Overcoming resistance and barriers to the use of local estrogen therapy for the treatment of vaginal atrophy

References

• SantoroNKomiJPrevalence and impact of vaginal symptoms among postmenopausal womenJ Sex Med2009682133214219493278
   PubMed Web of Science ®Google Scholar
• NappiREKokot-KierepaMWomen’s voices in the menopause: results from an international survey on vaginal atrophyMaturitas201067323323820828948
   PubMed Web of Science ®Google Scholar
• CrandallCPetersenLGanzPAGreendaleGAAssociation of breast cancer and its therapy with menopause-related symptomsMenopause200411551953015356404
   PubMed Web of Science ®Google Scholar
• SturdeeDWPanayNInternational Menopause Society Writing GroupRecommendations for the management of postmenopausal vaginal atrophyClimacteric201013650952220883118
   PubMed Web of Science ®Google Scholar
• LevineKBWilliamsREHartmannKEVulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal womenMenopause2008154 Pt 166166618698279
   PubMed Web of Science ®Google Scholar
• KrychmanMImpact of vaginal atrophy on quality of life and sexualityOBG Manage20102211S14S19
   Google Scholar
• KingsbergSKelloggSKrychmanMTreating dyspareunia caused by vaginal atrophy: a review of treatment options using vaginal estrogen therapyInt J Womens Health2010110511121072280
   PubMedGoogle Scholar
• ReimerAJohnsonLAtrophic vaginitis: signs, symptoms, and better outcomesNurse Pract2011361222821150811
   PubMedGoogle Scholar
• DenizGAntoineCLiebensFCarlyBPastijnARozenbergSTreatment of premature menopause in breast cancer patientsActa Chir Belg2007107326326617685250
   PubMed Web of Science ®Google Scholar
• LaraLAUsecheBFerrianiRAThe effects of hypoestrogenism on the vaginal wall: interference with the normal sexual responseJ Sex Med200961303919170834
   PubMed Web of Science ®Google Scholar
• Mac BrideMBRhodesDJShusterLTVulvovaginal atrophyMayo Clin Proc2010851879420042564
   PubMed Web of Science ®Google Scholar
• North American Menopause SocietyThe 2012 hormone therapy position statement of: The North American Menopause SocietyMenopause201219325727122367731
   PubMed Web of Science ®Google Scholar
• UtianWHShoupeDBachmannGPinkertonJVPickarJHRelief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetateFertil Steril20017561065107911384629
   PubMed Web of Science ®Google Scholar
• BachmannGASchaefersMUddinAUtianWHLowest effective transdermal 17beta-estradiol dose for relief of hot flushes in postmenopausal women: a randomized controlled trialObstet Gynecol2007110477177917906008
   PubMed Web of Science ®Google Scholar
• BachmannGASchaefersMUddinAUtianWHMicrodose transdermal estrogen therapy for relief of vulvovaginal symptoms in postmenopausal womenMenopause200916587788219458560
   PubMed Web of Science ®Google Scholar
• GuptaPOzelBStanczykFZFelixJCMishellDRJrThe effect of transdermal and vaginal estrogen therapy on markers of postmenopausal estrogen statusMenopause2008151949717882008
   PubMed Web of Science ®Google Scholar
• SimonJABouchardCWaldbaumAUtianWZborowskiJSnabesMCLow dose of transdermal estradiol gel for treatment of symptomatic postmenopausal women: a randomized controlled trialObstet Gynecol2007109358859617329509
   PubMed Web of Science ®Google Scholar
• JohnsonSREttingerBMacerJLEnsrudKEQuanJGradyDUterine and vaginal effects of unopposed ultralow-dose transdermal estradiolObstet Gynecol2005105477978715802405
   PubMed Web of Science ®Google Scholar
• PanayNYlikorkalaOArcherDFGutRLangEUltra-low-dose estradiol and norethisterone acetate: effective menopausal symptom reliefClimacteric200710212013117453860
   PubMed Web of Science ®Google Scholar
• BoothbyLADoeringPLKipersztokSBioidentical hormone therapy: a reviewMenopause200411335636715167316
   PubMed Web of Science ®Google Scholar
• BachmannGSantenRJClinical manifestations and diagnosis of vaginal atrophyBasowDSUpToDateWaltham, MAUpToDate2011 Available from: http://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-vaginal-atrophy?source=search_result&search=Clinical+manifestations+and+diagnosis+of+vaginal+atrophy&selectedTitle=1-45Accessed August 28, 2012
   Google Scholar
• BondSHortonLSManagement of postmenopausal vaginal symptoms in womenJ Gerontol Nurs201036737
   Web of Science ®Google Scholar
• RoySCaillouetteJCRoyTFadenJSVaginal pH is similar to follicle-stimulating hormone for menopause diagnosisAm J Obstet Gynecol200419051272127715167829
   PubMed Web of Science ®Google Scholar
• BrunnerRLAragakiABarnabeiVMenopausal symptom experience before and after stopping estrogen therapy in the Women’s Health Initiative randomized, placebo-controlled trialMenopause201017594695420505547
   PubMed Web of Science ®Google Scholar
• SucklingJLethabyAKennedyRLocal oestrogen for vaginal atrophy in postmenopausal womenCochrane Database Syst Rev20064CD00150017054136
   PubMedGoogle Scholar
• SimonJNachtigallLGutRLangEArcherDFUtianWEffective treatment of vaginal atrophy with an ultra-low-dose estradiol vaginal tabletObstet Gynecol200811251053106018978105
   PubMed Web of Science ®Google Scholar
• SimonJNachtigallLUlrichLGEugster-HausmannMGutREndometrial safety of ultra-low-dose estradiol vaginal tabletsObstet Gynecol2010116487688320859151
   PubMed Web of Science ®Google Scholar
• WeisbergEAytonRDarlingGEndometrial and vaginal effects of low-dose estradiol delivered by vaginal ring or vaginal tabletClimacteric200581839215804736
   PubMed Web of Science ®Google Scholar
• BachmannGBouchardCHoppeDEfficacy and safety of low-dose regimens of conjugated estrogens cream administered vaginallyMenopause200916471972719436223
   PubMed Web of Science ®Google Scholar
• PonzoneRBigliaNJacomuzziMEMaggiorottoFMarianiLSismondiPVaginal oestrogen therapy after breast cancer: is it safe?Eur J Cancer200541172673268116239103
   PubMed Web of Science ®Google Scholar
• PruthiSSimonJAEarlyAPCurrent overview of the management of urogenital atrophy in women with breast cancerBreast J201117440340821645165
   PubMed Web of Science ®Google Scholar
• DewJEWrenBGEdenJAA cohort study of topical vaginal estrogen therapy in women previously treated for breast cancerClimacteric200361455212725664
   PubMed Web of Science ®Google Scholar
• KendallADowsettMFolkerdESmithICaution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitorsAnn Oncol200617458458716443612
   PubMed Web of Science ®Google Scholar
• RossouwJEAndersonGLPrenticeRLWriting Group for the Women’s Health Initiative InvestigatorsRisks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trialJAMA2002288332133312117397
   PubMed Web of Science ®Google Scholar
• North American Menopause SocietyMenopause Practice: A Clinician’s Guide4th edMayfield Heights, OHThe North American Menopause Society2010
   Google Scholar
• LangerRDEfficacy, safety, and tolerability of low-dose hormone therapy in managing menopausal symptomsJ Am Board Fam Med200922556357319734403
   PubMed Web of Science ®Google Scholar
• Eugster-HausmannMWaitzingerJLehnickDMinimized estradiol absorption with ultra-low-dose 10 microg 17beta-estradiol vaginal tabletsClimacteric201013321922720423242
   PubMed Web of Science ®Google Scholar
• BachmannGThe estradiol vaginal ring – a study of existing clinical dataMaturitas199522SupplS21S298775773
   PubMed Web of Science ®Google Scholar
• MartinPLYenSSBurnierAMHermannHSystemic absorption and sustained effects of vaginal estrogen creamsJAMA19792422426992700228093
   PubMed Web of Science ®Google Scholar
• LabrieFCusanLGomezJLEffect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal womenMenopause2009161303618820592
   PubMed Web of Science ®Google Scholar
• WhitlockEPOrleansCTPenderNAllanJEvaluating primary care behavioral counseling interventions: an evidence-based approachAm J Prev Med200222426728411988383
   PubMed Web of Science ®Google Scholar