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Review

Latex Allergy: Current Status and Future Perspectives

, , &
Pages 385-398 | Published online: 28 Sep 2020

References

  • Dennis R, Ownby A. History of latex allergy. J Allergy Clin Immunol. 2002;110(2):S27–S32. doi:10.1067/mai.2002.12533612170240
  • Stern G. Überempfindlichkeit gegen Kautschuk als ursache von Urticaria und quinckeschem odem. Klin Wochenschr. 1927;6:1096–1097.
  • Grimm A. Uberempfindlichtkeit gegen kautschuk als uorsache von urticaria und quinckeschem ödem. Klin Wochenschr. 1927;6:1479. doi:10.1007/BF01718534
  • Nutter AF. Contact urticaria to rubber. Br J Dermatol. 1979;101(5):597–598. doi:10.1111/j.1365-2133.1979.tb11893.x518831
  • Wu M, McIntosh J, Liu J. Current prevalence rate of latex allergy: why it remains a problem? J Occup Health. 2016;58:138–144. doi:10.1539/joh.15-0275-RA27010091
  • Cremer R, Mennicken O. Longitudinal study on specific IgE against natural rubber latex, banana and kiwi in patients with spina bifida. Klin Padiatr. 2011;223(06):352–355. doi:10.1055/s-0031-127375221512968
  • Blumchen K, Bayer P, Buck D, et al. Effects of latex avoidance on latex sensitization, atopy and allergic diseases in patients with spina bifida. Allergy. 2010;65(12):1585–1593. doi:10.1111/j.1398-9995.2010.02447.x20659078
  • Tomazic VJ, Shampaine EL, Lamanna A, Withrow TJ, Adkinson NF Jr, Hamilton RG. Cornstarch powder on latex products is an allergen carrier. J Allergy Clin Immunol. 1994;93(4):751–758. doi:10.1016/0091-6749(94)90255-08163784
  • Agarwal N, McDonnell S, Khan W. Management of latex hypersensitivity in the perioperative setting. J Perioper Pract. 2020;30(7–8):199–203. doi:10.1177/175045891988222231694472
  • Brehler R, Theissen U, Mohr C, Luger T. Latex‐fruit syndrome: frequency of cross‐reacting IgE antibodies. Allergy. 1997;52:404–410. doi:10.1111/j.1398-9995.1997.tb01019.x9188921
  • Garcia Ortiz JC, Moyano JC, Alvarez M, Bellido J. Latex allergy in fruit‐allergic patients. Allergy. 1998;53:532–536. doi:10.1111/j.1398-9995.1998.tb04092.x9636814
  • Werfel T, Asero R, Ballmer-Weber BK, et al. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy. 2015;70(9):1079–1090. doi:10.1111/all.1266626095197
  • Shaffrali FC, Gawkrodger DG. Allergic contact dermatitis from natural rubber latex without immediate hypersensitivity. Contact Dermatitis. 1999;40:325–326. doi:10.1111/j.1600-0536.1999.tb06084.x10385336
  • Leuzzi M, Vincenzi C, Sechi A, et al. Delayed hypersensitivity to natural rubber latex: does it exist or not? Contact Dermatitis. 2019;81(5):404–405. doi:10.1111/cod.1335331290999
  • Alenius H, Kurup VP, Kelly KJ, Palosuo T, Turjanmaa K, Fink JN. Latex allergy: frequent occurrence of IgE antibodies to a cluster of 11 latex proteins in patients with spina bifida and histories of anaphylaxis. J Lab Clin Med. 1994;123(5):712–720.8195677
  • Kurup VP, Alenius H, Kelly KJ, Castillo L, Fink JN. A two-dimensional electrophoretic analysis of latex peptides reacting with IgE and IgG antibodies from patients with latex allergy. Int Arch Allergy Immunol. 1996;109(1):58–67. doi:10.1159/0002372328527952
  • Lu LJ, Kurup VP, Hoffman DR, Kelly KJ, Murali PS, Fink JN. Characterization of major latex allergen associated with hypersensitivity in spina bifida patients. J Immunol. 1995;155:2721–2728.7650400
  • Bernstein DI, Biagini RE, Karnani R, et al. In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex. J Allergy Clin Immunol. 2003;111(3):610–616. doi:10.1067/mai.2003.16412642845
  • Slater J, Vedvick T, Arthur-Smith A, Trybul DE, Kekwick RG. Identification, cloning, and sequence of a major allergen (Hev b 5) from natural rubber latex (Hevea brasiliensis). J Biol Chem. 1996;271(41):25394–25399. doi:10.1074/jbc.271.41.253948810306
  • Kotovuori A, Poikonen S, Niskanen E, et al. Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE mediated in vitro and in vivo reactions in latex-fruit syndrome. J Allergy Clin Immunol. 2005;115:598–605. doi:10.1016/j.jaci.2004.09.01515753910
  • Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergenes involved in the latex-fruit syndrome. J Allergy Clin Immunol. 1999;103:507–513. doi:10.1016/S0091-6749(99)70478-110069887
  • Rolland M 1, o’Hehir RE. Latex allergy: a model for therapy. Clin Exp Allergy. 2008;38(6):898–912. doi:10.1111/j.1365-2222.2008.02984.x18498539
  • Nucera E, Rizzi A, Buonomo A, et al. The clinical meaning of positive latex sige in patients with food/pollen adverse reactions. Int J Immunopathol Pharmacol. 2012;25(2):445–453. doi:10.1177/03946320120250021422697076
  • Chen Z, Cremer R, Posch A, Raulf-Heimsoth M, Rihs HP, Baur X. On the allergenicity of Hev b 1 among health care workers and patients with spina bifida allergic to natural rubber latex. J Allergy Clin Immunol. 1997;100(5):684–769. doi:10.1016/s0091-6749(97)70174-x9389300
  • Rihs HP, Sander I, Heimann H, Meurer U, Brüning T, Raulf M. The new latex allergen Hev b 15: IgE-binding properties of a recombinant serine protease inhibitor. J Investig Allergol Clin Immunol. 2015;25(2):133–162.
  • Woods JA, Lambert S, TAE P-M, Drake DB, Edlich R. Natural rubber latex allergy: spectrum, diagnostic approach, and therapy. J Emerg Med. 1997;15(1):71–85. doi:10.1016/s0736-4679(96)00256-99017491
  • Liccardi G, D’Amato G, Canonica W, Salzillo A, Piccolo A, Passalacqua G. Systemic reactions from skin testing: literature review. J Investig Allergol Clin Immunol. 2006;16(2):75–78.
  • Kelly KJ, Kurup VP, Zacharisen M, Resnick A, Fink JN. Skin and serologic testing in the diagnosis of latex allergy. J Allergy Clin Immunol. 1993;91:1140–1145.8509577
  • Nicolaou N, Johnston GA. Anaphylaxis following prick testing with natural rubber latex. Contact Dermatitis. 2002;47:251–252. doi:10.1034/j.1600-0536.2002.470422.x12492542
  • Nettis E, Dambra P, Traetta PL, Loria MP, Ferranini A, Tursi A. Systemic reactions on SPT to latex. Allergy. 2001;56:355–356. doi:10.1034/j.1398-9995.2001.00862.x11284810
  • Van Kampen V, Raulf-Heimsoth M, Sander I, Merget R. Diagnostics of occupational type I allergies-comparison of skin prick test solutions from different manufacturers for selected occupational allergens. Pneumologie. 2010;64(5):271–277.20455174
  • Bendewald MJ, Farmer SA, Davis MD. An 8-year retrospective review of patch testing with rubber allergens: the mayo clinic experience. Dermatitis. 2010;21(1):33–40. doi:10.2310/6620.2009.0902920137737
  • Ebo DG, Bridts CH, Rihs HP. Hevea latex associated allergies: piecing together the puzzle of the latex IgE reactivity profile. Expert Rev Mol Diagn. 2020;20(4):367–373. doi:10.1080/14737159.2020.173081732056456
  • Nowakowska-Świrta E, Wiszniewska M, Walusiak-Skorupa J. Allergen-specific IgE to recombinant latex allergens in occupational allergy diagnostics. J Occup Health. 2019;61(5):378–386. doi:10.1002/1348-9585.1206431090202
  • Sanz ML, García-Avilés MC, Tabar AI, et al. Basophil activation test and specific IgE measurements using a panel of recombinant natural rubber latex allergens to determine the latex allergen sensitization profile in children. Pediatr Allergy Immunol. 2006;17(2):148–156. doi:10.1111/j.1399-3038.2005.00359.x16618365
  • Agache I, Bilò MB, Braunstahl GJ, et al. In vivo diagnosis of allergic diseases–allergen provocation tests. Allergy. 2015;70(4):355–365. doi:10.1111/all.1258625640808
  • Nucera E, Pollastrini E, Sabato V, et al. Challenge tests in the diagnosis of latex allergy. Int J Immunopathol Pharmacol. 2010;23(2):543–552. doi:10.1177/03946320100230021620646349
  • Vandenplas O, Suojalehto H, Aasen TB, et al. Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement. Eur Respir J. 2014;43(6):1573‐1587. doi:10.1183/09031936.00175113
  • Chelminska M, Niedoszytko M, Jassem E. Clinical value of conjunctival allergen challenge in diagnosing allergic conjunctivitis related to latex. Int Arch Allergy Immunol. 2011;154(2):149‐154.
  • Cabañes N, Igea JM, de la Hoz B, et al. Latex allergy: position paper. J Investig Allergol Clin Immunol. 2012;22(5):313–330.
  • Bernstein DI. Management of natural rubber latex allergy. J Allergy Clin Immunol. 2002;110(2):S111. doi:10.1067/mai.2002.12533012170251
  • Palosuo T, Antoniadou I, Gottrup F, Phillips P. Latex medical gloves: time for a reappraisal. Int Arch Allergy Immunol. 2011;156:234–246. doi:10.1159/00032389221720169
  • Kelly KJ, Wang ML, Klancnik M, Petsonk EL. Prevention of IgE sensitization to latex in health care workers after reduction of antigen exposures. J Occup Environ Med. 2011;53(8):934–940. doi:10.1097/JOM.0b013e31822589dc21775898
  • Allergen nomenclature. Available from: http://www.allergen.org/search.php?allergensource=Hevea+brasiliensis . Accessed September 17, 2020.
  • Vandenplas O, Raulf M. Occupational latex allergy: the current state of affairs. Curr Allergy Asthma Rep. 2017;17(3):14. doi:10.1007/s11882-017-0682-528251426
  • Korniewicz DM, Chookaew N, El-Masri M, Mudd K, Bollinger ME. Conversion to low-protein, powder-free surgical gloves: is it worth the cost? Am Assoc Occup Health Nurses. 2005;53(9):388–393.
  • Yip E, Cacioli P. The manufacture of gloves from natural rubber latex. J Allergy Clin Immunol. 2002;110(Suppl 2):S3–14. doi:10.1067/mai.2002.12449912170237
  • Critchley E, Pemberton MN. Latex and synthetic rubber glove usage in UK general dental practice: changing trends. Heliyon. 2020;6(5):e03889.32405551
  • Raulf M. Current state of occupational latex allergy. Curr Opin Allergy Clin Immunol. 2020;20(2):112–116. doi:10.1097/ACI.000000000000061131850921
  • Cornish K. Assessment of the risk of type I latex allergy sensitization or reaction during use of products made from latex derived from guayule and other alternative rubber producing species. Rubber Sci. 2012;25:139–155.
  • Caballero ML, Quirce S. Identification and practical management of latex allergy in occupational settings. Expert Rev Clin Immunol. 2015;11(9):977–992. doi:10.1586/1744666X.2015.105975426099284
  • Crepy MN. Rubber: new allergens and preventive measures. Eur J Dermatol. 2016;26(6):523–530. doi:10.1684/ejd.2016.283928007673
  • CDC’s recommendations on the use of PPE during the COVID-19 outbreak. Available from: https://www.cdc.gov/coronavirus/2019-ncov/infection-control/controlrecommendations.html. Accessed 815, 2020.
  • Food and Drug Administration. Enforcement policy for gowns, other apparel, and gloves during the Coronavirus Disease (COVID–19) public health emergency. Guidance for Industry and Food and Drug Administration Staff (March 2020). Docket Number FDA–2020–D–1138. Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/enforcement-policy-gowns-other-apparel-and-gloves-during-coronavirus-disease-covid-19-public-health. Accessed 629, 2020.
  • Food and Drug Administration. Process for Making Available Guidance Documents Related to Coronavirus Disease. 2019 Available from: https://www.govinfo.gov/content/pkg/FR-2020-03-25/pdf/2020-06222.pdf. Accessed 629, 2020.
  • Allmers H, Schmengler J, Skudlik C. Primary prevention of natural rubber latex allergy in the German health care system through education and intervention. J Allergy Clin Immunol. 2002;110(2):318–323. doi:10.1067/mai.2002.12646112170275
  • Nieto A, Mazon A, Pamies R, et al. Efficacy of latex avoidance for primary prevention of latex sensitization in children with spina bifida. J Pediatr. 2002;140(3):370–372. doi:10.1067/mpd.2002.12273211953738
  • Cremer R, Kleine-Diepenbruck U, Hering F, Holschneider AM. Reduction of latex sensitization in spina bifida patients by a primary prophylaxis programme (five years experience). Eur J Pediatr Surg. 2002;12:S19–S21. doi:10.1055/s-2002-3686612541209
  • Stinkens R, Verbeke N, Van de Velde M, et al. Safety of a powder-free latex allergy protocol in the operating theatre: a prospective, observational cohort study. Eur J Anaesthesiol. 2019;36(4):312–313. doi:10.1097/EJA.000000000000095330817368
  • American Society of Anesthesiologists Committee on Occupational Health of Operating Room Personnel. Natural Ruber Latex Allergy: Considerations for Anesthesiologists. Park Ridge, IL: American Society of Anesthesiologists; 2005.
  • Australasian Society of Clinical Immunology and Allergy. ASCIA Guidelines – Management of Latex-Allergic Individuals. Balgowlah NSW: Australasian Society of Clinical Immunology and Allergy; 2010.
  • Sussman GL, Lem D, Liss G, Beezhold D. Latex allergy in housekeeping personnel. Ann Allergy Asthma Immunol. 1995;74:415–418.7749973
  • Sanguanchaiyakrit N, Povey AC, de Vocht F. Personal exposure to inhalable dust and the specific latex aero-allergen, Hev b6.02, in latex glove manufacturing in Thailand. Ann Occup Hyg. 2014;58:542–550. doi:10.1093/annhyg/meu01324569810
  • Havmose M, Thyssen JP, Zachariae C, Johansen JD. Use of protective gloves by hairdressers: a review of efficacy and potential adverse effects. Contact Dermatitis. 2020;83(2):75–82. doi:10.1111/cod.1356132311093
  • Madan I, Cullinan P, Ahmed SM. Occupational management of type I latex allergy. Occup Med. 2013;63(6):395–404. doi:10.1093/occmed/kqt055
  • Crepy MN, Lecuen J, Ratour-Bigot C, Stocks J, Bensefa-Colas L. Accelerator-free gloves as alternatives in cases of glove allergy in healthcare workers. Contact Dermatitis. 2018;78(1):28–32. doi:10.1111/cod.1286028748553
  • Gentili A, Lima M, Ricci G, et al. Secondary prevention of latex allergy in children: analysis of results. Pediatr Med Chir. 2006;28:83.17533902
  • Reider N, Kretz B, Menardi G, Ulmer H, Fritsch P. Outcome of a latex avoidance program in a high‐risk population for latex allergy – a five‐year follow‐up study. Clin Exp Allergy. 2002;32(5):708–713. doi:10.1046/j.1365-2222.2002.01390.x11994094
  • Crippa M, Belleri L, Mistrello G, Tedoldi C, Alessio L. Prevention of latex allergy among health care workers and in the general population: latex protein content in devices commonly used in hospitals and general practice. Int Arch Occup Environ Health. 2006;79(7):550–557. doi:10.1007/s00420-005-0080-516468057
  • Emergency treatment of anaphylactic reactions. Guidelines for healthcare providers. Working Group of the Resuscitation Council (UK). 2016 Available from: www.resus.org.uk. Accessed 815, 2020.
  • Truhlář A, Deakin CD, Soar J, et al. Cardiac arrest in special circumstances section collaborators. European resuscitation council guidelines for resuscitation 2015: section 4. Cardiac arrest in special circumstances. Resuscitation. 2015;95:148–201. doi:10.1016/j.resuscitation.2015.07.01726477412
  • Kraft M, Dölle-Bierke S, Turner PJ, et al. EAACI task force clinical epidemiology of anaphylaxis: experts’ perspective on the use of adrenaline autoinjectors in Europe. Clin Transl Allergy. 2020;10(1):12. doi:10.1186/s13601-020-00317-y32426107
  • Noon L. Prophylactic inoculation against hay fever. Lancet. 1911;1:1572–1573. doi:10.1016/S0140-6736(00)78276-6
  • Freeman J. Further observation on the treatment of hay-fever by hypodermic inoculation of pollen vaccine. Lancet. 1911;2:814–817. doi:10.1016/S0140-6736(01)40417-X
  • Ring J, Gutermuth J. 100 years of hyposensitization: history of allergen-specific immunotherapy (ASIT). Allergy. 2011;66(6):713–724. doi:10.1111/j.1398-9995.2010.02541.x21320133
  • Nucera E, Schiavino D, Pollastrini E, et al. Desensitization to latex by percutaneous route. J Investig Allergol Clin Immunol. 2002;12:134–135.
  • Patriarca G, Nucera E, Buonomo A, et al. Latex allergy desensitization by exposure protocol: five case reports. Anesth Analg. 2002;94:754–758.11867411
  • Pereira C, Rico P, Lourenço M, Lombardero M, Pinto-Mendes J, Chieira C. Specific immunotherapy for occupational latex allergy. Allergy. 1999;54:291–293. doi:10.1034/j.1398-9995.1999.00954.x10321572
  • Leynadier F, Herman D, Vervloet D, Andre C. Specific immunotherapy with a standardized latex extract versus placebo in allergic healthcare workers. J Allergy Clin Immunol. 2000;106(3):585–590. doi:10.1067/mai.2000.10917310984382
  • Sastre J, Fernández-Nieto M, Rico P. Specific immunotherapy with a standardized latex extract in allergic workers: a double-blind, placebo-controlled study. J Allergy Clin Immunol. 2003;111(5):985–994. doi:10.1067/mai.2003.139012743562
  • Tabar AI, Anda M, Bonifazi F, et al. Specific Immunotherapy with standardized latex extract versus placebo in latex-allergic patients. Int Arch Allergy Immunol. 2006;141(4):369–376. doi:10.1159/00009546316943675
  • Nucera E, Schiavino D, Buonomo A, et al. Latex rush desensitization. Allergy. 2001;56:86–87. doi:10.1034/j.1398-9995.2001.00904.x
  • Smith DM, Freeman TM. Sublingual immunotherapy for other indications: venom large local, latex, atopic dermatitis, and food. Immunol Allergy Clin North Am. 2020;40(1):41–57. doi:10.1016/j.iac.2019.09.01131761120
  • Nettis E, Delle Donne P, Di Leo E, et al. Latex immunotherapy: state of the art. Ann Allergy Asthma Immunol. 2012;109(3):160–165. doi:10.1016/j.anai.2012.07.00422920069
  • Patriarca G, Nucera E, Roncallo C, et al. Sublingual desensitization: a new approach to latex allergy problem. Anesth Analg. 2002;95:956–960. doi:10.1097/00000539-200210000-0003112351276
  • Cistero Bahima A, Sastre J, Enrique E, et al. Tolerance and effects on skin reactivity to latex of sublingual rush immunotherapy with a latex extract. J Investig Allergol Clin Immunol. 2004;14:17–25.
  • Antico A, Pagani M, Crema A. Anaphylaxis by latex sublingual immunotherapy. Allergy. 2006;61(10):1236–1237. doi:10.1111/j.1398-9995.2006.01155.x16942577
  • Nettis E, Colanardi MC, Soccio AL, et al. Double-blind, placebo-controlled study of sublingual immunotherapy in patients with latex-induced urticaria: a 12-month study. Br J Dermatol. 2007;156(4):674–681. doi:10.1111/j.1365-2133.2006.07738.x17493066
  • Bernardini R, Campodonico P, Burastero S, et al. Sublingual immunotherapy with a latex extract in paediatric patients: a double-blind, placebo-controlled study. Curr Med Res Opin. 2006;22(8):1515–1522. doi:10.1185/030079906X11571116870076
  • Bernardini R, Pecora S, Milani M, Burastero SE. Natural rubber latex allergy in children: clinical and immunological effects of 3-years sublingual immunotherapy. Eur Ann Allergy Clin Immunol. 2008;40(4):142–147.19227650
  • Nucera E, Schiavino D, Pollastrini E, et al. Sublingual desensitization in children with congenital malformations and latex. Allergy Pediatr Allergy Immunol. 2006;17(8):606–612. doi:10.1111/j.1399-3038.2006.00458.x17121589
  • Nucera E, Schiavino D, Sabato V, et al. Sublingual immunotherapy for latex allergy: tolerability and safety profile of rush build-up phase. Curr Med Res Opin. 2008;24(4):1147–1154. doi:10.1185/030079908X29190318334054
  • Buyukozturk S, Gelincik A, Ferhan F, Colakoğlu B, Dal M. Latex sublingual immunotherapy: can its safety be predicted? Ann Allergy Asthma Immunol. 2010;104:339–342. doi:10.1016/j.anai.2010.01.01420408345
  • Lasa Luaces EM, Tabar Purroy AI, García Figueroa BE, et al. Component-resolved immunologic modifications, efficacy, and tolerance of latex sublingual immunotherapy in children. Ann Allergy Asthma Immunol. 2012;108(5):367–372. doi:10.1016/j.anai.2012.03.00522541410
  • Nucera E, Mezzacappa S, Buonomo A, et al. Latex immunotherapy: evidence of effectiveness. Postepy Dermatol Alergol. 2018;35(2):145–150. doi:10.5114/ada.2018.7523529760613
  • Morfin Maciel BM, Castillo Morfin BM. Failure of sublingual immunotherapy to treat latex allergy. A report of a case. Rev Alerg Mex. 2008;55(2):76–81.19058485
  • Gastaminza G, Algorta J, Uriel O, et al. Randomized, double-blind, placebo controlled clinical trial of sublingual immunotherapy in natural rubber latex allergic patients. Trials. 2011;12:191. doi:10.1186/1745-6215-12-19121827704
  • Nucera E, Urbani S, Buonomo A, Andriollo G, Aruanno A. Eosinophilic Esophagitis during latex desensitization. J Investig Allergol Clin Immunol. 2020;30(1):61–63. doi:10.18176/jiaci.0440
  • Alfredo J, Lucendo AJ, Arias A, Tenias JM. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2014;113:624–629. doi:10.1016/j.anai.2014.08.00425216976
  • Yoshimichi O, Hisako M, Hiroshi O, Shunsuke T, Kimihiro MH. Roles of Omalizumab in various allergic diseases. Allergol Int. 2020;69(2):167–177. doi:10.1016/j.alit.2020.01.00432067933
  • Incorvaia C, Mauro M, Makri E, Leo G, Ridolo E. Two decades with omalizumab: what we still have to learn. Biologics. 2018;12:135–142. doi:10.2147/BTT.S18084630464389
  • Leynadier F, Doudou O, Gaouar H, et al. Effect of omalizumab in healthcare workers with occupational latex allergy. J Allergy Clin Immunol. 2004;113:360–361. doi:10.1016/j.jaci.2003.11.02014767458
  • Di Leo E, Calogiuri G, Macchia L, Nettis E. Use of omalizumab in uncontrolled chronic spontaneous urticaria also improved latex-induced contact urticaria. J Allergy Clin Immunol Pract. 2019;7(1):300–302. doi:10.1016/j.jaip.2018.05.00529802908
  • Aruanno A, Chini R, Nucera E. Efficacy of omalizumab in reducing latex allergy. Postepy Dermatol Alergol. 2020.
  • Dantzer JA, Wood RA. The use of omalizumab in allergen immunotherapy. Clin Exp Allergy. 2018;48(3):232–240. doi:10.1111/cea.1308429315922
  • Hu K, Fan J, Li X, Gou X, Li X, Zhou X. The adverse skin reactions of health care workers using personal protective equipment for COVID-19. Medicine. 2020;99(24):e20603. doi:10.1097/MD.000000000002060332541493
  • Raulf M. The latex story. Chem Immunol Allergy. 2014;100:248–255.24925405
  • Pecora V, Aruanno A, Buonomo A, et al. Sublingual immunotherapy with natural rubber latex: a case report with 8-year follow-up. Contact Dermatitis. 2010;63(1):53–54. doi:10.1111/j.1600-0536.2010.01746.x20597936