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Commentary

Current Perspectives of Prenatal Sonography of Umbilical Cord Morphology

ORCID Icon, ORCID Icon, & ORCID Icon
Pages 939-971 | Published online: 18 Oct 2021

References

  • Benirschke K, Kaufman P. Anatomy and pathology of the umbilical cord and major fetal vessels. In: Benirschke K, Kaufman P, editors. Pathology of the Human Placenta. 3rd ed. New York, NY: Springer-Verlag; 1995:319–377.
  • Raio L, Ghezzi F, Di Naro E, Franchi M, Bruhwiler H. Prenatal assessment of the Hyrtl anastomosis and evaluation of its function: case report. Hum Reprod. 1999;14(7):1890–1893. doi:10.1093/humrep/14.7.1890
  • Raio L, Ghezzi F, Di Naro E, Balestrei D, Duria P, Scheinder H. In-utero characterization of the blood flow in Hyrtl anastomosis. Placenta. 2001;22(6):597–601. doi:10.1053/plac.2001.0685
  • Liu LC, Huang HB, Yu MH, Su HY. Analysis of intrauterine fetal demise – a hospital based study in Taiwan over a decade. Taiwan J Obstet Gynecol. 2013;52:546–550. doi:10.1016/j.tjog.2013.10.016
  • Lehtonen T, Marrkula T, Soidinsalo P, Otonkonski S, Laine J. Causes of stillbirth in Turku, Finland, 2001–2011. Pediatr Dev Pathol. 2017;20(1):5–15. doi:10.1177/1093526616686236
  • Hammad IA, Blue NR, Allhouse AA, et al.; the NICHD Stillbirth Collaborative Research Network Group. Umbilical cord abnormalities and stillbirth. Obstet Gynecol. 2020;135:644–652. doi:10.1097/AOG.0000000000003676
  • Parast MM, Crum CP, Boyd TK. Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth. Hum Pathol. 2008;39(6):948–953. doi:10.1016/j.humpath.2007.10.032
  • Ryan ED, Trivedi N, Bernirschke K, Lacoursiere DY, Parast MM. Placental histologic criteria for diagnosis of cord accident: sensitivity and specificity. Pediatr Dev Pathol. 2012;15(4):275–280. doi:10.2350/11-12-1127-OA.1
  • Singh V, Khanum S, Singh M. Umbilical cord lesions in early intrauterine fetal demise. Arch Pathol Lab Med. 2003;127(7):850–853. PMID 12823040. doi:10.5858/2003-127-850-UCLIEI
  • Sherer DM, Anyaegbunam A. Prenatal ultrasonographic assessment of the umbilical cord: a review Part I. Obstet Gynecol Surv. 1997;52:515–523. doi:10.1097/00006254-199708000-00023
  • Sherer DM, Anyaegbunam A. Prenatal ultrasonographic assessment of the umbilical cord: a review Part II. Obstet Gynecol Surv. 1997;52:506–514. doi:10.1097/00006254-199708000-00022
  • Sherer DM, Amoabeng O, Dryer A, Dalloul M. Current perspectives of prenatal sonographic diagnosis and clinical management challenges of true knot of the umbilical cord. Int J Womens Health. 2020;12:221–233. doi:10.2147/IJWH.S192260
  • Sherer DM, Ward K, Bennett DM, Dalloul M. Current perspectives of prenatal sonographic diagnosis and clinical management challenges of nuchal cord(s). Int J Womens Health. 2020;12:613–631. doi:10.2147/IJWH.S211124
  • Sherer DM, Roach C, Soyemi S, Dalloul M. Current perspectives of prenatal sonographic diagnosis and clinical management challenges of complex entanglement of the umbilical cord. Int J Womens Health. 2021;13:247–256. doi:10.2147/IJWH.S285860
  • Rayburn WF, Beyen A, Brinkman DE. Umbilical cord length and intrapartum complications. Obstet Gynecol. 1981;57:450–453.
  • Ente G, Penzer PH. The umbilical cord: normal parameters. J R Soc Health. 1991;111(4):138–140. doi:10.1177/146642409111100406
  • Algreisi F, Brown R, Shrim A, Albasri SF, Shamarani H, AlZoubiadi A. Effect of long and short umbilical cord upon perinatal outcome. IJRCOG. 2016;5(12):4228–4231. doi:10.18203/2320-1770.ijrcog/20164042
  • Berg TG, Rayburn WF. Umbilical cord length and acid-base balance at delivery. J Reprod Med. 1995;40(1):9–12. PMID7722985.
  • Schmid A, Jacquemyn Y, Loor JD. Intrauterine growth restriction associated with excessively long umbilical cord. Clin Pract. 2013;3(2):e23. PMID 24765511. doi:10.4081/cp.2013.323
  • Zbeidy R, Souki FG. One long umbilical cord, four nuchal loops and a true knot. BMJ Case Rep. 2017;2017:bcr2017–223241. PMID 29222212.
  • Taweevisit M, Thorner PS. Massive fetal thrombotic vasculopathy associated with excessively long umbilical cord and fetal demise: case report and literature review. Pediatr Dev Pathol. 2010;13(2):12–15. PMID 19888870. doi:10.2350/09-07-0680-CR.1
  • Adam S, Coetzee M, Honey EM. Pena-Shokeir syndrome: current management strategies and palliative care. Appl Clin Genet. 2018;11:111–120. PMID 30498368. doi:10.2147/TACG.S154643
  • Ho NC. Monozygotic twins with fetal akinesia: the importance of clinicopathological work-up in predicting risks of recurrence. Neuropediatrics. 2000;31(5):252–256. PMID 11204282. doi:10.1055/s-2000-9238
  • King JA, Gardner V, Chen H, Blackburn W. Neu-Laxova syndrome: pathological evaluation of a fetus a review of the literature. Pediatr Pathol Lab Med. 1995;15(1):57–79. PMID 873659. doi:10.3109/15513819509026940
  • Mau U, Kendziorra H, Kaiser P, Enders H. Restrictive dermopathy: report and review. Am J Med Genet. 1997;71(2):179–185. doi:10.1002/(sici)1096-8628(19970808)71:2<179:aid-ajmg11>3.0.co;2-b
  • Witt DR, Hayden MR, Holbrook KA, Dale BA, Baldwin VJ, Yaylor GP. Restrictive dermopathy; a newly recognized autosomal recessive skin dysplasia. Am J Med Genet. 1986;24(4):631–648. PMID 2426945. doi:10.1002/ajmg.1320240408
  • Dane B, Dane C, Aksoy F, Cetin A, Yayla M. Arthrogryposis multiplex congenital analysis of twelve cases. Clin Exp Obstet Gynecol. 2009;36(4):259–262. PMID 20101863.
  • Colpaert C, Bogers J, Hertveldt K, Loquet P, Dumon J, Willems P. Limb-body wall complex: 4 new cases illustrating the importance of examining placenta and umbilical cord. Pathol Res Pract. 2000;196(11):783–790. PMID 11186178.
  • Aguirre-Pascual E, Epelman M, Johnson AM, Chauvin NA, Coleman BG, Victoria T. Prenatal MRI evaluation of limb-body wall complex. Pediatr Radiol. 2014;44(11):1412–1420. doi:10.1007/s00247-014-3026-9
  • Iqbal CW, Derderian SC, Cheng Y, Lee H, Hirose S. Amniotic band syndrome: a single-institutional experience. Fetal Diagn Ther. 2015;37(1):1–5. doi:10.1159/000358301
  • Viscarello RR, Ferguson DD, Nores J, Hobbins JC. Limb-body wall complex associated with cocaine abuse: further evidence of cocaine’s teratogenicity. Obstet Gynecol. 1992;80(3 Pt 2):253–256. PMID 1386662.
  • Ginsberg NE, Cadkin A, Strom C. Prenatal diagnosis of body stalk anomaly in the first trimester of pregnancy. Ultrasound Obstet Gynecol. 1997;10(6):419–421. PMID 947329. doi:10.1046/j.1469-0705.1997.10060419.x
  • Negishi H, Yaegashi M, Kato EH, Yamada H, Okuyama K, Fujimoto S. Prenatal diagnosis of limb-body wall complex. J Reprod Med. 1998;43(8):659–664. PMID 9749415.
  • Daskalakis GJ, Nicolaides KH. Monozygotic twins discordant for body stalk anomaly. Ultrasound Obstet Gynecol. 2002;20(1):79–81. PMID 12100424. doi:10.1046/j.1469-0705.2002.00631.w
  • Jidha TD, Wiakjira T, Mekonnen T. Body stalk anomaly presenting as an emergency in Ethiopia: a case report. J Med Case Rep. 2020;14(1):205. doi:10.1186/s13256-13256-020-02509-3
  • Gajzer DC, Hirzel AC, Saigal G, Rojas CP, Rodriguez MM. Possible genetic origin of limb-body wall complex. Fetal Pediatr Pathol. 2015;34(4):257–270. PMID 26111189. doi:10.3109/15513815
  • Smrcek JM, Germer U, Krokowski M, et al. Prenatal ultrasound diagnosis and management of body stalk anomaly: analysis of nine singleton and two multiple pregnancies. Ultrasound Obstet Gynecol. 2003;21(4):322–328. PMID 12858309. doi:10.1002/uog.153
  • Türkyilmaz G, Avci S, Sivrikoz T, et al. Prenatal diagnosis and management of ectopia cordis: varied presentation spectrum. Fetal Pediatr Pathol. 2019;38(2):127–137. PMID 30600745. doi:10.1080/15513815.2018.1556367
  • Sornes T. Short umbilical cord as a cause of fetal distress. Acta Obstet Gynecol Scand. 1989;68(7):609–611. PMID 2631528. doi:10.31019/00016348909013279
  • Anath CV, Oyelese Y, Yeo L, Pradhan A, Vintzileos AM. Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants. Am J Obstet Gynecol. 2005;192(1):191–198. PMID 15672024. doi:10.1016/j.ajog.2004.05087
  • Georgiais A, Keski-Nisula L, Harju M, et al. Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study. Placenta. 2014;35(4):275–290. PMID 24560495. doi:10.1016/j.placenta.2014.02001
  • Wendel MP, Shanekel KL, Magann EF. Uterine inversion. A review of a life-threatening obstetrical emergency. Obstet Gynecol Surv. 2018;73(7):411–417. PMID 30062382. doi:10.1097/OGX.0000000000000580
  • Iwagaki S, Takahashi Y, Chiaki R, et al. Umbilical cord length affects the efficacy of amnioinfusion for repetitive variable decelerations during labor. J Matern Fetal Neonat Med. 2020;1–5. doi:10.1080/14767058.2020.1712703
  • Yamamoto Y, Aoki S, Oba MS, Seki K, Hirahara F. Short umbilical cord length: reflective of adverse pregnancy outcomes. Clin Exp Obstet Gynecol. 2017;44(2):216–219. PMID 29746025.
  • Solertre L. Three-dimensional multiplanar ultrasound in a limb-body wall complex fetus: clinical evidence for counseling. J Matern Fetal Neonatal Med. 2006;19(2):109–112. PMID 16581607. doi:10.1080/147670504000028840
  • Bijok J, Massalska D, Kuncinska-Chawan A, et al. Complex malformations involving the fetal body wall – definition and classification issues. Prenat Diagn. 2017;37(10):1033–1039. doi:10.1002/pd.5141
  • Sherer DM, Dalloul M, Garza M, Benton L, Abulafia O. Prenatal sonographic diagnosis of acardiac twin embedded within placenta. Ultrasound Obstet Gynecol. 2018;52(1):120–121. PMID 29155482. doi:10.1002/uog.18964
  • Hill LM, DiNofrio DM, Guzick D. Sonographic determination of first trimester umbilical cord length. J Clin Ultrasound. 1994;22(7):435–438. PMID 7962590. doi:10.1002/jcu.1870220704
  • Collins JH. Ultrasound measurement of umbilical cord length. Am J Obstet Gynecol. 1994;13(11):854.
  • Sherer DM, Dalloul M, Ajayi O, Kheyman M, Sokolvski M, Abulafia O. Prenatal diagnosis of short umbilical cord in a dichorionic twin with normal fetal anatomy. J Clin Ultrasound. 2010;38(2):91–93. PMID 19802888. doi:10.1002/jcu.20639
  • Ugurlucan FG, Yuskel A. Is complete umbilical cord scanning possible at the second-trimester ultrasound scan? J Clin Ultrasound. 2015;43(4):249–253. doi:10.1002/jcu.22242
  • Gur EB, Gulec ES, Aydogmus S, et al. Can the difference of Doppler indexes at different points of the umbilical cord predict to the umbilical cord length? J Matern Fetal Neonatal Med. 2020;33(5):847–851. PMID 30173592. doi:10.1080/14767058.2018.1506440
  • Katsura D, Takahashi Y, Shimizu T, et al. Prenatal measurement of umbilical cord length using magnetic resonance imaging. Eur J Obstet Gynecol Reprod Biol. 2018;231:142–146. PMID 30388608. doi:10.1016/j.ejogrb.2018.10.10.037
  • Ghezzi F, Raio L, Di Naro E, et al. First-trimester sonographic umbilical cord diameter and the growth of the human embryo. Ultrasound Obstet Gynecol. 2001;18(4):348–351. doi:10.1046/j.0960-7692.2001.00100507.x
  • Ghezzi F, Raio L, Di Naro E, Franchi M, Buttarelli M, Schneider H. First-trimester umbilical cord diameter: a novel marker of fetal aneuploidy. Ultrasound Obstet Gynecol. 2002;19(3):235–239. PMID 11936081. doi:10.1046/j.1469-0705.2002.00650.x
  • Axt-Fliedner R, Schwarze A, Kreiselmaier P, Krapp M, Smrcek JD, Diedrich K. Umbilical cord diameter ar 11–14 weeks of gestation: relationship to nuchal translucency, ductus venosus blood flow and chromosomal defects. Fetal Diagn Ther. 2006;21(4):390–395. doi:10.1159/000092472
  • Weissman A, Jakobi P, Bronshtein M, Goldstein I. Sonographic measurements of the umbilical cord and vessels during normal pregnancies. J Ultrasound Med. 1994;13(1):11–14. PMID 7636947. doi:10.7863/jum.1994.13.1.11
  • Debebe SK, Cahill LS, Kingdom JC, et al. Wharton’s jelly area and its association with placental morphology and pathology. Placenta. 2020;94:34–38. PMID 32421532.
  • Ghezzi F, Raio L, Di Naro E, Franch M, Balestreri D, D’Addario V. Nomogram of Wharton’s jelly as depicted in the sonographic cross-section of the umbilical cord. Ultrasound Obstet Gynecol. 2001;18(2):121–125. doi:10.1046/j.1469-0705.2001.00468.x
  • Raio L, Ghezzi F, Di Naro E, et al. Prenatal diagnosis of a lean umbilical cord: a simple marker for the fetus at risk of being small for gestational age at birth. Ultrasound Obstet Gynecol. 1999;13(3):176–180. doi:10.1046/j.1469-0705.1999.13030176.x
  • Raio LG, Di Naro E, Duwe DG, Cromi A, Scheider H, Schneider H. Umbilical cord morphologic characteristics and umbilical artery Doppler parameters in intrauterine growth-restricted fetuses. J Ultrasound Med. 2003;22(12):1341–1347. doi:10.7863/jum.2003.22.12.1341
  • Cromi A, Ghezzi F, Di Naro E, Siesto G, Beraminin V, Raio L. Large cross-sectional of the umbilical cord as a predictor of fetal macrosomia. Ultrasound Obstet Gynecol. 2007;30(6):861–866. doi:10.1002/uog.5183
  • Raio L, Ghezzi F, Di Naro E, Franchi M, Brühwiler H, Lüscher KP. Prenatal assessment of Wharton’s jelly in umbilical cords with single artery. Ultrasound Obstet Gynecol. 1999;14(1):42–46. doi:10.1046/j.1469-0705.1999.14010042.x
  • Sherer DM, Houry-Collado F, Dalloul M, et al. Recurrent antepartum compression of a single artery double nuchal cord necessitating Cesarean delivery. Am J Perinatol. 2005;22(8):437–440. doi:10.1055/s-2005-916286
  • Cromi A, Ghezzi F, Dürig P, Di Naro E, Raio L. Sonographic umbilical cord morphometry and coiling patterns in twin-twin transfusion syndrome. Prenat Diagn. 2005;25(9):851–855. PMID 16170861. doi:10.1002/pd.1273
  • Ulberg U, Sandstedt B, Limgman G. Hyrtl’s anastomosis, the only connection between the two umbilical arteries. A study in full term placentas from AGA infants with normal umbilical artery blood flow. Acta Obstet Gynecol Scand. 2001;80(1):1–6. PMID 11167180. doi:10.1034/j.1600-0412.2001.800101.x
  • Ulberg U, Lingman G, Ekman-Orderberg G, Sandstedt B. Hyrtl’s anastomosis is normally developed in placentas from small for gestational age infants. Acta Obstet Gynecol Scand. 2003;82(8):716–721. PMID 12848642. doi:10.1034/j.1600-0412.2003.00161.x
  • Gordon Z, Eytan O, Jaffa AJ, Elad D. Hemodynamic analysis of Hyrtl anastomosis in human placenta. Am J Physiol Regul Integr Comp Physiol. 2007;292(2):R977–R982. PMID 17038439. doi:10.1152/ajpregu.004.2006.
  • Bhutia KL, Sengupta R, Upreti B, Tamang BK. Pregnancy-induced hypertension is associated with altered anatomical patterns of Hyrtl’s anastomosis. Anat Rec (Hoboken). 2014;297(5):819–825. PMID 24592334. doi:10.1002/ar.22894.
  • Donepudi RV, Moise KJ. Intrauterine transfusion complicated by umbilical artery thrombosis. Case Rep Obstet Gynecol. 2019;2019:5952326.
  • Rembouskos G, Cicero S, Longo D, Sacchini C, Nicolaides KH. Single umbilical artery at 11–14 weeks’ gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol. 2003;22(6):567–570. PMID 14689527. doi:10.1002/uog.901
  • Blazer D, Sujov P, Escholi Z, Itai BH, Bronshtein M. Single umbilical artery – right or left? Does it matter? Prenat Diagn. 1997;17(1):5–8. PMID 9021822. doi:10.1002/(sici)1097-0223(199701)17:1<5::aid-pd>3.0.co;2-4
  • Friebe-Hoffmann U, Hiltmann A, Friedl TWP, et al. Prenatally diagnosed single umbilical artery (SUA) – retrospective analysis of 1169 fetuses. Ultraschall Med. 2019;40(2):221–229. PMID 29590672. doi:10.1055/s-0043-1234
  • Gurvitz G, Walfish A, Beharier O, Sheiner E. Isolated single umbilical artery is an independent risk factors for perinatal mortality and adverse outcomes in term neonates. Arch Gynecol. 2016;294(5):931–935. PMID 27048509. doi:10.1007/s00404-016-4088-8.
  • Sepulveda W, Peek MJ, Hassan J, Hollingsworth J. Umbilical vein to artery ratio in fetuses with single umbilical artery. Ultrasound Obstet Gynecol. 1996;8(1):23–26. PMID 8843614. doi:10.1046/j.1469-0705.1996.08010023.x
  • Painter D, Russell P. Four-vessel umbilical cord associated with multiple congenital anomalies. Obstet Gynecol. 1977;50(4):505–507. PMID 904818.
  • Karatza A, Tsamandas A, Varvarigou A, Davlouros P, Pavlou V, Mantagos S. Supernumerary umbilical vein in a hydropic neonate with hypertrophic cardiomyopathy. Fetal Pediatr Pathol. 2011;30(3):173–176. PMID 21355676.
  • Puvabanditsin S, Garrow E, Bhatt M, et al. Four-vessel cord associated with multiple congenital anomalies: a case report and literature review. Fetal Pediatr Pathol. 2011;30(2):98–105. PMID 21391749. doi:10.3109/15513815.2010.524687
  • Panda S, Jah V, Khonglah Y, Dey B. A multivessel umbilical cord with a single umbilical artery. J Clin Diagn Res. 2013;7(7):1453–1454. PMID 23998091. doi:10.7860/JCDR/2013/5220.3153
  • Pérez-Cosio C, Sheiner E, Abramowicz JS. Four vessel umbilical cord not always a dire prognosis. J Ultrasound Med. 2008;27:1389–1391. doi:10.7863/jum.2008.27.9.1389
  • Schimmel MS, Eidelman AI. Supernumerary umbilical vein resulting in a four-vessel umbilical cord. Am J Perinatol. 1998;15:299–301. doi:10.1055/s-2007-993947
  • Du W, Yuan Q, Li Z, Li Y. Three umbilical arteries resulting in four-vessel umbilical cord in a stillbirth. Int J Clin Exp Med. 2015;8(3):4682–4685. PMID 26064402.
  • Cohen HL, Shapiro ML, Haller JO, Schwartz D. The multivessel umbilical cord: an antenatal indicator of possible conjoined twinning. J Clin Ultrasound. 1992;20(4):278–282. doi:10.1002/jcu.1870200409
  • Hecht C, Baumann M, Spinelli M, Tripple M, Raio L. Umbilical cord in conjoined twins: prenatal imaging and anatomopathological aspects. Ultrasound Obstet Gynecol. 2019;53:269–273. doi:10.1002/uog.20095
  • Thomas K, Dargent JL, Brans A, Flippidis M. Prenatal diagnosis of forked umbilical cord in monochorionic diamniotic pregnancy. Ultrasound Obstet Gynecol. 2006;28:343–346. doi:10.1002/uog.2833
  • Fraser RB, Liston RM, Thompson DL, Wright JR. Monoamniotic twins delivered liveborn with forked umbilical cord. Pediatr Pathol Lab Med. 1997;17:639–644. doi:10.1080/15513819709168742
  • Guo Y, Sun Y, Yang H. Growth discordance of monoamniotic twin because of difference of cords diameter in forked umbilical cord: case report. Medicine (Baltimore). 2017;96(37):e8042. PMID 28906394.
  • Frisch L, Groisman G, Hallak M. First trimester diagnosis of forked cord in monoamniotic twin pregnancy. Placenta. 2011;32(12):1057–1059. doi:10.1016/j.placenta.2011.09.008
  • Weston PJ, Ives EJ, Honore RL, Lees GM, Sinclair DB, Schiff D. Monochorionic diamniotic minimally conjoined twins: a case report. Am J Med Genet. 1990;37(4):558–561. PMID 2260608. doi:10.1002/amjg.1320370428
  • Rehder H, Schoner K, Kluge B, Louwen F, Schwinger E, Neesen J. Klinefelter twins presenting with discordant aneuploidies, acardia, forked umbilical cord with different gonadal sex despite monozygosity. Prenat Diagn. 2012;32(2):173–179. PMID 2241892. doi:10.1002/pd.2928
  • Strong TH, Jarles DL, Vega JS, Feldman DB. The umbilical coiling index. Am J Obstet Gynecol. 1994;170(1):29–32. doi:10.1016/S0002-9378(94)70378-7
  • Strong TH, Manriquez-Gilpin MP, Gilpin BG. Umbilical coiling and nuchal entanglement. J Matern Fetal Med. 1996;5(6):359–361.
  • Rana J, Ebert GA, Kappy KA. Adverse perinatal outcome in patients with an abnormal umbilical coiling index. Obstet Gynecol. 1995;85(4):573–577. PMID 7898836. doi:10.1016/0029-7844(94)00435-G.
  • Ernst LM, Minturn L, Huang MH, Curry E, Su EJ. Gross patterns of umbilical coiling: correlations with placental histology and stillbirth. Placenta. 2013;34(7):583–588. PMID 23642640. doi:10.1016/j.placenta.2013.04.002
  • Machin GA, Ackerman J, Gilbert-Barness E. Abnormal umbilical cord coiling is associated with adverse perinatal outcomes. Pediatr Dev Pathol. 2000;3(5):462–471. PMID 10890931. doi:10.1007/s100240010103
  • Ayala NK, Ernst LM, Miller ES. Is umbilical coiling determined? J Perinatol. 2018;38(6):653–657. PMID 29467518. doi:10.1038/s41372-018-0078
  • Dolkart LA, Reimers FT, Kuonen CA. Discordant umbilical arteries: ultrasonographic and Doppler analysis. Obstet Gynecol. 1992;79:59–63.
  • Petrikovski B, Schneider E. Prenatal diagnosis and clinical significance of hypoplastic umbilical artery. Prenat Diagn. 1996;16(10):938–940. doi:10.1002/(SICI)1097-0223(199610)16:10<938::AID-PD964>3.0.CO;2-S
  • Raio L, Ghezzi F, Di Naro E, Gomez R, Saile G, Brunhwiler H. The clinical significance of antenatal detection of discordant umbilical arteries. Obstet Gynecol. 1998;91:86–91. doi:10.1016/s0029-7844(97)00543-7
  • Predanic M, Perni SC. Antenatal assessment of discordant umbilical arteries n singleton pregnancies. Croat Med J. 2006;47(5):701–708. PMID 17042061.
  • Laberke PJ, Deubler G. Sudden intrauterine death associated with furcate insertion of the umbilical cord. Int J Legal Med. 2009;123:509–512. doi:10.1007/s00414-008-295-6
  • Cohen B, Wilson M, Cohen A, Yum M. Prenatal diagnosis of a furcate placenta. Obstet Gynecol. 2020;135(4):960–963. doi:10.1097/AOG.0000000000003744
  • Lamale-Smith LM, Snuttjer MJ, Harper TC. Furcate umbilical cord insertion: disparate outcomes of a rare obstetrical findings. A case report. J Reprod Med. 2015;60(7–8):365–368.
  • Fujita Y, Yumoto Y, Kato K. Prenatal diagnosis of abnormal umbilical cord insertion: a rare case of furcate insertion. J Med Ultrasound (2001). 2017;44(2):203–205. doi:10.1007/s10396-016-0758-1
  • Esakoff TF, Cheng YW, Snowden JM, Tran SH, Shaffer BL, Caughey AB. Velamentous cord insertion: is it associated with adverse perinatal outcomes? J Matern Fetal Neonatal Med. 2015;28(4):409–412. doi:10.3109/14767058.2014.918098
  • Ebbing A, Kiserud T, Johnson SL, Albrechtsen S, Rasmussen S. Prevalence, risk factors and outcomes of velamentous and marginal cord insertions: a population-based study of 634,741 pregnancies. PLosS One. 2013;8(7):e70380. PMID 23936197. doi:10.1371/journal.pone.0070380.
  • Sinkin JA, Craig WY, Jones M, Pintette MG, Wax JR. Perinatal outcomes associated with isolated velamentous cord insertion in singleton and twin pregnancies. J Ultrasound Med. 2018;37(2):471–478. PMID 28850682. doi:10.1002/jum.14357
  • Heinonen S, Ryynannen M, Kirkinen P, Saarikoski S. Perinatal diagnostic evaluation of velamentous umbilical cord insertion: clinical, Doppler, and ultrasonic findings. Obstet Gynecol. 1996;87(1):112–117. doi:10.1016/0029-7844(95)00339-8
  • Buchanan-Hughes A, Bobrowska A, Vistintin C, Attilakos G, John M. Velamentous cord insertion: results from a rapid review of incidence, risk factors, adverse outcomes and screening. Syst Rev. 2020;9(1):147. PMID 32576295. doi:10.1186/s13643-020-01355-0
  • Monteagudo A, Sfakianaki AK, Timor-Trisch IE. Velamentous insertion of the cord in the first trimester. Ultrasound Obstet Gynecol. 2000;16(5):498–499. doi:10.1046/j.1469-0705.2000.00282x
  • Derisbourg S, Boulay A, Lamy C, et al. First trimester ultrasound prediction of velamentous cord insertions: a prospective study. J Matern Fetal Neonatal Med. 2019:34:1–7. PMID 31558066. doi:10.1080/14767058.2019.167097
  • Sepulveda W, Rojas I, Robert JA, Scnapp C, Alcade JL. Prenatal detection of velamentous insertion of the umbilical cord: a prospective color Doppler study. Ultrasound Obstet Gynecol. 2003;21(6):564–569. PMID 12808673. doi:10.1002/uog.132
  • Sepulveda W. Velamentous insertion of the umbilical cord: a first-trimester sonographic screening study. J Ultrasound Med. 2006;25(8):963–8;quiz 970. doi:10.7863/jum.2006.25.8.963
  • Hasegawa J, Matsuoka R, Ichizuka K, Sekizawa A, Okai T. Velamentous cord insertion: significance of prenatal detection to predict perinatal complications. Taiwan J Obstet Gynecol. 2006;45(1):21–25. doi:10.1016/S1028-4559(09)60185-6
  • Nomiyama M, Toyota Y, Kawano H. Antenatal diagnosis of velamentous umbilical cord and vasa previa with color Doppler imaging. Ultrasound Obstet Gynecol. 1998;12(6):426–429. doi:10.1046/j.1469-0705.1998.1206042.x
  • Lee HM, Lee SW, Park MK, et al. Clinical significance of velamentous cord insertion prenatally diagnosed in twin pregnancy. J Clin Med. 2021;10(4):572. PMID 33546368. doi:10.3390/jcm10040572
  • Fries MH, Goldstein RB, Kilpatrick SJ, Golbus MS, Callen PW, Filly RA. The role of velamentous cord insertion on the etiology of twin-twin transfusion syndrome. Obstet Gynecol. 1993;81(4):69–74.
  • Costa-Castro T, De Villiers S, Montenegro N, Oepkes D, Matias A, Lopirore E. Velamentous cord insertion in monochorionic twins with or without twin-twin transfusion syndrome: does it matter? Placenta. 2013;34(11):10530–10538. PMID 24011780. doi:10.1016/j.placenta.2013.08.009
  • Yonenati N, Ishii K, Kawamura H, Mabuchi A, Hayashi S, Mitsuda N. Significance of velamentous cord insertion for twin-twin transfusion syndrome. Fetal Diagn Ther. 2015;38(4):276–281. PMID 25925425. doi:10.1159/000381639
  • Lopriore E, Suetres M, Middledorp JM, Oepkes D, Walther FJ, Vandenbussche FPHA. Velamentous cord insertion and unequal placental territories in monochorionic twins with and without twin-to-twin transfusion syndrome. Am J Obstet Gynecol. 2007;196(2):159.e1–5. doi:10.1016/j.acog.2006.10.865
  • Couke I, Mourad Tawfic N, Deprest J, De Catte L, Devlieger R, Lewi L. Does site of cord insertion increase risk of adverse outcome, twin-to-twin transfusion syndrome and discordant growth in monochorionic twin pregnancy. Ultrasound Obstet Gynecol. 2018;52(3):385–389. PMID 29024208. doi:10.1002/uog.18926
  • Kalafat E, Thilaganathan B, Papageorghiou A, Bhide A, Khalil A. Significance of placental cord insertion site in twin gestations. Ultrasound Obstet Gynecol. 2018;52(3):378–384. doi:10.1002/uog.18914
  • Lin D, Fan D, Wu S, et al. Role of velamentous cord insertion in monochorionic twin pregnancies: a PRISMA-compliant systematic review and meta-analysis of observational studies. J Matern Fetal Neonatal Med. 2020;33(14):2377–2386. PMID 30458694. doi:10.1080/14767058.2018.1551350
  • Sherer DM, Abramowicz JS, Sinkin RA, Metlay LA, Geilfuss CJ, Woods JR. Marked growth discordancy in three sets of twins associated with velamentous insertion of the umbilical cord of the smaller twin. J Matern Fetal Med. 1993;2:165. doi:10.3109/14767059309017335
  • Gulersen M, Miller RS, Rochelson B. An unusual velamentous cord insertion into the intertwin dividing membrane. Am J Obstet Gynecol. 2020;223(5):758–759. doi:10.1016/j.ajog.2020.04.008
  • Nelson LH, Fishburne JI, Stearns BR. Ultrasonographic description of succenturiate lobe. Obstet Gynecol. 1977;49(1 suppl):79–80.
  • Spirt BA, Kagan EH, Gordon LP, Massad LS. Antepartum diagnosis of a succenturiate lobe: sonographic and pathologic correlation. J Clin Ultrasound. 1981;9(3):139–140. doi:10.1002/jcu.1870090309
  • Anguaco TL, Boyd CM, Marks SR, Quirk JG, Galwas B. Sonographic diagnosis of the bilobate placenta. J Ultrasound Med. 1986;5(11):672–674. doi:10.7863/jum.1986.5.11.672
  • Hata K, Hata T, Aoki S, Takamori H, Takamiya O, Kitao M. Succenturiate placenta diagnosed by ultrasound. Gynecol Obstet Invest. 1988;25(4):273–276. doi:10.1159/000293798
  • Chihara H, Otsubo Y, Ohta Y, Araki T. Prenatal diagnosis of succenturiate lobe by ultrasonography and color Doppler imaging. Arch Gynecol Obstet. 2000;263(3):137–138. doi:10.1007/s004040050013
  • Oyelese KO, Turner M, Lees C, Campbell S. Vasa previa: and avoidable obstetric tragedy. Obstet Gynecol Surv. 1999;54(2):138–145. doi:10.1097/00006254-199902000-00024
  • Oyelese KO, Schärzler P, Coates S, Sansui FA, Hamid R, Campbell S. A strategy for reducing the mortality rate from vasa previa using transvaginal sonography with color Doppler. Ultrasound Obstet Gynecol. 1998;12(6):434–438. doi:10.1046/j.1469-0705.1998.12060434.x
  • Oyelese Y, Catanzarite V, Prefumo F, et al. Vasa previa: the impact of prenatal diagnosis on outcomes. Obstet Gynecol. 2004;103(5 Pt 1):937–942. doi:10.1097/01.AOG.0000123245.48645.98
  • Baulies S, Maiz N, Muñoz A, Torrents M, Echevarría MS, Serra B. Prenatal ultrasound diagnosis of vasa previa and analysis of risk factors. Prenat Diagn. 2007;27(7):595–599. doi:10.1002/pd.1753
  • Zhang W, Geris S, Beta J, Nicolaides KH, Akolekar R, Akolekar R. Prevention of stillbirth: impact of two-stage screening for vasa previa. Ultrasound Obstet Gynecol. 2020;55(5):605–612. doi:10.1002/uog.21953
  • Yang M, Zheng Y, Li M, et al. Clinical features of velamentous umbilical cord insertion and vasa previa: a retrospective analysis based on 501 cases. Medicine (Baltimore). 2020;99(51):e23166. PMID 33371061. doi:10.1097/MD.0000000000023166
  • Pavalagantharajah S, Villani LA, DSouza R. Vasa previa and associated risk factors: as systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(3):100117. doi:10.1016/j.ajogmf.2020.100117
  • Ruiter L, Kok N, Limpens J, et al. Systematic review of accuracy of ultrasound in the diagnosis of vasa previa. Ultrasound Obstet Gynecol. 2015;45(5):516–522. doi:10.1002/uog.14752
  • Rebarber A, Dolin C, Fox NS, Klauser CK, Saltzman DH, Roman AS. Natural history of vasa previa across gestation using a screening protocol. J Ultrasound Med. 2014;33(1):141–147. PMID 24371109. doi:10.7863/ultra.33.1.141
  • Ranzini AC, Oyelese Y. How to screen for vasa previa. Ultrasound Obstet Gynecol. 2020;57(5):720–725. doi:10.1002/uog.23520
  • Bohiltea RE, Cirsroiu MM, Ciuvica AI, et al. Velamentous insertion of umbilical cord with vasa praevia: case series and literature review. J Med Life. 2016;9(2):126–129. PMID 27453740.
  • Sullivan EA, Javid N, Duncombe G, et al. Vasa previa diagnosis, clinical practice, and outcomes in Australia. Obstet Gynecol. 2017;130(3):591–598. doi:10.1097/AOG.0000000000002198
  • Melcer Y, Maymon R, Jauniaux E. Vasa previa: prenatal diagnosis and management. Curr Opin Obstet Gynecol. 2018;30(6):385–391. doi:10.1097/GCO.0000000000000478
  • Lijoi AF, Brady J. Vasa previa diagnosis and management. J Am Board Fam Pract. 2003;16(6):543–548. PMID 14963081. doi:10.3122/jabfm.16.6.543
  • Catanzarite V, Maida C, Thjomas W, Mendoza A, Stanco L, Piacquadio KM. Prenatal sonographic diagnosis of vasa previa: ultrasound findings and obstetric outcome in ten cases. Ultrasound Obstet Gynecol. 2001;18(2):109–115. doi:10.1046/j.1469-0705.2001.00448.x
  • Kulkarni A, Powel J, Aziz M, et al. Vasa Previa: prenatal diagnosis and outcomes: thirty-five cases from a single maternal-fetal medicine practice. J Ultrasound Med. 2018;37(4):1017–1024. doi:10.1002/jum.14452
  • Klahr R, Fox NS, Zafman K, Hill MB, Connolly CT, Rebarber A. Frequency of spontaneous resolution of vasa previa with advancing gestational age. Am J Obstet Gynecol. 2019;221(6):646.e1–646.e7. PMID 31233708. doi:10.1016/j.ajog.2019.06.040
  • Sepulveda W, Rojas I, Robert JA, Schnapp C, Alcade JL. Prenatal detection of velamentous insertion of the umbilical cord: a prospective color Doppler ultrasound study. Ultrasound Obstet Gynecol. 2003;21(6):564–569. PMID 12808673. doi:10.1002/uog.132
  • American College of Obstetricians and Gynecologists. Medically indicated late-preterm and early term deliveries. ACOG Committee opinion no. 764. February 2019. Obstet Gynecol. 2013;121:908–910.
  • Sinkey RG, Odibo AO, Dashe JS; Society for Maternal-Fetal Medicine (SMFM) Publications Committee. Diagnosis and management of vasa previa. Am J Obstet Gynecol. 2015;213:615–619. doi:10.1016/j.ajog.2015.08.031
  • Sinkey RG, Odibo AO. Vasa previa screening strategies: decision and cost-effectiveness analysis. Ultrasound Obstet Gynecol. 2018;52(4):522–529. doi:10.1002/uog.19098
  • Melcer Y, Pekar-Zlotin N, Wolf B, et al. Is scanning for vasa previa important for singleton pregnancies that started as multiple conceptions? Eur J Obstet Gynecol Reprod Biol. 2019;238:100–103. PMID 31128531. doi:10.1016/j.ejogrb.2019.05.018
  • Kikuchi A, Uemura R, Serikawa T, Takakuwa K, Tanaka K. Clinical significance of magnetic resonance imaging in prenatal diagnosis of vasa previa in a woman with bilobed placentas. J Obstet Gynaecol Res. 2011;37(1):75–78. doi:10.1111/j.1447-0756.2010.01308.x
  • Oyelese Y, Chavez MR, Yeo L, et al. Three-dimensional sonographic diagnosis of vasa previa. Ultrasound Obstet Gynecol. 2004;24(2):211–215. doi:10.1002/uog.1097
  • Jauniaux E, Melcer Y, Maymon R. Prenatal diagnosis and management of vasa previa in twin pregnancies: a case series and systematic review. Am J Obstet Gynecol. 2017;216(6):568–575. PMID 28153653. doi:10.1016/j.ajog.2017.01.029
  • Oyelese Y, Spong C, Fernandez MA, McLaren RA. Second trimester low-lying placenta and in-vitro fertilization? Exclude vasa previa. J Matern Fetal Med. 2000;9:370–372.
  • Isotton AL, Salazar CC, Peralta CFA, Abdalla JML, Vettorazzi J. In vitro fertilization and vasa previa: a report of two cases. Rev Bras Ginecol Obstet. 2019;41(5):348–351. doi:10.1055/s-0039-1683354
  • Nkwabong E, Njikam F, Kalla G. Outcome of pregnancies with marginal umbilical cord insertion. J Matern Fetal Neonat Med. 2021;34(7):1133–1137. PMID 31164018. doi:10.1080/14767058.2019.1628206
  • Christopher CR, Spinelli A, Collins ML. Ultrasonic detection of “hourglass membranes” with funic presentation. Obstet Gynecol. 1979;54(1):130–132. doi:10.1097/000062250-197907000-00031
  • Vintzileos AM, Nochimson DJ, Lillo NL, Tohan N. Ultrasonic diagnosis of funic presentation. J Clin Ultrasound. 1983;11(9):520–521. doi:10.1002/jcu.1870110913
  • Oyelese Y, Yeo L, Kinzler W, Smulian J, Vintzileos AM. Persistent funic presentation resulting from marginal cord insertion into a low-lying placenta. Ultrasound Obstet Gynecol. 2004;24(6):692–693. PMID 15386613. doi:10.1002/uog.1069
  • Ezra Y, Strasberg SR, Farine D. Does cord presentation on ultrasound predict cord prolapse? Gynecol Obstet Invest. 2003;56:6–9. doi:10.1159/000072323
  • Raga F, Osborne N, Ballester M, Bonilla-Musoles F. Color flow Doppler: a useful instrument in the diagnosis of funic presentation. J Natl Med Assoc. 1996;88(2):94–96.
  • Jo YS, Kim MJ, Lee GSR, Kim SJ. A large amniocele with protruded umbilical cord diagnosed by 3D ultrasound. Int J Med Sci. 2012;9(5):387–390. doi:10.7150/ijms.3383
  • Zhu Y, Beejadhursing R, Liu Y. 10 cases of umbilical cord thrombosis in the third trimester. Arch Gynecol Obstet. 2021;304:59–64. PMID 33389094. doi:10.1007/s00404-020-05910-x
  • Lutfallah F, Oufkir N, Markou GA, Frimigacci D, Poncelet C. A case of umbilical artery thrombosis in the third trimester of pregnancy. Am J Case Rep. 2018;19:72–75. PMID 29348396. doi:10.12659/ajcr.906859
  • Shilling C, Walsh C, Downey P, Mooney E. Umbilical artery thrombosis is a rare but clinically important finding: a series of 7 cases with clinical outcomes. Pediatr Dev Pathol. 2014;17(2):89–93. PMID 24559159. doi:10.2350/13-11-1407-OA1
  • Sato Y, Benirschke K. Umbilical arterial thrombosis with vascular wall necrosis: clinicopathologic findings of 11 cases. Placenta. 2006;27(6–7):715–718. PMID 16112729. doi:10.1016/j.placenta.2005.05.006
  • Klaitsch P, Haeusler M, Karpf E, Schlembach D, Lang U. Spontaneous intrauterine umbilical artery thrombosis leading to severe fetal growth restriction. Placenta. 2008;29(4):374–377. PMID 18289672. doi:10.1016/j.plaxenta.2008.01.004
  • De Olivera GH, de Moraes Dias C, Vaz-Oliani DC, Oliani AH. Intrauterine thrombosis of umbilical artery – case report. San Paulo Med J. 2016;134(4):355–358. PMID 27276083. doi:10.1590/1616-3180.2016.00081203
  • Li H, Wu Q, Wei W, Lin X, Zhang X. Umbilical artery thrombosis: two case reports. Medicine (Baltimore). 2019;98(48):e18170. PMID 31770267. doi:10.1097/MD000000000008170
  • Sherer DM, Dalloul M, Guerra R, Bahamon C, Abulafia O. Prenatal sonographic depiction of large intra-amniotic vein thrombosis. J Ultrasound Med. 2018;37(11):2733–2734. PMID 29656547. doi:10.1002/jum.14620
  • Abrams SK, Callen PW, Filly RA. Umbilical vein thrombosis: sonographic detection in utero. J Ultrasound Med. 1985;4(6):283–285. doi:10.7863/jum.1985.4.6.283
  • Minakami H, Akahori A, Sakurai A, Yamauchi A, Sato I. Umbilical vein thrombosis as a possible cause of perinatal morbidity or mortality: report of two cases. J Obstet Gynaecol Res. 2001;27(2):97–101. PMID 11396646. doi:10.1111/j.1447-0756.2001.tb01228.x
  • White SP, Kofinas A. Prenatal diagnosis and management of umbilical vein varix. J Ultrasound Med. 1994;13:992–994. doi:10.7863/jum.1994.13.12.992
  • Kanenshi H, Akahori A, Sakurai S, Yamauchi A, Sato I. Umbilical vein thrombosis as a possible cause of perinatal morbidity or mortality: report of two cases. J Obstet Gynaecol Res. 2001;27:97–101. doi:10.1111/j.1447-0756.2001.tb01228.x
  • Di Pasquo E, Kuleva M, O’Gorman N, Ville Y, Salomon LJ. Fetal intra-abdominal umbilical vein varix: a retrospective cohort study, systematic review of the literature and meta-analysis. Ultrasound Obstet Gynecol. 2018;51(5):580–585. doi:10.1002/uog.18895
  • Matsumoto Y, Yanai A, Kamei S, Yamaguchi A, Nakamine H, Fujita K. A case report of umbilical vein varix with thrombosis: prenatal ultrasonographic diagnosis and management. Case Rep Obstet Gynecol. 2019;2019:7154560. PMID 31467748. doi:10.11155/2019/7154560
  • Schröcksnadel H, Holböck E, Mitterschiffthalet G, Tötsch M, Daount O. Thrombotic occlusion of an umbilical vein varix causing fetal death. Arch Gynecol Obstet. 1991;248(4):213–215. PMID 1898126. doi:10.1007/BF02390361
  • Jackson J, Castro E, Belfort M, Shamsirshaz AA, Nassr A, Espinoza J. Massive extra-abdominal umbilical vein varix: a case report. Fetal Diagn Ther. 2021;48(2):158–162. doi:10.1159/000512490
  • Cassidy-Vu L, Clark S, Cuka N. Extra-abdominal umbilical vein varix in a newborn. BMJ Case Rep. 2019;12(5):e227424. PMID 31061189. doi:10.1136/bcr-2018-227424
  • Io S, Kondoh E, Iemura Y, et al. Severe fetal anemia as a consequence of extra-abdominal umbilical vein varix: a case report and review of the literature. Congenit Anom (Kyoto). 2020;61(1):4–8. PMID 33099808. doi:10.1111/cga12397
  • Beraud E, Rozel C, Milon J, Darnault P. Umbilical vein varix: importance of ante- and post-natal monitoring by ultrasound. Diagn Interv Imaging. 2015;96(1):21–26. PMID 24631035. doi:10.1016/j.diii.2014.01.009
  • Sepulveda W, Mackenna A, Sancjez J, Corral E, Carstens E. Fetal prognosis in varix on the intrafetal umbilical vein. J Ultrasound Med. 1998;17:171–175. doi:10.7863/jum.1998.17.3.171
  • Rahemtullah A, Leiberman E, Benson C, Norton ME. Outcome of pregnancy after prenatal diagnosis of umbilical vein varix. J Ultrasound Med. 2001;20:135–139. doi:10.7863/jum.2001.20.2.135
  • Lee SW, Kim MY, Kim JE, Chung JH, Lee HJ, Yoon JY. Clinical characteristics and outcomes of antenatal fetal intra-abdominal umbilical vein varix detection. Obstet Gynecol Sci. 2014;57(3):181–186. PMID 24883288. doi:10.5468/ogs.2014.57.3.181
  • TRöbs RB, Teig N, Neid M, Gernaianu G, Kozlowski P. Pseudotumrous enlargement of the umbilical cord owing to an intra-amniotic varicosity associated with thrombocytopenia. J Pediatr Surg. 2012;47(9):1760–1762. PMID 22974620. doi:10.1016/j.pedsurg.2012.06.018
  • Batton DG, Amanullah A, Comstock C. Fetal schistocytic hemolytic anemia and umbilical vein varix. J Pediatr Hematol Oncol. 2000;22(3):259–261. doi:10.1097/00043426-200005000-00013
  • Weissman-Brenner A, Simchen MJ, Moran O, Kassif E, Achiron R, Zalel Y. Isolated fetal umbilical vein varix – prenatal sonographic diagnosis and suggested management. Prenat Diagn. 2009;29(3):229–233. PMID 19177454. doi:10.1002/pd.2219
  • Babay ZA, Lange IR, Elliott PD, Hwang WS. Varix dilatation of the umbilical vein and review of the literature. Fetal Diagn Ther. 1996;11(3):221–223. doi:10.1159/000264306
  • Vandevijver N, Hermans RH, Schrander-Stumpel CC, Arenda JW, Peeters LL, Moerman PL. Aneurysm of the umbilical vein: case report and review of the literature. Eur J Obstet Gynecol Reprod Biol. 2001;89(1):85–87. PMID 10733030. doi:10.1016/s0301-2115(99)00167-0
  • Panda B, Stiller R, Iruretagoyena I, Levi A. Prenatal diagnosis of an umbilical vein aneurysm. Conn Med. 2009;3(8):465–467. PMID 19777980.
  • Akar M, Dilli D, Sandal G, Öncel MY, Erdeve Ö, Dilmen U. Prenatally diagnosed umbilical vein aneurysm with good prognosis. J Clin Ultrasound. 2012;40(6):368–369. PMID 22565416. doi:10.1002/jcu.21938
  • Shipp TD, Bromley B, Benacerraf B. Sonographically detected abnormalities of the umbilical cord. Int J Gynaecol Obstet. 1995;48(2):179–185. PMID 7789592. doi:10.1016/0020-7292(94)02297-c
  • Sepulveda A, Corral E, Kottman C, Vasquez P, Monckeberg MJ, Monckeberg MJ. Umbilical artery aneurysm: prenatal identification on three fetuses with trisomy 18. Ultrasound Obstet Gynecol. 2003;21(3):292–296. PMID 12666226. doi:10.1002/uog.69
  • Berg C, Geipel A, Germer U, Gloeckner-Hoffman K, Gembruch U. Prenatal diagnosis of umbilical cord aneurysm in a fetus with trisomy 18. Ultrasound Obstet Gynecol. 2001;17(1):79–81. PMID 12244663. doi:10.1046/j.1469-0705.2001.00313.x
  • Siddiqi TA, Bendon R, Schultz DM, Miodovnik M. Umbilical artery aneurysm: prenatal diagnosis and management. Obstet Gynecol. 1992;80(3Pt2):530–533. PMID 1495730.
  • Shen O, Reinus CM, Baranov A, Rabinowitz RR. Prenatal diagnosis of umbilical artery aneurysm: a potentially lethal anomaly. J Ultrasound Med. 2007;26(2):251–253. doi:10.7863/jum.2007.26.2.251
  • Weber MA, Sau A, Maxwell DJ, Mounter NA, Lucas SB, Sebire NJ. Third trimester intrauterine fetal death caused by arterial aneurysm of the umbilical cord. Ped Dev Pathol. 2007;10(4):305–308. PMID 17638427. doi:10.2350/06-07-0136.1
  • Sentilhes L, Vivet-Lefébure A, Patrier S, et al. Umbilical artery aneurysm in a severe growth-restricted fetus with normal karyotype. Prenat Diag. 2007;27(11):1059–1061. PMID 17621386. doi:10.1002/pd.1817
  • Doehrman P, Derksen B, Perlow JH, Clewell WH, Fineberg HJ. Umbilical artery aneurysm: a case report, literature review, and management recommendations. Obstet Gynecol Surv. 2014;69(3):159–163. PMID 25102347. doi:10.1097/OGX.0000000000000051
  • Hill AJ, String TH, Elliott JP, Perlow JH. Umbilical artery aneurysm. Obstet Gynecol. 2010;116(Suppl 2):559–562. PMID 20664454. doi:10.1097/AOG.Ob013e3181e7d280
  • Olog A, Thomas JT, Petersen S, Cattanach S, Lourie R, Gardner G. Large umbilical artery aneurysm with a live healthy baby delivered at 31 weeks. Fetal Diagn Ther. 2011;29(4):331–333. PMID 21212655. doi:10.1159/000322960
  • Vyas NM, Manjeera L, Rai SD. Prenatal diagnosis of umbilical artery aneurysm with good fetal outcome and review of the literature. J Clin Diagn Res. 2016;10(1):QD1–QD03. PMID 26894129.
  • Matsuki R, Nakago S, Kato H, Shibata T, Kotera T, Kotsuji F. Management strategy of umbilical artery aneurysm complicated by cardiac anomaly: case study and literature review. J Matern Fetal Neonatal Med. 2017;30(15):1809–1812. PMID 27580274. doi:10.1080/14767058.2016.1226796
  • Peng HQ, Levitin-Smith M, Rochelson B, Kahn E. Umbilical cord stricture and overcoiling are common causes of fetal demise. Pediatr Dev Pathol. 2006;9(1):14–19. PMID 16808633. doi:10.2350/05-05-0052.2
  • French AE, Gregg VH, Newberry Y, Parsons T. Umbilical cord stricture: a cause of recurrent fetal death. Obstet Gynecol. 2005;105(5 Pt 2):123–129. PMID 15863594. doi:10.1097/01.AOG.0000159041.55845.f7
  • Sun Y, Arbuckle S, Hocking G, Billson V. Umbilical cord stricture and intrauterine fetal death. Pediatr Pathol Lab Med. 1995;15(5):723–732. PMID: 8597859. doi:10.3109/15513819509027008
  • Hallak M, Pryde PG, Quresji F, Johnson MP, Jauques SM, Evans MI. Constriction of the umbilical cord leading to fetal death. A report of three cases. J Reprod Med. 1994;39(7):561–565. PMID 7966052.
  • Langhe R, Akpan E, Selvamani S, McEntagart N. Umbilical cord stricture causing intrauterine death. Ir Med J. 2020;113(4):62. PMID 32268055.
  • Robertson RD, Rubinstein LM, Wolfson WL, Lebherz TB, Blanchard JB, Crandall BF. Constriction of the umbilical cord as a cause of fetal demise following midtrimester amniocentesis. J Reprod Med. 1981;26(6):325–327. PMID 7252953.
  • Askenazy M, Borenstein R, Katz Z, Segal M. Constriction of the umbilical cord by amniotic band after midtrimester amniocentesis. Acta Obstet Gynecol. 1982;61(1):89–91. PMID 7090754. doi:10.31109/00016348209156959
  • Hadar A, Hallak M. Single umbilical artery and umbilical cord torsion leading to fetal death. A case report. J Reprod Med. 2003;48(9):739–740. PMID 14562642.
  • Ben-Arie A, Weissman A, Steinberg Y, Levy R, Hagay Z. Oligohydramnios, intrauterine growth retardation and fetal death due to umbilical cord torsion. Arch Gynecol Obstet. 1995;256(3):159–161. PMID 7574909. doi:10.1007/BF01314645
  • Collins JC, Muller RJ, Collins CL. Prenatal observation of umbilical cord abnormalities: a triple knot and torsion of the umbilical cord. Am J Obstet Gynecol. 1993;169(1):102–104. PMID 8333430. doi:10.1016/0002-9378(93)90139-a
  • Collins JH. Prenatal observation of umbilical cord torsion with subsequent premature labor and delivery of a 31- week infant with mild nonimmune hydrops. Am J Obstet Gynecol. 1995;172(3):1048–1049. PMID 7892849. doi:10.1016/0002-9378(95)90045-4
  • Bakotic MW, Bord T, Poppiti R, Pflueger S. Recurrent umbilical cord torsion leading to fetal death in subsequent pregnancies: a case report and review of the literature. Arch Pathol Lab Med. 2000;124(9):1352–1355. PMID 10975937. doi:10.5858/2000-124-1352
  • Schiesser M, Lapaire O, Holtzgreve W, Tercanli S. Umbilical cord edema associated with patent urachus. Ultrasound Obstet Gynecol. 2003;22(6):646–647. PMID 14689541. doi:10.1002/uog.924
  • Osawa K, Ito M, Sugiyama M, Kanamori Y, Hashizume K, Marumo G. Vesicoallantoic cyst in the umbilical cord. Fetal Diagn Ther. 2003;18:87–90. doi:10.1159/000068067
  • Campo LR, Cornudella RS, Alderete FG, et al. Prenatal diagnosis of umbilical cord cyst; Clinical significance and prognosis. Taiwan J Obstet Gynecol. 2017;56:622–627. doi:10.1016/j.tjog.2017.08.008
  • Emura T, Kanamori Y, Ito M, et al. Omphalocele associated with large multilobar umbilical cord pseudocyst. Pediatr Surg Int. 2004;20(8):636–639. PMID 15449087. doi:10.1007/s00383-004-1247-y
  • Ross JA, Jurkovic D, Zosmer N, Jauniaux E, Hacket E, Nicolaides KH. Umbilical cord cysts in early pregnancy. Obstet Gynecol. 1997;89(3):442–445. PMID 9052602. doi:10.1016/S0029-7844(96)00526-1
  • Sepulveda W, Leible S, Ulloa A, Ivankovic C, Schnapp C. Clinical significance of first trimester umbilical cord cysts. J Ultrasound Med. 1999;18(2):95–99. PMID 10206815. doi:10.7863/jum.1999.18.2.95
  • Ghezzi F, Raio L, Di Naro E, Franchi M, Cromi A, Dürig P. Single and multiple umbilical cord cysts in early gestation: two different entities. Ultrasound Obstet Gynecol. 2003;21(3):215–219. doi:10.1002/uog.68
  • Gilboa Y, Kivilevitch Z, Katzora E, et al. Outcome of fetuses with umbilical cords cysts diagnosed during nuchal translucency examination. J Ultrasound Med. 2011;30(11):1547–1551. doi:10.7863/jum.2011.30.11.1547
  • Smith GN, Walker M, Johnson S, Ash K. The sonographic finding of persistent umbilical cord cystic masses is associated with lethal aneuploidy and/or congenital anomalies. Prenat Diagn. 1996;16(12):1141–1147. doi:10.1002/(SICI)1097-0223(199612)16:12<1141::AID-PD2>3.0.CO;2-4
  • Zangen R, Boldes R, Yaffe H, Schwed P, Weiner Z. Umbilical cord cysts in the second and third trimesters: significance and prenatal approach. Ultrasound Obstet Gynecol. 2010;36(3):296–301. PMID 20131340. doi:10.1002/uog.7576
  • Gualandri G, Rivasi F, Santunione AL, Silingardi E. Spontaneous umbilical cord hematoma; an unusual cause of fetal mortality: a report of 3 cases and review of the literature. Am J Forensic Med Pathol. 2008;29(2):185–190. PMID 18520492. doi:10.1097/PAF.Ob013318174e1
  • Abraham A, Rathore S, Gupta M, Benjamin SJ. Umbilical cord haematoma casing stillbirth – a case report. J Clin Diagn Res. 2015;9(12):QD01–QD02. PMID 26816950. doi:10.7860/JCDR/2015/16106.6856
  • Summerville JW, Powar JS, Ueland K. Umbilical cord hematoma resulting in intrauterine fetal demise. A case report. J Reprod Med. 1987;32(3):213–216. PMID 3572905.
  • Romero R, Chervenak FA, Coustan D, Berkowitz RL, Hobbins JC. Antenatal sonographic diagnosis of umbilical cord laceration. Am J Obstet Gynecol. 1982;143(6):719–720. PMID 7091248. doi:10.1016/0002-9378(82)90123-5.
  • Morin LR, Bonan J, Vendrolini G, Bourgeois C. Sonography of umbilical cord hematoma following genetic amniocentesis. Acta Obstet Gynecol Scand. 1987;66(7):669–670. PMID 3326394. doi:10.3109/00016348709022080
  • Zacut H, Lotan M, Achiron R. Umbilical cord damage and placental abruption during amniocentesis. Acta Obstet Gynecol Scand. 1984;63(3):279–281. PMID 6730948. doi:10.3109/00016348409155516
  • Kirshen EJ, Benirschke K. Fetal exsanguination after amniocentesis. Obstet Gynecol. 1973;42(4):615–616. PMID 4742667. doi:10.1097/00006250-197310000-00024
  • Keckstein G, Tshürtz S, Scheinder V, Hütter W, Terinde R, Jonatha WD. Umbilical cord hematoma as a complication of intrauterine intravascular blood transfusion. Prenat Diagn. 1990;10(1):59–65. PMID 2107537. doi:10.1002/pd.1970100109
  • Feldberg D, Ben-David M, Dicker D, Samuel N, Goldman J. Hematoma of the umbilical cord with acute antepartum fetal distress. J Reprod Med. 1986;31(1):65–66. PMID 3950887.
  • Sepulveda W, Wong AE, Gonzalez R, Vasquez P, Gutierrez J. Fetal death due to umbilical cord hematoma: a rare complication of umbilical cord cyst. J Matern Fetal Neonatal Med. 2005;18(6):387–390. PMID 16390804. doi:10.1080/14767050500277602
  • Sánchez-Códez MI, Lubián-Gutiérrez M, Méndez-Abad P. Umbilical cord hematoma. Fetal Pediatr Pathol. 2019;38(4):359–360. PMID 30947594. doi:10.1080/15513815.2019.1584656
  • Naidu M, Nama V, Karoshi M, Kakumani V, Worth R. Umbilical cord rupture: a case report and review of the literature. Int J Fertil Womens Med. 2007;52(2–3):107–110. PMID 18320869.
  • Petrikovsky BM, Cooperman B, Kahn E, Pestrak H. Prenatal diagnosis of non-iatrogenic hematoma of the umbilical cord. J Clin Ultrasound. 1996;24(1):37–39. PMID 8655666. doi:10.1002/(SICI)1097-0096(19960)24:1<37::AID-JCU><37::AID-JCU>3.0CO;2-M
  • Chou ZY, Chen YR, Wu CF, et al. Spontaneous umbilical hematoma diagnosed antenatally with ultrasonography. Acta Obstet Gynecol Scand. 2003;82:1056–1057. doi:10.1034/j.1600-0412.2003.00087.x
  • Brown R, Nicolaides K. Umbilical cord hematoma associated with an umbilical cord cyst and fetal death at 28 weeks of gestation. J Ultrasound Med. 2000;19(3):223–225. doi:10.7863/jum.2000.19.3.223
  • Curtin WM, Maines JL, DeAngeleis CT, Condon NA, Ural SH, Millington KA. Hemorrhage from umbilical cord ulceration identified on real-times ultrasound in a fetus with duodenal atresia. Case Report Obstet Gynecol. 2019;2019:2680170. doi:10.1155/2019/2680170
  • Angelico G, Spadola A, Ieni A, et al. Hemangioma of umbilical cord with associated amniotic inclusion cyst: two uncommon entities occurring simultaneously. Pathologica. 2019;111:13–17. doi:10.32074/1591-951X-26-17
  • Kamitomo M, Sueyoshi K, Matsukita S, Matsuda Y, Hatae M, Ikenoe T. Hemangioma of the umbilical cord: stenotic change of the umbilical vessels. Fetal Diagn Ther. 1999;14(6):328–331. PMID 10640869. doi:10.1159/000020951
  • Seifer D, Ferguson JE, Behrens CM, Zemel S, Stevenson DK, Rose JC. Nonimmune hydrops fetalis in association with hemangioma of the umbilical cord. Obstet Gynecol. 1985;66(2):283–286. PMID 3895076.
  • Drombrowski MP, Budev H, Wolfe HM, Sokol RJ, Perrin E. Fetal hemorrhage from umbilical cord hemangioma. Obstet Gynecol. 1987;70(3 Pt 2):439–442. PMID 3627598.
  • Smulian JC, Sarno AP, Rochon ML, Loven VA. The natural history of an umbilical cord hemangioma. J Clin Ultrasound. 2016;44(7):455–458. PMID 26899634. doi:10.1002/jcu.22346.
  • Vougiouklakis T, Mitselou A, Zikopoulos K, Dallas P, Charalabopulous K. Ruptured hemangioma of the umbilical cord and intrauterine fetal death, with review data. Pathol Res Pract. 2006;202(7):537–540. PMID 16684589. doi:10.1016/j.prp.2006.02.008
  • Jacques SM, Qureshi F. Hemangioma of the umbilical cord with amniotic epithelial inclusion cyst. Fetal Pediatr Pathol. 2013;32(3):235–239. PMID 23017112. doi:10.3109/15513815.2012.721478
  • Matsuda S, Sato Y, Marutsuka K, et al. Hemangioma of the umbilical cord with pseudocyst. Fetal Pediatr Pathol. 2011;30(1):16–21. PMID 21204661. doi:10.3109/15513811003796920
  • Resta RG, Luthy DA, Mahony BS. Umbilical cord hemangioma associated with extremely high alpha-fetoprotein levels. Obstet Gynecol. 1988;72(3 Pt 2):488–491. PMID 2457194.
  • Miller KA, Gauderer MW. Hemangioma of the umbilical cord mimicking an omphalocele. J Pediatr Surg. 1997;32(6):810–812. PMID 9200074. doi:10.1016/s0022-3468(97)90625-4
  • Pollack MS, Bound NM. Hemangioma of the umbilical cord. Sonographic appearance. J Ultrasound Med. 1989;8(3):163–166. doi:10.7863/jum/1989.8.3.163
  • Mishriki YY, Vanyselbaum Y, Epstein H, Blanc W. Hemangioma of the umbilical cord. Pediatr Pathol. 1987;7(1):43–49. doi:10.1080/15513818709177113
  • Ghidini A, Romero R, Eisen RN, Smith GJ, Hobbins JC. Umbilical cord hemangioma. Prenatal identification and review of the literature. J Ultrasound Med. 1990;9(5):297–300. PMID 2188011. doi:10.7863/jum.1990.9.5.297
  • Schwickert A, Seeger KH, Rancourt RC, Henrich W. Prenatally detected umbilical cord tumor as a sign of diffuse neonatal hemangiomas. J Clin Ultrasound. 2019;47(6):366–368. PMID 30673136. doi:10.1002/jcu.22689
  • Sahinoglu Z, Uludogan M, Deilkara NM. Prenatal sonographic diagnosis of Klippel-Trenaunay-Weber syndrome associated with umbilical cord hemangioma. Am J Perinatol. 2003;20(1):1–6. PMID 12638074. doi:10.1055/s-2003-37950
  • Yu D, Sun L, Chen T. Prenatal ultrasound diagnosis of Klippel-Trenaunay-Weber syndrome associated with umbilical cord hemangioma. J Clin Ultrasound. 2020;49(3):254–256. PMID 33210306. doi:10.1002/jc22896.
  • Göksever H, Celilogu M, Küpelioglu A. Angiomyxoma: a rare tumor of the umbilical cord. J Turk Ger Gynecol Assoc. 2010;11(1):58–60. PMID 24691896.
  • Jauniaux E, Moscoso G, Chitty L, Gibb D, Driver M, Cambell S. An angiomyxoma involving the whole length of the umbilical cord. Prenatal diagnosis by ultrasonography. J Ultrasound Med. 1990;9(7):419–422. PMID 2197425. doi:10.7863/jum.1990.9.7.419
  • Yavner DL, Redile RW. Angiomyxoma of the umbilical cord with massive cystic degeneration of Wharton’s jelly. Arch Pathol. 1989;113(8):935–937. PMID 2547350.
  • Cheng HP, Hsu CY, Chen CP, Su TH. Angiomyxoma of the umbilical cord. Taiwan J Obstet Gynecol. 2006;45(4):360–362. PMID 17175501. doi:10.1016/S1028-4559(09)60262-X
  • Wilson RD, Magee JF, Sorensen PH, Johnson A. In utero decompression of umbilical cord angiomyxoma followed by vaginal delivery. Am J Obstet Gynecol. 1994;171(5):1383–1385. PMID 7977553. doi:10.1016/0002-937(94)90167-8
  • Gramellini D, Pedrazzoli G, Sacchini C, Montalto M, Pianelli G. Color Doppler ultrasound in prenatal diagnosis of umbilical cord angiomyxoma. Case Report. Clin Exp Obstet Gynecol. 1993;20(4):241–244.
  • Tennstedt C, Chaoul R, Bollman R, Dietel M. Angiomyxoma of the umbilical cord in one twin with cystic degeneration of Wharton’s jelly. A case report. Pathol Res Pract. 1998;194(1):55–58. PMID 9542748. doi:10.1016/SO344-0344(98)80012.5
  • Zhang L, Hunag S, Li J, et al. A case of umbilical cord angiomyxoma with massive arteriovenous shunts diagnosed with HDlive Flow. J Med Ultrason (2001). 2021;48(1):109–110. doi:10.1007/s10396-020-01063-1
  • Adams KV, Berniieh A, Morris RW, Saad AG. Umbilical cord teratomas associated with congenital malformations. Arch Pathol Lab Med. 2019;144(2):156–159. PMID 31644321. doi:10.5858/arpa.2019-0161-RA.
  • Diwakar RK, Dwivedi MK. Benign neoplasm of umbilical cord: sonographic diagnosis and short literature review. Arch Radiol. 2019;2(2):24–27.
  • Satgé DCL, Laumond MA, Desfrages F, Chenard MPR. An umbilical cord teratoma in a 17-week-old fetus. Prenat Diagn. 2001;21(4):284–288. PMID 11288118. doi:10.1002/pd.47
  • Bakhru S, Jmalpuri V, Koneti NR. Diagnosis and management of congenital umbilical arteriovenous malformation. Cardiol Young. 2020;31:1–3. PMID33261691. doi:10.1017/S1047951120004138
  • Boglione MM, D’Alessandro P, Reusman A, Rubio M, Lipsich J, Goldsmith G. Umbilical arteriovenous malformation in a healthy neonate with umbilical hernia. J Neonat Surg. 2013;2(3):35. doi:10.47338/jns.v2.47
  • Meyer M, Barsness KA. Umbilical arteriovenous malformation: a case report and literature review. Pediatr Surg Int. 2013;29(8):851–853. PMID 23474574. doi:10.1007/s00383-013-3297-5
  • Gregorio-Hernández R, Sanz-López E, Aguado-Del Hoyo A, Manrigue-Martín G, De Agustín JC, Sánchez-Luna M. A rare complex case of congenital umbilical arteriovenous malformation and review of the literature. Am J Perinatol Rep. 2016;6(2):e216–e221. PMID 27294008. doi:10.1055/s-0036-1584239
  • Shinata M, Kanehiro H, Shinkawa T, et al. A neonate with umbilical arteriovenous malformation showing hemorrhagic shock massive umbilical hemorrhage. Am J Perinatol. 2009;26(8):583–586. PMID 19399703. doi:10.1055/s-0029-1220778
  • Suzui I, Masuyama H, Hirano Y, Nishida T, Hayata K, Hiramatsu Y. Prenatal diagnosis of umbilical arteriovenous malformation. J Matern Fetal Neonatal Med. 2017;30(1):85–87. PMID 26952649. doi:10.3109/14767058.2016.1163542
  • Richards DS, Lutfi E, Mullins D, Sandler DL, Raynor BD. Prenatal diagnosis of fetal disseminated intravascular coagulation associated with umbilical cord arteriovenous malformation. Obstet Gynecol. 1995;85(5 Pt 2):860–862. PMID 7724138.
  • Baylis MS, Jones RY, Hughes M. Angiomyxoma of the umbilical cord detected antenatally by ultrasound. J Obstet Gynecol. 1984;4:243–244.
  • Mei-Dan E, Glanc P, Hui D, Barrett J. Spontaneous resolution of an umbilical cord arteriovenous fistula. Case Rep Perinat Med. 2014;4(1):25–27. doi:10.1515/crpm-2014-0013
  • Pellerito J, Bromley B, Allison S, et al. AIUM-ACR-ACOG-SMFM-SRU practice parameter for the performance of standard diagnostic obstetrical ultrasound examinations. J Ultrasound Med. 2018;37:E13–E24. doi:10.1002/jum.14831
  • Salomon LJ, Alfirevic Z, Berghella V, et al.; on behalf of the ISUOG Clinical Standards Committee. Practice guidelines for performance of the routine mid-trimester fetal ultrasound scan. Ultrasound Obstet Gynecol. 2011;37(1):116–126. doi:10.1002/uog.8831.
  • Kumar I, Verma A, Jain M, Shuka RC. Structured evaluation and reporting in imaging of placenta and umbilical cord. Acta Radiol. 2020;61(5):685–704. doi:10.1177/0284185119875644
  • NASA. Ed White, the first American to perform extravehicular activity, outside of Gemini IV; 1965. Available from: https://en.wikipedia.org/wiki/Gemini_4#/media/File:Ed_White_First_American_Spacewalker_-_GPN-2000-001180.jpg. Accessed October 1, 2021;