-κB signaling and osteoclastic bone resorption. Food Funct. 2020;11(7):6251–6264. doi:10.1039/d0fo00396d
   PubMed Web of Science ®Google Scholar
• Wang Q, Jiang H, Li Y, et al. Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy. Biomaterials. 2017;122:10–22. doi:10.1016/j.biomaterials.2017.01.008
   PubMed Web of Science ®Google Scholar
• Kubota A, Suguro T, Nakajima A, et al. Effect of biological agents on synovial tissues from patients with rheumatoid arthritis. Mod Rheumatol. 2020;30(2):282–286. doi:10.1080/14397595.2019.1583783
   PubMed Web of Science ®Google Scholar
• Luo S, Li H, Liu J, et al. Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund’s adjuvant-induced arthritis. Chem Biol Interact. 2020;319:108984. doi:10.1016/j.cbi.2020.108984
   PubMed Web of Science ®Google Scholar
• Wang Y, Yan M, Zheng GY, et al. A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists. Acta Pharmacol Sin. 2014;35(7):957–966. doi:10.1038/aps.2014.21
   PubMed Web of Science ®Google Scholar
• Deng C, Zhang Q, He P, et al. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis. Nat Commun. 2021;12(1):2174. doi:10.1038/s41467-021-22454-z
   PubMed Web of Science ®Google Scholar
• Maître JM, Boss G, Testa B. High-performance liquid chromatographic separation of the enantiomers of anti-inflammatory 2-arylpropionates: suitability of the method for in vitro metabolic studies. J Chromatogr. 1984;299(2):397–403. doi:10.1016/s0021-9673(01)97855-0
   PubMed Web of Science ®Google Scholar
• Huckaby JT, Jacobs TM, Li Z, et al. Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers. Commun Chem. 2020;3(1):124. doi:10.1038/s42004-020-00369-y
   PubMed Web of Science ®Google Scholar
• Sun Y, Kang C, Liu F, et al. RGD peptide-based target drug delivery of doxorubicin nanomedicine. Drug Dev Res. 2017;78(6):283–291. doi:10.1002/ddr.21399
   PubMed Web of Science ®Google Scholar
• Davies NM. Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet. 1995;28(2):100–114. doi:10.2165/00003088-199528020-00002
   PubMed Web of Science ®Google Scholar