Key Characteristics of Asthma Patients with COVID-19 Vary Substantially by Age

References

• Gao Y, Ding M, Dong X. et al. Risk factors for severe and critically ill COVID‐19 patients: a review. Allergy. 2021;76(2):428–455. doi:10.1111/all.14657
   PubMed Web of Science ®Google Scholar
• Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using openSAFELY. Nature. 2020;584(7821):430–436. doi:10.1038/s41586-020-2521-4
   PubMed Web of Science ®Google Scholar
• Sunjaya AP, Allida SM, Di Tanna GL, Jenkins CR. Asthma and COVID-19 risk: a systematic review and meta-analysis. Eur Respir J. 2022;59(3):2101209. doi:10.1183/13993003.01209-2021
   PubMed Web of Science ®Google Scholar
• Ubah CS, Kearney GD, Pokhrel LR. Asthma may not be a potential risk factor for severe COVID-19 illness: a scoping review. Environ Health Ins. 2024;18:11786302231221925. doi:10.1177/11786302231221925
   Web of Science ®Google Scholar
• Otunla A, Rees K, Dennison P, et al. Risks of infection, hospital and ICU admission, and death from COVID-19 in people with asthma: systematic review and meta-analyses. BMJ EBM. 2022;27(5):263–273. doi:10.1136/bmjebm-2021-111788
   Google Scholar
• Bloom C. Covid‐19 pandemic and asthma: what did we learn? Respirology. 2023;28(7):603–614. doi:10.1111/resp.14515
   PubMed Web of Science ®Google Scholar
• Assaf S, Stenberg H, Jeseňák M, Tarasevych S, Hanania N, Diamant Z. Asthma in the era of COVID-19. Respir Med. 2023;null:107373. doi:10.1016/j.rmed.2023.107373
   Google Scholar
• Izquierdo JL, Almonacid C, González Y, et al. The impact of COVID-19 on patients with asthma. Eur Respir J. doi:10.1183/13993003.03142-2020
   Web of Science ®Google Scholar
• Lee SC, Son KJ, Han CH, Jung JY, Park SC. Impact of comorbid asthma on severity of coronavirus disease (COVID-19). Sci Rep. 2020;10(1):21805. doi:10.1038/s41598-020-77791-8
   PubMed Web of Science ®Google Scholar
• Calmes D, Graff S, Maes N, et al. Asthma and COPD are not risk factors for ICU stay and death in case of SARS-CoV2 Infection. J Allergy Clin Immunol Pract. 2020;(1):160–169. doi:10.1016/j.jaip.2020.09.044
   PubMed Web of Science ®Google Scholar
• Chhiba KD, Patel GB, THT V, et al. Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19. J Allergy Clin Immunol. 2020;146(2):307–314.e4. doi:10.1016/j.jaci.2020.06.010
   PubMed Web of Science ®Google Scholar
• Skevaki C, Chinthrajah RS, Fomina D, et al. Comorbidity defines asthmatic patients’ risk of COVID-19 hospitalization: a global perspective. J Allergy Clin Immunol. 2023;151(1):110–117. doi:10.1016/j.jaci.2022.09.039
   PubMed Web of Science ®Google Scholar
• Bloom CI, Cullinan P, Wedzicha JA. Asthma phenotypes and COVID-19 risk: a population-based observational study. Am J Respir Crit Care Med. 2022;205(1):36–45. doi:10.1164/rccm.202107-1704OC
   PubMed Web of Science ®Google Scholar
• Karlsson Sundbaum J, Vanfleteren LEGW, Konradsen JR, Nyberg F, Ekberg-Jansson A, Stridsman C. Severe COVID-19 among patients with asthma and COPD: a report from the Swedish national airway register. Ther Adv Respir Dis. 2021;15:175346662110497. doi:10.1177/17534666211049738
   Web of Science ®Google Scholar
• Selberg S, Karlsson Sundbaum J, Konradsen JR, et al. Multiple manifestations of uncontrolled asthma increase the risk of severe COVID-19. Respir Med. 2023;216:107308. doi:10.1016/j.rmed.2023.107308
   PubMed Web of Science ®Google Scholar
• Zein JG, Mitri J, Bell JM, Lopez D, Strauss R, Attaway AH. The relationship of asthma severity to COVID-19 outcomes. J Aller Clini Immun in Prac. 2022;10(1):318–321.e2. doi:10.1016/j.jaip.2021.10.041
   PubMed Web of Science ®Google Scholar
• Dolby T, Nafilyan V, Morgan A, Kallis C, Sheikh A, Quint JK. Relationship between asthma and severe COVID-19: a national cohort study. Thorax. 2023;78(2):120–127. doi:10.1136/thoraxjnl-2021-218629
   PubMed Web of Science ®Google Scholar
• Furci F, Caminati M, Senna G, Gangemi S. The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19. Clin Mol Allergy. 2021;19(1):19. doi:10.1186/s12948-021-00159-4
   PubMedGoogle Scholar
• Schultze A, Walker AJ, MacKenna B, et al. Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform. Lancet Respir Med. 2020;8(11):1106–1120. doi:10.1016/S2213-2600(20)30415-X
   PubMed Web of Science ®Google Scholar
• Shi T, Pan J, Vasileiou E, Robertson C, Sheikh A. Risk of serious COVID-19 outcomes among adults with asthma in Scotland: a national incident cohort study. Lancet Respir Med. 2022;10(4):347–354. doi:10.1016/S2213-2600(21)00543-9
   PubMed Web of Science ®Google Scholar
• Karlsson Sundbaum J, Konradsen JR, LEGW V, et al. Uncontrolled asthma predicts severe COVID-19: a report from the Swedish national airway register. Ther Adv Respir Dis. 2022;16:175346662210911. doi:10.1177/17534666221091183
   Web of Science ®Google Scholar
• Poddighe D, Kovzel E. Impact of anti-type 2 inflammation biologic therapy on COVID-19 clinical course and outcome. JIR. 2021;Volume 14:6845–6853. doi:10.2147/JIR.S345665
   Google Scholar
• Adir Y, Humbert M, Saliba W. COVID-19 risk and outcomes in adult asthmatic patients treated with biologics or systemic corticosteroids: nationwide real-world evidence. J Allergy Clin Immunol. 2021;148(2):361–367.e13. doi:10.1016/j.jaci.2021.06.006
   PubMed Web of Science ®Google Scholar
• Rial MJ, Valverde M, Del Pozo V, et al. Clinical characteristics in 545 patients with severe asthma on biological treatment during the COVID-19 outbreak. J Aller Clini Immun in Prac. 2021;9(1):487–489.e1. doi:10.1016/j.jaip.2020.09.050
   PubMed Web of Science ®Google Scholar
• Papaioannou AI, Fouka E, Tzanakis N, et al. SARS-Cov-2 infection in severe asthma patients treated with biologics. J Aller Clini Immun in Prac. 2022;10(10):2588–2595. doi:10.1016/j.jaip.2022.05.041
   PubMed Web of Science ®Google Scholar
• 2023 GINA Main Report. Global Initiative for Asthma - GINA. https://ginasthma.org/2023-gina-main-report/.
   Google Scholar
• Romero Starke K, Petereit-Haack G, Schubert M, et al. The age-related risk of severe outcomes due to COVID-19 infection: a rapid review, meta-analysis, and meta-regression. IJERPH. 2020;17(16):5974. doi:10.3390/ijerph17165974
   Web of Science ®Google Scholar
• Nyberg F, Franzén S, Lindh M, et al. Swedish covid-19 investigation for future insights – a population epidemiology approach using register Linkage (SCIFI-PEARL). CLEP. 2021;Volume 13:649–659. doi:10.2147/CLEP.S312742
   Google Scholar
• Stridsman C, Konradsen J, Vanfleteren L, et al. The Swedish National Airway Register (SNAR): development, design and utility to date. European Clinic Respira Jour. 2020;7(1):1833412. doi:10.1080/20018525.2020.1833412
   PubMed Web of Science ®Google Scholar
• Rolfhamre P, Jansson A, Arneborn M, Ekdahl K. SmiNet-2: description of an internet-based surveillance system for communicable diseases in Sweden. Euro Surveill. 2006;11(5):103–107. doi:10.2807/esm.11.05.00626-en
   PubMedGoogle Scholar
• Ludvigsson JF, Andersson E, Ekbom A, et al. External review and validation of the Swedish national inpatient register. BMC Public Health. 2011;11(1):450. doi:10.1186/1471-2458-11-450
   PubMed Web of Science ®Google Scholar
• Brooke HL, Talbäck M, Hörnblad J, et al. The Swedish cause of death register. Eur J Epidemiol. 2017;32(9):765–773. doi:10.1007/s10654-017-0316-1
   PubMed Web of Science ®Google Scholar
• Ludvigsson JF, Almqvist C, Bonamy AKE, et al. Registers of the Swedish total population and their use in medical research. Eur J Epidemiol. 2016;31(2):125–136. doi:10.1007/s10654-016-0117-y
   PubMed Web of Science ®Google Scholar
• Ludvigsson JF, Svedberg P, Olén O, Bruze G, Neovius M. The longitudinal integrated database for health insurance and labour market studies (LISA) and its use in medical research. Eur J Epidemiol. 2019;34(4):423–437. doi:10.1007/s10654-019-00511-8
   PubMed Web of Science ®Google Scholar
• Wettermark B, Hammar N, MichaelFored C, et al. The new Swedish prescribed drug register—opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidem Drug Safe. 2007;16(7):726–735. doi:10.1002/pds.1294
   PubMed Web of Science ®Google Scholar
• Hedenström H, Malmberg P, Agarwal K. Reference values for lung function tests in females. Regression equations with smoking variables. Bull Eur Physiopathol Respir. 1985;21(6):551–557.
   PubMedGoogle Scholar
• Sullivan GM, Feinn R. Using effect size—or why the P value Is Not Enough. J Grad Med Educa. 2012;4(3):279–282. doi:10.4300/JGME-D-12-00156.1
   PubMedGoogle Scholar
• Yoshida K, Bartel A, Chipman JJ, et al. tableone: Create “Table 1” to Describe Baseline Characteristics. Available from: https://CRAN.R-project.org/package=tableone. Accessed June 13, 2024.
   Google Scholar
• Austin PC. Using the standardized difference to compare the prevalence of a binary variable between two groups in observational research. Commun Statis Simula Compu. 2009;38(6):1228–1234. doi:10.1080/03610910902859574
   Web of Science ®Google Scholar
• Yang D, Dalton JE. A unified approach to measuring the effect size between two groups using SAS. 2012. Available from: https://api.semanticscholar.org/CorpusID:9425733. Accessed June 13.
   Google Scholar
• Flury BK, Riedwyl H. Standard Distance in Univariate and Multivariate Analysis. The American Statistician. 1986;40(3):249–251. doi:10.1080/00031305.1986.10475403
   Web of Science ®Google Scholar
• Austin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Statist Med. 2009;28(25):3083–3107. doi:10.1002/sim.3697
   PubMed Web of Science ®Google Scholar
• Beurnier A, Jutant EM, Jevnikar M, et al. Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation. Eur Respir J. 2020;56(5). doi:10.1183/13993003.01875-2020
   PubMed Web of Science ®Google Scholar
• Wang L, Foer D, Bates DW, Boyce JA, Zhou L. Risk factors for hospitalization, intensive care, and mortality among patients with asthma and COVID-19. J Allergy Clin Immunol. 2020;146(4):808–812. doi:10.1016/j.jaci.2020.07.018
   PubMed Web of Science ®Google Scholar
• Lieberman-Cribbin W, Rapp J, Alpert N, Tuminello S, Taioli E. The impact of asthma on mortality in patients with COVID-19. Chest. 2020;158(6):2290–2291. doi:10.1016/j.chest.2020.05.575
   PubMed Web of Science ®Google Scholar
• Robinson LB, Wang L, Fu X, et al. COVID-19 severity in asthma patients: a multi-center matched cohort study. J Asthma Pub Online Mar. 2(2021):1–14. doi:10.1080/02770903.2020.1857396
   Google Scholar
• Choi YJ, Park JY, Lee HS, et al. Effect of Asthma and asthma medication on the prognosis of patients with COVID-19. Eur Respir J. 2020. doi:10.1183/13993003.02226-2020
   Web of Science ®Google Scholar
• Bloom CI, Drake TM, Docherty AB, et al. Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO clinical characterisation protocol UK. Lancet Respir Med. 2021;9(7):699–711. doi:10.1016/S2213-2600(21)00013-8
   PubMed Web of Science ®Google Scholar
• Nwaru CA, Santosa A, Franzén S, Nyberg F. Occupation and COVID-19 diagnosis, hospitalisation and ICU admission among foreign-born and Swedish-born employees: a register-based study. J Epidemiol Community Health. 2022;76(5):440–447. doi:10.1136/jech-2021-218278
   PubMed Web of Science ®Google Scholar
• Anaya JM, Shoenfeld Y, Rojas-Villarraga A, Levy RA, Cervera R. Autoimmunity: From Bench to Bedside. First edition ed. Center for Autoimmune Diseases Research, School of Medicine and Health Sciences, El Rosario University; 2013.
   Google Scholar
• Smith ML, Gradus JL. Psychiatric disorders and risk of infections: early lessons from COVID-19. Lancet Healthy Longe. 2020;1(2):e51–e52. doi:10.1016/S2666-7568(20)30020-9
   PubMedGoogle Scholar
• Yang H, Chen W, Hu Y, et al. Pre-pandemic psychiatric disorders and risk of COVID-19: a UK Biobank cohort analysis. Lancet Healthy Longe. 2020;1(2):e69–e79. doi:10.1016/S2666-7568(20)30013-1
   PubMedGoogle Scholar
• Scala E, Abeni D, Tedeschi A, et al. Atopic status protects from severe complications of COVID‐19. Allergy. 2021;76(3):899–902. doi:10.1111/all.14551
   PubMed Web of Science ®Google Scholar
• Chen C, Song X, Murdock DJ, et al. Association between allergic conditions and COVID-19 susceptibility and outcomes. Ann Allergy Asthma Immunol. 2024;132(5):637–645.e7. doi:10.1016/j.anai.2024.01.011
   PubMed Web of Science ®Google Scholar
• Kimura H, Francisco D, Conway M, et al. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. J Allergy Clin Immunol. 2020;146(1):80–88.e8. doi:10.1016/j.jaci.2020.05.004
   PubMed Web of Science ®Google Scholar
• Liuzzo Scorpo M, Ferrante G, La Grutta S. An overview of asthma and COVID-19: protective factors against SARS-COV-2 in pediatric patients. Front Pediatr. 2021;9:661206. doi:10.3389/fped.2021.661206
   PubMed Web of Science ®Google Scholar
• Jackson DJ, Busse WW, Bacharier LB, et al. Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. J Allergy Clin Immunol. 2020;146(1):203–206.e3. doi:10.1016/j.jaci.2020.04.009
   PubMed Web of Science ®Google Scholar
• Melén E, Nwaru BI, Wiklund F, et al. Short-acting β2 </sub> -agonist use and asthma exacerbations in Swedish children: a SABINA Junior study., Pediatric Allergy Immunology, 2022;3311:e13885. 10.1111/pai.13885. Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology
   PubMed Web of Science ®Google Scholar
• Nassoro DD, Mujwahuzi L, Mwakyula IH, Possi MK, Lyantagaye SL. 2021. Asthma and COVID-19: emphasis on adequate asthma control. In: Radovanovic D, editor. Canadian Respiratory Journal. 2021;1–12. doi:10.1155/2021/9621572
   Google Scholar
• Lovinsky-Desir S, Deshpande DR, De A, et al. Asthma among hospitalized patients with COVID-19 and related outcomes. J Allergy Clin Immunol. 2020;146(5):1027–1034.e4. doi:10.1016/j.jaci.2020.07.026
   PubMed Web of Science ®Google Scholar