Tuning Peptide-Based Nanofibers for Achieving Selective Doxorubicin Delivery in Triple-Negative Breast Cancer

References

• Upadhyay K, Tamrakar RK, Thomas S, et al. Surface functionalized nanoparticles: a boon to biomedical science. Chem Biol Interact. 2023;380:110537. doi:10.1016/j.cbi.2023.110537
   PubMed Web of Science ®Google Scholar
• Khan MI, Hossain MI, Hossain MK, et al. Recent progress in nanostructured smart drug delivery systems for cancer therapy: a review. ACS Appl Bio Mater. 2022;5:971–1012. doi:10.1021/acsabm.2c00002
   PubMedGoogle Scholar
• Wang X, Li C, Wang Y, et al. Smart drug delivery systems for precise cancer therapy. Acta Pharm Sin B. 2022;12:4098–4121. doi:10.1016/j.apsb.2022.08.013
   PubMed Web of Science ®Google Scholar
• Li C, Wang M, Li PF, et al. Construction of smart DNA-based drug delivery systems for cancer therapy. Small;2024. e2306257. doi:10.1002/smll.202306257
   PubMed Web of Science ®Google Scholar
• Zhou Y, Li Q, Wu Y, et al. Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy. ACS Nano. 2023;17:8004–8025. doi:10.1021/acsnano.3c01452
   PubMed Web of Science ®Google Scholar
• Li T, Lu XM, Zhang MR, et al. Peptide-based nanomaterials: self-assembly, properties and applications. Bioact Mater. 2022;11:268–282. doi:10.1016/j.bioactmat.2021.09.029
   PubMed Web of Science ®Google Scholar
• Kianfar E. Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles. J Nanobiotechnology. 2021;19:159. doi:10.1186/s12951-021-00896-3
   PubMed Web of Science ®Google Scholar
• Sangji MH, Sai H, Chin SM, et al. Supramolecular interactions and morphology of self-assembling peptide amphiphile nanostructures. Nano Lett. 2021;21:6146–6155. doi:10.1021/acs.nanolett.1c01737
   PubMed Web of Science ®Google Scholar
• Lombardi L, Falanga A, Del Genio V, et al. A new hope: self-assembling peptides with antimicrobial activity. Pharmaceutics. 2019;11:166. doi:10.3390/pharmaceutics11040166
   PubMed Web of Science ®Google Scholar
• Du Z, Fan B, Dai Q. Supramolecular peptide nanostructures: self-assembly and biomedical applications. Giant. 2022;9:100082. doi:10.1016/j.giant.2021.100082
   Google Scholar
• Ghosh G, Barman R, Mukherjee A, et al. Control over multiple nano- and secondary structures in peptide self-assembly. Angew Chem Int Ed Engl. 2022;61:e202113403.
   PubMed Web of Science ®Google Scholar
• Ghosh G, Kartha KK, Fernández G. Tuning the mechanistic pathways of peptide self-assembly by aromatic interactions. Chem Comm. 2021;57:1603–1606. doi:10.1039/D0CC07199D
   PubMed Web of Science ®Google Scholar
• Hu X, Liao M, Gong H, et al. Recent advances in short peptide self-assembly: from rational design to novel applications. Curr Opin Coll Interface Sci. 2020;45:1–13.
   Web of Science ®Google Scholar
• Lee S, Trinh THT, Yoo M. Self-assembling peptides and their application in the treatment of diseases. Int J Mol Sci. 2019;20:5850. doi:10.3390/ijms20235850
   PubMed Web of Science ®Google Scholar
• Moyer TJ, Kassam HA, Bahnson ES. Shape-dependent targeting of injured blood vessels by peptide amphiphile supramolecular nanostructures. Small. 2015;11:2750–2755. doi:10.1002/smll.201403429
   PubMed Web of Science ®Google Scholar
• Lee KL, Shukla S, Wu M, et al. Stealth filaments: polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X. Acta Biomater. 2015;19:166–179. doi:10.1016/j.actbio.2015.03.001
   PubMed Web of Science ®Google Scholar
• Dasgupta A, Das D. Designer peptide amphiphiles: self-assembly to applications. Langmuir. 2019;35:10704–10724. doi:10.1021/acs.langmuir.9b01837
   PubMed Web of Science ®Google Scholar
• Mitchell MJ, Billingsley MM, Haley RM, et al. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20:101–124. doi:10.1038/s41573-020-0090-8
   PubMed Web of Science ®Google Scholar
• Kang EB, Lee JE, Mazrad ZAI, et al. pH-Responsible fluorescent carbon nanoparticles for tumor selective theranostics via pH-turn on/off fluorescence and photothermal effect in vivo and in vitro. Nanoscale. 2018;10:2512–2523. doi:10.1039/C7NR07900A
   PubMed Web of Science ®Google Scholar
• Fu Q, Wang J, Liu H. Chemo-immune synergetic therapy of esophageal carcinoma: trastuzumab modified, cisplatin and fluorouracil co-delivered lipid-polymer hybrid nanoparticles. Drug Deliv. 2020;27:1535–1543. doi:10.1080/10717544.2020.1837294
   PubMed Web of Science ®Google Scholar
• Awad K, Dalby M, Cree I, et al. The precision medicine approach to cancer therapy: part 1 — solid tumours. Pharm J. 2019;2019:1.
   Google Scholar
• DeSantis C, Ma J, Bryan L, et al. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64:52–62. doi:10.3322/caac.21203
   PubMed Web of Science ®Google Scholar
• Zheng Y, Li M, Weng B, et al. Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer. Biomater Sci. 2022;10:1607–1625. doi:10.1039/D2BM00062H
   PubMed Web of Science ®Google Scholar
• Perou CM, Sørlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747–752. doi:10.1038/35021093
   PubMed Web of Science ®Google Scholar
• Nguyen HM, Paulishak W, Oladejo M, et al. Dynamic tumor microenvironment, molecular heterogeneity, and distinct immunologic portrait of triple-negative breast cancer: an impact on classification and treatment approaches. Breast Cancer. 2023;30:167–186. doi:10.1007/s12282-022-01415-4
   PubMed Web of Science ®Google Scholar
• Hashmi AA, Naz S, Hashmi SK. Epidermal growth factor receptor (EGFR) overexpression in triple-negative breast cancer: association with clinicopathologic features and prognostic parameters. Surg Exp Pathol. 2019;2:6. doi:10.1186/s42047-018-0029-0
   Google Scholar
• Ali R, Wendt MK. The paradoxical functions of EGFR during breast cancer progression. Signal Transduct Target Ther. 2017;2:16042. doi:10.1038/sigtrans.2016.42
   PubMed Web of Science ®Google Scholar
• Lehmann BD, Jovanović B, Chen X, et al. Refinement of triple-negative breast cancer molecular subtypes: implications for neoadjuvant chemotherapy selection. PLoS One. 2016;11:e0157368.
   PubMed Web of Science ®Google Scholar
• Hwang SY, Park S, Kwon Y. Recent therapeutic trends and promising targets in triple negative breast cancer. Pharmacol Ther. 2019;199:30–57. doi:10.1016/j.pharmthera.2019.02.006
   PubMed Web of Science ®Google Scholar
• Rej RK, Roy J, Allu SR. Therapies for the treatment of advanced/metastatic estrogen receptor-positive breast cancer: current situation and future directions. Cancers (Basel). 2024;16:552. doi:10.3390/cancers16030552
   PubMed Web of Science ®Google Scholar
• Hou K, Ning Z, Chen H, Wu Y. Nanomaterial technology and triple negative breast cancer. Front Oncol. 2021;11:828810. doi:10.3389/fonc.2021.828810
   PubMedGoogle Scholar
• Loap P, Loirat D, Berger F, et al. Concurrent olaparib and radiotherapy in patients with triple-negative breast cancer: the phase 1 olaparib and radiation therapy for triple-negative breast cancer trial. JAMA Oncol. 2022;8:1802–1808. doi:10.1001/jamaoncol.2022.5074
   PubMed Web of Science ®Google Scholar
• Loap P, Loirat D, Berger F, et al. Combination of olaparib and radiation therapy for triple negative breast cancer: preliminary results of the RADIOPARP phase 1 trial. Int J Radiat Oncol Biol Phys. 2021;109:436–440. doi:10.1016/j.ijrobp.2020.09.032
   PubMed Web of Science ®Google Scholar
• Furlanetto J, Loibl S. Optimal systemic treatment for early triple-negative breast cancer. Breast Care. 2020;15:217–226. doi:10.1159/000508759
   PubMed Web of Science ®Google Scholar
• Pogorzelska A, Mazur M, Świtalska M, et al. Anticancer effect and safety of doxorubicin and nutraceutical sulforaphane liposomal formulation in triple-negative breast cancer (TNBC) animal model. Biomed Pharmacother. 2023;161:114490. doi:10.1016/j.biopha.2023.114490
   PubMed Web of Science ®Google Scholar
• Hartgerink JD, Beniash E, Stupp SI. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science. 2001;294:1684–1688. doi:10.1126/science.1063187
   PubMed Web of Science ®Google Scholar
• Berndt P, Fields GB, Tirrell M. Synthetic lipidation of peptides and amino acids: monolayer structure and properties. J Am Chem Soc. 1995;117:9515–9522. doi:10.1021/ja00142a019
   Web of Science ®Google Scholar
• Galdiero S, Falanga A, Morelli G, Galdiero M. gH625: a milestone in understanding the many roles of membranotropic peptides. Biochim Biophys Acta. 2015;1848:16–25. doi:10.1016/j.bbamem.2014.10.006
   PubMed Web of Science ®Google Scholar
• Falanga A, Galdiero M, Galdiero S. Membranotropic cell penetrating peptides: the outstanding journey. Int J Mol Sci. 2015;16:25323–25337. doi:10.3390/ijms161025323
   PubMed Web of Science ®Google Scholar
• Ben Djemaa S, Hervé-Aubert K, Lajoie L. gH625 cell-penetrating peptide promotes the endosomal escape of nanovectorized siRNA in a triple-negative breast cancer cell line. Biomacromolecules. 2019;20:3076–3086. doi:10.1021/acs.biomac.9b00637
   PubMed Web of Science ®Google Scholar
• Barra T, Falanga A, Bellavita R. Neuroprotective effects of gH625-lipoPACAP in an in vitro fluid dynamic model of parkinson’s disease. Biomedicines. 2022;10:2644. doi:10.3390/biomedicines10102644
   PubMed Web of Science ®Google Scholar
• Hossein-Nejad-Ariani H, Althagafi E, Kaur K. Small peptide ligands for targeting EGFR in triple negative breast cancer cells. Sci Rep. 2019;9:2723. doi:10.1038/s41598-019-38574-y
   PubMed Web of Science ®Google Scholar
• Huang H. Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances. Sensors. 2018;18:3249. doi:10.3390/s18103249
   PubMed Web of Science ®Google Scholar
• Perillo E, Porto S, Falanga A, et al. Liposome armed with herpes virus-derived gH625 peptide to overcome doxorubicin resistance in lung adenocarcinoma cell lines. Oncotarget. 2016;7:4077–4092. doi:10.18632/oncotarget.6013
   PubMed Web of Science ®Google Scholar
• Falanga A, Maione A, La Pietra A, et al. Competitiveness during dual-species biofilm formation of fusarium oxysporum and candida albicans and a novel treatment strategy. Pharmaceutics. 2022;14:1167. doi:10.3390/pharmaceutics14061167
   PubMed Web of Science ®Google Scholar
• Del Genio V, Falanga A, Allard-Vannier E, et al. Design and validation of nanofibers made of self-assembled peptides to become multifunctional stimuli-sensitive nanovectors of anticancer drug doxorubicin. Pharmaceutics. 2022;14:1544. doi:10.3390/pharmaceutics14081544
   PubMed Web of Science ®Google Scholar
• Yousif AM, Ingangi V, Merlino F, et al. Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration. Eur J Med Chem. 2018;143:348–360. doi:10.1016/j.ejmech.2017.11.030
   PubMed Web of Science ®Google Scholar
• Bellavita R, Falanga A, Merlino F, et al. Unveiling the mechanism of action of acylated temporin L analogues against multidrug-resistant Candida albicans. J Enzyme Inhib Med Chem. 2023;38:36–50. doi:10.1080/14756366.2022.2134359
   PubMed Web of Science ®Google Scholar
• Bellavita R, Falanga A, Buommino E, et al. Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs. J Enzyme Inhib Med Chem. 2020;35:1751–1764. doi:10.1080/14756366.2020.1819258
   PubMed Web of Science ®Google Scholar
• Stuart MCA, van de Pas JC, Engberts JBFN. The use of Nile Red to monitor the aggregation behavior in ternary surfactant–water–organic solvent systems. J Phys Org Chem. 2005;18:929–934. doi:10.1002/poc.919
   Web of Science ®Google Scholar
• Wi S, Pancoska P, Keiderling TA. Predictions of protein secondary structures using factor analysis on Fourier transform infrared spectra: effect of Fourier self-deconvolution of the amide I and amide II bands. Biospectroscopy. 1998;4:93–106. doi:10.1002/(SICI)1520-6343(1998)4:2<93::AID-BSPY2>3.0.CO;2-T
   PubMedGoogle Scholar
• Portaccio M, Gravagnuolo AM, Longobardi S, et al. ATR FT-IR spectroscopy on Vmh2 hydrophobin self-assembled layers for Teflon membrane bio-functionalization. Appl Surf Sci. 2015;351:673–680. doi:10.1016/j.apsusc.2015.05.182
   Web of Science ®Google Scholar
• Rea I, Sansone L, Terracciano M, et al. Photoluminescence of graphene oxide infiltrated into mesoporous silicon. J Phys Chem C. 2014;118:27301–27307. doi:10.1021/jp506539n
   Web of Science ®Google Scholar
• Nemoto K, Kubo T, Nomachi M, et al. Simple and effective 3D recognition of domoic acid using a molecularly imprinted polymer. J Am Chem Soc. 2007;129:13626–13632. doi:10.1021/ja0741426
   PubMed Web of Science ®Google Scholar
• Yamawaki Y, Yufu T, Kato T. The effect of a peptide substrate containing an unnatural branched amino acid on chymotrypsin activity. Processes. 2021;9:242. doi:10.3390/pr9020242
   Web of Science ®Google Scholar
• Marulanda K, Mercel A, Gillis DC, et al. Intravenous delivery of lung-targeted nanofibers for pulmonary hypertension in mice. Adv Healthc Mater. 2021;10:e2100302.
   PubMed Web of Science ®Google Scholar
• Piccolo M, Ferraro MG, Raucci F, et al. Safety and efficacy evaluation in vivo of a cationic nucleolipid nanosystem for the nanodelivery of a ruthenium(III) complex with superior anticancer bioactivity. Cancers. 2021;13:5164. doi:10.3390/cancers13205164
   PubMed Web of Science ®Google Scholar
• Ferraro MG, Bocchetti M, Riccardi C, et al. Triple negative breast cancer preclinical therapeutic management by a cationic ruthenium-based nucleolipid nanosystem. Int J Mol Sci. 2023;24:6473. doi:10.3390/ijms24076473
   PubMed Web of Science ®Google Scholar
• Guarnieri D, Biondi M, Yu H, et al. Tumor-activated prodrug (TAP)-conjugated nanoparticles with cleavable domains for safe doxorubicin delivery. Biotechnol Bioeng. 2015;112:601–611. doi:10.1002/bit.25454
   PubMed Web of Science ®Google Scholar
• Lombardi L, Shi Y, Falanga A. Enhancing the potency of antimicrobial peptides through molecular engineering and self-assembly. Biomacromolecules. 2019;20:1362–1374. doi:10.1021/acs.biomac.8b01740
   PubMed Web of Science ®Google Scholar
• Barra T, Falanga A, Bellavita R, et al. gH625-liposomes deliver PACAP through a dynamic in vitro model of the blood-brain barrier. Front Physiol. 2022;13:932099. doi:10.3389/fphys.2022.932099
   PubMed Web of Science ®Google Scholar
• Yousef EM, Tahir MR, St-Pierre Y, Gaboury LA. MMP-9 expression varies according to molecular subtypes of breast cancer. BMC Cancer. 2014;14:609. doi:10.1186/1471-2407-14-609
   PubMed Web of Science ®Google Scholar
• Jain RK, Stylianopoulos T. Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol. 2010;7:653–664. doi:10.1038/nrclinonc.2010.139
   PubMed Web of Science ®Google Scholar
• Amdursky N, Erez Y, Huppert D. Molecular rotors: what lies behind the high sensitivity of the thioflavin-T fluorescent marker. Acc Chem Res. 2012;45:1548–1557. doi:10.1021/ar300053p
   PubMed Web of Science ®Google Scholar
• Jobin PG, Butler GS, Overall CM. New intracellular activities of matrix metalloproteinases shine in the moonlight. Biochim Biophys Acta Mol Cell Res. 2017;1864:2043–2055. doi:10.1016/j.bbamcr.2017.05.013
   PubMed Web of Science ®Google Scholar
• Drin G, Cottin S, Blanc E, Rees AR, Temsamani J. Studies on the internalization mechanism of cationic cell-penetrating peptides. J Biol Chem. 2003;278:31192–31201. doi:10.1074/jbc.M303938200
   PubMed Web of Science ®Google Scholar