292
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Exploring Factors Underlying Poorly-Controlled Asthma in Adults by Integrating Phenotypes and Genotypes Associated with Obesity and Asthma: A Case-Control Study

, ORCID Icon, , , , , ORCID Icon & ORCID Icon show all
Pages 135-147 | Received 10 Nov 2022, Accepted 10 Jan 2023, Published online: 21 Jan 2023

References

  • Vos T, Lim SS, Abbafati C., et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204–1222.
  • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention (2022 updated); 2022. Available from: www.ginasthma.org. Accessed January 12, 2023.
  • Backman H, Jansson S-A, Stridsman C, et al. Severe asthma among adults: prevalence and clinical characteristics. Eur Respir J. 2018;52(suppl 62):PA3918.
  • Rönnebjerg L, Axelsson M, Kankaanranta H, et al. Severe Asthma in a General Population Study: prevalence and Clinical Characteristics. J Asthma Allergy. 2021;14:1105–1115. doi:10.2147/JAA.S327659
  • Volmer T, Effenberger T, Trautner C, Buhl R. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J. 2018;52:4. doi:10.1183/13993003.00703-2018
  • Kerkhof M, Tran TN, Soriano JB, et al. Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population. Thorax. 2018;73(2):116–124. doi:10.1136/thoraxjnl-2017-210531
  • Wang E, Wechsler ME, Tran TN, et al. Characterization of Severe Asthma Worldwide: data From the International Severe Asthma Registry. Chest. 2020;157(4):790–804. doi:10.1016/j.chest.2019.10.053
  • Huang Y-J, Chu Y-C, Huang H-L, Hwang J-S, Chan T-C. The Effects of Asthma on the Association Between Pulmonary Function and Obesity: a 16-Year Longitudinal Study. J Asthma Allergy. 2021;14:347–359. doi:10.2147/JAA.S299186
  • Yiallouros PK, Kouis P, Kolokotroni O, et al. Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus. Ital J Pediatr. 2016;42(1):67. doi:10.1186/s13052-016-0276-1
  • Melén E, Himes BE, Brehm JM, et al. Analyses of shared genetic factors between asthma and obesity in children. J Allergy Clin Immunol. 2010;126(3):e631–638. doi:10.1016/j.jaci.2010.06.030
  • Zhu Z, Guo Y, Shi H, et al. Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. J Allergy Clin Immunol. 2020;145(2):537–549. doi:10.1016/j.jaci.2019.09.035
  • Mohamed NA, Abdel-Rehim AS. Influence of vitamin D receptor gene FokI and ApaI polymorphisms on glucocorticoid response in patients with asthma. Int Forum Allergy Rhinol. 2020;10(4):556–563. doi:10.1002/alr.22511
  • Hikino K, Kobayashi S, Ota E, Mushiroda T, Urayama KY, Kobayashi T. A meta-analysis of the influence of ADRB2 genetic polymorphisms on albuterol (salbutamol) therapy in patients with asthma. Br J Clin Pharmacol. 2021;87(4):1708–1716. doi:10.1111/bcp.14570
  • Toraih EA, Hussein MH, Ibrahim A, et al. Beta(2)-adrenergic receptor variants in children and adolescents with bronchial asthma. Front Biosci. 2019;11(1):61–78. doi:10.2741/E846
  • Zondervan KT, Cardon LR. Designing candidate gene and genome-wide case-control association studies. Nat Protoc. 2007;2(10):2492–2501. doi:10.1038/nprot.2007.366
  • Fan CT, Lin JC, Lee CH. Taiwan Biobank: a project aiming to aid Taiwan’s transition into a biomedical island. Pharmacogenomics. 2008;9(2):235–246. doi:10.2217/14622416.9.2.235
  • Hsing AW, Ioannidis JP. Nationwide population science: lessons from the Taiwan national health insurance research database. JAMA Intern Med. 2015;175(9):1527–1529. doi:10.1001/jamainternmed.2015.3540
  • Gold LS, Thompson P, Salvi S, Faruqi RA, Sullivan SD. Level of asthma control and health care utilization in Asia-Pacific countries. Respir Med. 2014;108(2):271–277. doi:10.1016/j.rmed.2013.12.004
  • Ho -C-C, Chen L-J, Hwang J-S. Estimating ground-level PM2.5 levels in Taiwan using data from air quality monitoring stations and high coverage of microsensors. Environ Pollut. 2020;264:114810. doi:10.1016/j.envpol.2020.114810
  • Taiwan Health Promotion Administration (THPA). Evidences-based guideline on adult obesity prevention and management; 2018. Available from: https://www.hpa.gov.tw/File/Attach/10042/File_12271.pdf. Accessed 1, June 2021.
  • Browning LM, Hsieh SD, Ashwell M. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0.5 could be a suitable global boundary value. Nutr Res Rev. 2010;23(2):247–269. doi:10.1017/S0954422410000144
  • Chen CH, Yang JH, Chiang CWK, et al. Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project. Hum Mol Genet. 2016;25(24):5321–5331. doi:10.1093/hmg/ddw346
  • Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4(1):s13742–13748. doi:10.1186/s13742-015-0047-8
  • Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–909. doi:10.1038/ng1847
  • Gögele M, Minelli C, Thakkinstian A, et al. Methods for Meta-Analyses of Genome-wide Association Studies: critical Assessment of Empirical Evidence. Am J Epidemiol. 2012;175(8):739–749. doi:10.1093/aje/kwr385
  • Budtz–Jørgensen E, Keiding N, Grandjean P, Weihe P. Confounder Selection in Environmental Epidemiology: assessment of Health Effects of Prenatal Mercury Exposure. Ann Epidemiol. 2007;17(1):27–35. doi:10.1016/j.annepidem.2006.05.007
  • Consortium G, Ardlie KG, Deluca DS, et al. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348(6235):648–660. doi:10.1126/science.1262110
  • Wang J, Vasaikar S, Shi Z, Greer M, Zhang B. WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit. Nucleic Acids Res. 2017;45(W1):W130–W137. doi:10.1093/nar/gkx356
  • Schatz M, Zeiger RS, Zhang F, Chen W, Yang S-J, Camargo CA. Overweight/Obesity and Risk of Seasonal Asthma Exacerbations. J Allergy Clin Immunol Pract. 2013;1(6):618–622. doi:10.1016/j.jaip.2013.07.009
  • Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018;141(4):1169–1179. doi:10.1016/j.jaci.2018.02.004
  • Ashwell M, Gunn P, Gibson S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev. 2012;13(3):275–286. doi:10.1111/j.1467-789X.2011.00952.x
  • Jiang D, Wang L, Bai C, Chen O. Association between abdominal obesity and asthma: a meta-analysis. Allergy Asthma Clin Immunol. 2019;15(1):16. doi:10.1186/s13223-019-0333-6
  • Baffi CW, Winnica DE, Holguin F. Asthma and obesity: mechanisms and clinical implications. Asthma Res Practice. 2015;1(1):1. doi:10.1186/s40733-015-0001-7
  • McNelis JC, Olefsky JM. Macrophages, immunity, and metabolic disease. Immunity. 2014;41(1):36–48. doi:10.1016/j.immuni.2014.05.010
  • Bruno A, Pace E, Chanez P, et al. Leptin and leptin receptor expression in asthma. J Allergy Clin Immunol. 2009;124(2):230–237, 237.e231–234. doi:10.1016/j.jaci.2009.04.032
  • Thomsen SF. Exploring the origins of asthma: lessons from twin studies. Eur Clin Respir J. 2014;1(Suppl1). doi:10.3402/ecrj.v3401.25535
  • Farooqi IS, O’Rahilly S. Recent advances in the genetics of severe childhood obesity. Arch Dis Child. 2000;83(1):31–34. doi:10.1136/adc.83.1.31
  • Figueiredo RG, Costa RS, Figueiredo CA, Cruz AA. Genetic Determinants of Poor Response to Treatment in Severe Asthma. Int J Mol Sci. 2021;22(8):4251. doi:10.3390/ijms22084251
  • Weiss ST. Obesity: insight into the origins of asthma. Nat Immunol. 2005;6(6):537–539. doi:10.1038/ni0605-537
  • Koopmans T, Hesse L, Nawijn MC, et al. Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation. Sci Rep. 2020;10(1):6754. doi:10.1038/s41598-020-63741-x
  • Cao X, Ding L, Mersha TB. Development and validation of an RNA-seq-based transcriptomic risk score for asthma. Sci Rep. 2022;12(1):8643. doi:10.1038/s41598-022-12199-0
  • Liu MJ, Bao S, Gálvez-Peralta M, et al. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep. 2013;3(2):386–400. doi:10.1016/j.celrep.2013.01.009