3,614
Views
413
CrossRef citations to date
0
Altmetric
Review

Treatment options for polycystic ovary syndrome

&
Pages 25-35 | Published online: 08 Feb 2011

References

  • SperoffLFritzMAAnovulation and the polycystic ovarySperoffLFritzMAClinical Gynecologic Endocrinology and Infertility7th edPhiladelphia (PA)Lippincott Williams & Wilkins2005470483
  • AzzizRDiagnostic criteria for polycystic ovary syndrome: a reappraisalFertil Steril20058351343134615866567
  • LakhaniKPrelevicGMSeifalianAMAtiomoWUHardimanPPolycystic ovary syndrome, diabetes and cardiovascular disease: risks and risk factorsJ Obstet Gynaecol200424661362116147598
  • EhrmannDAPolycystic ovary syndromeN Engl J Med2005352121223123615788499
  • DunaifAInsulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesisEndocr Rev19971867748009408743
  • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop GroupRevised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndromeFertil Steril20048111925
  • AzzizRCarminaEDewaillyDPosition statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guidelineJ Clin Endocrinol Metab200691114237424516940456
  • AdamsJMTaylorAECrowleyWFJrHallJEPolycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndromeJ Clin Endocrinol Metab20048994343435015356031
  • BarberTMWassJAMcCarthyMIFranksSMetabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndromeClin Endocrinol (Oxf)200766451351717371468
  • PasqualiRPelusiCGenghiniSCacciariMGambineriAObesity and reproductive disorders in womenHum Reprod Update20039435937212926529
  • BoomsmaCMEijkemansMJHughesEGVisserGHFauserBCMacklonNSA meta-analysis of pregnancy outcomes in women with polycystic ovary syndromeHum Reprod Update200612667368316891296
  • GjønnaessHOvarian electrocautery in the treatment of women with polycystic ovary syndrome (PCOS). Factors affecting the resultsActa Obstet Gynecol Scand19947354074128009973
  • PatelSMNestlerJEFertility in polycystic ovary syndromeEndocrinol Metab Clin North Am2006351137155vii16310646
  • ReavenGMThe insulin resistance syndrome: definition and dietary approaches to treatmentAnnu Rev Nutr20052539140616011472
  • BrunerBChadKChizenDEffects of exercise and nutritional counseling in women with polycystic ovary syndromeAppl Physiol Nutr Metab200631438439116900227
  • MoranLJBrinkworthGNoakesMNormanRJEffects of lifestyle modification in polycystic ovarian syndromeReprod Biomed Online200612556957816790100
  • Escobar-MorrealeHFBotella-CarreteroJIAlvarez-BlascoFSanchoJSan MillánJLThe polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgeryJ Clin Endocrinol Metab200590126364636916189250
  • HomburgRClomiphene citrate – end of an era? A mini-reviewHum Reprod20052082043205115878925
  • LegroRSBarnhartHXSchlaffWDClomiphene, metformin, or both for infertility in the polycystic ovary syndromeN Engl J Med2007356655156617287476
  • MessinisIEOvulation induction: a mini reviewHum Reprod200520102688269716006478
  • SamSDunaifAPolycystic ovary syndrome: syndrome XX?Trends Endocrinol Metab200314836537014516934
  • GrundySMObesity, metabolic syndrome, and coronary atherosclerosisCirculation2002105232696269812057978
  • HarborneLRSattarNNormanJEFlemingRMetformin and weight loss in obese women with polycystic ovary syndrome: comparison of dosesJ Clin Endocrinol Metab20059084593459815886247
  • GlueckCJWangPGoldenbergNSieve-SmithLPregnancy outcomes among women with polycystic ovary syndrome treated with metforminHum Reprod200217112858286412407039
  • PalombaSOrioFJrZulloFWhat is the best first-step therapeutic approach in treating anovulatory infertility in patients with polycystic ovary syndrome? Questions that are still unansweredGynecol Endocrinol200723524524717558680
  • MollEBossuytPMKorevaarJCLambalkCBvan der VeenFEffect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trialBMJ20063327556148516769748
  • CreangaAABradleyHMMcCormickCWitkopCTUse of metformin in polycystic ovary syndrome: a meta-analysisObstet Gynecol2008111495996818378757
  • HwuYMLinSYHuangWYLinMHLeeRKUltra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndromeInt J Gynaecol Obstet2005901394315921686
  • AzzizREhrmannDLegroRSTroglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trialJ Clin Endocrinol Metab20018641626163211297595
  • TangTLordJMNormanRJYasminEBalenAHInsulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, d-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertilityCochrane Database Syst Rev20101CD00305310.1002/14651858.CD00305320091537
  • BadawyAAbdel AalIAbulattaMClomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trialFertil Steril200992384985217582406
  • CarrollNPalmerJRA comparison of intrauterine versus intracervical insemination in fertile single womenFertil Steril200175465666011287014
  • BadawyAShokeirTAllamAFAbdelhadyHPregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertilityActa Obstet Gynecol Scand200988218719119089782
  • ElnasharAAbdelmageedEFayedMSharafMClomiphene citrate and dexamethazone in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective placebo-controlled studyHum Reprod20062171805180816543255
  • NugentDVandekerckhovePHughesEArnotMLilfordRGonadotrophin therapy for ovulation induction in subfertility associated with polycystic ovary syndromeCochrane Database Syst Rev20004CD00041010.1002/14651858.CD00041011034687
  • ParsanezhadMEAlborziSMotazedianSOmraniGUse of dexamethasone and clomiphene citrate in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome and normal dehydroepiandrosterone sulfate levels: a prospective, double-blind, placebo-controlled trialFertil Steril20027851001100412413984
  • SastreMEPratMOChecaMACarrerasRCCurrent trends in the treatment of polycystic ovary syndrome with desire for childrenTher Clin Risk Manag20095235336019536311
  • DelbaereASmitsGOlatunbosunOPiersonRVassartGCostagliolaSNew insights into the pathophysiology of ovarian hyper-stimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?Hum Reprod200419348648914998941
  • Christin-MaitreSHuguesJNRecombinant FSH Study GroupA comparative randomized multicentric study comparing the step-up versus step-down protocol in polycystic ovary syndromeHum Reprod20031881626163112871872
  • FilicoriMCognigniGETaraborrelliSLuteinizing hormone activity in menotropins optimizes folliculogenesis and treatment in controlled ovarian stimulationJ Clin Endocrinol Metab200186133734311232021
  • MaggsDGBuchananTABurantCFMetabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trialAnn Intern Med199812831761859454525
  • PalombaSZulloFDiamanti-KandarakisEOrioFJrSurgery and laser diathermyDiamanti-KandarakisENestlerJEPanidisDPasqualiRInsulin Resistance and Polycystic Ovarian SyndromeTotowa (NJ)Humana Press2007 Chap 33461477
  • Al-FadhliRTulandiTLaparoscopic treatment of polycystic ovaries: is its place diminishing?Curr Opin Obstet Gynecol200416429529815232482
  • PalombaSOrioFJrFalboAMetformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo-anovulatory CC-resistant women with polycystic ovary syndromeClin Endocrinol (Oxf)200563663163516343096
  • Van SantbrinkEJFauserBCIs there a future for ovulation induction in the current era of assisted reproduction?Hum Reprod200318122499250214645162
  • DorJShulmanALevranDBen-RafaelZRudakEMashiachSThe treatment of patients with polycystic ovarian syndrome by in-vitro fertilization and embryo transfer: a comparison of results with those of patients with tubal infertilityHum Reprod1990578168182266154
  • GriesingerGDiedrichKTarlatzisBCKolibianakisEMGnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysisReprod Biomed Online200613562863817169171
  • Hamilton-FairleyDKiddyDWatsonHSagleMFranksSLow-dose gonadotrophin therapy for induction of ovulation in 100 women with polycystic ovary syndromeHum Reprod199168109510991806568
  • HeijnenEMEijkemansMJHughesEGLavenJSMacklonNSFauserBCA meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndromeHum Reprod Update2006121132116123051
  • TangTGlanvilleJOrsiNBarthJHBalenAHThe use of metformin for women with PCOS undergoing IVF treatmentHum Reprod20062161416142516501038
  • BalenAPolycystic ovary syndrome and cancerHum Reprod Update20017652252511727859
  • NaderSTreatment for polycystic ovary syndrome: a critical appraisal of treatment optionsExpert Rev Endocrinol Metab200833349359
  • KorytkowskiMTMokanMHorwitzMJBergaSLMetabolic effects of oral contraceptives in women with polycystic ovary syndromeJ Clin Endocrinol Metab19958011332733347593446
  • CalafJLópezEMilletALong-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trialJ Clin Endocrinol Metab20079293446345217566093
  • AzzizRUse of combination oral contraceptives in the treatment of hyperandrogenism and hirsutismUpToDateClinical Reference Library2006 Available from: http://www.uptodate.com. Accessed Dec 2, 2010.
  • FalsettiLGamberaATisiGEfficacy of the combination ethinyl oestradiol and cyproterone acetate on endocrine, clinical and ultrasonographic profile in polycystic ovarian syndromeHum Reprod2001161364211139533
  • NaderSDiamanti-KandarakisEPolycystic ovary syndrome, oral contraceptives and metabolic issues: new perspectives and a unifying hypothesisHum Reprod200722231732217099212
  • FalsettiLGamberaAPlattoCLegrenziLManagement of hirsutismAm J Clin Dermatol200012899911702316
  • LoboRAShoupeDSerafiniPBrintonDHortonRThe effects of two doses of spironolactone on serum androgens and anagen hair in hirsute womenFertil Steril19854322002053967781
  • SpritzerPMLisboaKOMattielloSLhullierFSpironolactone as a single agent for long-term therapy of hirsute patientsClin Endocrinol (Oxf)200052558759410792338
  • VenturoliSMarescalchiOColomboFMA prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutismJ Clin Endocrinol Metab19998441304131010199771
  • RosenfieldRLClinical practice. HirsutismN Engl J Med2005353242578258816354894
  • LegroRSChiuPKunselmanARBentleyCMDodsonWCDunaifAPolycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotypeJ Clin Endocrinol Metab20059052571257915713728
  • IbáñezLde ZegherFLow-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and womenHum Reprod Update200612324325216407452
  • LumachiFRondinoneRUse of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutismFertil Steril200379494294612749435
  • BayramFMüderrisIISahinYKeleştimurFFinasteride treatment for one year in 35 hirsute patientsExp Clin Endocrinol Diabetes1999107319519710376445
  • BeigiASobhiAZarrinkoubFFinasteride versus cyproterone acetate-estrogen regimens in the treatment of hirsutismInt J Gynaecol Obstet2004871293315464773
  • AzzizRBlackVHinesGAFoxLMBootsLRAdrenal androgen excess in the polycystic ovary syndrome: sensitivity and responsivity of the hypothalamic-pituitary-adrenal axisJ Clin Endocrinol Metab1998837231723239661602
  • SahinYDilberSKeleştimurFComparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutismFertil Steril200175349650011239530
  • SpritzerPBillaudLThalabardJCCyproterone acetate versus hydrocortisone treatment in late-onset adrenal hyperplasiaJ Clin Endocrinol Metab19907036426462137832
  • CristelloFCelaVArtiniPGGenazzaniARTherapeutic strategies for ovulation induction in infertile women with polycystic ovary syndromeGynecol Endocrinol200521634035216390783
  • YilmazMKarakoçATörünerFBThe effects of rosiglitazone and metformin on menstrual cyclicity and hirsutism in polycystic ovary syndromeGynecol Endocrinol200521315416016335907
  • OlsenEAMethods of hair removalJ Am Acad Dermatol1999402 Pt 114315510025738
  • HaedersdalMWulfHCEvidence-based review of hair removal using lasers and light sourcesJ Eur Acad Dermatol Venereol200620192016405602
  • MalhotraBNoveckRBehrDPalmisanoMPercutaneous absorption and pharmacokinetics of eflornithine HCL 13.9% cream in women with unwanted facial hairJ Clin Pharmacol200141997297811549102
  • MartinKAChangRJEhrmannDAEvaluation and treatment of hirsutism in premenopausal women: an Endocrine Society clinical practice guidelineJ Clin Endocrinol Metab20089341105112018252793
  • HuberJWalchKTreating acne with oral contraceptives: use of lower dosesContraception2006731232916371290
  • ShapiroJClinical practice. Hair loss in womenN Engl J Med2007357161620163017942874
  • Stener-VictorinEWaldenströmUTägnforsULundebergTLindstedtGJansonPOEffects of electro-acupuncture on anovulation in women with polycystic ovary syndromeActa Obstet Gynecol Scand200079318018810716298
  • JedelELabrieFOdénAImpact of electroacupuncture and exercise on hyperandrogenism and oligo/amenorrhoea in women with polycystic ovary syndrome: a randomized controlled trialAm J Physiol Endocrinol Metab20101013 Epub ahead of print.