171
Views
3
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles

, ORCID Icon, , , , , , , , , & show all
Pages 6743-6761 | Received 28 Jul 2023, Accepted 20 Oct 2023, Published online: 15 Nov 2023

References

  • Zerem E, Kurtcehajic A, Kunosić S, Zerem Malkočević D, Zerem O. Current trends in acute pancreatitis: diagnostic and therapeutic challenges. World J Gastroenterol. 2023;29(18):2747–2763. doi:10.3748/wjg.v29.i18.2747
  • Kang H, Yang Y, Zhu L, et al. Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis. Chin Med J. 2022;135(23):2773–2784. doi:10.1097/CM9.0000000000002359
  • Ge P, Luo Y, Okoye CS, et al. Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis. Biomed Pharmacother. 2020;132:110770. doi:10.1016/j.biopha.2020.110770
  • Lanyu Z, Feilong H. Emerging role of extracellular vesicles in lung injury and inflammation. Biomed Pharmacother. 2019;113:108748. doi:10.1016/j.biopha.2019.108748
  • Khalaj K, Figueira RL, Antounians L, Lauriti G, Zani A. Systematic review of extracellular vesicle-based treatments for lung injury: are EVs a potential therapy for COVID-19. J Extracell Vesicles. 2020;9(1):1795365. doi:10.1080/20013078.2020.1795365
  • Yang Q, Luo Y, Lan B, et al. Fighting Fire with Fire: exosomes and Acute Pancreatitis-Associated Acute Lung Injury. Bioengineering. 2022;9(11). doi:10.3390/bioengineering9110615
  • Hu Y, Yang L, Lai Y. Recent findings regarding the synergistic effects of emodin and its analogs with other bioactive compounds: insights into new mechanisms. Biomed Pharmacother. 2023;162:114585. doi:10.1016/j.biopha.2023.114585
  • Sharifi-Rad J, Herrera-Bravo J, Kamiloglu S, et al. Recent advances in the therapeutic potential of emodin for human health. Biomed Pharmacother. 2022;154:113555. doi:10.1016/j.biopha.2022.113555
  • Xiang H, Zhang Q, Qi B, et al. Chinese Herbal Medicines Attenuate Acute Pancreatitis: pharmacological Activities and Mechanisms. Front Pharmacol. 2017;8:216. doi:10.3389/fphar.2017.00216
  • Xu C, Luo Y, Ntim M, et al. Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. J Cell Mol Med. 2021;25(4):1851–1866. doi:10.1111/jcmm.15525
  • Xu C, Zhang J, Liu J, et al. Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity. J Proteomics. 2020;220:103760. doi:10.1016/j.jprot.2020.103760
  • Hu Q, Yao J, Wu X, et al. Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation. Acta Pharm Sin B. 2022;12(10):3986–4003. doi:10.1016/j.apsb.2021.10.008
  • Cui Y, Wang X, Lin F, et al. MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis. Aging Dis. 2022;13(3):899–909. doi:10.14336/AD.2021.1023
  • Xu Q, Wang M, Guo H, et al. Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1β/CXCL1 Signaling. Front Pharmacol. 2021;12:655372. doi:10.3389/fphar.2021.655372
  • Zhang XP, Li ZF, Liu XG, et al. Effects of emodin and baicalein on rats with severe acute pancreatitis. World J Gastroenterol. 2005;11(14):2095–2100. doi:10.3748/wjg.v11.i14.2095
  • Ning JW, Zhang Y, Yu MS, et al. Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition. Hepatobiliary Pancreat Dis Int. 2017;16(4):431–436. doi:10.1016/S1499-3872(17)60041-9
  • Wang G, Sun B, Gao Y, Meng QH, Jiang HC. The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury. Mediators Inflamm. 2007;2007:29638. doi:10.1155/2007/29638
  • Xia XM, Wang FY, Wang ZK, Wan HJ, Xu WA, Lu H. Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. World J Gastroenterol. 2010;16(24):2994–3001. doi:10.3748/wjg.v16.i24.2994
  • Ni Q, Sun K, Chen G, Shang D. In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome. Mol Med Rep. 2014;9(1):355–359. doi:10.3892/mmr.2013.1771
  • Wang GJ, Wang Y, Teng YS, et al. Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca(2+)-Caspase 12 Pathway against SIRS in Rats with Severe Acute Pancreatitis. Biomed Res Int. 2016;2016:1736024. doi:10.1155/2016/1736024
  • Shao Y, Li Y, Jiang Y, Li H, Wang J, Zhang D. Circulating exosomal miR-155-5p contributes to severe acute pancreatitis-associated intestinal barrier injury by targeting SOCS1 to activate NLRP3 inflammasome-mediated pyroptosis. FASEB J. 2023;37(6):e23003. doi:10.1096/fj.202300237R
  • Wu XB, Sun HY, Luo ZL, Cheng L, Duan XM, Ren JD. Plasma-derived exosomes contribute to pancreatitis-associated lung injury by triggering NLRP3-dependent pyroptosis in alveolar macrophages. Biochim Biophys Acta Mol Basis Dis. 2020;1866(5):165685. doi:10.1016/j.bbadis.2020.165685
  • Guo Y, Cao F, Ding Y, Lu J, Liu S, Li F. Acinar Cells Derived Exosomes Alleviate the Severity of Acute Pancreatitis. Discov Med. 2021;31(163):95–105.
  • Park EJ, Shimaoka M, Kiyono H. Functional Flexibility of Exosomes and MicroRNAs of Intestinal Epithelial Cells in Affecting Inflammation. Front Mol Biosci. 2022;9:854487. doi:10.3389/fmolb.2022.854487
  • Tang DS, Cao F, Yan CS, et al. Acinar Cell-Derived Extracellular Vesicle MiRNA-183-5p Aggravates Acute Pancreatitis by Promoting M1 Macrophage Polarization Through Downregulation of FoxO1. Front Immunol. 2022;13:869207. doi:10.3389/fimmu.2022.869207
  • Carrascal M, Areny-Balagueró A, de-Madaria E, et al. Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease. J Pathol. 2022;256(1):83–92. doi:10.1002/path.5811
  • Zhu Q, Luo J, Li HP, et al. Robust Acute Pancreatitis Identification and Diagnosis: rAPIDx. ACS Nano. 2023;17(9):8564–8574. doi:10.1021/acsnano.3c00922
  • Qu Y, Ding Y, Lu J, et al. Identification of key microRNAs in exosomes derived from patients with the severe acute pancreatitis. Asian J Surg. 2023;46(1):337–347. doi:10.1016/j.asjsur.2022.04.032
  • Han L, Zhao Z, Chen X, et al. Human umbilical cord mesenchymal stem cells-derived exosomes for treating traumatic pancreatitis in rats. Stem Cell Res Ther. 2022;13(1):221. doi:10.1186/s13287-022-02893-1
  • Chen M, Chen J, Huang W, et al. Exosomes from human induced pluripotent stem cells derived mesenchymal stem cells improved myocardial injury caused by severe acute pancreatitis through activating Akt/Nrf2/HO-1 axis. Cell Cycle. 2022;21(15):1578–1589. doi:10.1080/15384101.2022.2057762
  • Shen W, Zhao X, Li S. Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway. Inflammation. 2022;45(1):331–342. doi:10.1007/s10753-021-01548-2
  • Zhang T, Lu L, Li M, et al. Exosome from BMMSC Attenuates Cardiopulmonary Bypass-Induced Acute Lung Injury Via YAP/β-Catenin Pathway: downregulation of Pyroptosis. Stem Cells. 2022;40(12):1122–1133. doi:10.1093/stmcls/sxac063
  • Shen K, Wang X, Wang Y, et al. miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury. Redox Biol. 2023;62:102655. doi:10.1016/j.redox.2023.102655
  • Wen X, He B, Tang X, Wang B, Chen Z. Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1. Mol Med Rep. 2021;24(5). doi:10.3892/mmr.2021.12425
  • Zhen J, Chen W, Liu Y, Zang X. Baicalin Protects Against Acute Pancreatitis Involving JNK Signaling Pathway via Regulating miR-15a. Am J Chin Med. 2021;49(1):147–161. doi:10.1142/S0192415X21500087
  • Zhu QJ, Wang J, Li Y, Bai ZJ, Guo XB, Pan T. PRKCA Promotes Mitophagy through the miR-15a-5p/PDK4 Axis to Relieve Sepsis-Induced Acute Lung Injury. Infect Immun. 2023;91(1):e0046522. doi:10.1128/iai.00465-22
  • Zhang X, Zhang Y, Meng Q, et al. MicroRNA-382-5p is involved in pulmonary inflammation induced by fine particulate matter exposure. Environ Pollut. 2020;262:114278. doi:10.1016/j.envpol.2020.114278
  • Peng Y, Wang Q, Yang W, Yang Q, Pei Y, Zhang W. MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease. Acta Biochim Pol. 2020;67(2):157–163. doi:10.18388/abp.2020_5152
  • Chen J, Liu Q, Ding Z, et al. LncRNA NEAT1 aggravates lipopolysaccharide-induced acute lung injury by regulating the miR-98-5p/TLR4 axis. J Biochem Mol Toxicol. 2021;35(12):e22927. doi:10.1002/jbt.22927
  • Fukata T, Mizushima T, Nishimura J, et al. The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis. Mol Ther Nucleic Acids. 2018;12:658–671. doi:10.1016/j.omtn.2018.07.007
  • Tian R, Guan X, Qian H, et al. Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis. Biofactors. 2021;47(3):414–426. doi:10.1002/biof.1712
  • Bai Y, Liu X, Chen Q, Chen T, Jiang N, Guo Z. Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p. Sci Rep. 2021;11(1):19637. doi:10.1038/s41598-021-98916-7
  • Ren S, Pan L, Yang L, et al. miR-29a-3p transferred by mesenchymal stem cells-derived extracellular vesicles protects against myocardial injury after severe acute pancreatitis. Life Sci. 2021;272:119189. doi:10.1016/j.lfs.2021.119189