References
- SankaranarayananRFerlayJWorldwide burden of gynaecological cancer: the size of the problemBest Pract Res Clin Obstet Gynaecol200620220722516359925
- GrulichAESwerdlowAJHeadJMarmotMGCancer mortality in African and Caribbean migrants to England and WalesBr J Cancer19926659059111419634
- WhittemoreASHarrisRItnyreJCollaborative Ovarian Cancer GroupCharacteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. IV. The pathogenesis of epithelial ovarian cancerAm J Epidemiol199213610121212201476143
- DalyMObramsGIEpidemiology and risk assessment for ovarian cancerSemin Oncol19982532552649633839
- ParkinDMMuirCSCancer Incidence in Five Continents Comparability and quality of dataIARC Sci Publ1992120451731284606
- ChiDSEisenhauerELZivanovicOImproved progression-free and overall survival in advanced ovarian cancer as a result of a change in surgical paradigmGynecol Oncol20091141263119395008
- HerrinVEThigpenJTHigh-dose chemotherapy in ovarian carcinomaSemin Oncol19992619910510073566
- SonodaYManagement of early ovarian cancerOncology (Williston Park)200418334335615065703
- McGuireWPHoskinsWJBradyMFCyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancerN Engl J Med19963341167494563
- NeijtJPEngelholmSATuxenMKExploratory phase III study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancerJ Clin Oncol200018173084309210963636
- BookmanMABradyMFMcGuireWPEvaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer IntergroupJ Clin Oncol20092791419142519224846
- KatsumataNYasudaMIsonishiSJapanese Gynecologic Oncology GroupLong-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trialLancet Oncol201314101020102623948349
- HowellSBPfeifleCLWungWEIntraperitoneal cisplatin with systemic thiosulfate protectionAnn Intern Med19829768458516890785
- MarkmanMRowinskyEHakesTPhase I trial of intraperitoneal taxol: a Gynecoloic Oncology Group studyJ Clin Oncol1992109148514911355523
- ArmstrongDKBundyBWenzelLGynecologic Oncology GroupIntraperitoneal cisplatin and paclitaxel in ovarian cancerN Engl J Med20063541344316394300
- TewariDSillMMonkBPhase III randomized clinical trial of cisplatin plus paclitaxel vs the non-platinum chemotherapy doublet of topotecan plus paclitaxel in women with recurrent, persistent, or advanced cervical carcinoma: A Gynecologic Oncology Group studyGynecol Oncol20131e2
- JaabackKJohnsonNLawrieTAIntraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancerCochrane Database Syst Rev201111CD00534022071822
- VaughanSCowardJIBastRCJrRethinking ovarian cancer: recommendations for improving outcomesNat Rev Cancer2011111071972521941283
- BurgerRASillMWMonkBJGreerBESoroskyJIPhase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group StudyJ Clin Oncol200725335165517118024863
- CannistraSAMatulonisUAPensonRTPhase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancerJ Clin Oncol200725335180518618024865
- BurgerRABradyMFBookmanMAGynecologic Oncology GroupIncorporation of bevacizumab in the primary treatment of ovarian cancerN Engl J Med2011365262473248322204724
- PerrenTJSwartAMPfistererJICON7 InvestigatorsA phase 3 trial of bevacizumab in ovarian cancerN Engl J Med2011365262484249622204725
- LedermannJARajaFAFotopoulouCESMO Guidelines Working GroupNewly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upAnn Oncol201324Suppl 6vi24vi3224078660
- GourleyCMcCaviganAPerrenTMolecular subgroup of high-grade serous ovarian cancer (HGSOC) as a predictor of outcome following bevacizumabPresented at: 2014 ASCO Annual MeetingMay 30–June 3, 2014Chicago, Illinois Abstract 5502
- AghajanianCBlankSVGoffBAOCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancerJ Clin Oncol201230172039204522529265
- Pujade-LauraineEHilpertFWeberBBevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trialJ Clin Oncol201432131302130824637997
- HallMGourleyCMcNeishITargeted anti-vascular therapies for ovarian cancer: current evidenceBr J Cancer2013108225025823385789
- LearyAThe PI3K/Akt/mTOR Pathway in Ovarian Cancer: Biological Rationale and Therapeutic OpportunitiesRijeka, CroatiaIntech2013 Available from: http://dx.doi.org/10.5772/54170Accessed December 1, 2014
- AravantinosGPectasidesDBevacizumab in combination with chemotherapy for the treatment of advanced ovarian cancer: a systematic reviewJ Ovarian Res201475724864163
- ColemanRLDuskaLRRamirezPTPhase 1–2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancerLancet Oncol201112121109111721992853
- GotliebWHAmantFAdvaniSIntravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: a phase 2, randomised, double-blind, placebo-controlled studyLancet Oncol201213215416222192729
- LedermannJAHackshawAKayeSRandomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancerJ Clin Oncol201129283798380421859991
- Du BoisAKristensenGRay-CoquardIAGO-OVAR 12: a randomized placebo-controlled GCIG/ENGOT-Intergroup phase III trial of standard frontline chemotherapy/−nintedanib for advanced ovarian cancer [abstract]Int J Gynecol Cancer201323suppl 1LBA1
- CarmelietPJainRKAngiogenesis in cancer and other diseasesNature2000407680124925711001068
- MonkBJPovedaAVergoteIA phase III, randomized, double-blind trial of weekly paclitaxel plus the angiopoietin 1 and 2 inhibitor, trebananib, or placebo in women with recurrent ovarian cancer [abstract]: TRINOVA-1Eur J Cancer2013493LBA:41
- DavidsonBASecordAAProfile of pazopanib and its potential in the treatment of epithelial ovarian cancerInt J Womens Health2014136 :289–300.
- FriedlanderMHancockKCRischinDA Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancerGynecol Oncol20101191323720584542
- du BoisAFloquetAKimJWIncorporation of pazopanib in maintenance therapy of ovarian cancerJ Clin Oncol201432303374338225225436
- MendelDBLairdADXinXIn vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationshipClin Cancer Res20039132733712538485
- BiagiJJOzaAMChalchalHIA phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group StudyAnn Oncol201122233534020705911
- BaumannKHdu BoisAMeierWA phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapyAnn Oncol20122392265227122377563
- CamposSMPensonRTMatulonisUA phase II trial of Sunitinib malate in recurrent and refractory ovarian, fallopian tube and peritoneal carcinomaGynecol Oncol2013128221522022885865
- MateiDSillMWLankesHAActivity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trialJ Clin Oncol2011291697521098323
- HerzogTJScambiaGKimBGA randomized phase II trial of maintenance therapy with Sorafenib in front-line ovarian carcinomaGynecol Oncol20131301253023591401
- ThompsonDSDudleyBSBismayerJAPaclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer: A randomized phase II study of the Sarah Cannon Research InstitutePresented at: 2013 ASCO Annual MeetingMay 31–June 4, 2014Chicago, Illinois Abstract 5513
- MatulonisUABerlinSIvyPCediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancerJ Clin Oncol200927335601560619826113
- LedermannJAPerrenTJRajaFARandomized double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: Results of the ICON6 trialEuropean J of Cancer201349Suppl 3 Abstract 10
- ChoKRShihIeMOvarian cancerAnnu Rev Pathol20094128731318842102
- GershensonDMSunCCBodurkaDRecurrent low-grade serous ovarian carcinoma is relatively chemoresistantGynecol Oncol20091141485219361839
- SchmelerKMSunCCBodurkaDCNeoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneumGynecol Oncol2008108351051418155273
- LiJFadareOXiangLKongBZhengWOvarian serous carcinoma: recent concepts on its origin and carcinogenesisJ Hematol Oncol20125822405464
- BellDBerchuckABirrerMCancer Genome Atlas Research NetworkIntegrated genomic analyses of ovarian carcinomaNature2011474735360961521720365
- FarleyJBradyWEVathipadiekalVSelumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm, phase 2 studyLancet Oncol201314213414023261356
- GershensonDMThe life and times of low-grade serous carcinoma of the ovaryPresented at: 2013 ASCO Annual MeetingMay 31–June 4, 2014Chicago, Illinois
- BastRCJrMolecular approaches to personalizing management of ovarian cancerAnn Oncol201122Suppl 8viii5viii1522180401
- KojimaKKonoplevaMMcQueenTO’BrienSPlunkettWAndreeffMMdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemiaBlood20061083993100016543464
- KimAUedaYNakaTEnomotoTTherapeutic strategies in epithelial ovarian cancer. Journal of experimental and clinical cancer researchCR (East Lansing, Mich)20123114
- KurmanRJShihIeMMolecular pathogenesis and extraovarian origin of epithelial ovarian cancer – shifting the paradigmHum Pathol201142791893121683865
- AnglesioMSGeorgeJKulbeHIL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancerClin Cancer Res20111782538254821343371
- StanyMPVathipadiekalVOzbunLIdentification of novel therapeutic targets in microdissected clear cell ovarian cancersPLoS ONE201167e2112121754983
- AlexandreJRay-CoquardISelleFGINECOMucinous advanced epithelial ovarian carcinoma: clinical presentation and sensitivity to platinum-paclitaxel-based chemotherapy, the GINECO experienceAnn Oncol201021122377238120494964
- AnglesioMSKommossSTolcherMCMolecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomasJ Pathol2013229111112022899400
- SyriosJBanerjeeSKayeSBAdvanced epithelial ovarian cancer: from standard chemotherapy to promising molecular pathway targets – where are we now?Anticancer Res20143452069207724778008
- BookmanMADarcyKMClarke-PearsonDBoothbyRAHorowitzIREvaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology GroupJ Clin Oncol200321228329012525520
- McAlpineJNWiegandKCVangRHER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapyBMC Cancer20099143320003286
- BehbakhtKSillMWDarcyKMPhase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group studyGynecol Oncol20111231192621752435
- FarmerHMcCabeNLordCJTargeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyNature2005434703591792115829967
- BryantHESchultzNThomasHDSpecific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymeraseNature2005434703591391715829966
- VirágLSzabóCThe therapeutic potential of poly(ADP-ribose) polymerase inhibitorsPharmacol Rev200254337542912223530
- AshworthAA synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repairJ Clin Oncol200826223785379018591545
- AntoniouAPharoahPDNarodSAverage risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studiesAm J Hum Genet20037251117113012677558
- WalshTCasadeiSLeeMKMutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencingProc Natl Acad Sci U S A201110844180321803722006311
- BellDBerchuckABirrerMCancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinomaNature2011474735360961521720365
- TanDSRothermundtCThomasK“BRCAness” syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutationsJ Clin Oncol200826345530553618955455
- PenningtonKPWalshTHarrellMIGermline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomasClin Cancer Res201420376477524240112
- MuraiJHuangSYDasBBTrapping of PARP1 and PARP2 by Clinical PARP InhibitorsCancer Res201272215588559923118055
- FongPCBossDSYapTAInhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriersN Engl J Med2009361212313419553641
- FongPCYapTABossDSPoly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free intervalJ Clin Oncol201028152512251920406929
- AudehMWCarmichaelJPensonRTOral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trialLancet2010376973724525120609468
- GelmonKATischkowitzMMackayHOlaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised studyLancet Oncol201112985286121862407
- KayeSBLubinskiJMatulonisUPhase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly(ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancerJ Clin Oncol201230437237922203755
- LedermannJHarterPGourleyCOlaparib maintenance therapy in platinum-sensitive relapsed ovarian cancerN Engl J Med2012366151382139222452356
- LedermannJHarterPGourleyCOlaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trialLancet Oncol201415885286124882434
- EversBDrostRSchutESelective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatinClin Cancer Res200814123916392518559613
- RottenbergSJaspersJEKersbergenAHigh sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugsProc Natl Acad Sci U S A200810544170791708418971340
- RajanACarterCAKellyRJA phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumorsClin Cancer Res20121882344235122371451
- KhanOAGoreMLoriganPA phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumoursBr J Cancer2011104575075521326243
- SamolJRansonMScottESafety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I studyInvest New Drugs20123041493150021590367
- LeeJMHaysJLAnnunziataCMPhase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associated breast or ovarian cancer with biomarker analysesJ Natl Cancer Inst20141066dju08924842883
- LiuJFlemingGFTolaneySMA phase I trial of the PARP inhibitor olaparib (AZD2281) in combination with the antiangiogenic cediranib (AZD2171) in recurrent ovarian or triple-negative breast cancerPresented at: 2011 ASCO Annual MeetingJune 3–7, 2014Chicago, Illinois Abstract 5028
- SandhuSKSchelmanWRWildingGThe poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trialLancet Oncol201314988289223810788
- LordCJAshworthAMechanisms of resistance to therapies targeting BRCA-mutant cancersNat Med201319111381138824202391
- TebbuttNPedersenMWJohnsTGTargeting the ERBB family in cancer: couples therapyNat Rev Cancer201313966367323949426
- LafkyJMWilkenJABaronATMaihleNJClinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancerBiochim Biophys Acta20081785223226518291115
- SecordAABlessingJAArmstrongDKPhase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: a Gynecologic Oncology Group studyGynecol Oncol2008108349349918191993
- SchilderRJSillMWChenXPhase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group StudyClin Cancer Res200511155539554816061871
- VergoteIBJimenoAJolyFRandomized phase III study of erlotinib versus observation in patients with no evidence of disease progression after first-line platin-based chemotherapy for ovarian carcinoma: a European Organisation for Research and Treatment of Cancer-Gynaecological Cancer Group, and Gynecologic Cancer Intergroup studyJ Clin Oncol201432432032624366937
- BookmanMADarcyKMClarke-PearsonDBoothbyRAHorowitzIREvaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology GroupJ Clin Oncol200321228329012525520
- FarleyJFuchiujiSDarcyKMAssociations between ERBB2 amplification and progression-free survival and overall survival in advanced stage, suboptimally-resected epithelial ovarian cancers: a Gynecologic Oncology Group StudyGynecol Oncol2009113334134719272639
- GordonMSMateiDAghajanianCClinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation statusJ Clin Oncol200624264324433216896006
- KayeSBPooleCJDańska-BidzińskaAA randomized phase II study evaluating the combination of carboplatin-based chemotherapy with pertuzumab versus carboplatin-based therapy alone in patients with relapsed, platinum-sensitive ovarian cancerAnn Oncol201324114515223002282
- DaviesSHolmesALomoLHigh incidence of ErbB3, ErbB4, and MET expression in ovarian cancerInt J Gynecol Pathol201433440241024901400
- TannerBHasencleverDSternKErbB-3 predicts survival in ovarian cancerJ Clin Oncol200624264317432316896008
- SchoeberlBFaberACLiDAn ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activationCancer Res20107062485249420215504
- ShengQLiuXFlemingEAn activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cellsCancer Cell201017329831020227043
- BalkwillFMantovaniAInflammation and cancer: back to Virchow?Lancet2001357925553954511229684
- MadhusudanSMuthuramalingamSRBraybrookeJPStudy of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancerJ Clin Oncol200523255950595916135466
- BrownERCharlesKAHoareSAA clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancerAnn Oncol20081971340134618325912
- CowardJKulbeHChakravartyPInterleukin-6 as a therapeutic target in human ovarian cancerClin Cancer Res20111517 (18):6083–6096.
- HamanishiJMandaiMIkedaTEfficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancerPresented at: 2014 ASCO Annual MeetingMay 30–June 3, 2014Chicago, Illinois Abstract 5511
- BrahmerJRTykodiSSChowLQSafety and activity of anti-PD-L1 antibody in patients with advanced cancerN Engl J Med2012366262455246522658128
- MiottiSCanevariSMénardSCharacterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificityInt J Cancer19873932973032434438
- KalliKRObergALKeeneyGLFolate receptor alpha as a tumor target in epithelial ovarian cancerGynecol Oncol2008108361962618222534
- ChenYLChangMCHuangCYSerous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-responseMol Oncol20126336036922265591
- ToffoliGRussoAGalloAExpression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancerInt J Cancer19987921211269583724
- ArmstrongDKWhiteAJWeilSCPhillipsMColemanRLFarletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancerGynecol Oncol2013129345245823474348
- ElitLKonnerJArmstrongDKA randomized, double-blind, placebo-controlled phase II study of the efficacy and safety of farletuzumab (MORAb-003) in combination with weekly paclitaxel in subjects with platinum-resistant or refractory relapsed ovarian cancerPresented at: 2013 ASCO Annual MeetingMay 31–June 4, 2014Chicago, Illinois Abstract TPS255
- NaumannRWColemanRLBurgerRAPRECEDENT: A randomized phase II trial comparing EC145 and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in subjects with platinum resistant ovarian cancerJ Clin Oncol201129343s Abstract 5045.
- WernerHWeinsteinDBentovISimilarities and differences between insulin and IGF-I: structures, receptors, and signalling pathwaysArch Physiol Biochem20081141172218465355
- FürstenbergerGSennHJInsulin-like growth factors and cancerLancet Oncol20023529830212067807
- BruchimIWernerHTargeting IGF-1 signaling pathways in gynecologic malignanciesExpert Opin Ther Targets201317330732023294364
- BuckEGokhalePCKoujakSCompensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancerMol Cancer Ther20109102652266420924128