Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations

References

• SinghNManshianBJenkinsGJNanoGenotoxicology: the DNA damaging potential of engineered nanomaterialsBiomaterials20093023–243891391419427031
   PubMed Web of Science ®Google Scholar
• Lux report. Nanomaterials state of the market: stealth success, broad impact Available from: http://portal.luxresearchinc.com/research/document/3735Accessed January 17, 2008
   Google Scholar
• BrownCFisherJInghamEBiological effects of clinically relevant wear particles from metal-on-metal hip prosthesesProc Inst Mech Eng H2006220235536916669401
   PubMed Web of Science ®Google Scholar
• BallestriMBaraldiAGattiAMLiver and kidney foreign bodies granulomatosis in a patient with malocclusion, bruxism, and worn dental prosthesesGastroenterology200112151234123811677217
   PubMed Web of Science ®Google Scholar
• HartAJHesterTSinclairKThe association between metal ions from hip resurfacing and reduced T-cell countsJ Bone Joint Surg Br200688444945416567777
   PubMedGoogle Scholar
• FerrariMCancer nanotechnology: opportunities and challengesNat Rev Cancer20055316117115738981
   PubMed Web of Science ®Google Scholar
• SahooSKParveenSPandaJJThe present and future of nanotechnology in human health careNanomedicine200731203117379166
   PubMed Web of Science ®Google Scholar
• DuXHeJElaborate control over the morphology and structure of mercapto-functionalized mesoporous silicas as multipurpose carriersDalton Trans201039389063907220730188
   PubMed Web of Science ®Google Scholar
• MaS WYZhuYA simple room temperature synthesis of mesoporous silica nanoparticles for drug storage and pressure pulsed deliveryJournal of Porous Material2011182233239
   Web of Science ®Google Scholar
• BarickKCNigamSBahadurDNanoscale assembly of mesoporous ZnO: a potential drug carrierJ Mater Chem20102064466452
   Web of Science ®Google Scholar
• BormPJABerubeDA tale of opportunities, uncertainties and risksNano Today200835659
   Web of Science ®Google Scholar
• DusinskaMFjellsboLMagdolenovaZTesting strategies for the safety of nanoparticles used in medical applicationsNanomedicine (Lond)20094660560719663587
   PubMed Web of Science ®Google Scholar
• KumarAPandeyAShankerRDhawanAMicroorganism: a versatile model for toxicity assessment of engineered nanomaterialsCioffiNRaiMNano-Antimicrobials: Progress and ProspectsBerlin, GermanySpringer Verlag GmbH2012
   Google Scholar
• MaynardADNanotechnology: the next big thing, or much ado about nothing?Ann Occup Hyg20075111217041243
   PubMed Web of Science ®Google Scholar
• ElsaesserAHowardCVToxicology of nanoparticlesAdv Drug Deliv Rev201264212913721925220
   PubMed Web of Science ®Google Scholar
• NavarroEBaunABehraREnvironmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungiEcotoxicology200817537238618461442
   PubMed Web of Science ®Google Scholar
• KumarAPandeyAKSinghSSShankerRDhawanAA flow cytometric method to assess nanoparticle uptake in bacteriaCytometry A201179970771221638764
   PubMed Web of Science ®Google Scholar
• AitkenRJKoopmanPLewisSESeeds of concernNature20044327013485215525979
   PubMed Web of Science ®Google Scholar
• AitkenRJ HSTranCLDonaldsonKMultidisciplinary approach to the identification of reference materials for engineered nanoparticle toxicologyNanotoxicology200827178
   Web of Science ®Google Scholar
• FeliuNFadeelBNanotoxicology: no small matterNanoscale20102122514252020877789
   PubMed Web of Science ®Google Scholar
• PanHHouseMGHaoXJiangHWFabrication and characterization of a silicon metal-oxide-semiconductor based triple quantum dotAppl Phys Lett201210026310915
   Google Scholar
• ShpaismanNGivanUKwiatMPevznerAElnathanRPatolskyFControlled synthesis of ferromagnetic semiconducting silicon nanotubesJ Phys Chem C20121161480008007
   Web of Science ®Google Scholar
• SachetELosegoMDGuskeJFranzenSMariaJPMid-infrared surface plasmon resonance in zinc oxide semiconductor thin filmsAppl Phys Lett20131025051111051114
   Web of Science ®Google Scholar
• RoweDJJeongJSMkhoyanKAKortshagenURPhosphorus-doped silicon nanocrystals exhibiting mid-infrared localized surface plasmon resonanceNano Lett20131331317132223413833
   PubMed Web of Science ®Google Scholar
• ZhouWJHalpernARSeefeldTHCornRMNear infrared surface plasmon resonance phase imaging and nanoparticle-enhanced surface plasmon resonance phase imaging for ultrasensitive protein and DNA biosensing with oligonucleotide and aptamer microarraysAnal Chem201284144044522126812
   PubMed Web of Science ®Google Scholar
• JoshiRFeldmannVKoestnerWMultifunctional silica nanoparticles for optical and magnetic resonance imagingBiological Chemistry2013394112513523096570
   PubMed Web of Science ®Google Scholar
• OrlovAFAgagonovYBalagurovLABublikVTStudy of structural characteristics of ferromagnetic silicon implanted with manganeseCrystallography Reports2008535796799
   Web of Science ®Google Scholar
• Science Daily. Nanoparticle Available from: http://www.sciencedaily.com/articles/n/nanoparticle.htmAccessed February 17, 2013
   Google Scholar
• DufourEKKumaravelTNohynekGJKirklandDToutainHClastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cellsMutat Res2006607221522416797222
   PubMed Web of Science ®Google Scholar
• Yuan FangliHPChunleiYinShulanHuangJinlinLiPreparation and properties of zinc oxide nanoparticles coated with zinc aluminateJ Mater Chem200313634637
   Web of Science ®Google Scholar
• Qi QiTZYuQingjiangWangRuiZengYiLiuLiYangHaibinProperties of humidity sensing ZnO nanorods-base sensor fabricated by screen-printingSens Actuators B Chem2008133638643
   Web of Science ®Google Scholar
• SayesCMReedKLWarheitDBAssessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profilesToxicol Sci200797116318017301066
   PubMed Web of Science ®Google Scholar
• JengHASwansonJToxicity of metal oxide nanoparticles in mammalian cellsJ Environ Sci Health A Tox Hazard Subst Environ Eng200641122699271117114101
   PubMed Web of Science ®Google Scholar
• KumarADhawanAGenotoxic and carcinogenic potential of engineered nanoparticles: an updateArch Toxicol201387111883190024068037
   PubMed Web of Science ®Google Scholar
• MankeAWangLRojanasakulYMechanisms of nanoparticle-induced oxidative stress and toxicityBiomed Res Int2013201394291624027766
   PubMed Web of Science ®Google Scholar
• SharmaVSinghPPandeyAKDhawanAInduction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticlesMutat Res20127451–2849122198329
   PubMed Web of Science ®Google Scholar
• SurekhaPKishoreASSrinivasARepeated dose dermal toxicity study of nano zinc oxide with Sprague-Dawley ratsCutan Ocul Toxicol2012311263221830917
   PubMed Web of Science ®Google Scholar
• RobJVandebrielWimDe JongHA review of mammalian toxicity of ZnO nanoparticlesNanotechnol Sci Appl20125617124198497
   PubMedGoogle Scholar
• SharmaVShuklaRKSaxenaNParmarDDasMDhawanADNA damaging potential of zinc oxide nanoparticles in human epidermal cellsToxicol Lett2009185321121819382294
   PubMed Web of Science ®Google Scholar
• JangYeon SueLeeEun YoungParkYoon-HeeThe potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticlesMol Cell Toxicol201282171177
   Web of Science ®Google Scholar
• LeeSeung HoPieJae EunKimYu RiLeeHee RaSonSang WookKimMeyoung-KonEffects of zinc oxide nanoparticles on gene expression profile in human keratinocytesMol Cell Toxicol201282113118
   Web of Science ®Google Scholar
• SCCNFPThe scientific committee on cosmetic products and non-food products intended for consumers concerning zinc oxide2003 Available from: http://ec.europa.eu/health/ph_risk/committees/sccp/documents/out222_en.pdfAccessed April 15, 2014
   Google Scholar
• WangSQBalagulaYOsterwalderUPhotoprotection: a review of the current and future technologiesDermatol Ther2010231314720136907
   PubMed Web of Science ®Google Scholar
• TranDTSalmonRPotential photocarcinogenic effects of nanoparticle sunscreensAustralas J Dermatol20115211621332685
   PubMed Web of Science ®Google Scholar
• KaewamatawongTShimadaAOkajimaMAcute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillationToxicol Pathol200634795896517178696
   PubMed Web of Science ®Google Scholar
• LinWHuangYWZhouXDMaYIn vitro toxicity of silica nanoparticles in human lung cancer cellsToxicol Appl Pharmacol2006217325225917112558
   PubMed Web of Science ®Google Scholar
• ChangJSChangKLHwangDFKongZLIn vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell lineEnviron Sci Technol20074162064206817410806
   PubMed Web of Science ®Google Scholar
• JinYKannanSWuMZhaoJXToxicity of luminescent silica nanoparticles to living cellsChem Res Toxicol20072081126113317630705
   PubMed Web of Science ®Google Scholar
• ChenMvon MikeczAFormation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticlesExp Cell Res20053051516215777787
   PubMed Web of Science ®Google Scholar
• ValkoMRhodesCJMoncolJIzakovicMMazurMFree radicals, metals and antioxidants in oxidative stress-induced cancerChem Biol Interact2006160114016430879
   PubMed Web of Science ®Google Scholar
• BarnesCAElsaesserAArkuszJReproducible comet assay of amorphous silica nanoparticles detects no genotoxicityNano Lett2008893069307418698730
   PubMed Web of Science ®Google Scholar
• WangJJSandersonBJWangHCytotoxicity and genotoxicity of ultrafine crystalline SiO2 particulate in cultured human lymphoblastoid cellsEnviron Mol Mutagen200748215115717285640
   PubMed Web of Science ®Google Scholar
• Fruijtier-PollothCThe toxicological mode of action and the safety of synthetic amorphous silica-a nanostructured materialToxicology20122942–3617922349641
   PubMed Web of Science ®Google Scholar
• ParkYHBaeCHJangYEffect of the size and surface charge of silica nanoparticles on cutaneous toxicityMol Cell Toxicol2013916774
   Web of Science ®Google Scholar
• MusaMKannanTPMasudiSMAb RahmanIAssessment of DNA damage caused by locally produced hydroxyapatite-silica nanocom-posite using comet assay on human lung fibroblast cell lineMol Cell Toxicol2012815360
   Web of Science ®Google Scholar
• ChoiJEParkY-HYoung LeeEA safety assessment of phototoxicity and sensitization of SiO2 nanoparticlesMol Cell Toxicol201172171176
   Web of Science ®Google Scholar
• KimY-JIk YangSNeurotoxic effects by silica TM nanoparticle is independent of differentiation of SH-SY5Y cellsMol Cell Toxicol201174381388
   Web of Science ®Google Scholar
• YoshidaTYoshiokaYMatsuyamaKSurface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cellsBiochem Biophys Res Commun2012427474875223044420
   PubMed Web of Science ®Google Scholar
• WangFJiaoCLiuJYuanHLanMGaoFOxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cellsToxicol In Vitro20112581548155621635944
   PubMed Web of Science ®Google Scholar
• SergentJAPagetVChevillardSToxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell lineAnn Occup Hyg201256562263022378843
   PubMed Web of Science ®Google Scholar
• PassagneIMorilleMRoussetMPujalteIL’AzouBImplication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cellsToxicology20122992–311212422627296
   PubMed Web of Science ®Google Scholar
• NabeshiHYoshikawaTMatsuyamaKAmorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytesPart Fibre Toxicol20118121235812
   PubMed Web of Science ®Google Scholar
• LandsiedelRMa-HockLVan RavenzwaayBGene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV- protection in cosmetic formulationsNanotoxicology2010436438120925445
   PubMed Web of Science ®Google Scholar
• LiCHShenCCChengYWOrgan biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in miceNanotoxicology20126774675621950449
   PubMed Web of Science ®Google Scholar
• Monteiro-RiviereNAWienchKLandsiedelRSchulteSInmanAORiviereJESafety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo studyToxicol Sci2011123126428021642632
   PubMed Web of Science ®Google Scholar
• GopalanROsmanIAmaniAMatasMAndersonDThe effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytesNanotoxicology2009313339
   Web of Science ®Google Scholar
• GerloffKAlbrechtCBootsAWFörsterISchinsRPFCytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cellsNanotoxicology200934355364
   Web of Science ®Google Scholar
• YangHLiuCYangDZhangHXiZComparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and compositionJ Appl Toxicol2009291697818756589
   PubMed Web of Science ®Google Scholar
• YoshidaRKitamuraDMaenosonoSMutagenicity of water-soluble ZnO nanoparticles in Ames testJ Toxicol Sci200934111912219182441
   PubMed Web of Science ®Google Scholar
• OsmanIFBaumgartnerACemeliEFletcherJNAndersonDGenotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cellsNanomedicine (Lond)2010581193120321039197
   PubMed Web of Science ®Google Scholar
• YinHCaseyPSMcCallMJFenechMEffects of surface chemistry on cytotoxicity, genotoxicity, and the generation of reactive oxygen species induced by ZnO nanoparticlesLangmuir20102619153991540820809599
   PubMed Web of Science ®Google Scholar
• SharmaVAndersonDDhawanAZinc oxide nanoparticles induce oxidative stress and genotoxicity in human liver cells (HepG2)J Biomed Nanotechnol201171989921485822
   PubMed Web of Science ®Google Scholar
• SharmaVSinghSKAndersonDTobinDJDhawanAZinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytesJ Nanosci Nanotechnol20111153782378821780369
   PubMed Web of Science ®Google Scholar
• HackenbergSZimmermannFZScherzedARepetitive exposure to zinc oxide nanoparticles induces dna damage in human nasal mucosa mini organ culturesEnviron Mol Mutagen201152758258921786336
   PubMed Web of Science ®Google Scholar
• YinHCaseyPSMcCallMJSurface modifications of ZnO nanoparticles and their cytotoxicityJ Nanosci Nanotechnol201010117565757021137983
   PubMed Web of Science ®Google Scholar
• ZhangXQYinLHTangMPuYPZnO, TiO(2), SiO(2,) and Al(2) O(3) nanoparticles-induced toxic effects on human fetal lung fibroblastsBiomed Environ Sci201124666166922365403
   PubMed Web of Science ®Google Scholar
• XiaTKovochichMLiongMComparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress propertiesACS Nano20082102121213419206459
   PubMed Web of Science ®Google Scholar
• De BerardisBCivitelliGCondelloMExposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cellsToxicol Appl Pharmacol Epub April 29, 2010
   Web of Science ®Google Scholar
• SharmaVAndersonDDhawanAZinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)Apoptosis201217885287022395444
   PubMed Web of Science ®Google Scholar
• AlarifiSAliDAlkahtaniSInduction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticlesInt J Nanomedicine2013898399323493450
   PubMed Web of Science ®Google Scholar
• GuoDBiHLiuBWuQWangDCuiYReactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cellsToxicol In Vitro201327273173823232460
   PubMed Web of Science ®Google Scholar
• JohnstonCJDriscollKEFinkelsteinJNPulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silicaToxicol Sci200056240541310911000
   PubMed Web of Science ®Google Scholar
• SayesCMReedKLGloverKPChanging the dose metric for inhalation toxicity studies: short-term study in rats with engineered aerosolized amorphous silica nanoparticlesInhal Toxicol201022434835420001567
   PubMed Web of Science ®Google Scholar
• LiuXKeaneMJZhongBZOngTMWallaceWEMicronucleus formation in V79 cells treated with respirable silica dispersed in medium and in simulated pulmonary surfactantMutat Res19963612–389948980693
   PubMed Web of Science ®Google Scholar
• ECETOCEuropean Centre for Ecotoxicology and Toxicology of Chemicals. Synthetic amorphous silica (CAS No 7631-86-9)Brussels, BelgiumJACC Report2006237
   Google Scholar
• EPA. US Environmental Protection AgencyScreening-level hazard characterization of silane, dichlorodimethyl-, reaction product with silica (CASRN 68611-44-9)2011
   Google Scholar
• OECDOrganisation for Economic Co-operation and Development. SIDS dossier on synthetic amorphous silica and silicates2004
   Google Scholar
• YangKLinDXingBInteractions of humic acid with nanosized inorganic oxidesLangmuir20092563571357619708146
   PubMed Web of Science ®Google Scholar
• GonzalezLThomassenLCPlasGExploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as modelsNanotoxicology2010438239520925446
   PubMed Web of Science ®Google Scholar
• ParkMVVerharenHWZwartEGenotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assayNanotoxicology20115216818120735203
   PubMed Web of Science ®Google Scholar
• ParkYHKimJNJeongSHAssessment of dermal toxicity of nanosilica using cultured keratinocytes, a human skin equivalent model and an in vivo modelToxicology20102671–317818119850098
   PubMed Web of Science ®Google Scholar
• WangFGaoFLanMYuanHHuangYLiuJOxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cellsToxicol In Vitro200923580881519401228
   PubMed Web of Science ®Google Scholar
• YeYLiuJXuJSunLChenMLanMNano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell lineToxicol In Vitro201024375175820060462
   PubMed Web of Science ®Google Scholar
• YeYLiuJChenMSunLLanMIn vitro toxicity of silica nanoparticles in myocardial cellsEnviron Toxicol Pharmacol201029213113721787594
   PubMed Web of Science ®Google Scholar
• ChenQXueYSunJKupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivoInt J Nanomedicine201381129114023515466
   PubMed Web of Science ®Google Scholar
• ParkY-HBaeHCJangYEffect of the size and surface charge of silica nanoparticles on cutaneous toxicityMol Cell Toxicol2013916774
   Web of Science ®Google Scholar
• MagdolenovaZCollinsAKumarADhawanAStoneVDusinskaMMechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticlesNanotoxicology2014823327823379603
   PubMed Web of Science ®Google Scholar
• GeiserMRothen-RutishauserBKappNUltrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cellsEnviron Health Perspect2005113111555156016263511
   PubMed Web of Science ®Google Scholar
• LiuLTakenakaTZinchenlcoAACationic silica nanoparticles are efficiently transferred into mammalian cellsMicro- NanoMechatronics and Human ScienceInternational Symposium on MHS ’072007281285
   Google Scholar
• YeoMKParkHGGene expression in zebrafish embryos following exposure to Cu-doped TiO2 and pure TiO2 nanometer-sized photocatalystsMol Cell Toxicol201282127137
   Web of Science ®Google Scholar
• YeoMKKangMThe biological toxicities of two crystalline phases and differential sizes of TiO2 nanoparticles during zebrafish embryogenesis developmentMol Cell Toxicol201284317326
   Web of Science ®Google Scholar
• NabievIMitchellSDaviesANonfunctionalized nanocrystals can exploit a cell’s active transport machinery delivering them to specific nuclear and cytoplasmic compartmentsNano Lett20077113452346117949046
   PubMed Web of Science ®Google Scholar
• ToyokuniSOxidative stress and cancer: the role of redox regulationBiotherapy1998112–31471549677046
   PubMedGoogle Scholar
• RimKTKimSJSongSWParkJSEffect of cerium oxide nanoparticles to inflammation and oxidative DNA damages in H9c2 cellsMol Cell Toxicol201283271280
   Web of Science ®Google Scholar
• ZastawnyTHAltmanSARanders-EichhornLDNA base modifications and membrane damage in cultured mammalian cells treated with iron ionsFree Radic Biol Med1995186101310227628727
   PubMed Web of Science ®Google Scholar
• BrownDMWilsonMRMacNeeWStoneVDonaldsonKSize-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafinesToxicol Appl Pharmacol2001175319119911559017
   PubMed Web of Science ®Google Scholar
• KnaapenAMBormPJAlbrechtCSchinsRPInhaled particles and lung cancer. Part A: mechanismsInt J Cancer2004109679980915027112
   PubMed Web of Science ®Google Scholar
• KarlssonHLCronholmPGustafssonJMollerLCopper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubesChem Res Toxicol20082191726173218710264
   PubMed Web of Science ®Google Scholar
• LeeBCKimKTChoJGOxidative stress in juvenile common carp (Cyprinus carpio) exposed to TiO2 nanoparticlesMol Cell Toxicol201284357366
   Web of Science ®Google Scholar
• ParkH-GYeoM-KComparison of gene expression changes induced by exposure to Ag, Cu-TiO2, and TiO2 nanoparticles in zebrafish embryosMol Cell Toxicol201392129139
   Web of Science ®Google Scholar
• ParkEJYiJChungKHRyuDYChoiJParkKOxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cellsToxicol Lett2008180322222918662754
   PubMed Web of Science ®Google Scholar
• PapageorgiouIBrownCSchinsRThe effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitroBiomaterials200728192946295817379299
   PubMed Web of Science ®Google Scholar
• GurrJRWangASChenCHJanKYUltrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cellsToxicology20052131–2667315970370
   PubMed Web of Science ®Google Scholar
• BonvallotVBaeza-SquibanABauligAOrganic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expressionAm J Respir Cell Mol Biol200125451552111694458
   PubMed Web of Science ®Google Scholar
• AbeSTakizawaHSugawaraIKudohSDiesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitroAm J Respir Cell Mol Biol200022329630310696066
   PubMed Web of Science ®Google Scholar
• DonaldsonKTranCLAn introduction to the short-term toxicology of respirable industrial fibresMutat Res20045531–25915288528
   PubMed Web of Science ®Google Scholar
• WaldmanWJKristovichRKnightDADuttaPKInflammatory properties of iron-containing carbon nanoparticlesChem Res Toxicol20072081149115417672513
   PubMed Web of Science ®Google Scholar
• BlancoDVicentSFragaMFMolecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathwayNeoplasia200791084085217971904
   PubMed Web of Science ®Google Scholar
• O’ByrneKJDalgleishAGChronic immune activation and inflammation as the cause of malignancyBr J Cancer200185447348311506482
   PubMed Web of Science ®Google Scholar
• OberdorsterGGeleinRJohnstonCJMercerPCorsonNFinkelsteinJNAmbient ultrafine particles: inducers of acute lung injury?MohrUDungworthDLBrainJDDriscollKEGrafstromRCHarrisCCRelationships between respiratory disease and exposure to air pollutionWashingtonILSI Press1998216229
   Google Scholar
• LiXYGilmourPSDonaldsonKMacNeeWFree radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitroThorax19965112121612228994518
   PubMed Web of Science ®Google Scholar
• GojovaAGuoBKotaRSRutledgeJCKennedyIMBarakatAIInduction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle compositionEnviron Health Perspect2007115340340917431490
   PubMed Web of Science ®Google Scholar
• PetersKUngerREKirkpatrickCJGattiAMMonariEEffects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammationJ Mater Sci Mater Med200415432132515332593
   PubMed Web of Science ®Google Scholar
• LaneDPCancer. p53, guardian of the genomeNature1992358638115161614522
   PubMed Web of Science ®Google Scholar
• GeorgeSPokhrelSXiaTUse of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron dopingACS Nano201041152920043640
   PubMed Web of Science ®Google Scholar
• FujitaKMorimotoYOgamiAGene expression profiles in rat lung after inhalation exposure to C60 fullerene particlesToxicology20092581475519167457
   PubMed Web of Science ®Google Scholar
• LiuXSunJEndothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kappaB pathwaysBiomaterials201031328198820920727582
   PubMed Web of Science ®Google Scholar
• XiaTKovochichMBrantJComparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigmNano Lett2006681794180716895376
   PubMed Web of Science ®Google Scholar
• MossmanBTBignonJCornMSeatonAGeeJBAsbestos: scientific developments and implications for public policyScience199024749402943012153315
   PubMed Web of Science ®Google Scholar
• MossmanBTChurgAMechanisms in the pathogenesis of asbestosis and silicosisAm J Respir Crit Care Med19981575 Pt 1166616809603153
   PubMed Web of Science ®Google Scholar
• RobinsonBWLakeRAAdvances in malignant mesotheliomaN Engl J Med2005353151591160316221782
   PubMed Web of Science ®Google Scholar
• MossmanBTGeeJBAsbestos-related diseasesN Engl J Med198932026172117302659987
   PubMed Web of Science ®Google Scholar
• GuthrieGDJrMossmanBTHealth effects of mineral dustsWashington, DCMineralogical Society of America199328
   Google Scholar
• HeintzNHJanssen-HeiningerYMMossmanBTAsbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathwaysAm J Respir Cell Mol Biol201042213313920068227
   PubMed Web of Science ®Google Scholar
• ToyokuniSMechanisms of asbestos-induced carcinogenesisNagoya J Med Sci2009711–211019358470
   PubMed Web of Science ®Google Scholar
• MagnaniCAgudoAGonzalezCAMulticentric study on malignant pleural mesothelioma and non-occupational exposure to asbestosBr J Cancer200083110411110883677
   PubMed Web of Science ®Google Scholar
• SenyigitABayramHBabayigitCMalignant pleural mesothelioma caused by environmental exposure to asbestos in the southeast of Turkey: CT findings in 117 patientsRespiration200067661562211124643
   PubMed Web of Science ®Google Scholar
• Biomarkers Definitions Working GroupBiomarkers and surrogate endpoints: preferred definitions and conceptual frameworkClin Pharmacol Ther2001693899511240971
   PubMed Web of Science ®Google Scholar
• XiaTLiNNelAEPotential health impact of nanoparticlesAnnu Rev Public Health20093013715019705557
   PubMed Web of Science ®Google Scholar
• LuoJCHsuKHShenWSInflammatory responses and oxidative stress from metal fume exposure in automobile weldersJ Occup Environ Med20095119510319136878
   PubMed Web of Science ®Google Scholar
• AntoniniJMStoneSRobertsJREffect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in ratsToxicol Appl Pharmacol2007223323424517706736
   PubMed Web of Science ®Google Scholar
• BydashJKasmaniRNaraharisettyKMetal fume-induced diffuse alveolar damageJ Thorac Imaging2010252W27W2920351582
   PubMed Web of Science ®Google Scholar
• CooperRGZinc toxicology following particulate inhalationIndian J Occup Environ Med2008121101320040991
   PubMedGoogle Scholar
• XiaoGGWangMLiNLooJANelAEUse of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell lineJ Biol Chem200327850507815079014522998
   PubMed Web of Science ®Google Scholar
• WangMXiaoGGLiNXieYLooJANelAEUse of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicalsElectrophoresis200526112092210815880549
   PubMed Web of Science ®Google Scholar
• JungEJAvliyakulovNKBoontheungPLooJANelAEPro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysisProteomics20077213906391817922515
   PubMed Web of Science ®Google Scholar
• ZhangLWangMKangXOxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluidJ Proteome Res2009841631163819714806
   PubMed Web of Science ®Google Scholar
• KangXLiNWangMAdjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluidProteomics201010352053120029843
   PubMed Web of Science ®Google Scholar
• LiNWangMBrambleLAThe adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potentialEnviron Health Perspect200911771116112319654922
   PubMed Web of Science ®Google Scholar
• LiNHarkemaJRLewandowskiRPAmbient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flaresAm J Physiol Lung Cell Mol Physiol20102993L374L38320562226
   PubMed Web of Science ®Google Scholar
• OhshimaHTazawaHSyllaBSSawaTPrevention of human cancer by modulation of chronic inflammatory processesMutat Res20055911–211012216083916
   PubMed Web of Science ®Google Scholar
• BaggsRBFerinJOberdorsterGRegression of pulmonary lesions produced by inhaled titanium dioxide in ratsVet Pathol19973465925979396140
   PubMed Web of Science ®Google Scholar
• OberdorsterGPulmonary effects of inhaled ultrafine particlesInt Arch Occup Environ Health20017411811196075
   PubMed Web of Science ®Google Scholar
• WangBFengWYWangTCAcute toxicity of nano- and micro-scale zinc powder in healthy adult miceToxicol Lett2006161211512316165331
   PubMed Web of Science ®Google Scholar
• MullerJHuauxFFonsecaAStructural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspectsChem Res Toxicol20082191698170518636756
   PubMed Web of Science ®Google Scholar
• ChithraniBDChanWCElucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapesNano Lett2007761542155017465586
   PubMed Web of Science ®Google Scholar
• GrattonSERoppPAPohlhausPDThe effect of particle design on cellular internalization pathwaysProc Natl Acad Sci U S A200810533116131161818697944
   PubMed Web of Science ®Google Scholar
• PacurariMYinXJZhaoJRaw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cellsEnviron Health Perspect200811691211121718795165
   PubMed Web of Science ®Google Scholar
• MaplesKRJohnsonNFFiber-induced hydroxyl radical formation: correlation with mesothelioma induction in rats and humansCarcinogenesis19921311203520391330349
   PubMed Web of Science ®Google Scholar
• DonaldsonKBeswickPHGilmourPSFree radical activity associated with the surface of particles: a unifying factor in determining biological activity?Toxicol Lett1996881–32932988920751
   PubMed Web of Science ®Google Scholar
• GhioAJStonehuernerJDaileyLACarterJDMetals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stressInhal Toxicol1999111374910380158
   PubMed Web of Science ®Google Scholar
• KaganVETyurinaYYTyurinVADirect and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of ironToxicol Lett200616518810016527436
   PubMed Web of Science ®Google Scholar
• LamCWJamesJTMcCluskeyRHunterRLPulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillationToxicol Sci200477112613414514958
   PubMed Web of Science ®Google Scholar
• WickPManserPLimbachLKThe degree and kind of agglomeration affect carbon nanotube cytotoxicityToxicol Lett2007168212113117169512
   PubMed Web of Science ®Google Scholar
• FubiniBGhiazzaMFenoglioIPhysico-chemical features of engineered nanoparticles relevant to their toxicityNanotoxicology20104434736320858045
   PubMed Web of Science ®Google Scholar
• MaynardADBaronPAFoleyMShvedovaAAKisinERCastranovaVExposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube materialJ Toxicol Environ Health A20046718710714668113
   PubMed Web of Science ®Google Scholar
• ShvedovaAAKisinERMercerRUnusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in miceAm J Physiol Lung Cell Mol Physiol20052895L698L70815951334
   PubMed Web of Science ®Google Scholar
• ThessALeeRNikolaevPCrystalline ropes of metallic carbon nanotubesScience199627352744834878662534
   PubMed Web of Science ®Google Scholar
• KimYHParkHWRyooZYLeeHSKimDHLeeSAbnormal effects of unpurified and purified multi-walled carbon nanotubes in A549, Jurkat and THP-1 cell linesMol Cell Toxicol201281103112
   Web of Science ®Google Scholar
• ChandraSBarickKCBahadurDOxide and hybrid nanostructures for therapeutic applicationsAdv Drug Deliv Rev20116314–151267128121729727
   PubMed Web of Science ®Google Scholar
• MagdolenovaZBilanicovaDPojanaGImpact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicityJ Environ Monit201214245546422277962
   PubMedGoogle Scholar
• FuYSDuXWKulinichSAStable aqueous dispersion of ZnO quantum dots with strong blue emission via simple solution routeJ Am Chem Soc200712951160291603318044896
   PubMed Web of Science ®Google Scholar
• MunnierECohen-JonathanSLinassierCNovel method of doxorubicin-SPION reversible association for magnetic drug targetingInt J Pharm20083631–217017618687392
   PubMed Web of Science ®Google Scholar
• ValoisCRBrazJMNunesESThe effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a beta2 integrin-dependent pathwayBiomaterials201031236637419822361
   PubMed Web of Science ®Google Scholar
• MauriziLBishtHBouyerFMillotNEasy route to functionalize iron oxide nanoparticles via long-term stable thiol groupsLangmuir200925168857885919572525
   PubMed Web of Science ®Google Scholar
• LimJKMajetichSATiltonRDStabilization of superparamagnetic iron oxide core-gold shell nanoparticles in high ionic strength mediaLangmuir20092523133841339319928938
   PubMed Web of Science ®Google Scholar
• XieJXuCKohelrNHouYSunSControlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake by macrophage cellsAdv Mater2007192031633166
   Web of Science ®Google Scholar
• SoenenSJHHodeniusMSchmitz-RodeTDe CuyperMProtein-stabilized magnetic fluidsJ Magn Magn Mater20083205634641
   Web of Science ®Google Scholar
• NasongklaNBeyERenJMultifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systemsNano Lett20066112427243017090068
   PubMed Web of Science ®Google Scholar
• PradhanPGiriJRiekenFTargeted temperature sensitive magnetic liposomes for thermo-chemotherapyJ Control Release2010142110812119819275
   PubMed Web of Science ®Google Scholar
• SayesCMLiangFHudsonJLFunctionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitroToxicol Lett2006161213514216229976
   PubMed Web of Science ®Google Scholar
• SinghRPantarottoDLacerdaLTissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracersProc Natl Acad Sci U S A200610393357336216492781
   PubMed Web of Science ®Google Scholar
• ChenPKuoCWLaiJJLCytotoxicity of the functionalized gold and silver nanorodsMat Res Soc2007951105110
   Google Scholar
• YimWCLeeB-MKwonYCross-experimental analysis of microarray gene expression datasets for in silico risk assessment of TiO2 nano-particlesMol Cell Toxicol201283229239
   Web of Science ®Google Scholar
• ParkS-KKimJ-JYuA-RLeeM-YParkS-KElectrolyzed-reduced water confers increased resistance to environmental stressesMol Cell Toxicol201283241247
   Web of Science ®Google Scholar
• JiangJOberdörsterGBiswasPCharacterisation of size, surface charge and agglomeration state of nanoparticle dispersions for toxicological studiesJ Nanopart Res2009117789
   Web of Science ®Google Scholar
• Harush-FrenkelODebottonNBenitaSAltschulerYTargeting of nanoparticles to the clathrin-mediated endocytic pathwayBiochem Biophys Res Commun20073531263217184736
   PubMed Web of Science ®Google Scholar
• LockmanPRKoziaraJMMumperRJAllenDDNanoparticle surface charges alter blood-brain barrier integrity and permeabilityJ Drug Target2004129–1063564115621689
   PubMed Web of Science ®Google Scholar
• NanABaiXSonSJLeeSBGhandehariHCellular uptake and cytotoxicity of silica nanotubesNano Lett2008882150215418624386
   PubMed Web of Science ®Google Scholar
• CliftMJRothen-RutishauserBBrownDMThe impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell lineToxicol Appl Pharmacol2008232341842718708083
   PubMed Web of Science ®Google Scholar
• GonzalezLLisonDKirsch-VoldersMGenotoxicity of engineered nanomaterials:a critical reviewNanotoxicology20082252273
   Web of Science ®Google Scholar
• LandsiedelRKappMDSchulzMWienchKOeschFGentoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations- many questions, some answersMutat Res200968124125819041420
   PubMed Web of Science ®Google Scholar