DIC in Pregnancy – Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments

References

• Singh B, Hanson AC, Alhurani R, et al. Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004–2010): a population-based study. Chest. 2013;143:1235–1242. doi:10.1378/chest.12-2112
   PubMed Web of Science ®Google Scholar
• Cunningham FG, Nelson DB. Disseminated intravascular coagulation syndromes in obstetrics. Obstet Gynecol. 2015;126:999–1011. doi:10.1097/AOG.0000000000001110
   PubMed Web of Science ®Google Scholar
• Gulumser C, Engin-Ustun Y, Keskin L, et al. Maternal mortality due to hemorrhage: population-based study in Turkey. J Mater Fetal Neonatal Med. 2019;32:3998–4004. doi:10.1080/14767058.2018.1481029
   PubMed Web of Science ®Google Scholar
• Rattray DD, O’Connell CM, Baskett TF. Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009). J Obstet Gynaecol Can. 2012;34:341–347. doi:10.1016/S1701-2163(16)35214-8
   PubMedGoogle Scholar
• Erez O, Novack L, Beer-Weisel R, et al. DIC score in pregnant women–a population based modification of the International Society on Thrombosis and Hemostasis score. PLoS One. 2014;9:e93240. doi:10.1371/journal.pone.0093240
   PubMed Web of Science ®Google Scholar
• Onishi K, Tsuda H, Fuma K, et al. The impact of the abruption severity and the onset-to-delivery time on the maternal and neonatal outcomes of placental abruption. J Mater Fetal Neonatal Med. 2019;33:1–9.
   Web of Science ®Google Scholar
• Qiu Y, Wu L, Xiao Y, Zhang X. Clinical analysis and classification of placental abruption. J Mater Fetal Neonatal Med. 2019;2:1–5.
   Google Scholar
• Kilicci C, Ozkaya E, Karakus R, et al. Early low molecular weight heparin for postpartum hemorrhage in women with pre-eclampsia. Is it effective to prevent consumptive coagulopathy? J Mater Fetal Neonatal Med. 2020;33:410–414. doi:10.1080/14767058.2018.1494708
   PubMed Web of Science ®Google Scholar
• Thachil J, Toh CH. Disseminated intravascular coagulation in obstetric disorders and its acute haematological management. Blood Rev. 2009;23:167–176. doi:10.1016/j.blre.2009.04.002
   PubMed Web of Science ®Google Scholar
• Romero R, Copel JA, Hobbins JC. Intrauterine fetal demise and hemostatic failure: the fetal death syndrome. Clin Obstet Gynecol. 1985;28:24–31. doi:10.1097/00003081-198528010-00004
   PubMed Web of Science ®Google Scholar
• Levi M, de Jonge E, van der Poll T, Ten Cate H. Advances in the understanding of the pathogenetic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies. Semin Thromb Hemost. 2001;27:569–575. doi:10.1055/s-2001-18862
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G, Manzato F. Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation. Thromb J. 2006;4:4. doi:10.1186/1477-9560-4-4
   PubMedGoogle Scholar
• Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86:1327–1330. doi:10.1055/s-0037-1616068
   PubMed Web of Science ®Google Scholar
• Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol. 2009;145:24–33. doi:10.1111/j.1365-2141.2009.07600.x
   PubMed Web of Science ®Google Scholar
• Gando S, Levi M. Disseminated intravascular coagulation. Nat Rev Dis Primers. 2016;2:16038. doi:10.1038/nrdp.2016.38
   PubMed Web of Science ®Google Scholar
• Erez O, Mastrolia SA, Thachil J. Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management. Am J Obstet Gynecol. 2015;213:452–463. doi:10.1016/j.ajog.2015.03.054
   PubMed Web of Science ®Google Scholar
• Thachil J. Disseminated Intravascular Coagulation: a Practical Approach. Anesthesiology. 2016;125:230–236. doi:10.1097/ALN.0000000000001123
   PubMed Web of Science ®Google Scholar
• Matevosyan K, Sarode R. Thrombosis, Microangiopathies, and Inflammation. Semin Thromb Hemost. 2015;41:556–562. doi:10.1055/s-0035-1556587
   PubMed Web of Science ®Google Scholar
• Bockmeyer CL, Claus RA, Budde U, et al. Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor. Haematologica. 2008;93:137–140. doi:10.3324/haematol.11677
   PubMed Web of Science ®Google Scholar
• Miodownik S, Pikovsky O, Erez O, Kezerle Y, Lavon O, Rabinovich A. Unfolding the pathophysiology of congenital thrombotic thrombocytopenic purpura in pregnancy: lessons from a cluster of familial cases. Am J Obstet Gynecol. 2021;225:177.e1–77.e15. doi:10.1016/j.ajog.2021.02.018
   PubMed Web of Science ®Google Scholar
• Thachil J, Toh CH. Current concepts in the management of disseminated intravascular coagulation. Thromb Res. 2012;129(Suppl 1):S54–9. doi:10.1016/S0049-3848(12)70017-8
   PubMed Web of Science ®Google Scholar
• Erez O, Gotsch F, Mazaki-Tovi S, et al. Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with fetal death. J Mater Fetal Neonatal Med. 2009;22:672–687. doi:10.1080/14767050902853117
   PubMed Web of Science ®Google Scholar
• Wada H, Matsumoto T, Yamashita Y, Hatada T. Disseminated intravascular coagulation: testing and diagnosis. Int J Clin Chem. 2014;436:130–134.
   Google Scholar
• Thachil J. The Elusive Diagnosis of Disseminated Intravascular Coagulation: does a Diagnosis of DIC Exist Anymore? Semin Thromb Hemost. 2019;45:100–107. doi:10.1055/s-0038-1677042
   PubMed Web of Science ®Google Scholar
• Thachil J. Disseminated intravascular coagulation - new pathophysiological concepts and impact on management. Expert Rev Hematol. 2016;9:803–814. doi:10.1080/17474086.2016.1203250
   PubMed Web of Science ®Google Scholar
• Levi M, Meijers JC. DIC: which laboratory tests are most useful. Blood Rev. 2011;25:33–37. doi:10.1016/j.blre.2010.09.002
   PubMed Web of Science ®Google Scholar
• Hossain N, Paidas MJ. Disseminated intravascular coagulation. Semin Perinatol. 2013;37:257–266. doi:10.1053/j.semperi.2013.04.008
   PubMed Web of Science ®Google Scholar
• Kobayashi T. Obstetrical disseminated intravascular coagulation score. J Obstet Gynaecol Res. 2014;40:1500–1506. doi:10.1111/jog.12426
   PubMed Web of Science ®Google Scholar
• Kor-anantakul O, Lekhakula A. Overt disseminated intravascular coagulation in obstetric patients. J Med Assoc Thai. 2007;90:857–864.
   PubMedGoogle Scholar
• Creanga AA, Berg CJ, Syverson C, Seed K, Bruce FC, Callaghan WM. Pregnancy-related mortality in the United States, 2006–2010. Obstet Gynecol. 2015;125:5–12. doi:10.1097/AOG.0000000000000564
   PubMed Web of Science ®Google Scholar
• Callaghan WM, Creanga AA, Kuklina EV. Severe maternal morbidity among delivery and postpartum hospitalizations in the United States. Obstet Gynecol. 2012;120:1029–1036. doi:10.1097/AOG.0b013e31826d60c5
   PubMed Web of Science ®Google Scholar
• Naz H, Fawad A, Islam A, Shahid H, Abbasi AU. Disseminated intravascular coagulation. J Ayub Med Coll Abbottabad. 2011;23:111–113.
   PubMedGoogle Scholar
• Haram K, Mortensen JH, Mastrolia SA, Erez O. Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know? J Mater Fetal Neonatal Med. 2017;30:779–788. doi:10.1080/14767058.2016.1189897
   PubMed Web of Science ®Google Scholar
• Latif E, Adam S, Rungruang B, et al. Use of uterine artery embolization to prevent peripartum hemorrhage of placental abruption with fetal demise & severe DIC. J Neonatal Perinatal Med. 2016;9:325–331. doi:10.3233/NPM-16915108
   PubMedGoogle Scholar
• Myers J, Wu G, Shapiro RE, Vallejo MC. Preeclampsia Induced Liver Dysfunction Complicated by Disseminated Intravascular Coagulopathy and Placental Abruption: a Case Report and Review of the Literature. Case Rep Anesthesiol. 2019;2019:4305849.
   PubMedGoogle Scholar
• Ni S, Wang X, Cheng X. The comparison of placental abruption coupled with and without preeclampsia and/or intrauterine growth restriction in singleton pregnancies. J Mater Fetal Neonatal Med. 2019;54:1–6.
   Google Scholar
• Onishi K, Tsuda H, Fuma K, et al. The impact of the abruption severity and the onset-to-delivery time on the maternal and neonatal outcomes of placental abruption. J Mater Fetal Neonatal Med. 2020;33:3775–3783. doi:10.1080/14767058.2019.1585424
   PubMed Web of Science ®Google Scholar
• Takeda J, Takeda S. Management of disseminated intravascular coagulation associated with placental abruption and measures to improve outcomes. Obstet Gynecol Sci. 2019;62:299–306. doi:10.5468/ogs.2019.62.5.299
   PubMedGoogle Scholar
• Gomez-Tolub R, Rabinovich A, Kachko E. et al. Placental abruption as a trigger of DIC in women with HELLP syndrome: a population-based study. J Mater Fetal Neonatal Med. 2020;2:1–11. doi:10.1080/14767058.2020.1818200
   Web of Science ®Google Scholar
• Montagnana M, Franchi M, Danese E, Gotsch F, Guidi GC. Disseminated intravascular coagulation in obstetric and gynecologic disorders. Semin Thromb Hemost. 2010;36:404–418. doi:10.1055/s-0030-1254049
   PubMed Web of Science ®Google Scholar
• Rabinovich A, Abdul-Kadir R, Thachil J, Iba T, Othman M, Erez O. DIC in obstetrics: diagnostic score, highlights in management, and international registry-communication from the DIC and Women’s Health SSCs of the International Society of Thrombosis and Haemostasis. J Thromb Haemost. 2019;17:1562–1566. doi:10.1111/jth.14523
   PubMed Web of Science ®Google Scholar
• Sher G. Pathogenesis and management of uterine inertia complicating abruptio placentae with consumption coagulopathy. Am J Obstet Gynecol. 1977;129:164–170. doi:10.1016/0002-9378(77)90739-6
   PubMed Web of Science ®Google Scholar
• Naccasha N, Gervasi MT, Chaiworapongsa T, et al. Phenotypic and metabolic characteristics of monocytes and granulocytes in normal pregnancy and maternal infection. Am J Obstet Gynecol. 2001;185:1118–1123. doi:10.1067/mob.2001.117682
   PubMed Web of Science ®Google Scholar
• Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol. 1998;179:80–86. doi:10.1016/S0002-9378(98)70254-6
   PubMed Web of Science ®Google Scholar
• Zhu A, Romero R, Huang JB, Clark A, Petty HR. Maltooligosaccharides from JEG-3 trophoblast-like cells exhibit immunoregulatory properties. Am J Reprod Immunol. 2011;65:54–64. doi:10.1111/j.1600-0897.2010.00851.x
   PubMed Web of Science ®Google Scholar
• Romero R, Kadar N, Vaisbuch E, Hassan SS. Maternal death following cardiopulmonary collapse after delivery: amniotic fluid embolism or septic shock due to intrauterine infection? Am J Reprod Immunol. 2010;64:113–125.
   PubMed Web of Science ®Google Scholar
• Anas AA, Wiersinga WJ, de Vos AF, van der Poll T. Recent insights into the pathogenesis of bacterial sepsis. Neth J Med. 2010;68:147–152.
   PubMed Web of Science ®Google Scholar
• Takai H, Kondoh E, Sato Y, Kakui K, Tatsumi K, Konishi I. Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy. J Obstet Gynaecol Res. 2011;37:1717–1719. doi:10.1111/j.1447-0756.2011.01561.x
   PubMed Web of Science ®Google Scholar
• Levi M. Disseminated intravascular coagulation. Crit Care Med. 2007;35:2191–2195. doi:10.1097/01.CCM.0000281468.94108.4B
   PubMed Web of Science ®Google Scholar
• Levi M. Pathogenesis and management of peripartum coagulopathic calamities (disseminated intravascular coagulation and amniotic fluid embolism). Thromb Res. 2013;131(Suppl 1):S32–4. doi:10.1016/S0049-3848(13)70017-3
   PubMed Web of Science ®Google Scholar
• Levi M, van der Poll T. Inflammation and coagulation. Crit Care Med. 2010;38:S26–34. doi:10.1097/CCM.0b013e3181c98d21
   PubMed Web of Science ®Google Scholar
• Seki Y, Wada H, Kawasugi K, et al. A prospective analysis of disseminated intravascular coagulation in patients with infections. Intern Med. 2013;52:1893–1898. doi:10.2169/internalmedicine.52.0571
   PubMed Web of Science ®Google Scholar
• Sung JY, Kim JE, Kim KS, Han KS, Kim HK. Differential expression of leukocyte receptors in disseminated intravascular coagulation: prognostic value of low protein C receptor expression. Thromb Res. 2014;134:1130–1134. doi:10.1016/j.thromres.2014.08.026
   PubMed Web of Science ®Google Scholar
• Kvolik S, Jukic M, Matijevic M, Marjanovic K, Glavas-Obrovac L. An overview of coagulation disorders in cancer patients. Surg Oncol. 2010;19:e33–46. doi:10.1016/j.suronc.2009.03.008
   PubMed Web of Science ®Google Scholar
• Levi M, van der Poll T. Disseminated intravascular coagulation: a review for the internist. Intern Emerg Med. 2013;8:23–32. doi:10.1007/s11739-012-0859-9
   PubMed Web of Science ®Google Scholar
• Osterud B. Tissue factor expression by monocytes: regulation and pathophysiological roles. Blood Coagul Fibrinolysis. 1998;9(Suppl 1):S9–14.
   PubMed Web of Science ®Google Scholar
• Levi M, de Jonge E, van der Poll T. Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation. Crit Care Med. 2001;29:S90–4. doi:10.1097/00003246-200107001-00028
   PubMed Web of Science ®Google Scholar
• Choi Q, Hong KH, Kim JE, Kim HK. Changes in plasma levels of natural anticoagulants in disseminated intravascular coagulation: high prognostic value of antithrombin and protein C in patients with underlying sepsis or severe infection. Ann Lab Med. 2014;34:85–91. doi:10.3343/alm.2014.34.2.85
   PubMed Web of Science ®Google Scholar
• Himmelreich G, Jochum M, Bechstein WO, et al. Mediators of leukocyte activation play a role in disseminated intravascular coagulation during orthotopic liver transplantation. Transplantation. 1994;57:354–358.
   PubMed Web of Science ®Google Scholar
• Esmon CT. Role of coagulation inhibitors in inflammation. Thromb Haemost. 2001;86:51–56. doi:10.1055/s-0037-1616200
   PubMed Web of Science ®Google Scholar
• Levi M. The imbalance between tissue factor and tissue factor pathway inhibitor in sepsis. Crit Care Med. 2002;30:1914–1915. doi:10.1097/00003246-200208000-00046
   PubMed Web of Science ®Google Scholar
• Slofstra SH, Spek CA, Ten Cate H. Disseminated intravascular coagulation. Hematol J. 2003;4:295–302. doi:10.1038/sj.thj.6200263
   PubMedGoogle Scholar
• Löwenberg EC, Meijers JC, Levi M. Platelet-vessel wall interaction in health and disease. Neth J Med. 2010;68:242–251.
   PubMed Web of Science ®Google Scholar
• Furie B, Furie BC. Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. Trends Mol Med. 2004;10:171–178.
   PubMed Web of Science ®Google Scholar
• Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020;18:1648–1652. doi:10.1111/jth.14856
   PubMed Web of Science ®Google Scholar
• Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thrombosis Haemostasis. 2020;18:844–847. doi:10.1111/jth.14768
   PubMed Web of Science ®Google Scholar
• Kadir RA, Kobayashi T, Iba T, et al. COVID-19 coagulopathy in pregnancy: critical review, preliminary recommendations, and ISTH registry-Communication from the ISTH SSC for Women’s Health. J Thromb Haemost. 2020;18:3086–3098. doi:10.1111/jth.15072
   PubMed Web of Science ®Google Scholar
• Seppälä M, Wahlström T, Bohn H. Circulating levels and tissue localization of placental protein five (PP5) in pregnancy and trophoblastic disease: absence of PP5 expression in the malignant trophoblast. Int J Cancer. 1979;24:6–10. doi:10.1002/ijc.2910240103
   PubMed Web of Science ®Google Scholar
• Obiekwe BC, Chard T. Placental protein 5: circulating levels in twin pregnancy and some observations on the analysis of biochemical data from multiple pregnancy. Eur J Obstet Gynecol Reprod Biol. 1981;12:135–141. doi:10.1016/0028-2243(81)90068-X
   PubMed Web of Science ®Google Scholar
• Than G, Bohn H, Szabo D. Advances in Pregnancy- Related Protein Research. Boca Raton: CRC Press; 2020.
   Google Scholar
• Reverdiau P, Jarousseau AC, Thibault G, et al. Tissue factor activity of syncytiotrophoblast plasma membranes and tumoral trophoblast cells in culture. Thromb Haemost. 1995;73:49–54. doi:10.1055/s-0038-1653724
   PubMed Web of Science ®Google Scholar
• Aharon A, Brenner B, Katz T, Miyagi Y, Lanir N. Tissue factor and tissue factor pathway inhibitor levels in trophoblast cells: implications for placental hemostasis. Thromb Haemost. 2004;92:776–786. doi:10.1160/TH04-01-0033
   PubMed Web of Science ®Google Scholar
• Hubé F, Reverdiau P, Iochmann S, Trassard S, Thibault G, Gruel Y. Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas. Biol Reprod. 2003;68:1888–1894. doi:10.1095/biolreprod.102.011858
   PubMed Web of Science ®Google Scholar
• Udagawa K, Miyagi Y, Hirahara F, et al. Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization. Placenta. 1998;19:217–223. doi:10.1016/S0143-4004(98)90011-X
   PubMed Web of Science ®Google Scholar
• van Wersch JW, Ubachs JM. Blood coagulation and fibrinolysis during normal pregnancy. Eur J Clin Chem Clin Biochem. 1991;29:45–50.
   PubMedGoogle Scholar
• Robb AO, Mills NL, Din JN, et al. Acute endothelial tissue plasminogen activator release in pregnancy. J Thromb Haemost. 2009;7:138–142. doi:10.1111/j.1538-7836.2008.03207.x
   PubMed Web of Science ®Google Scholar
• Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006;108:1005–1016. doi:10.1097/01.AOG.0000239439.04364.9a
   PubMed Web of Science ®Google Scholar
• Krikun G, Huang ST, Schatz F, Salafia C, Stocco C, Lockwood CJ. Thrombin activation of endometrial endothelial cells: a possible role in intrauterine growth restriction. Thromb Haemost. 2007;97:245–253. doi:10.1160/TH06-07-0387
   PubMed Web of Science ®Google Scholar
• Schneider CL. The active principle of placental toxin; thromboplastin; its inactivator in blood; antithromboplastin. Am J Physiol. 1947;149:123–129. doi:10.1152/ajplegacy.1947.149.1.123
   PubMed Web of Science ®Google Scholar
• Collins NF, Bloor M, McDonnell NJ. Hyperfibrinolysis diagnosed by rotational thromboelastometry in a case of suspected amniotic fluid embolism. Int J Obstet Anesth. 2013;22:71–76. doi:10.1016/j.ijoa.2012.09.008
   PubMed Web of Science ®Google Scholar
• Schneider CL. Fibrin embolism (disseminated intravascular coagulation) with defibrination as one of the end results during placenta abruptio. Surg Gynecol Obstet. 1951;92:27–34.
   PubMedGoogle Scholar
• Beller FK, Douglas GW, Debrovner CH, Robinson R. The fibrinolytic system in amniotic fluid embolism. Am J Obstet Gynecol. 1963;87:48–55. doi:10.1016/S0002-9378(16)35142-0
   Web of Science ®Google Scholar
• McLintock C, James AH. Obstetric hemorrhage. J Thromb Haemost. 2011;9:1441–1451. doi:10.1111/j.1538-7836.2011.04398.x
   PubMed Web of Science ®Google Scholar
• Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341:586–592. doi:10.1056/NEJM199908193410807
   PubMed Web of Science ®Google Scholar
• Weiner CP. The obstetric patient and disseminated intravascular coagulation. Clin Perinatol. 1986;13:705–717. doi:10.1016/S0095-5108(18)30794-2
   PubMed Web of Science ®Google Scholar
• Grönvall M, Tikkanen M, Metsätähti M, Loukovaara M, Paavonen J, Stefanovic V. Pelvic arterial embolization in severe obstetric hemorrhage. Acta Obstet Gynecol Scand. 2014;93:716–719. doi:10.1111/aogs.12376
   PubMed Web of Science ®Google Scholar
• Rath WH. Postpartum hemorrhage–update on problems of definitions and diagnosis. Acta Obstet Gynecol Scand. 2011;90:421–428. doi:10.1111/j.1600-0412.2011.01107.x
   PubMed Web of Science ®Google Scholar
• Knight M. The findings of the MBRRACE-UK confidential enquiry into Maternal Deaths and Morbidity. Obstet Gynaecol Reproduct Med. 2019;29:21–23. doi:10.1016/j.ogrm.2018.12.003
   Google Scholar
• Green L, Knight M, Seeney FM, et al. The epidemiology and outcomes of women with postpartum haemorrhage requiring massive transfusion with eight or more units of red cells: a national cross-sectional study. Bjog. 2016;123:2164–2170. doi:10.1111/1471-0528.13831
   PubMed Web of Science ®Google Scholar
• Levi M. Disseminated intravascular coagulation (DIC) in pregnancy and the peri-partum period. Thromb Res. 2009;123(Suppl 2):S63–4. doi:10.1016/S0049-3848(09)70013-1
   PubMed Web of Science ®Google Scholar
• de Boer K, Ten Cate JW, Sturk A, Borm JJ, Treffers PE. Enhanced thrombin generation in normal and hypertensive pregnancy. Am J Obstet Gynecol. 1989;160:95–100. doi:10.1016/0002-9378(89)90096-3
   PubMed Web of Science ®Google Scholar
• Lockwood CJ. Pregnancy-associated changes in the hemostatic system. Clin Obstet Gynecol. 2006;49:836–843. doi:10.1097/01.grf.0000211952.82206.16
   PubMed Web of Science ®Google Scholar
• Kuczyński J, Uszyński W, Zekanowska E, Soszka T, Uszyński M. Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the placenta and myometrium. Eur J Obstet Gynecol Reprod Biol. 2002;105:15–19. doi:10.1016/S0301-2115(02)00113-6
   PubMed Web of Science ®Google Scholar
• Beller FK, Ebert C. The coagulation and fibrinolytic enzyme system in pregnancy and in the puerperium. Eur J Obstet Gynecol Reprod Biol. 1982;13:177–197. doi:10.1016/0028-2243(82)90028-4
   PubMed Web of Science ®Google Scholar
• Castro MA, Goodwin TM, Shaw KJ, Ouzounian JG, McGehee WG. Disseminated intravascular coagulation and antithrombin III depression in acute fatty liver of pregnancy. Am J Obstet Gynecol. 1996;174:211–216.
   PubMed Web of Science ®Google Scholar
• Reyes H, Sandoval L, Wainstein A, et al. Acute fatty liver of pregnancy: a clinical study of 12 episodes in 11 patients. Gut. 1994;35:101–106. doi:10.1136/gut.35.1.101
   PubMed Web of Science ®Google Scholar
• Pockros PJ, Peters RL, Reynolds TB. Idiopathic fatty liver of pregnancy: findings in ten cases. Medicine. 1984;63:1–11. doi:10.1097/00005792-198401000-00001
   PubMed Web of Science ®Google Scholar
• Riely CA, Latham PS, Romero R, Duffy TP. Acute fatty liver of pregnancy. A reassessment based on observations in nine patients. Ann Intern Med. 1987;106:703–706. doi:10.7326/0003-4819-106-5-703
   PubMed Web of Science ®Google Scholar
• Slater DN, Hague WM. Renal morphological changes in idiopathic acute fatty liver of pregnancy. Histopathology. 1984;8:567–581. doi:10.1111/j.1365-2559.1984.tb02369.x
   PubMed Web of Science ®Google Scholar
• Vigil-de Gracia P. Acute fatty liver and HELLP syndrome: two distinct pregnancy disorders. Int J Gynaecol Obstet. 2001;73:215–220. doi:10.1016/S0020-7292(01)00364-2
   PubMed Web of Science ®Google Scholar
• Nelson DB, Yost NP, Cunningham FG. Hemostatic dysfunction with acute fatty liver of pregnancy. Obstet Gynecol. 2014;124:40–46. doi:10.1097/AOG.0000000000000296
   PubMed Web of Science ®Google Scholar
• Taylor FB, Toh CH, Hoots WK, Wada H, Levi M. (ISTH) SSoDICDotISoTaH. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86:1327–1330.
   PubMed Web of Science ®Google Scholar
• Bakhtiari K, Meijers JC, de Jonge E, Levi M. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004;32:2416–2421. doi:10.1097/01.CCM.0000147769.07699.E3
   PubMed Web of Science ®Google Scholar
• Gasem T, Al Jama FE, Burshaid S, Rahman J, Al Suleiman SA, Rahman MS. Maternal and fetal outcome of pregnancy complicated by HELLP syndrome. J Matern Fetal Neonatal Med. 2009;22:1140–1143. doi:10.3109/14767050903019627
   PubMed Web of Science ®Google Scholar
• Gando S, Wada H, Thachil J; (ISTH) SaSCoDotISoTaH. Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). J Thromb Haemost. 2013;11:826–835. doi:10.1111/jth.12190
   PubMed Web of Science ®Google Scholar
• Wada H, Thachil J, Di Nisio M, et al. Harmonized guidance for disseminated intravascular coagulation from the International Society on Thrombosis and Haemostasis and the current status of anticoagulant therapy in Japan: a rebuttal. J Thromb Haemost. 2013;11(11):2078–2079. doi:10.1111/jth.12366
   PubMed Web of Science ®Google Scholar
• Gando S, Iba T, Eguchi Y, et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. 2006;34:625–631. doi:10.1097/01.CCM.0000202209.42491.38
   PubMed Web of Science ®Google Scholar
• Angstwurm MW, Dempfle CE, Spannagl M. New disseminated intravascular coagulation score: a useful tool to predict mortality in comparison with Acute Physiology and Chronic Health Evaluation II and Logistic Organ Dysfunction scores. Crit Care Med. 2006;34:314–20; quiz 28. doi:10.1097/01.CCM.0000196832.27501.B2
   PubMed Web of Science ®Google Scholar
• Asakura H, Wada H, Okamoto K, et al. Evaluation of haemostatic molecular markers for diagnosis of disseminated intravascular coagulation in patients with infections. Thromb Haemost. 2006;95:282–287. doi:10.1160/TH05-04-0286
   PubMed Web of Science ®Google Scholar
• Cavkaytar S, Ugurlu EN, Karaer A, Tapisiz OL, Danisman N. Are clinical symptoms more predictive than laboratory parameters for adverse maternal outcome in HELLP syndrome? Acta Obstet Gynecol Scand. 2007;86:648–651. doi:10.1080/00016340601185384
   PubMed Web of Science ®Google Scholar
• Yuen PM, Yin JA, Lao TT. Fibrinopeptide A levels in maternal and newborn plasma. Eur J Obstet Gynecol Reprod Biol. 1989;30:239–244. doi:10.1016/0028-2243(89)90007-5
   PubMed Web of Science ®Google Scholar
• Sørensen JD, Secher NJ, Jespersen J. Perturbed (procoagulant) endothelium and deviations within the fibrinolytic system during the third trimester of normal pregnancy. A possible link to placental function. Acta Obstet Gynecol Scand. 1995;74:257–261. doi:10.3109/00016349509024445
   PubMed Web of Science ®Google Scholar
• Walker MC, Garner PR, Keely EJ, Rock GA, Reis MD. Changes in activated protein C resistance during normal pregnancy. Am J Obstet Gynecol. 1997;177:162–169. doi:10.1016/S0002-9378(97)70456-3
   PubMed Web of Science ®Google Scholar
• Bellart J, Gilabert R, Miralles RM, Monasterio J, Cabero L. Endothelial cell markers and fibrinopeptide A to D-dimer ratio as a measure of coagulation and fibrinolysis balance in normal pregnancy. Gynecol Obstet Invest. 1998;46:17–21. doi:10.1159/000009989
   PubMed Web of Science ®Google Scholar
• Chaiworapongsa T, Espinoza J, Yoshimatsu J, et al. Activation of coagulation system in preterm labor and preterm premature rupture of membranes. J Mater Fetal Neonatal Med. 2002;11:368–373. doi:10.1080/jmf.11.6.368.373
   PubMedGoogle Scholar
• Yoneyama Y, Suzuki S, Sawa R, Otsubo Y, Power GG, Araki T. Plasma adenosine levels increase in women with normal pregnancies. Am J Obstet Gynecol. 2000;182:1200–1203. doi:10.1067/mob.2000.104832
   PubMed Web of Science ®Google Scholar
• Sheu JR, Hsiao G, Luk HN, et al. Mechanisms involved in the antiplatelet activity of midazolam in human platelets. Anesthesiology. 2002;96:651–658. doi:10.1097/00000542-200203000-00022
   PubMed Web of Science ®Google Scholar
• Bremme KA. Haemostatic changes in pregnancy. Best Pract Res Clin Haematol. 2003;16:153–168. doi:10.1016/S1521-6926(03)00021-5
   PubMed Web of Science ®Google Scholar
• Eichinger S, Weltermann A, Philipp K, et al. Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden. Thromb Haemost. 1999;82:1232–1236. doi:10.1055/s-0037-1614366
   PubMed Web of Science ®Google Scholar
• Reinthaller A, Mursch-Edlmayr G, Tatra G. Thrombin-antithrombin III complex levels in normal pregnancy with hypertensive disorders and after delivery. Br J Obstet Gynaecol. 1990;97:506–510. doi:10.1111/j.1471-0528.1990.tb02520.x
   PubMedGoogle Scholar
• Uszyński M. Generation of thrombin in blood plasma of non-pregnant and pregnant women studied through concentration of thrombin-antithrombin III complexes. Eur J Obstet Gynecol Reprod Biol. 1997;75:127–131. doi:10.1016/S0301-2115(97)00101-2
   PubMed Web of Science ®Google Scholar
• Reber G, Amiral J, de Moerloose P. Modified antithrombin III levels during normal pregnancy and relationship with prothrombin fragment F1 + 2 and thrombin-antithrombin complexes. Thromb Res. 1998;91:45–47. doi:10.1016/S0049-3848(98)00043-7
   PubMed Web of Science ®Google Scholar
• Mallaiah S, Barclay P, Harrod I, Chevannes C, Bhalla A. Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage. Anaesthesia. 2015;70:166–175. doi:10.1111/anae.12859
   PubMed Web of Science ®Google Scholar
• Andersson T, Lorentzen B, Hogdahl H, Clausen T, Mowinckel MC, Abildgaard U. Thrombin-inhibitor complexes in the blood during and after delivery. Thromb Res. 1996;82:109–117. doi:10.1016/0049-3848(96)00057-6
   PubMed Web of Science ®Google Scholar
• Ku DH, Arkel YS, Paidas MP, Lockwood CJ. Circulating levels of inflammatory cytokines (IL-1 beta and TNF-alpha), resistance to activated protein C, thrombin and fibrin generation in uncomplicated pregnancies. Thromb Haemost. 2003;90:1074–1079. doi:10.1160/TH03-02-0119
   PubMed Web of Science ®Google Scholar
• Faught W, Garner P, Jones G, Ivey B. Changes in protein C and protein S levels in normal pregnancy. Am J Obstet Gynecol. 1995;172:147–150. doi:10.1016/0002-9378(95)90104-3
   PubMed Web of Science ®Google Scholar
• Lockwood CJ, Krikun G, Schatz F. The decidua regulates hemostasis in human endometrium. Semin Reprod Endocrinol. 1999;17:45–51. doi:10.1055/s-2007-1016211
   PubMedGoogle Scholar
• Lockwood CJ, Krikun G, Schatz F. Decidual cell-expressed tissue factor maintains hemostasis in human endometrium. Ann N Y Acad Sci. 2001;943:77–88. doi:10.1111/j.1749-6632.2001.tb03793.x
   PubMed Web of Science ®Google Scholar
• Erlich J, Parry GC, Fearns C, et al. Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation. Proc Natl Acad Sci U S A. 1999;96:8138–8143. doi:10.1073/pnas.96.14.8138
   PubMed Web of Science ®Google Scholar
• Creter D. Amnioplastin: new reagent for coagulation tests. Lancet. 1977;2:251. doi:10.1016/S0140-6736(77)92871-9
   PubMed Web of Science ®Google Scholar
• Omsjø IH, Oian P, Maltau JM, Osterud B. Thromboplastin activity in amniotic fluid. Gynecol Obstet Invest. 1985;19:1–5. doi:10.1159/000299000
   PubMed Web of Science ®Google Scholar
• Lockwood CJ, Bach R, Guha A, Zhou XD, Miller WA, Nemerson Y. Amniotic fluid contains tissue factor, a potent initiator of coagulation. Am J Obstet Gynecol. 1991;165:1335–1341. doi:10.1016/S0002-9378(12)90756-5
   PubMed Web of Science ®Google Scholar
• Uszyński M, Zekanowska E, Uszyński W, Kuczyński J. Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in amniotic fluid and blood plasma: implications for the mechanism of amniotic fluid embolism. Eur J Obstet Gynecol Reprod Biol. 2001;95:163–166. doi:10.1016/S0301-2115(00)00448-6
   PubMed Web of Science ®Google Scholar
• Jonard M, Ducloy-Bouthors AS, Fourrier F. Comparison of two diagnostic scores of disseminated intravascular coagulation in pregnant women admitted to the ICU. PLoS One. 2016;11:e0166471. doi:10.1371/journal.pone.0166471
   PubMed Web of Science ®Google Scholar
• Hizkiyahu R, Rabinovich A, Thachil J, et al. Modified ISTH pregnancy-specific DIC score in parturients with liver rupture: population-based case series. J Mater Fetal Neonatal Med. 2019;32:2517–2523. doi:10.1080/14767058.2018.1439469
   PubMed Web of Science ®Google Scholar
• Goksever Celik H, Celik E, Ozdemir I, Ozge Savkli A, Sanli K, Gorgen H. Is blood transfusion necessary in all patients with disseminated intravascular coagulation associated postpartum hemorrhage? J Mater Fetal Neonatal Med. 2019;32:1004–1008. doi:10.1080/14767058.2017.1397125
   PubMed Web of Science ®Google Scholar
• Clark SL, Romero R, Dildy GA, et al. Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies. Am J Obstet Gynecol. 2016;215:408–412. doi:10.1016/j.ajog.2016.06.037
   PubMed Web of Science ®Google Scholar
• Erez O. Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies. Am J Obstet Gynecol. 2017;217:228–229. doi:10.1016/j.ajog.2017.04.009
   PubMed Web of Science ®Google Scholar
• Terao T, Maki M, Ikenoue T. A prospective study in 38 patients with abruptio placentae of 70 cases complicated by DIC. Asia Oceania J Obstet Gynaecol. 1987;13:1–13. doi:10.1111/j.1447-0756.1987.tb00001.x
   PubMedGoogle Scholar
• Windsperger K, Lehner R. The fibrinogen/CRP ratio as a new parameter for the diagnosis of disseminated intravascular coagulation in patients with HELLP syndrome and as a predictive factor for neonatal outcome. Am J Obstet Gynecol. 2013;208:118.e1–7. doi:10.1016/j.ajog.2012.11.025
   PubMed Web of Science ®Google Scholar
• Bick RL. Disseminated intravascular coagulation: objective clinical and laboratory diagnosis, treatment, and assessment of therapeutic response. Semin Thromb Hemost. 1996;22:69–88. doi:10.1055/s-2007-998993
   PubMed Web of Science ®Google Scholar
• Toh CH, Dennis M. Disseminated intravascular coagulation: old disease, new hope. BMJ. 2003;327:974–977. doi:10.1136/bmj.327.7421.974
   PubMed Web of Science ®Google Scholar
• Mallaiah S, Barclay P, Harrod I, Chevannes C, Bhalla A. Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage. Anaesthesia. 2014;1:5874.
   Google Scholar
• Yang J, Yang H, Tang A, et al. Trimester-specific reference intervals for kaolin-activated thromboelastography (TEG®) in healthy Chinese pregnant women. Thromb Res. 2019;184:81–85. doi:10.1016/j.thromres.2019.09.030
   PubMed Web of Science ®Google Scholar
• Shamshirsaz AA, Fox KA, Erfani H, et al. Trimester-specific thromboelastic values and coagulation activation markers in pregnancy compared across trimesters and compared to the nonpregnant state. Int J Lab Hematol. 2021;1:5487. doi:10.1111/ijlh.13472
   Web of Science ®Google Scholar
• Rigouzzo A, Louvet N, Favier R, et al. Assessment of coagulation by thromboelastography during ongoing postpartum hemorrhage: a retrospective cohort analysis. Anesth Analg. 2020;130:416–425. doi:10.1213/ANE.0000000000004422
   PubMed Web of Science ®Google Scholar
• Karlsson O, Jeppsson A, Hellgren M. Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both? Int J Obstet Anesth. 2014;23:10–17. doi:10.1016/j.ijoa.2013.07.003
   PubMed Web of Science ®Google Scholar
• Downey C, Kazmi R, Toh CH. Early identification and prognostic implications in disseminated intravascular coagulation through transmittance waveform analysis. Thromb Haemost. 1998;80:65–69. doi:10.1055/s-0037-1615140
   PubMed Web of Science ®Google Scholar
• Sharma P, Saxena R. A novel thromboelastographic score to identify overt disseminated intravascular coagulation resulting in a hypocoagulable state. Am J Clin Pathol. 2010;134:97–102. doi:10.1309/AJCPPZ4J6CAFYDVM
   PubMed Web of Science ®Google Scholar
• de Lange NM, Lance MD, de Groot R, Beckers EA, Henskens YM, Scheepers HC. Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage. Obstet Gynecol Surv. 2012;67:426–435. doi:10.1097/OGX.0b013e3182605861
   PubMed Web of Science ®Google Scholar
• Collis RE, Collins PW. Haemostatic management of obstetric haemorrhage. Anaesthesia. 2015;70 Suppl 1:78–86, e27–e28. doi:10.1111/anae.12913
   PubMed Web of Science ®Google Scholar
• Abdul-Kadir R, McLintock C, Ducloy AS, et al. Evaluation and management of postpartum hemorrhage: consensus from an international expert panel. Transfusion. 2014;54:1756–1768. doi:10.1111/trf.12550
   PubMed Web of Science ®Google Scholar
• Wada H, Thachil J, Di Nisio M, Kurosawa S, Gando S, Toh CH. Harmonized guidance for disseminated intravascular coagulation from the International Society on Thrombosis and Haemostasis and the current status of anticoagulant therapy in Japan: a rebuttal. J Thromb Haemost. 2013;11:2078–2079.
   PubMed Web of Science ®Google Scholar
• Dzik WH, Blajchman MA, Fergusson D, et al. Clinical review: Canadian national advisory committee on blood and blood products–massive transfusion consensus conference 2011: report of the panel. Crit Care. 2011;15:242. doi:10.1186/cc10498
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists. ACOG Practice Bulletin: clinical Management Guidelines for Obstetrician-Gynecologists Number 76, October 2006: postpartum hemorrhage. Obstet Gynecol. 2006;108:1039–1047.
   PubMedGoogle Scholar
• WHO. WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. WHO edGeneva: WHO; 2012.
   Google Scholar
• Gynaecologists RAaNZCoOa. Management of Postpartum Haemorrhage (PPH). 2017:1–17
   Google Scholar
• Marshall AL, Durani U, Bartley A, et al. The impact of postpartum hemorrhage on hospital length of stay and inpatient mortality: a National Inpatient Sample-based analysis. Am J Obstet Gynecol. 2017;217:344.e1–44.e6. doi:10.1016/j.ajog.2017.05.004
   Web of Science ®Google Scholar
• Leduc D, Senikas V, Lalonde AB. No. 235-Active Management of the Third Stage of Labour: prevention and Treatment of Postpartum Hemorrhage. J Obstet Gynaecol Can. 2018;40:e841–e55. doi:10.1016/j.jogc.2018.09.024
   PubMed Web of Science ®Google Scholar
• Collins P, Abdul-Kadir R, Thachil J. Management of coagulopathy associated with postpartum hemorrhage: guidance from the SSC of the ISTH. J Thromb Haemost. 2016;14:205–210. doi:10.1111/jth.13174
   PubMed Web of Science ®Google Scholar
• Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth. 2012;109:851–863. doi:10.1093/bja/aes361
   PubMed Web of Science ®Google Scholar
• Huissoud C, Carrabin N, Audibert F, et al. Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry. BJOG. 2009;116:1097–1102. doi:10.1111/j.1471-0528.2009.02187.x
   PubMed Web of Science ®Google Scholar
• Hill JS, Devenie G, Powell M. Point-of-care testing of coagulation and fibrinolytic status during postpartum haemorrhage: developing a thrombelastographyI-guided transfusion algorithm. Anaesth Intensive Care. 2012;40:1007–1015. doi:10.1177/0310057X1204000612
   PubMed Web of Science ®Google Scholar
• Chitlur M, Lusher J. Standardization of thromboelastography: values and challenges. Semin Thromb Hemost. 2010;36:707–711. doi:10.1055/s-0030-1265287
   PubMed Web of Science ®Google Scholar
• Collins PW, Lilley G, Bruynseels D, et al. Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study. Blood. 2014;124:1727–1736. doi:10.1182/blood-2014-04-567891
   PubMed Web of Science ®Google Scholar
• McNamara H, Mallaiah S, Barclay P, Chevannes C, Bhalla A. Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. Int J Obstet Anesth. 2015;24:174–179. doi:10.1016/j.ijoa.2014.12.005
   PubMed Web of Science ®Google Scholar
• Collins PW, Bell SF, de Lloyd L, Collis RE. Management of postpartum haemorrhage: from research into practice, a narrative review of the literature and the Cardiff experience. Int J Obstet Anesth. 2019;37:106–117. doi:10.1016/j.ijoa.2018.08.008
   PubMed Web of Science ®Google Scholar
• Collins PW, Cannings-John R, Bruynseels D, et al. Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study. Br J Anaesth. 2017;119:422–434. doi:10.1093/bja/aex245
   PubMed Web of Science ®Google Scholar
• Collins PW, Cannings-John R, Bruynseels D, et al. Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial. Br J Anaesth. 2017;119:411–421. doi:10.1093/bja/aex181
   PubMed Web of Science ®Google Scholar
• Amgalan A, Allen T, Othman M, Ahmadzia HK. Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendations from the women’s SSC of the ISTH. J Thromb Haemost. 2020;18:1813–1838. doi:10.1111/jth.14882
   PubMed Web of Science ®Google Scholar
• Amgalan A, Othman M. TEG in pregnancy: current challenges and future potential applications. Thromb Res. 2020;191:140–141. doi:10.1016/j.thromres.2020.03.017
   PubMed Web of Science ®Google Scholar
• Favaloro EJ, Amgalan A, Allen T, Othman M, Ahmadzia HK. “Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendation from the women’s SSC of the ISTH”: response to comment from Kitchen et al. J Thromb Haemost. 2020;18:2420–2422. doi:10.1111/jth.15007
   PubMed Web of Science ®Google Scholar
• Othman M, Han K, Elbatarny M, Abdul-Kadir R. The use of viscoelastic hemostatic tests in pregnancy and puerperium: review of the current evidence - communication from the Women’s Health SSC of the ISTH. J Thromb Haemost. 2019;17:1184–1189. doi:10.1111/jth.14461
   PubMed Web of Science ®Google Scholar
• Spiezia L, Bogana G, Campello E, et al. Whole blood thromboelastometry profiles in women with preeclampsia. Clin Chem Lab Med. 2015;53:1793–1798. doi:10.1515/cclm-2014-1128
   PubMed Web of Science ®Google Scholar
• Annecke T, Geisenberger T, Kürzl R, Penning R, Heindl B. Algorithm-based coagulation management of catastrophic amniotic fluid embolism. Blood Coagul Fibrinolysis. 2010;21:95–100. doi:10.1097/MBC.0b013e328332cfe2
   PubMed Web of Science ®Google Scholar
• Alam A, Choi S. Prophylactic Use of Tranexamic Acid for Postpartum Bleeding Outcomes: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Transfus Med Rev. 2015;29:231–241. doi:10.1016/j.tmrv.2015.07.002
   PubMed Web of Science ®Google Scholar
• Novikova N, Hofmeyr GJ, Cluver C. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev. 2015;2:CD007872.
   Google Scholar
• Sentilhes L, Lasocki S, Ducloy-Bouthors AS, et al. Tranexamic acid for the prevention and treatment of postpartum haemorrhage. Br J Anaesth. 2015;114:576–587. doi:10.1093/bja/aeu448
   PubMed Web of Science ®Google Scholar
• Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V. Tranexamic acid for preventing postpartum blood loss after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand. 2016;95:28–37. doi:10.1111/aogs.12798
   PubMed Web of Science ®Google Scholar
• Ahmadzia HK, Phillips JM, Katler QS, James AH. Tranexamic acid for prevention and treatment of postpartum hemorrhage: an update on management and clinical outcomes. Obstet Gynecol Surv. 2018;73:587–594. doi:10.1097/OGX.0000000000000597
   PubMed Web of Science ®Google Scholar
• Ducloy-Bouthors AS, Duhamel A, Kipnis E, et al. Postpartum haemorrhage related early increase in D-dimers is inhibited by tranexamic acid: haemostasis parameters of a randomized controlled open labelled trial. Br J Anaesth. 2016;116:641–648. doi:10.1093/bja/aew021
   PubMed Web of Science ®Google Scholar
• Mannucci PM, Levi M. Prevention and treatment of major blood loss. N Engl J Med. 2007;356:2301–2311. doi:10.1056/NEJMra067742
   PubMed Web of Science ®Google Scholar
• Shakur H, Roberts I, Fawole B, et al. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017;389:2105–2116. doi:10.1016/S0140-6736(17)30638-4
   PubMed Web of Science ®Google Scholar
• Franchini M, Lippi G, Franchi M. The use of recombinant activated factor VII in obstetric and gynaecological haemorrhage. BJOG. 2007;114:8–15. doi:10.1111/j.1471-0528.2006.01156.x
   PubMed Web of Science ®Google Scholar
• Alfirevic Z, Elbourne D, Pavord S, et al. Use of recombinant activated factor VII in primary postpartum hemorrhage: the Northern European registry 2000–2004. Obstet Gynecol. 2007;110:1270–1278. doi:10.1097/01.AOG.0000288515.48066.99
   PubMed Web of Science ®Google Scholar
• Franchini M, Manzato F, Salvagno GL, Lippi G. Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. Blood Coagul Fibrinolysis. 2007;18:589–593. doi:10.1097/MBC.0b013e32822d2a3c
   PubMed Web of Science ®Google Scholar
• Franchini M, Franchi M, Bergamini V, Salvagno GL, Montagnana M, Lippi G. A critical review on the use of recombinant factor VIIa in life-threatening obstetric postpartum hemorrhage. Semin Thromb Hemost. 2008;34:104–112. doi:10.1055/s-2008-1066022
   PubMed Web of Science ®Google Scholar
• Lavigne-Lissalde G, Aya AG, Mercier FJ, et al. Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial. J Thromb Haemost. 2015;13:520–529. doi:10.1111/jth.12844
   PubMed Web of Science ®Google Scholar
• Wikkelsø AJ, Edwards HM, Afshari A, et al. Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial. Br J Anaesth. 2015;114:623–633. doi:10.1093/bja/aeu444
   PubMed Web of Science ®Google Scholar
• Trigg DE, Stergiotou I, Peitsidis P, Kadir RA. A systematic review: the use of desmopressin for treatment and prophylaxis of bleeding disorders in pregnancy. Haemophilia. 2012;18:25–33. doi:10.1111/j.1365-2516.2011.02573.x
   PubMed Web of Science ®Google Scholar
• Ekelund K, Hanke G, Stensballe J, Wikkelsøe A, Albrechtsen CK, Afshari A. Hemostatic resuscitation in postpartum hemorrhage - a supplement to surgery. Acta Obstet Gynecol Scand. 2015;94:680–692. doi:10.1111/aogs.12607
   PubMed Web of Science ®Google Scholar
• Vincent JL, Ramesh MK, Ernest D, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med. 2013;41:2069–2079. doi:10.1097/CCM.0b013e31828e9b03
   PubMed Web of Science ®Google Scholar
• Saito H, Maruyama I, Shimazaki S, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a Phase III, randomized, double-blind clinical trial. J Thromb Haemost. 2007;5:31–41. doi:10.1111/j.1538-7836.2006.02267.x
   PubMed Web of Science ®Google Scholar
• Yamakawa K, Fujimi S, Mohri T, et al. Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study. Crit Care. 2011;15:R123. doi:10.1186/cc10228
   PubMed Web of Science ®Google Scholar
• Yoshihara M, Uno K, Tano S, et al. The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study. Crit Care. 2015;19:369. doi:10.1186/s13054-015-1086-3
   PubMed Web of Science ®Google Scholar
• Pernerstorfer T, Hollenstein U, Hansen J, et al. Heparin blunts endotoxin-induced coagulation activation. Circulation. 1999;100:2485–2490. doi:10.1161/01.CIR.100.25.2485
   PubMed Web of Science ®Google Scholar
• Sakuragawa N, Hasegawa H, Maki M, Nakagawa M, Nakashima M. Clinical evaluation of low-molecular-weight heparin (FR-860) on disseminated intravascular coagulation (DIC)–a multicenter co-operative double-blind trial in comparison with heparin. Thromb Res. 1993;72:475–500. doi:10.1016/0049-3848(93)90109-2
   PubMed Web of Science ®Google Scholar
• Brenner B. Haemostatic changes in pregnancy. Thromb Res. 2004;114(5–6):409–414. doi:10.1016/j.thromres.2004.08.004
   PubMed Web of Science ®Google Scholar
• Hunt BJ. Bleeding and Coagulopathies in Critical Care. N Engl J Med. 2014;370:847–859. doi:10.1056/NEJMra1208626
   PubMed Web of Science ®Google Scholar
• Erez O. Disseminated intravascular coagulation in pregnancy - Clinical phenotypes and diagnostic scores. Thromb Res. 2017;151(Suppl 1):S56–S60. doi:10.1016/S0049-3848(17)30069-5
   PubMed Web of Science ®Google Scholar
• ROTEM Protocol (For use in postpartum haemorrhage); 2018. Obstetric Bleeding Strategy for Wales. Available from: https://phw.nhs.wales/services-and-teams/improvement-cymru/improvement-cymru-programmes/maternity-cymru/obs-cymru/obstetric-bleeding-strategy-cymru/rotem-point-of-care-testing. Accessed September 25, 2021.
   Google Scholar