Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation

References

• BoeckhMLeisenringWRiddellSRLate cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunityBlood2003101240741412393659
   PubMed Web of Science ®Google Scholar
• BrunsteinCGWeisdorfDJDeForTMarked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantationBlood200610882874288016804113
   PubMed Web of Science ®Google Scholar
• MyersGDKranceRAWeissHAdenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (Campath)Bone Marrow Transplant200536111001100816184180
   PubMed Web of Science ®Google Scholar
• NeofytosDHornDAnaissieEEpidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registryClin Infect Dis200948326527319115967
   PubMed Web of Science ®Google Scholar
• AveryRUpdate in management of ganciclovir-resistant cytomegalovirus infectionCurr Opin Infect Dis200821443343718594298
   PubMed Web of Science ®Google Scholar
• BironKKAntiviral drugs for cytomegalovirus diseasesAntiviral Res2006712–315416316765457
   PubMed Web of Science ®Google Scholar
• NicholsWGCoreyLGooleyTRising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomesBlood200197486787411159510
   PubMed Web of Science ®Google Scholar
• LjungmanPDeliliersGLPlatzbeckerUCidofovir for cytomegalovirus infection and disease in allogeneic stem cell transplant recipients. The Infectious Diseases Working Party of the European Group for Blood and Marrow TransplantationBlood200197238839211154213
   PubMed Web of Science ®Google Scholar
• KuehnleIHulsMHLiuZCD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantationBlood20009541502150510666232
   PubMed Web of Science ®Google Scholar
• KomanduriKVSt JohnLSde LimaMDelayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewingBlood2007110134543455117671230
   PubMed Web of Science ®Google Scholar
• RubinsteinPCarrierCScaradavouAOutcomes among 562 recipients of placental-blood transplants from unrelated donorsN Engl J Med199833922156515779828244
   PubMed Web of Science ®Google Scholar
• PapadopoulosEBLadanyiMEmanuelDInfusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantationN Engl J Med199433017118511918093146
   PubMed Web of Science ®Google Scholar
• SlezakSLBettinottiMSelleriSAdamsSMarincolaFMStroncekDFCMV pp65 and IE-1 T cell epitopes recognized by healthy subjectsJ Transl Med200751717391521
   PubMed Web of Science ®Google Scholar
• LeenAMChristinAKhalilMIdentification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapyJ Virol200882154655417942545
   PubMed Web of Science ®Google Scholar
• BollardCMRooneyCMHeslopHET-cell therapy in the treatment of post-transplant lymphoproliferative diseaseNat Rev Clin Oncol20129951051922801669
   PubMed Web of Science ®Google Scholar
• HanleyPJCruzCRSavoldoBFunctionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopesBlood200911491958196719443656
   PubMed Web of Science ®Google Scholar
• LeenAMMyersGDSiliUMonoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individualsNat Med200612101160116616998485
   PubMed Web of Science ®Google Scholar
• SiliUHulsMHDavisARLarge-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapyJ Immunother200326324125612806278
   PubMed Web of Science ®Google Scholar
• KernFFaulhaberNFrommelCAnalysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptidesEur J Immunol20003061676168210898504
   PubMed Web of Science ®Google Scholar
• HanleyPJShafferDRCruzCRExpansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell transplantationCytotherapy201113897698621539497
   PubMed Web of Science ®Google Scholar
• KalosMJuneCHAdoptive T cell transfer for cancer immunotherapy in the era of synthetic biologyImmunity2013391496023890063
   PubMed Web of Science ®Google Scholar
• SellarRSPeggsKSThe role of virus-specific adoptive T-cell therapy in hematopoietic transplantationCytotherapy201214439140022420834
   PubMed Web of Science ®Google Scholar
• HansenSGPowersCJRichardsREvasion of CD8+ T cells is critical for superinfection by cytomegalovirusScience2010328597410210620360110
   PubMed Web of Science ®Google Scholar
• NeudorferJSchmidtBHusterKMReversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigensJ Immunol Methods20073201–211913117306825
   PubMed Web of Science ®Google Scholar
• SchmittATonnTBuschDHAdoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantationTransfusion201151359159921133926
   PubMed Web of Science ®Google Scholar
• BollardCMKuehnleILeenARooneyCMHeslopHEAdoptive immunotherapy for posttransplantation viral infectionsBiol Blood Marrow Transplant200410314315514993880
   PubMed Web of Science ®Google Scholar
• GattinoniLKlebanoffCAPalmerDCAcquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsJ Clin Invest200511561616162615931392
   PubMed Web of Science ®Google Scholar
• HeslopHESlobodKSPuleMALong-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipientsBlood2010115592593519880495
   PubMed Web of Science ®Google Scholar
• MelenhorstJJLeenAMBollardCMAllogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjectsBlood2010116224700470220709906
   PubMed Web of Science ®Google Scholar
• PeggsKSVerfuerthSPizzeyAAdoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell linesLancet200336293931375137714585640
   PubMed Web of Science ®Google Scholar
• HeslopHESlobodKSPuleMALong-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipientsBlood2010115592593519880495
   PubMed Web of Science ®Google Scholar
• WalterEAGreenbergPDGilbertMJReconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donorN Engl J Med199533316103810447675046
   PubMed Web of Science ®Google Scholar
• TrivediDWilliamsRYO’ReillyRJKoehneGGeneration of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapyBlood200510572793280115514011
   PubMed Web of Science ®Google Scholar
• GerdemannUKeirnanJMKatariULRapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infectionsMol Ther20122081622163222801446
   PubMed Web of Science ®Google Scholar
• HanleyPJCruizRYMelenhorstJNaïve T-cell-derived CTL recognize atypical epitopes of CMVpp65 with higher avidity than CMV-seropositive donor-derived CTL – a basis for treatment of post-transplant viral infection by adoptive transfer of T-cells from virus-naïve donorsCytotherapy2013154S9
   PubMed Web of Science ®Google Scholar
• BergerCJensenMCLansdorpPMGoughMElliottCRiddellSRAdoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primatesJ Clin Invest2008118129430518060041
   PubMed Web of Science ®Google Scholar
• WillingerTFreemanTHasegawaHMcMichaelAJCallanMFMolecular signatures distinguish human central memory from effector memory CD8 T cell subsetsJ Immunol200517595895590316237082
   PubMed Web of Science ®Google Scholar
• CobboldMKhanNPourgheysariBAdoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramersJ Exp Med2005202337938616061727
   PubMed Web of Science ®Google Scholar
• FeuchtingerTOpherkKBethgeWAAdoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantationBlood2010116204360436720625005
   PubMed Web of Science ®Google Scholar
• PeggsKSThomsonKSamuelEDirectly selected cytomegalovirus-reactive donor T cells confer rapid and safe systemic reconstitution of virus-specific immunity following stem cell transplantationClin Infect Dis2011521495721148519
   PubMed Web of Science ®Google Scholar
• FeuchtingerTMatthes-MartinSRichardCSafe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantationBr J Haematol20061341647616803570
   PubMed Web of Science ®Google Scholar
• UhlinMOkasMGertowJUzunelMBrismarTBMattssonJA novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantationCancer Immunol Immunother201059347347719908041
   PubMed Web of Science ®Google Scholar
• MoosmannABigalkeITischerJEffective and long-term control of EBV PTLD after transfer of peptide-selected T cellsBlood2010115142960297020103780
   PubMed Web of Science ®Google Scholar
• LeenAMChristinAMyersGDCytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantationBlood2009114194283429219700662
   PubMed Web of Science ®Google Scholar
• MicklethwaiteKPClancyLSandherUProphylactic infusion of cytomegalovirus-specific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantationBlood2008112103974398118768783
   PubMed Web of Science ®Google Scholar
• BlythEClancyLSimmsRDonor-derived CMV- specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantationBlood2013121183745375823435462
   PubMed Web of Science ®Google Scholar
• VeraJFBrennerLJGerdemannUAccelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex)J Immunother201033330531520445351
   PubMed Web of Science ®Google Scholar
• GerdemannUChristinASVeraJFNucleofection of DCs to generate multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised hostMol Ther20091791616162519584818
   PubMed Web of Science ®Google Scholar
• CruzCRHanleyPJLiuHAdverse events following infusion of T cells for adoptive immunotherapy: a 10-year experienceCytotherapy201012674374920429793
   PubMed Web of Science ®Google Scholar
• BarkerJNDoubrovinaESauterCSuccessful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytesBlood2010116235045504920826724
   PubMed Web of Science ®Google Scholar
• LeenAMBollardCMMendizabalAMMulticenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantationBlood2013121265113512323610374
   PubMed Web of Science ®Google Scholar
• UhlinMGertowJUzunelMRapid salvage treatment with virus-specific T cells for therapy-resistant diseaseClin Infect Dis20125581064107322806594
   PubMed Web of Science ®Google Scholar
• Wy IpWQasimWManagement of adenovirus in children after allogeneic hematopoietic stem cell transplantationAdv Hematol2013201317641824288536
   PubMedGoogle Scholar
• QasimWDerniameSGilmourKThird-party virus-specific T cells eradicate adenoviraemia but trigger bystander graft-versus-host diseaseBr J Haematol2011154115015321501134
   PubMed Web of Science ®Google Scholar
• BalduzziALucchiniGHirschHHPolyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipientBone Marrow Transplant201146798799220921942
   PubMed Web of Science ®Google Scholar
• RamosCANaralaNVyasGMHuman papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignanciesJ Immunother2013361667623211628
   PubMed Web of Science ®Google Scholar
• SchubASchusterIGHammerschmidtWMoosmannACMV-specific TCR-transgenic T cells for immunotherapyJ Immunol2009183106819683019864595
   PubMed Web of Science ®Google Scholar
• XueSAGaoLAhmadiMHuman MHC Class I-restricted high avidity CD4 T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivoOncoimmunology201321e2259023483821
   PubMed Web of Science ®Google Scholar
• FrumentoGZhengYAubertGCord blood T cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificityAm J Transplant2013131455523016879
   PubMed Web of Science ®Google Scholar
• MRCCMV TCR Gene Therapy: A Phase I/II Safety, Toxicity and Feasibility Study of Adoptive Immunotherapy in Allo-HSCT Available from: http://gtr.rcuk.ac.uk/project/644662DD-8EE2-4A77-82F2-24DB-D79B1B87. Project reference: G0701703Accessed June 11, 2014
   Google Scholar
• MilnerJDHollandSMThe cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseasesNat Rev Immunol201313963564823887241
   PubMed Web of Science ®Google Scholar
• KimCJMcKinnonLRKovacsCMucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activationJ Immunol201319152164217323894197
   PubMed Web of Science ®Google Scholar
• CruzCRLamSHanleyPJRobust T cell responses to aspergillosis in chronic granulomatous disease: implications for immunotherapyClin Exp Immunol20131741899623763437
   PubMed Web of Science ®Google Scholar
• BeckOToppMSKoehlUGeneration of highly purified and functionally active human TH1 cells against Aspergillus fumigatusBlood200610762562256916322466
   PubMed Web of Science ®Google Scholar
• TramsenLSchmidtSBoenigHClinical-scale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetesCytotherapy201315334435123579059
   PubMed Web of Science ®Google Scholar
• KhannaNStuehlerCConradBGeneration of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154Blood201111841121113121642594
   PubMed Web of Science ®Google Scholar
• GomezMJMarasBBarcaALa ValleRBarraDCassoneABiochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicansInfect Immun200068269470110639435
   PubMed Web of Science ®Google Scholar
• JolinkHMeijssenICHagedoornRSCharacterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individualsJ Infect Dis2013208584785623698813
   PubMed Web of Science ®Google Scholar
• PerruccioKTostiABurchielliETransferring functional immune responses to pathogens after haploidentical hematopoietic transplantationBlood2005106134397440616123217
   PubMed Web of Science ®Google Scholar
• De AngelisBDottiGQuintarelliCGeneration of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)Blood2009114234784479119759356
   PubMed Web of Science ®Google Scholar
• BrewinJMancaoCStraathofKGeneration of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative diseaseBlood2009114234792480319770360
   PubMed Web of Science ®Google Scholar
• GerdemannUKatariULPapadopoulouASafety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplantMol Ther201321112113212123783429
   PubMed Web of Science ®Google Scholar