Identifying the Potential of miRNAs in Houttuynia cordata-Derived Exosome-Like Nanoparticles Against Respiratory RNA Viruses

References

• Reiss S, Rebhan I, Backes P, et al. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe. 2011;9(1):32–45. doi:10.1016/j.chom.2010.12.002
   PubMed Web of Science ®Google Scholar
• Uyeki TM, Hui DS, Zambon M, Wentworth DE, Monto AS. Influenza. Lancet. 2022;400(10353):693–706. doi:10.1016/S0140-6736(22)00982-5
   PubMed Web of Science ®Google Scholar
• Nam HH, Ison MG. Respiratory syncytial virus infection in adults. BMJ. 2019;366:l5021. doi:10.1136/bmj.l5021
   PubMedGoogle Scholar
• Lamers MM, Haagmans BL. SARS-CoV-2 pathogenesis. Nat Rev Microbiol. 2022;20(5):270–284. doi:10.1038/s41579-022-00713-0
   PubMed Web of Science ®Google Scholar
• Saiyed AN, Vasavada AR, Johar SRK. Recent trends in miRNA therapeutics and the application of plant miRNA for prevention and treatment of human diseases. Future J Pharm Sci. 2022;8(1):24. doi:10.1186/s43094-022-00413-9
   PubMed Web of Science ®Google Scholar
• Stern-Ginossar N, Elefant N, Zimmermann A, et al. Host immune system gene targeting by a viral miRNA. Science. 2007;317(5836):376–381. doi:10.1126/science.1140956
   PubMed Web of Science ®Google Scholar
• Zhang L, Hou D, Chen X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2012;22(1):107–126. doi:10.1038/cr.2011.158
   PubMed Web of Science ®Google Scholar
• Zhou LK, Zhou Z, Jiang XM, et al. Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. Cell Discov. 2020;6(1):54. doi:10.1038/s41421-020-00197-3
   PubMed Web of Science ®Google Scholar
• Zhou Z, Li X, Liu J, et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res. 2015;25(1):39–49. doi:10.1038/cr.2014.130
   PubMed Web of Science ®Google Scholar
• Kang W, Bang-Berthelsen CH, Holm A, et al. Survey of 800+ data sets from human tissue and body fluid reveals xenomiRs are likely artifacts. Rna. 2017;23(4):433–445. doi:10.1261/rna.059725.116
   PubMed Web of Science ®Google Scholar
• Heintz-Buschart A, Yusuf D, Kaysen A, et al. Small RNA profiling of low biomass samples: identification and removal of contaminants. BMC Biol. 2018;16(1):52. doi:10.1186/s12915-018-0522-7
   PubMedGoogle Scholar
• Yin L, Yan L, Yu Q, et al. Characterization of the MicroRNA profile of ginger exosome-like nanoparticles and their anti-inflammatory effects in intestinal Caco-2 cells. J Agric Food Chem. 2022;70(15):4725–4734. doi:10.1021/acs.jafc.1c07306
   PubMed Web of Science ®Google Scholar
• Karamanidou T, Tsouknidas A. Plant-derived extracellular vesicles as therapeutic nanocarriers. Int J Mol Sci. 2021;23(1):191. doi:10.3390/ijms23010191
   PubMed Web of Science ®Google Scholar
• Cui Y, Gao J, He Y, Jiang L. Plant extracellular vesicles. Protoplasma. 2020;257(1):3–12. doi:10.1007/s00709-019-01435-6
   PubMed Web of Science ®Google Scholar
• Chen X, Zhou Y, Yu J. Exosome-like nanoparticles from ginger rhizomes inhibited NLRP3 inflammasome activation. Mol Pharm. 2019;16(6):2690–2699. doi:10.1021/acs.molpharmaceut.9b00246
   PubMedGoogle Scholar
• Zhang M, Xiao B, Wang H, et al. Edible ginger-derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon cancer therapy. Mol Ther. 2016;24(10):1783–1796. doi:10.1038/mt.2016.159
   PubMed Web of Science ®Google Scholar
• Teng Y, Xu F, Zhang X, et al. Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12. Mol Ther. 2021;29(8):2424–2440. doi:10.1016/j.ymthe.2021.05.005
   PubMed Web of Science ®Google Scholar
• Zhang M, Viennois E, Prasad M, et al. Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials. 2016;101:321–340. doi:10.1016/j.biomaterials.2016.06.018
   PubMed Web of Science ®Google Scholar
• Zhuang X, Deng ZB, Mu J, et al. Ginger-derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles. 2015;4:28713. doi:10.3402/jev.v4.28713
   PubMed Web of Science ®Google Scholar
• Kalarikkal SP, Sundaram GM. Edible plant-derived exosomal microRNAs: exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2. Toxicol Appl Pharmacol. 2021;414:115425. doi:10.1016/j.taap.2021.115425
   PubMed Web of Science ®Google Scholar
• Wu Z, Deng X, Hu Q, et al. Houttuynia cordata Thunb: an Ethnopharmacological Review. Front Pharmacol. 2021;12:714694. doi:10.3389/fphar.2021.714694
   PubMed Web of Science ®Google Scholar
• Rafiq S, Hao H, Ijaz M, Raza A. Pharmacological effects of Houttuynia cordata Thunb (H. cordata): a comprehensive review. Pharmaceuticals. 2022;15(9):1079. doi:10.3390/ph15091079
   Web of Science ®Google Scholar
• Woranam K, Senawong G, Utaiwat S, Yunchalard S, Sattayasai J, Senawong T. Anti-inflammatory activity of the dietary supplement Houttuynia cordata fermentation product in RAW264.7 cells and Wistar rats. PLoS One. 2020;15(3):e0230645. doi:10.1371/journal.pone.0230645
   PubMed Web of Science ®Google Scholar
• Hsu CC, Yang HT, Ho JJ, Yin MC, Hsu JY. Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice. Eur J Nutr. 2016;55(2):845–854. doi:10.1007/s00394-015-0994-y
   PubMed Web of Science ®Google Scholar
• Das SK, Mahanta S, Tanti B, Tag H, Hui PK. Identification of phytocompounds from Houttuynia cordata Thunb. as potential inhibitors for SARS-CoV-2 replication proteins through GC-MS/LC-MS characterization, molecular docking and molecular dynamics simulation. Mol Divers. 2022;26(1):365–388. doi:10.1007/s11030-021-10226-2
   PubMed Web of Science ®Google Scholar
• Ling LJ, Lu Y, Zhang YY, et al. Flavonoids from Houttuynia cordata attenuate H1N1-induced acute lung injury in mice via inhibition of influenza virus and toll-like receptor signalling. Phytomedicine. 2020;67:153150. doi:10.1016/j.phymed.2019.153150
   PubMed Web of Science ®Google Scholar
• Hung PY, Ho BC, Lee SY, et al. Houttuynia cordata targets the beginning stage of herpes simplex virus infection. PLoS One. 2015;10(2):e0115475. doi:10.1371/journal.pone.0115475
   PubMed Web of Science ®Google Scholar
• Cheng D, Sun L, Zou S, et al. Antiviral effects of houttuynia cordata polysaccharide extract on murine norovirus-1 (MNV-1)-A human norovirus surrogate. Molecules. 2019;24(9):1835. doi:10.3390/molecules24091835
   PubMed Web of Science ®Google Scholar
• Lau KM, Lee KM, Koon CM, et al. Immunomodulatory and anti-SARS activities of Houttuynia cordata. J Ethnopharmacol. 2008;118(1):79–85.
   PubMed Web of Science ®Google Scholar
• Li L, Gao F, Jiang Y, et al. Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo. Sci Rep. 2015;5:17010. doi:10.1038/srep17010
   PubMed Web of Science ®Google Scholar
• Li L, Wei Z, Zhou Y, et al. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons. Virus Res. 2015;195:86–94. doi:10.1016/j.virusres.2014.08.012
   PubMed Web of Science ®Google Scholar
• Wang X, Wu B, Sun G, et al. Selenium biofortification enhanced miR167a expression in broccoli extracellular vesicles inducing apoptosis in human pancreatic cancer cells by targeting IRS1. Int J Nanomedicine. 2023;18:2431–2446. doi:10.2147/IJN.S394133
   PubMed Web of Science ®Google Scholar
• Haunsberger SJ, Connolly NM, Prehn JH. miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions. Bioinformatics. 2017;33(4):592–593. doi:10.1093/bioinformatics/btw660
   PubMed Web of Science ®Google Scholar
• Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R. Fast and effective prediction of microRNA/target duplexes. Rna. 2004;10(10):1507–1517. doi:10.1261/rna.5248604
   PubMed Web of Science ®Google Scholar
• Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57. doi:10.1038/nprot.2008.211
   PubMed Web of Science ®Google Scholar
• Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 2003;31(13):3406–3415. doi:10.1093/nar/gkg595
   PubMed Web of Science ®Google Scholar
• Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E. The role of site accessibility in microRNA target recognition. Nat Genet. 2007;39(10):1278–1284. doi:10.1038/ng2135
   PubMed Web of Science ®Google Scholar
• Zhu H, He W. Ginger: a representative material of herb-derived exosome-like nanoparticles. Front Nutr. 2023;10:1223349. doi:10.3389/fnut.2023.1223349
   PubMed Web of Science ®Google Scholar
• Zhu H, Li Y, Li H. Necessity of the development of fresh Chinese medicine decoction pieces by analysis from the quantity of fresh Houttuynia cordata Thunb. Mod Tradit Chin Med Materia Medica--World Sci Technol. 2019;21(12):2753–2758.
   Google Scholar
• Minutolo A, Potesta M, Roglia V, et al. Plant microRNAs from Moringa oleifera Regulate Immune Response and HIV Infection. Front Pharmacol. 2020;11:620038. doi:10.3389/fphar.2020.620038
   PubMed Web of Science ®Google Scholar
• Trivedi TS, Patel MP, Nanavaty V, Mankad AU, Rawal RM, Patel SK. MicroRNAs from Holarrhena pubescens stems: identification by small RNA sequencing and their potential contribution to human gene targets. Funct Integr Genomics. 2023;23(2):149. doi:10.1007/s10142-023-01078-0
   PubMed Web of Science ®Google Scholar
• Ehrhardt C, Ludwig S. A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. Cell Microbiol. 2009;11(6):863–871. doi:10.1111/j.1462-5822.2009.01309.x
   PubMed Web of Science ®Google Scholar
• Ranadheera C, Coombs KM, Kobasa D. Comprehending a killer: the Akt/mTOR signaling pathways are temporally high-jacked by the highly pathogenic 1918 influenza virus. EBioMedicine. 2018;32:142–163. doi:10.1016/j.ebiom.2018.05.027
   PubMed Web of Science ®Google Scholar
• Lin L, An L, Chen H, et al. Integrated network pharmacology and lipidomics to reveal the inhibitory effect of qingfei oral liquid on excessive autophagy in RSV-induced lung inflammation. Front Pharmacol. 2021;12:777689. doi:10.3389/fphar.2021.777689
   PubMed Web of Science ®Google Scholar
• Al-Qahtani AA, Pantazi I, Alhamlan FS, et al. SARS-CoV-2 modulates inflammatory responses of alveolar epithelial type II cells via PI3K/AKT pathway. Front Immunol. 2022;13:1020624. doi:10.3389/fimmu.2022.1020624
   PubMed Web of Science ®Google Scholar
• Kyriakopoulos AM, Nigh G, McCullough PA, Seneff S. Mitogen activated protein kinase (MAPK) Activation, p53, and autophagy inhibition characterize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein induced neurotoxicity. Cureus. 2022;14(12):e32361. doi:10.7759/cureus.32361
   PubMed Web of Science ®Google Scholar
• Cheng Y, Sun F, Wang L, et al. Virus-induced p38 MAPK activation facilitates viral infection. Theranostics. 2020;10(26):12223–12240. doi:10.7150/thno.50992
   PubMed Web of Science ®Google Scholar
• Canovas B, Nebreda AR. Diversity and versatility of p38 kinase signalling in health and disease. Nat Rev Mol Cell Biol. 2021;22(5):346–366. doi:10.1038/s41580-020-00322-w
   PubMed Web of Science ®Google Scholar
• Marchant D, Singhera GK, Utokaparch S, et al. Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J Virol. 2010;84(21):11359–11373. doi:10.1128/JVI.00804-10
   PubMed Web of Science ®Google Scholar
• Shin HB, Choi MS, Yi CM, Lee J, Kim NJ, Inn KS. Inhibition of respiratory syncytial virus replication and virus-induced p38 kinase activity by berberine. Int Immunopharmacol. 2015;27(1):65–68. doi:10.1016/j.intimp.2015.04.045
   PubMed Web of Science ®Google Scholar
• Faist A, Schloer S, Mecate-Zambrano A, et al. Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier. Antiviral Res. 2023;209:105475. doi:10.1016/j.antiviral.2022.105475
   PubMedGoogle Scholar