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Original Research

Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass

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Pages 319-327 | Published online: 05 Nov 2020

References

  • EAU Guidelines on Male Hypogonadism. Edn Presented at the EAU Annual Congress Barcelona 2019. EAU Guidelines Office:Arnhem, The Nederlands.
  • Hall SA, Esche GR, Araujo AB, et al. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample. J Clin Endocrinol Metab. 2008;93(10):3870‐3877. doi:10.1210/jc.2008-0021.
  • Carrero JJ, Stenvinkel P. The vulnerable man: impact of testosterone deficiency on the uraemic phenotype. Nephrol Dialysis Transplant. 2012;27(11):4030–4041. doi:10.1093/ndt/gfs383.
  • Thirumavalavan N, Wilken NA, Ramasamy R. Hypogonadism and renal failure: an update. Indian J Urol. 2015;31(2):89–93. doi:10.4103/0970-1591.15429725878406
  • Reinhardt W, Kübber H, Dolff S, Benson S, Führer D, Tan S. Rapid recovery of hypogonadism in male patients with end stage renal disease after renal transplantation. Endocrine. 2018;60(1):159‐166. doi:doi:10.1007/s12020-018-1543-2
  • Fugl-Meyer KS, Nilsson M, Hylander B, Lehtihet M. Sexual function and testosterone level in men with conservatively treated chronic kidney disease. Am J Mens Health. 2017;11(4):1069‐1076. doi:10.1177/1557988317703207
  • Cobo G, Gallar P, Di Gioia C, et al. Hypogonadism associated with muscle atrophy, physical inactivity and ESA hyporesponsiveness in men undergoing haemodialysis. Nefrologia. 2017;37(1):54‐60. doi:10.1016/j.nefro.2016.04.009
  • Khurana KK, Navaneethan SD, Arrigain S, Schold JD, Nally JV Jr, Shoskes DA. Serum testosterone levels and mortality in men with CKD stages 3-4. Am J Kidney Dis. 2014;64(3):367‐374. doi:10.1053/j.ajkd.2014.03.010
  • Zdravevski E, Lameski P, Kulakov A, Weight of evidence as a tool for attribute transformation in the preprocessing stage of supervised learning algorithms. The 2011 International Joint Conference on Neural Networks, San Jose, CA; 2011: 181–188. doi:10.1109/IJCNN.2011.6033219.
  • Listen data. Weight Of Evidence (WOE) and Information Value (IV) explained Available from: https://www.listendata.com/2015/03/weight-of-evidence-woe-and-information.html. Accessed 722, 2020.
  • Wu FC, Tajar A, Pye SR, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008;93(7):2737‐2745. doi:10.1210/jc.2007-1972
  • Carrero JJ, Kyriazis J, Sonmez A, et al. Prolactin levels, endothelial dysfunction, and the risk of cardiovascular events and mortality in patients with CKD. Clin J Am Soc Nephrol. 2012;7(2):207‐215. doi:10.2215/CJN.06840711
  • Yilmaz MI, Sonmez A, Qureshi AR, et al. Endogenous testosterone, endothelial dysfunction, and cardiovascular events in men with nondialysis chronic kidney disease. Clin J Am Soc Nephrol. 2011;6(7):1617‐1625. doi:10.2215/CJN.10681210
  • Edey MM. Male sexual dysfunction and chronic kidney disease. Front Med (Lausanne). 2017;4:32. doi:10.3389/fmed.2017.0003228382300
  • Dousdampanis P, Trigka K, Fourtounas C. Hypomagnesemia, chronic kidney disease and cardiovascular mortality: pronounced association but unproven causation. Hemodial Int. 2014;18(4):730‐739. doi:10.1111/hdi.12159
  • Hylander B, Lehtihet M. Testosterone and gonadotropins but not SHBG vary with CKD stages in young and middle aged men. Basic Clin Androl. 2015;25:9. doi:10.1186/s12610-015-0027-y26635963
  • Rymarz A, Bartoszewicz Z, Szamotulska K, Niemczyk S. The associations between body cell mass and nutritional and inflammatory markers in patients with chronic kidney disease and in subjects without kidney disease. J Ren Nutr. 2016;26(2):87‐92. doi:10.1053/j.jrn.2015.09.005
  • Grossmann M, Ng Tang Fui M, Cheung AS. Late-onset hypogonadism: metabolic impact. Andrology. 2019. doi:10.1111/andr.12705
  • Cobo G, Cordeiro AC, Amparo FC, Amodeo C, Lindholm B, Carrero JJ. Visceral adipose tissue and leptin hyperproduction are associated with hypogonadism in men with chronic kidney disease. J Ren Nutr. 2017;27(4):243‐248. doi:10.1053/j.jrn.2017.01.023
  • Kelly DM, Jones TH. Testosterone: a metabolic hormone in health and disease. J Endocrinol. 2013;217(3):25‐45. doi:10.1530/JOE-12-0455
  • Gungor O, Kircelli F, Carrero JJ, et al. Endogenous testosterone and mortality in male hemodialysis patients: is it the result of aging? Clin J Am Soc Nephrol. 2010;5(11):2018‐2023. doi:10.2215/CJN.03600410
  • Fouque D, Kalantar-Zadeh K, Kopple J, et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int. 2008;73(4):391‐398. doi:10.1038/sj.ki.5002585
  • Carrero JJ, Qureshi AR, Nakashima A, et al. Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease. Nephrol Dial Transplant. 2011;26(1):184‐190. doi:10.1093/ndt/gfq397
  • Chiang JM, Kaysen GA, Segal M, Chertow GM, Delgado C, Johansen KL. Low testosterone is associated with frailty, muscle wasting and physical dysfunction among men receiving hemodialysis: a longitudinal analysis. Nephrol Dial Transplant. 2019;34(5):802‐810. doi:10.1093/ndt/gfy252
  • Harada K, Suzuki S, Ishii H, et al. Impact of skeletal muscle mass on long-term adverse cardiovascular outcomes in patients with chronic kidney disease. Am J Cardiol. 2017;119(8):1275‐1280. doi:10.1016/j.amjcard.2017.01.003
  • Zhou Y, Hellberg M, Svensson P, Höglund P, Clyne N. Sarcopenia and relationships between muscle mass, measured glomerular filtration rate and physical function in patients with chronic kidney disease stages 3-5. Nephrol Dial Transplant. 2018;33(2):342‐348. doi:10.1093/ndt/gfw466
  • Watanabe H, Enoki Y, Maruyama T. Sarcopenia in chronic kidney disease: factors, mechanisms, and therapeutic interventions. Biol Pharm Bull. 2019;42(9):1437‐1445. doi:10.1248/bpb.b19-00513
  • Cigarrán S, Pousa M, Castro MJ, et al. Endogenous testosterone, muscle strength, and fat-free mass in men with chronic kidney disease. J Ren Nutr. 2013;23(5):89‐95. doi:10.1053/j.jrn.2012.08.007
  • Rymarz A, Matyjek A, Gomółka M, Niemczyk S. Lean tissue index and body cell mass can be predictors of low free testosterone levels in men on hemodialysis. J Ren Nutr. 2019;29(6):529‐535. doi:10.1053/j.jrn.2019.03.078
  • Amiri M, Ramezani Tehrani F, Rahmati M, et al. Low serum testosterone levels and the incidence of chronic kidney disease among male adults: a prospective population-based study. Andrology. 2020;8(3):575–582. doi:doi:10.1111/andr.1272831697870
  • Mouser JG, Loprinzi PD, Loenneke JP. The association between physiologic testosterone levels, lean mass, and fat mass in a nationally representative sample of men in the United States. Steroids. 2016;115:62‐66. doi:1016/j.steroids.2016.08.009
  • Supasyndh O, Satirapoj B, Aramwit P, et al. Effect of oral anabolic steroid on muscle strength and muscle growth in hemodialysis patients. Clin J Am Soc Nephrol. 2013;8(2):271‐279. doi:10.2215/CJN.00380112