Type 2-High Severe Asthma with and without Bronchiectasis: A Prospective Observational Multicentre Study

References

• Holguin F, Cardet JC, Chung KF, et al. Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2020;55(1):1900588. doi:10.1183/13993003.00588-2019
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. doi:10.1183/09031936.00202013
   PubMed Web of Science ®Google Scholar
• Hekking PW, Wener RR, Amelink M, Zwinderman AH, Bouvy ML, Bel EH. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015;135(4):896–902. doi:10.1016/j.jaci.2014.08.042
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). GINA Report, global strategy for asthma management and prevention; 2019. Available from: http://ginasthma.org. Accessed February 05, 2021.
   Google Scholar
• Melero Moreno C, Quirce S, Huerta A, Uría E, Cuesta M. Economic impact of severe asthma in Spain: multicentre observational longitudinal study. J Asthma. 2019;56(8):861–871. doi:10.1080/02770903.2018.1499035
   PubMed Web of Science ®Google Scholar
• Kuruvilla ME, Lee FE, Lee GB. Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clin Rev Allergy Immunol. 2019;56(2):219–233. doi:10.1007/s12016-018-8712-1
   PubMed Web of Science ®Google Scholar
• Bardin PG, Rangaswamy J, Yo SW. Managing comorbid conditions in severe asthma. Med J Aust. 2018;209(S2):S11–S17. doi:10.5694/mja18.00196
   PubMed Web of Science ®Google Scholar
• Boulet LP, Boulay MÈ. Asthma-related comorbidities. Expert Rev Respir Med. 2011;5(3):377–393. doi:10.1586/ers.11.34
   PubMed Web of Science ®Google Scholar
• Polverino E, Dimakou K, Hurst J, et al. The overlap between bronchiectasis and chronic airway diseases: state of the art and future directions. Eur Respir J. 2018;52(3):1800328. doi:10.1183/13993003.00328-2018
   PubMed Web of Science ®Google Scholar
• Crimi C, Ferri S, Crimi N. Bronchiectasis and asthma: a dangerous liaison? Curr Opin Allergy Clin Immunol. 2019;19(1):46–52. doi:10.1097/ACI.0000000000000492
   PubMed Web of Science ®Google Scholar
• García-Clemente M, Enríquez-Rodríguez AI, Iscar-Urrutia M, et al. Severe asthma and bronchiectasis. J Asthma. 2020;57(5):505–509. doi:10.1080/02770903.2019.1579832
   PubMed Web of Science ®Google Scholar
• Polverino E, Goeminne PC, McDonnell MJ, et al. European respiratory society guidelines for the management of adult bronchiectasis. Eur Respir J. 2017;50(3):1700629. doi:10.1183/13993003.00629-2017
   PubMed Web of Science ®Google Scholar
• Crimi C, Ferri S, Campisi R, Crimi N. The link between asthma and bronchiectasis: state of the art. Respiration. 2020;99(6):463–476. doi:10.1159/000507228
   PubMed Web of Science ®Google Scholar
• Smith SG, Chen R, Kjarsgaard M, et al. Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia. J Allergy Clin Immunol. 2016;137(1):75–86.e8. doi:10.1016/j.jaci.2015.05.037
   PubMed Web of Science ®Google Scholar
• Choi Y, Sim S, Park HS. Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications. Korean J Intern Med. 2020;35(4):823–833. doi:10.3904/kjim.2020.022
   PubMed Web of Science ®Google Scholar
• Gramegna A, Aliberti S, Seia M, et al. When and how ruling out cystic fibrosis in adult patients with bronchiectasis. Multidiscip Respir Med. 2018;13(Suppl 1):29. doi:10.1186/s40248-018-0142-7
   Web of Science ®Google Scholar
• Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009;180(1):59–99. doi:10.1164/rccm.200801-060ST
   PubMed Web of Science ®Google Scholar
• Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–338. doi:10.1183/09031936.05.00034805
   PubMed Web of Science ®Google Scholar
• Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59–65. doi:10.1016/j.jaci.2003.09.008
   PubMed Web of Science ®Google Scholar
• Crimi C, Campisi R, Noto A, et al. Comparability of asthma control test scores between self and physician-administered test. Respir Med. 2020;170:106015. doi:10.1016/j.rmed.2020.10601
   PubMed Web of Science ®Google Scholar
• Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602–615. doi:10.1164/rccm.9120-11ST
   PubMed Web of Science ®Google Scholar
• Murray MP, Pentland JL, Turnbull K, MacQuarrie S, Hill AT. Sputum colour: a useful clinical tool in non-cystic fibrosis bronchiectasis. Eur Respir J. 2009;34(2):361–364. doi:10.1183/09031936.00163208
   PubMed Web of Science ®Google Scholar
• Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(SupplS29):1–464. doi:10.4193/Rhin20.600
   Google Scholar
• Padilla-Galo A, Olveira C, Fernández de Rota-garcia L, et al. Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients. Respir Res. 2018;19(1):43. doi:10.1186/s12931-018-0746-7
   PubMed Web of Science ®Google Scholar
• Lynch DA, Newell JD, Tschomper BA, Cink TM, Newman LS, Bethel R. Uncomplicated asthma in adults: comparison of CT appearance of the lungs in asthmatic and healthy subjects. Radiology. 1993;188(3):829–833. doi:10.1148/radiology.188.3.8351357
   PubMed Web of Science ®Google Scholar
• Naidich DP, McCauley DI, Khouri NF, Stitik FP, Siegelman SS. Computed tomography of bronchiectasis. J Comput Assist Tomogr. 1982;6(3):437–444. doi:10.1097/00004728-198206000-00001
   PubMed Web of Science ®Google Scholar
• Bhalla M, Turcios N, Aponte V, et al. Cystic fibrosis: scoring system with thin-section CT. Radiology. 1991;179(3):783–788. doi:10.1148/radiology.179.3.2027992
   PubMed Web of Science ®Google Scholar
• Lm REID. Reduction in bronchial subdivision in bronchiectasis. Thorax. 1950;5(3):233–247. doi:10.1136/thx.5.3.233
   Web of Science ®Google Scholar
• Pasteur MC, Helliwell SM, Houghton SJ, et al. An investigation into causative factors in patients with bronchiectasis. Am J Respir Crit Care Med. 2000;162(4 Pt 1):1277–1284. doi:10.1164/ajrccm.162.4.9906120
   PubMed Web of Science ®Google Scholar
• Kwok WC, Ho JCM, Tam TCC, et al. Risk factors for Pseudomonas aeruginosa colonization in non-cystic fibrosis bronchiectasis and clinical implications. Respir Res. 2021;22(132). doi:10.1186/s12931-021-01729-5
   Web of Science ®Google Scholar
• Chalmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med. 2014;189(5):576–585. doi:10.1164/rccm.201309-1575OC
   PubMed Web of Science ®Google Scholar
• Dimakou K, Gousiou A, Toumbis M, et al. Investigation of bronchiectasis in severe uncontrolled asthma. Clin Respir J. 2018;12(3):1212–1218. doi:10.1111/crj.12653
   PubMed Web of Science ®Google Scholar
• Ferri S, Crimi C, Campisi R, et al. Impact of asthma on bronchiectasis severity and risk of exacerbations. J Asthma. 2020:1–12. doi: 10.1080/02770903.2020.1857395.
   Web of Science ®Google Scholar
• Perez-Miranda J, Traversi L, Polverino E. Bronchiectasis in severe asthma: a distinct phenotype? Curr Opin Pulm Med. 2019;25(1):71–78. doi:10.1097/MCP.0000000000000542
   PubMed Web of Science ®Google Scholar
• Coman I, Pola-Bibián B, Barranco P, et al. Bronchiectasis in severe asthma: clinical features and outcomes. Ann Allergy Asthma Immunol. 2018;120(4):409–413. doi:10.1016/j.anai.2018.02.016
   PubMed Web of Science ®Google Scholar
• Handley E, Nicolson CH, Hew M, Lee AL. Prevalence and clinical implications of chronic rhinosinusitis in people with bronchiectasis: a systematic review. J Allergy Clin Immunol Pract. 2019;7(6):2004–2012.e1. doi:10.1016/j.jaip.2019.02.026
   PubMed Web of Science ®Google Scholar
• Canonica GW, Malvezzi L, Blasi F, et al. Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: evidences from the Severe Asthma Network Italy (SANI) registry. Respir Med. 2020;166:105947. doi:10.1016/j.rmed.2020.105947
   PubMed Web of Science ®Google Scholar
• Martínez-Rivera C, Crespo A, Pinedo-Sierra C, et al. Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations. Respir Med. 2018;135:22–28. doi:10.1016/j.rmed.2017.12.013
   PubMed Web of Science ®Google Scholar
• Peters AT, Bose S, Guo A, et al. Prevalence of bronchiectasis in patients with chronic rhinosinusitis in a tertiary care center. J Allergy Clin Immunol Pract. 2021;9(8):3188–3195.e2. doi:10.1016/j.jaip.2021.04.054
   Web of Science ®Google Scholar
• Boucher RC. Muco-Obstructive Lung Diseases. N Engl J Med. 2019;380(20):1941–1953. doi:10.1056/NEJMra1813799
   PubMed Web of Science ®Google Scholar
• Fanta CH. Clinical aspects of mucus and mucous plugging in asthma. J Asthma. 1985;22(6):295–301. doi:10.3109/02770908509087113
   PubMed Web of Science ®Google Scholar
• Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–1485. doi:10.1016/j.cell.2021.02.016
   PubMed Web of Science ®Google Scholar
• Crespo-Lessmann A, Bernal S, Del Río E, et al. Association of the CFTR gene with asthma and airway mucus hypersecretion. PLoS One. 2021;16(6):e0251881. doi:10.1371/journal.pone.0251881
   PubMed Web of Science ®Google Scholar
• Dunican EM, Elicker BM, Gierada DS, et al. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018;128(3):997–1009. doi:10.1172/JCI95693
   PubMed Web of Science ®Google Scholar
• Hoshino M, Matsuoka S, Handa H, Miyazawa T, Yagihashi K. Correlation between airflow limitation and airway dimensions assessed by multidetector CT in asthma. Respir Med. 2010;104(6):794–800. doi:10.1016/j.rmed.2009.12.005
   Web of Science ®Google Scholar
• King PT, Holdsworth SR, Freezer NJ, Villanueva E, Holmes PW. Characterisation of the onset and presenting clinical features of adult bronchiectasis. Respir Med. 2006;100(12):2183–2189. doi:10.1016/j.rmed.2006.03.012
   PubMed Web of Science ®Google Scholar
• Crimi C, Campisi R, Cacopardo G, et al. Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities. World Allergy Organ J. 2020;13(9):100462. doi:10.1016/j.waojou.2020.100462
   PubMed Web of Science ®Google Scholar
• Crimi C, Campisi R, Nolasco S, et al. Mepolizumab effectiveness in patients with severe eosinophilic asthma and co-presence of bronchiectasis: a real-world retrospective pilot study. Respir Med. 2021;185:106491. doi:10.1016/j.rmed.2021.106491
   PubMed Web of Science ®Google Scholar
• Henderson WR, Chi EY, Klebanoff SJ. Eosinophil peroxidase-induced mast cell secretion. J Exp Med. 1980;152(2):265–279. doi:10.1084/jem.152.2.265
   Web of Science ®Google Scholar
• Carr TF, Berdnikovs S, Simon HU, Bochner BS, Rosenwasser LJ. Eosinophilic bioactivities in severe asthma. World Allergy Organ J. 2016;9:21. doi:10.1186/s40413-016-0112-5
   PubMed Web of Science ®Google Scholar
• Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol. 2007;19(6):676–680. doi:10.1016/j.coi.2007.07.017
   PubMed Web of Science ®Google Scholar
• Cho JY. Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic. Korean J Intern Med. 2011;26(4):367–383. doi:10.3904/kjim.2011.26.4.367
   Google Scholar
• Coverstone AM, Seibold MA, Peters MC. Diagnosis and management of T2-high asthma. J Allergy Clin Immunol Pract. 2020;8(2):442–450. doi:10.1016/j.jaip.2019.11.020
   PubMed Web of Science ®Google Scholar
• Kudlaty E, Patel GB, Prickett ML, Yeh C, Peters AT. Efficacy of type 2-targeted biologics in patients with asthma and bronchiectasis. Ann Allergy Asthma Immunol. 2021;126(3):302–304. doi:10.1016/j.anai.2020.11.014
   PubMed Web of Science ®Google Scholar
• Pelaia C, Crimi C, Vatrella A, Tinello C, Terracciano R, Pelaia G. Molecular Targets for Biological Therapies of Severe Asthma. Front Immunol. 2020;11:603312. doi:10.3389/fimmu.2020.603312
   PubMed Web of Science ®Google Scholar
• Nolasco S, Crimi C, Pelaia C, et al. Benralizumab effectiveness in severe eosinophilic asthma with and without chronic rhinosinusitis with nasal polyps: a Real-World Multicenter Study. J Allergy Clin Immunol Pract. 2021:S2213-2198(21) 00903-X. doi: 10.1016/j.jaip.2021.08.004.
   Web of Science ®Google Scholar
• Carpagnano GE, Scioscia G, Lacedonia D, Curradi G, Foschino Barbaro MP. Severe uncontrolled asthma with bronchiectasis: a pilot study of an emerging phenotype that responds to mepolizumab. J Asthma Allergy. 2019;12:83–90. doi:10.2147/JAA.S196200
   PubMed Web of Science ®Google Scholar
• Ferri S, Crimi C, Heffler E, Campisi R, Noto A, Crimi N. Vitamin D and disease severity in bronchiectasis. Respir Med. 2019;148:1–5. doi:10.1016/j.rmed.2019.01.009
   Web of Science ®Google Scholar
• Pelaia C, Crimi C, Benfante A, et al. Therapeutic effects of benralizumab assessed in patients with severe eosinophilic asthma: real-life evaluation correlated with allergic and non-allergic phenotype expression. J Asthma Allergy. 2021;14:163–173. doi:10.2147/JAA.S297273
   PubMed Web of Science ®Google Scholar
• Nolasco S, Campisi R, Intravaia R, et al. Case Report: acute effect of benralizumab on asthma exacerbation without concomitant corticosteroid use. F1000Res. 2020;9:637. doi:10.12688/f1000research.24603.2
   Google Scholar
• Sugita K, Kabashima K. Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases. J Leukoc Biol. 2020;107(5):749–762. doi:10.1002/JLB.5MR0120-230R
   Web of Science ®Google Scholar