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ORIGINAL RESEARCH

Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles

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Pages 1971-1979 | Received 05 Oct 2023, Accepted 14 Dec 2023, Published online: 20 Dec 2023

References

  • Ozturk S, Demir R. Particular functions of estrogen and progesterone in establishment of uterine receptivity and embryo implantation. Histol Histopathol. 2010;25(9):1215–1228. doi:10.14670/HH-25.1215
  • Cheng J, Sha Z, Li J, et al. Progress on the role of estrogen and progesterone signaling in mouse embryo implantation and decidualization. Reprod Sci. 2023;30(6):1746–1757. doi:10.1007/s43032-023-01169-0
  • Melo MA, Meseguer M, Garrido N, Bosch E, Pellicer A, Remohi J. The significance of premature luteinization in an oocyte-donation programme. Hum Reprod. 2006;21(6):1503–1507. doi:10.1093/humrep/dei474
  • Li R, Qiao J, Wang L, Zhen X, Lu Y. Serum progesterone concentration on day of HCG administration and IVF outcome. Reprod Biomed Online. 2008;16(5):627–631. doi:10.1016/S1472-6483(10)60475-0
  • Nikas G, Makrigiannakis A. Endometrial pinopodes and uterine receptivity. Ann N Y Acad Sci. 2003;997(1):120–123. doi:10.1196/annals.1290.042
  • Labarta E, Martinez-Conejero JA, Alama P, et al. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011;26(7):1813–1825. doi:10.1093/humrep/der126
  • Zhang J, Du M, Wu Y, Wei Z, Guan Y. Effect of serum progesterone levels on hCG trigger day on pregnancy outcomes in GnRH antagonist cycles. Front Endocrinol. 2022;13:982830. doi:10.3389/fendo.2022.982830
  • Kalakota NR, George LC, Morelli SS, Douglas NC, Babwah AV. Towards an improved understanding of the effects of elevated progesterone levels on human endometrial receptivity and oocyte/embryo quality during assisted reproductive technologies. Cells. 2022;11(9):1405. doi:10.3390/cells11091405
  • Papanikolaou EG, Pados G, Grimbizis G, et al. GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Hum Reprod. 2012;27(6):1822–1828. doi:10.1093/humrep/des066
  • Jiang W, Li D, Zhu L, et al. Elevated serum progesterone levels on the hCG trigger day have a negative impact on the live birth rate in the first fresh IVF-ET cycle. J Obstet Gynaecol. 2022;42(8):3503–3508. doi:10.1080/01443615.2022.2151345
  • Huang C, Shen X, Shi Q, et al. Adverse impact of elevated serum progesterone and luteinizing hormone levels on the hCG trigger day on clinical pregnancy outcomes of modified natural frozen-thawed embryo transfer cycles. Front Endocrinol. 2022;13:1000047. doi:10.3389/fendo.2022.1000047
  • Lepage J, Keromnes G, Epelboin S, Luton D, Yazbeck C. Premature progesterone rise on day of hCG negatively correlated with live birth rate in IVF cycles: an analysis of 1022 cycles. J Gynecol Obstet Hum. 2019;48(1):51–54. doi:10.1016/j.jogoh.2018.05.005
  • Martinez F, Coroleu B, Clua E, et al. Serum progesterone concentrations on the day of HCG administration cannot predict pregnancy in assisted reproduction cycles. Reprod Biomed Online. 2004;8(2):183–190. doi:10.1016/S1472-6483(10)60514-7
  • Doldi N, Marsiglio E, Destefani A, Gessi A, Merati G, Ferrari A. Elevated serum progesterone on the day of HCG administration in IVF is associated with a higher pregnancy rate in polycystic ovary syndrome. Hum Reprod. 1999;14(3):601–605. doi:10.1093/humrep/14.3.601
  • Wu Z, Dong Y, Ma Y, et al. Progesterone elevation on the day of hCG trigger has detrimental effect on live birth rate in low and intermediate ovarian responders, but not in high responders. Sci Rep. 2019;9(1):5127. doi:10.1038/s41598-019-41499-1
  • Bosch E, Labarta E, Crespo J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25(8):2092–2100. doi:10.1093/humrep/deq125
  • Papanikolaou EG, Kolibianakis EM, Pozzobon C, et al. Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer. Fertil Sterility. 2009;91(3):949–952. doi:10.1016/j.fertnstert.2006.12.064
  • Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update. 2013;19(5):433–457. doi:10.1093/humupd/dmt014
  • Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96(2):344–348. doi:10.1016/j.fertnstert.2011.05.050
  • Yding Andersen C, Bungum L, Nyboe Andersen A, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online. 2011;23(2):187–195. doi:10.1016/j.rbmo.2011.04.003
  • Tanada MS, Yoshida IH, Santos M, et al. The impact of high progesterone levels on the day of HCG administration in assisted human reproduction treatments. JBRA Assist Reprod. 2018;22(2):99–101. doi:10.5935/1518-0557.20180020
  • Huang Y, Wang EY, Du QY, et al. Progesterone elevation on the day of human chorionic gonadotropin administration adversely affects the outcome of IVF with transferred embryos at different developmental stages. Reprod Biol Endocrinol. 2015;13:82. doi:10.1186/s12958-015-0075-3
  • Corti L, Papaleo E, Pagliardini L, et al. Fresh blastocyst transfer as a clinical approach to overcome the detrimental effect of progesterone elevation at hCG triggering: a strategy in the context of the Italian law. Eur J Obstet Gynecol Reprod Biol. 2013;171(1):73–77. doi:10.1016/j.ejogrb.2013.08.017
  • Kong N, Liu J, Jiang Y, et al. Adverse impact of elevated progesterone levels on human chorionic gonadotropin trigger day on blastocyst transfer outcomes in gonadotropin-releasing hormone agonist cycles. Eur J Obstet Gynecol Reprod Biol. 2022;276:107–112. doi:10.1016/j.ejogrb.2022.07.007
  • Ochsenkuhn R, Arzberger A, von Schonfeldt V, et al. Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2555 fresh embryo transfers. Fertil Sterility. 2012;98(2):347–354.
  • Elgindy EA, Abou-Setta AM, Mostafa MI. Blastocyst-stage versus cleavage-stage embryo transfer in women with high oestradiol concentrations: randomized controlled trial. Reprod Biomed Online. 2011;23(6):789–798. doi:10.1016/j.rbmo.2011.08.011
  • Song J, Duan C, Cai W, Wu W, Lv H, Xu J. Comparison of GnRH-a prolonged protocol and short GnRH-a long protocol in patients with thin endometrium for assisted reproduction: a retrospective cohort study. Drug Des Devel Ther. 2020;14:3673–3682. doi:10.2147/DDDT.S270519
  • Liu Y, Ma L, Zhu M, Yin H, Yan H, Shi M. STROBE-GnRHa pretreatment in frozen-embryo transfer cycles improves clinical outcomes for patients with persistent thin endometrium: a case-control study. Medicine. 2022;101(31):e29928. doi:10.1097/MD.0000000000029928
  • Maheshwari A, Pandey S, Amalraj Raja E, Shetty A, Hamilton M, Bhattacharya S. Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Human Reproduction Update. 2018;24(1):35–58. doi:10.1093/humupd/dmx031
  • Sciorio R, Esteves SC. Clinical utility of freeze-all approach in ART treatment: a mini-review. Cryobiology. 2020;92:9–14. doi:10.1016/j.cryobiol.2019.11.041
  • Duarte-Filho OB, Podgaec S. Freeze-all policy for in vitro fertilization in women with normal response to ovarian stimulation. Einstein. 2021;19:eAO6290. doi:10.31744/einstein_journal/2021AO6290
  • Chen ZJ, Shi Y, Sun Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. New Engl J Med. 2016;375(6):523–533. doi:10.1056/NEJMoa1513873
  • Zhu Y, Zhang F, Chen H, Sun X, Jiang F. The use of frozen embryos and frozen sperm have complementary IVF outcomes: a retrospective analysis in couples experiencing IVF/Donor and IVF/Husband. BMC Pregnancy Childbirth. 2022;22(1):776. doi:10.1186/s12884-022-05088-x
  • Gullo G, Basile G, Cucinella G, et al. Fresh vs. frozen embryo transfer in assisted reproductive techniques: a single center retrospective cohort study and ethical-legal implications. Eur Rev Med Pharmacol Sci. 2023;27(14):6809–6823. doi:10.26355/eurrev_202307_33152
  • Gullo G, Scaglione M, Cucinella G, et al. Neonatal outcomes and long-term follow-up of children born from frozen embryo, a narrative review of latest research findings. Medicina. 2022;58(9):1218. doi:10.3390/medicina58091218
  • Medenica S, Zivanovic D, Batkoska L, et al. The future is coming: artificial intelligence in the treatment of infertility could improve assisted reproduction outcomes-the value of regulatory frameworks. Diagnostics. 2022;12(12):2979. doi:10.3390/diagnostics12122979
  • Burgio S, Polizzi C, Buzzaccarini G, et al. Psychological variables in medically assisted reproduction: a systematic review. Prz Menopauzalny. 2022;21(1):47–63. doi:10.5114/pm.2022.114404
  • Griesinger G, Mannaerts B, Andersen CY, Witjes H, Kolibianakis EM, Gordon K. Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. Fertil Sterility. 2013;100(6):1622–1623. doi:10.1016/j.fertnstert.2013.08.045
  • Requena A, Cruz M, Bosch E, Meseguer M, Garcia-Velasco JA. High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study. Reprod Biol Endocrinol. 2014;12(1):69. doi:10.1186/1477-7827-12-69
  • Xu B, Li Z, Zhang H, et al. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Sterility. 2012;97(6):1321–1324. doi:10.1016/j.fertnstert.2012.03.014