Higher Cumulative Live Birth Rate but Also Higher Late Miscarriage Risk in Non-Obese Women with Polycystic Ovary Syndrome Undergoing the First IVF/ICSI Cycle

References

• Robin G, Gallo C, Catteau-Jonard S, et al. Polycystic Ovary-Like Abnormalities (PCO-L) in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 2012;97(11):4236–4243. doi:10.1210/jc.2012-1836
   PubMed Web of Science ®Google Scholar
• Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352(12):1223–1236. doi:10.1056/NEJMra041536
   PubMed Web of Science ®Google Scholar
• Dapas M, Dunaif A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr Rev. 2022;43(6):927–965. doi:10.1210/endrev/bnac001
   PubMed Web of Science ®Google Scholar
• Radwan RA, Abuelezz NZ, Abdelraouf SM, Bakeer EM, Rahman A. Decreased serum level of gamma-amino butyric acid in Egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) Vitamin D levels. J Med Biochem. 2019;38(4):512–518. doi:10.2478/jomb-2018-0051
   PubMed Web of Science ®Google Scholar
• Ullah A, Jahan S, Razak S, et al. Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. J Ovarian Res. 2017;10(1):62. doi:10.1186/s13048-017-0359-7
   PubMedGoogle Scholar
• Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016;31(12):2841–2855. doi:10.1093/humrep/dew218
   PubMed Web of Science ®Google Scholar
• Diamanti-Kandarakis E, Kandarakis H, Legro RS. The role of genes and environment in the etiology of PCOS. Endocrine. 2006;30(1):19–26. doi:10.1385/ENDO:30:1:
   PubMed Web of Science ®Google Scholar
• Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106(1):6–15. doi:10.1016/j.fertnstert.2016.05.003
   PubMed Web of Science ®Google Scholar
• March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010;25(2):544–551. doi:10.1093/humrep/dep399
   PubMed Web of Science ®Google Scholar
• Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057. doi:10.1038/nrdp.2016.57
   PubMed Web of Science ®Google Scholar
• Balen AH, Morley LC, Misso M, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687–708. doi:10.1093/humupd/dmw025
   PubMed Web of Science ®Google Scholar
• Gilbert EW, Tay CT, Hiam DS, Teede HJ, Moran LJ. Comorbidities and complications of polycystic ovary syndrome: an overview of systematic reviews. Clin Endocrinol. 2018;89(6):683–699. doi:10.1111/cen.13828
   PubMed Web of Science ®Google Scholar
• Kalra S, Aggarwal S, Khandelwal D. Thyroid dysfunction and dysmetabolic syndrome: the need for enhanced thyrovigilance strategies. Int J Endocrinol. 2021;2021:9641846. doi:10.1155/2021/9641846
   PubMed Web of Science ®Google Scholar
• Della Corte L, Foreste V, Barra F, et al. Current and experimental drug therapy for the treatment of polycystic ovarian syndrome. Expert Opin Investig Drugs. 2020;29(8):819–830. doi:10.1080/13543784.2020.1781815
   PubMed Web of Science ®Google Scholar
• Devesa M, Tur R, Rodriguez I, Coroleu B, Martinez F, Polyzos NP. Cumulative live birth rates and number of oocytes retrieved in women of advanced age. A single centre analysis including 4500 women >/=38 years old. Hum Reprod. 2018;33(11):2010–2017. doi:10.1093/humrep/dey295
   PubMed Web of Science ®Google Scholar
• Maheshwari A, McLernon D, Bhattacharya S. Cumulative live birth rate: time for a consensus? Hum Reprod. 2015;30(12):2703–2707. doi:10.1093/humrep/dev263
   PubMed Web of Science ®Google Scholar
• Mackens S, Drakopoulos P, Moeykens MF, et al. Cumulative live birth rate after ovarian stimulation with freeze-all in women with polycystic ovaries: does the polycystic ovary syndrome phenotype have an impact? Reprod Biomed Online. 2022;44(3):565–571. doi:10.1016/j.rbmo.2021.11.009
   PubMed Web of Science ®Google Scholar
• Palomba S, La Sala GB. Pregnancy complications in women with polycystic ovary syndrome: importance of diagnostic criteria or of phenotypic features? Hum Reprod. 2016;31(1):223–224. doi:10.1093/humrep/dev284
   PubMed Web of Science ®Google Scholar
• Bahri Khomami M, Boyle JA, Tay CT, et al. Polycystic ovary syndrome and adverse pregnancy outcomes: current state of knowledge, challenges and potential implications for practice. Clin Endocrinol. 2018;88(6):761–769. doi:10.1111/cen.13579
   PubMed Web of Science ®Google Scholar
• Li Y, Ruan X, Wang H, et al. Comparing the risk of adverse pregnancy outcomes of Chinese patients with polycystic ovary syndrome with and without antiandrogenic pretreatment. Fertil Steril. 2018;109(4):720–727. doi:10.1016/j.fertnstert.2017.12.023
   PubMed Web of Science ®Google Scholar
• Kelley AS, Smith YR, Padmanabhan V. A narrative review of placental contribution to adverse pregnancy outcomes in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2019;104(11):5299–5315. doi:10.1210/jc.2019-00383
   PubMed Web of Science ®Google Scholar
• Ademoglu EN, Gorar S, Carlıoglu A, et al. Plasma nesfatin-1 levels are increased in patients with polycystic ovary syndrome. J Endocrinol Invest. 2014;37(8):715–719. doi:10.1007/s40618-014-0089-2
   PubMed Web of Science ®Google Scholar
• Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian J Med Res. 2019;150(4):333–344. doi:10.4103/ijmr.IJMR_1937_17
   PubMed Web of Science ®Google Scholar
• Toosy S, Sodi R, Pappachan JM. Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach. J Diabetes Metab Disord. 2018;17(2):277–285. doi:10.1007/s40200-018-0371-5
   PubMed Web of Science ®Google Scholar
• Mirza FG, Tahlak MA, Rjeili RB, et al. Polycystic Ovarian Syndrome (PCOS): does the challenge end at conception? Int J Environ Res Public Health. 2022;19(22):14914 doi:10.3390/ijerph192214914.
   PubMed Web of Science ®Google Scholar
• Ribeiro LM, Sasaki LMP, Silva AA, et al. Overweight, obesity and assisted reproduction: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2022;271:117–127. doi:10.1016/j.ejogrb.2022.01.019
   PubMed Web of Science ®Google Scholar
• Rotterdam EA-SPCWG. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19–25. doi:10.1016/j.fertnstert.2003.10.004
   Web of Science ®Google Scholar
• Chen ZJ, Shi Y, Sun Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375(6):523–533. doi:10.1056/NEJMoa1513873
   PubMed Web of Science ®Google Scholar
• Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW. The role of infection in miscarriage. Hum Reprod Update. 2016;22(1):116–133. doi:10.1093/humupd/dmv041
   PubMed Web of Science ®Google Scholar
• Webber LJ, Stubbs S, Stark J, et al. Formation and early development of follicles in the polycystic ovary. Lancet. 2003;362(9389):1017–1021. doi:10.1016/s0140-6736(03)14410-8
   PubMed Web of Science ®Google Scholar
• Drakopoulos P, Blockeel C, Stoop D, et al. Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod. 2016;31(2):370–376. doi:10.1093/humrep/dev316
   PubMed Web of Science ®Google Scholar
• Polyzos NP, Drakopoulos P, Parra J, et al. Cumulative live birth rates according to the number of oocytes retrieved after the first ovarian stimulation for in vitro fertilization/intracytoplasmic sperm injection: a multicenter multinational analysis including approximately 15,000 women. Fertil Steril. 2018;110(4):661–670 e1. doi:10.1016/j.fertnstert.2018.04.039
   PubMed Web of Science ®Google Scholar
• Su N, Zhan J, Xie M, et al. High anti-Mullerian hormone level is adversely associated with cumulative live birth rates of two embryo transfers after the first initiated cycle in patients with polycystic ovary syndrome. Front Endocrinol. 2023;14:1123125. doi:10.3389/fendo.2023.1123125
   PubMed Web of Science ®Google Scholar
• Kuivasaari-Pirinen P, Hippelainen M, Hakkarainen H, Randell K, Heinonen S. Cumulative baby take-home rate among women with PCOS treated by IVF. Gynecol Endocrinol. 2010;26(8):582–589. doi:10.3109/09513591003632043
   PubMed Web of Science ®Google Scholar
• Mai Z, Liu M, Pan P, et al. Comparison of cumulative live birth rate between aged PCOS women and controls in IVF/ICSI cycles. Front Endocrinol. 2021;12:724333. doi:10.3389/fendo.2021.724333
   PubMed Web of Science ®Google Scholar
• Guan Y, Kong P, Xiao Z, et al. Independent variables for determining the cumulative live birth rates of aged patients with polycystic ovary syndrome or tubal factor infertility: a retrospective cohort study. Front Endocrinol. 2021;12:728051. doi:10.3389/fendo.2021.728051
   PubMed Web of Science ®Google Scholar
• Lin J, Huang J, Wang N, Kuang Y, Cai R. Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women with PCOS undergoing frozen embryo transfer. BMC Pregnancy Childbirth. 2019;19(1):487. doi:10.1186/s12884-019-2611-1
   PubMed Web of Science ®Google Scholar
• Pinborg A, Gaarslev C, Hougaard CO, et al. Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples. Reprod Biomed Online. 2011;23(4):490–499. doi:10.1016/j.rbmo.2011.06.010
   PubMed Web of Science ®Google Scholar
• Provost MP, Acharya KS, Acharya CR, et al. Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for Assisted Reproductive Technology registry. Fertil Steril. 2016;105(3):663–669. doi:10.1016/j.fertnstert.2015.11.008
   PubMed Web of Science ®Google Scholar
• Singh N, Mishra N, Dogra Y. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of in vitro fertilization cycles in polycystic ovary syndrome? J Hum Reprod Sci. 2021;14(1):21–27. doi:10.4103/jhrs.JHRS_96_20
   PubMedGoogle Scholar
• Jayasena CN, Franks S. The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol. 2014;10(10):624–636. doi:10.1038/nrendo.2014.102
   PubMed Web of Science ®Google Scholar
• Sha T, Wang X, Cheng W, Yan Y. A meta-analysis of pregnancy-related outcomes and complications in women with polycystic ovary syndrome undergoing IVF. Reprod Biomed Online. 2019;39(2):281–293. doi:10.1016/j.rbmo.2019.03.203
   PubMed Web of Science ®Google Scholar
• Yu HF, Chen HS, Rao DP, Gong J. Association between polycystic ovary syndrome and the risk of pregnancy complications: a PRISMA-compliant systematic review and meta-analysis. Medicine. 2016;95(51):e4863. doi:10.1097/MD.0000000000004863
   PubMed Web of Science ®Google Scholar
• Bahri Khomami M, Joham AE, Boyle JA, et al. Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity-A systematic review, meta-analysis, and meta-regression. Obes Rev. 2019;20(5):659–674. doi:10.1111/obr.12829
   PubMed Web of Science ®Google Scholar
• Matorras R, Pijoan JI, Lainz L, et al. Polycystic ovarian syndrome and miscarriage in IVF: systematic revision of the literature and meta-analysis. Arch Gynecol Obstet. 2023;308(2):363–377. doi:10.1007/s00404-022-06757-0
   PubMed Web of Science ®Google Scholar
• Cai H, Mol BW, Gordts S, et al. Early and late pregnancy loss in women with polycystic ovary syndrome undergoing IVF/ICSI treatment: a retrospective cohort analysis of 21 820 pregnancies. BJOG. 2021;128(7):1160–1169. doi:10.1111/1471-0528.16590
   PubMed Web of Science ®Google Scholar
• Jie HY, Zhou X, Zhao MP, Hu M, Mai QY, Zhou CQ. Pregnancy outcomes in patients with polycystic ovary syndrome who conceived after single thawed blastocyst transfer: a propensity score-matched study. BMC Pregnancy Childbirth. 2022;22(1):718. doi:10.1186/s12884-022-05011-4
   PubMed Web of Science ®Google Scholar
• Liu S, Mo M, Xiao S, et al. Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: a retrospective cohort study with 7678 patients. Front Endocrinol. 2020;11:575337. doi:10.3389/fendo.2020.575337
   PubMed Web of Science ®Google Scholar
• Yang AM, Xu X, Han Y, et al. Risk factors for different types of pregnancy losses: analysis of 15,210 pregnancies after embryo transfer. Front Endocrinol. 2021;12:683236. doi:10.3389/fendo.2021.683236
   PubMed Web of Science ®Google Scholar
• Yang L, Ni T, Huang Y, et al. Impact of a previous late miscarriage on subsequent pregnancy outcomes: a retrospective cohort study over 10 years. Int J Gynaecol Obstet. 2023;163(2): 610–617. doi:10.1002/ijgo.14862
   PubMed Web of Science ®Google Scholar
• Talmor A, Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015;29(4):498–506. doi:10.1016/j.bpobgyn.2014.10.014
   PubMed Web of Science ®Google Scholar
• Dhadhal S, Nampoothiri L. Decoding the molecular cascade of embryonic-uterine modulators in pregnancy loss of PCOS mother- an ”in vivo” study. Reprod Biol Endocrinol. 2022;20(1):165. doi:10.1186/s12958-022-01041-x
   PubMed Web of Science ®Google Scholar
• Patil K, Hinduja I, Mukherjee S. Alteration in angiogenic potential of granulosa-lutein cells and follicular fluid contributes to luteal defects in polycystic ovary syndrome. Hum Reprod. 2021;36(4):1052–1064. doi:10.1093/humrep/deaa351
   PubMed Web of Science ®Google Scholar
• Yang ST, Liu CH, Ma SH, et al. Association between pre-pregnancy overweightness/obesity and pregnancy outcomes in women with polycystic ovary syndrome: a systematic review and meta-analysis. Int J Environ Res Public Health. 2022;19(15):9094 doi:10.3390/ijerph19159094.
   PubMed Web of Science ®Google Scholar
• Romanski PA, Bortoletto P, Magaoay B, Chung A, Rosenwaks Z, Spandorfer SD. Live birth outcomes in infertile patients with class III and class IV obesity following fresh embryo transfer. J Assist Reprod Genet. 2021;38(2):347–355. doi:10.1007/s10815-020-02011-1
   PubMed Web of Science ®Google Scholar
• Teede HJ, Misso ML, Costello MF, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod. 2018;33(9):1602–1618. doi:10.1093/humrep/dey256
   PubMed Web of Science ®Google Scholar
• Saxena P, Prakash A, Nigam A, Mishra A. Polycystic ovary syndrome: is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index. Indian J Endocrinol Metab. 2012;16(6):996–999. doi:10.4103/2230-8210.103011
   PubMedGoogle Scholar
• Doh E, Mbanya A, Kemfang-Ngowa JD, et al. The relationship between adiposity and insulin sensitivity in African women living with the polycystic ovarian syndrome: a clamp study. Int J Endocrinol. 2016;2016:9201701. doi:10.1155/2016/9201701
   PubMed Web of Science ®Google Scholar
• Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981–1030. doi:10.1210/er.2011-1034
   PubMed Web of Science ®Google Scholar
• Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. Endocr Rev. 2015;36(5):487–525. doi:10.1210/er.2015-1018
   PubMed Web of Science ®Google Scholar
• Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril. 2006;85(5):1319–1340. doi:10.1016/j.fertnstert.2005.10.054
   PubMed Web of Science ®Google Scholar
• Stepto NK, Cassar S, Joham AE, et al. Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Hum Reprod. 2013;28(3):777–784. doi:10.1093/humrep/des463
   PubMed Web of Science ®Google Scholar
• Han Y, Kim HS, Lee HJ, Oh JY, Sung YA. Metabolic effects of polycystic ovary syndrome in adolescents. Ann Pediatr Endocrinol Metab. 2015;20(3):136–142. doi:10.6065/apem.2015.20.3.136
   PubMedGoogle Scholar
• Song DK, Hong YS, Sung YA, Lee H. Insulin resistance according to beta-cell function in women with polycystic ovary syndrome and normal glucose tolerance. PLoS One. 2017;12(5):e0178120. doi:10.1371/journal.pone.0178120
   PubMed Web of Science ®Google Scholar
• Kakoly NS, Khomami MB, Joham AE, et al. Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression. Hum Reprod Update. 2018;24(4):455–467. doi:10.1093/humupd/dmy007
   PubMed Web of Science ®Google Scholar
• Ke RW. Endocrine basis for recurrent pregnancy loss. Obstet Gynecol Clin North Am. 2014;41(1):103–112. doi:10.1016/j.ogc.2013.10.003
   PubMed Web of Science ®Google Scholar
• Grodnitskaya EE, Kurtser MA. Homocysteine metabolism in polycystic ovary syndrome. Gynecol Endocrinol. 2012;28(3):186–189. doi:10.3109/09513590.2011.589927
   PubMed Web of Science ®Google Scholar
• Glueck CJ, Streicher P, Wang P. Treatment of polycystic ovary syndrome with insulin-lowering agents. Expert Opin Pharmacother. 2002;3(8):1177–1189. doi:10.1517/14656566.3.8.1177
   PubMedGoogle Scholar
• Chappell NR, Zhou B, Schutt AK, Gibbons WE, Blesson CS. Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes. Endocr Connect. 2020;9(3):261–270. doi:10.1530/EC-19-0553
   PubMed Web of Science ®Google Scholar
• Palomba S, Piltonen TT, Giudice LC. Endometrial function in women with polycystic ovary syndrome: a comprehensive review. Hum Reprod Update. 2021;27(3):584–618. doi:10.1093/humupd/dmaa051
   PubMed Web of Science ®Google Scholar
• Palomba S, Russo T, Falbo A, et al. Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome: an experimental case-control study. J Clin Endocrinol Metab. 2012;97(7):2441–2449. doi:10.1210/jc.2012-1100
   PubMed Web of Science ®Google Scholar
• Palomba S, Falbo A, Chiossi G, et al. Early trophoblast invasion and placentation in women with different PCOS phenotypes. Reprod Biomed Online. 2014;29(3):370–381. doi:10.1016/j.rbmo.2014.04.010
   PubMed Web of Science ®Google Scholar
• Zhang B, Wei D, Legro RS, et al. Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial. Fertil Steril. 2018;109(2):324–329. doi:10.1016/j.fertnstert.2017.10.020
   PubMed Web of Science ®Google Scholar
• Schulte MM, Tsai JH, Moley KH. Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation. Reprod Sci. 2015;22(1):6–14. doi:10.1177/1933719114561552
   PubMed Web of Science ®Google Scholar