Polyethylene glycol in spinal cord injury repair: a critical review

References

• CenterNSFacts and Figures at A GlanceBirmingham, ALUniversity of Alabama at Birmingham2016
   Google Scholar
• FrenchDDCampbellRRSabharwalSNelsonALPalaciosPAGavin-DreschnackDHealth care costs for patients with chronic spinal cord injury in the Veterans Health AdministrationJ Spinal Cord Med200730547748118092564
   PubMed Web of Science ®Google Scholar
• SilverJMillerJHRegeneration beyond the glial scarNat Rev Neurosci20045214615614735117
   PubMed Web of Science ®Google Scholar
• BibleEDell’AcquaFSolankyBNon-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by (19)F- and diffusion-MRIBiomaterials201233102858287122244696
   PubMed Web of Science ®Google Scholar
• RitfeldGJRauckBMNovosatTLThe effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repairBiomaterials20143561924193124331711
   PubMed Web of Science ®Google Scholar
• ZiembaAMGilbertRJBiomaterials for local, controlled drug delivery to the injured spinal cordFront Pharmacol2017824528539887
   PubMed Web of Science ®Google Scholar
• LuoJBorgensRShiRPolyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injuryJ Neurotrauma2004218994100715318999
   PubMed Web of Science ®Google Scholar
• WilemsTSLuXKurosuYEKhanZLimHJSmith CallahanLAEffects of free radical initiators on polyethylene glycol dimethacrylate hydrogel properties and biocompatibilityJ Biomed Mater Res A2017105113059306828744952
   PubMed Web of Science ®Google Scholar
• PeraleGRossiFSundstromEHydrogels in spinal cord injury repair strategiesACS Chem Neurosci20112733634522816020
   PubMed Web of Science ®Google Scholar
• BoomerJAQuallsMMInerowiczHDCytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugateBioconjug Chem2009201475919072698
   PubMed Web of Science ®Google Scholar
• KangCETatorCHShoichetMSPoly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery systemJ Control Release20101441253120114065
   PubMed Web of Science ®Google Scholar
• ZustiakSPLeachJBHydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical propertiesBiomacromolecules20101151348135720355705
   PubMed Web of Science ®Google Scholar
• SoderquistRGMilliganEDSloaneEMPEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distributionJ Biomed Mater Res A200991371972919048635
   PubMed Web of Science ®Google Scholar
• ZhengJSmith CallahanLAHaoJStrain-promoted cross-linking of PEG-based hydrogels via copper-free cycloadditionACS Macro Lett2012181071107323205321
   PubMed Web of Science ®Google Scholar
• TurecekPLBossardMJSchoetensFIvensIAPEGylation of biopharmaceuticals: a review of chemistry and nonclinical safety information of approved drugsJ Pharm Sci2016105246047526869412
   PubMed Web of Science ®Google Scholar
• RobertsMJBentleyMDHarrisJMChemistry for peptide and protein PEGylationAdv Drug Deliv Rev201264116127
   Web of Science ®Google Scholar
• GeckilHXuFZhangXMoonSDemirciUEngineering hydrogels as extracellular matrix mimicsNanomedicine (Lond)20105346948420394538
   PubMed Web of Science ®Google Scholar
• LinCCAnsethKSPEG hydrogels for the controlled release of bio-molecules in regenerative medicinePharm Res200926363164319089601
   PubMed Web of Science ®Google Scholar
• MahoneyMJAnsethKSThree-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogelsBiomaterials200627102265227416318872
   PubMed Web of Science ®Google Scholar
• Smith CallahanLAPolicastroGMBernardSLChildersEPBoettcherRBeckerMLInfluence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogelsBiomacromolecules20131493047305423844746
   PubMed Web of Science ®Google Scholar
• WilliamsCGMalikANKimTKMansonPNElisseeffJHVariable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulationBiomaterials200526111211121815475050
   PubMed Web of Science ®Google Scholar
• LinSSangajNRazafiarisonTZhangCVargheseSInfluence of physical properties of biomaterials on cellular behaviorPharm Res20112861422143021331474
   PubMed Web of Science ®Google Scholar
• KimJKongYPNiedzielskiSMSinghRKPutnamAJShikanovACharacterization of the crosslinking kinetics of multi-arm poly(ethylene glycol) hydrogels formed via Michael-type additionSoft matter20161272076208526750719
   PubMed Web of Science ®Google Scholar
• TanHMarraKGInjectable, biodegradable hydrogels for tissue engineering applicationsMaterials20103317461767
   Web of Science ®Google Scholar
• SongARaneAAChristmanKLAntibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healingActa Biomaterialia201281415022023748
   PubMed Web of Science ®Google Scholar
• HutanuDFrishbergMDGuoLDarieCCRecent applications of polyethylene glycols (PEGs) and PEG derivativesMod Chem Appl2014221000132
   Google Scholar
• SpencerKCSyJCRamadiKBGraybielAMLangerRCimaMJCharacterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implantsSci Rep2017711952
   Google Scholar
• BradburyEJCarterLMManipulating the glial scar: chondroitinase ABC as a therapy for spinal cord injuryBrain Res Bull201184430631620620201
   PubMed Web of Science ®Google Scholar
• Nazari-RobatiMKhajehKAminianMMollaniaNGolestaniAEnhancement of thermal stability of chondroitinase ABC I by site-directed mutagenesis: an insight from Ramachandran plotBiochim Biophys Acta20131834247948623159774
   PubMed Web of Science ®Google Scholar
• ShahaboddinMEKhajehKMalekiMGolestaniAImprovement of activity and stability of Chondroitinase ABC I by introducing an aromatic cluster at the surface of proteinEnzyme Microb Technol2017105384428756859
   PubMed Web of Science ®Google Scholar
• BrownJMXiaJZhuangBA sulfated carbohydrate epitope inhibits axon regeneration after injuryProc Natl Acad Sci USA2012109134768477322411830
   PubMed Web of Science ®Google Scholar
• StephenDSThe biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptorsCNS Neurol Disord Drug Targets200871466218289031
   PubMed Web of Science ®Google Scholar
• O’LearyPDHughesRADesign of potent peptide mimetics of brain-derived neurotrophic factorJ Biol Chem200327828257382574412730196
   PubMed Web of Science ®Google Scholar
• LangBTCreggJMDePaulMAModulation of the proteoglycan receptor PTPsigma promotes recovery after spinal cord injuryNature2015518753940440825470046
   PubMed Web of Science ®Google Scholar
• MaoYTonkinRSNguyenTSystemic administration of connexin43 mimetic peptide improves functional recovery after traumatic spinal cord injury in adult ratsJ Neurotrauma201734370771927629792
   PubMed Web of Science ®Google Scholar
• OhtakeYParkDAbdul-MuneerPMThe effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injuryBiomaterials201435164610462624630093
   PubMed Web of Science ®Google Scholar
• IwasakiMWilcoxJTNishimuraYSynergistic effects of self-assembling peptide and neural stem/progenitor cells to promote tissue repair and forelimb functional recovery in cervical spinal cord injuryBiomaterials20143592617262924406216
   PubMed Web of Science ®Google Scholar
• ZweckbergerKAhujaCSLiuYWangJFehlingsMGSelf-assembling peptides optimize the post-traumatic milieu and synergistically enhance the effects of neural stem cell therapy after cervical spinal cord injuryActa Biomater201642778927296842
   PubMed Web of Science ®Google Scholar
• ZustiakSPDurbalRLeachJBInfluence of cell-adhesive peptide ligands on poly(ethylene glycol) hydrogel physical, mechanical and transport propertiesActa Biomater2010693404341420385260
   PubMed Web of Science ®Google Scholar
• NaghdiPTiraihiTGanjiFDarabiSTaheriTKazemiHSurvival, proliferation and differentiation enhancement of neural stem cells cultured in three-dimensional polyethylene glycol-RGD hydrogel with tenascinJ Tissue Eng Regen Med201610319920825312025
   PubMed Web of Science ®Google Scholar
• TashiroKSephelGCWeeksBA synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowthJ Biol Chem19892642716174161822777785
   PubMed Web of Science ®Google Scholar
• SilvaGACzeislerCNieceKLSelective differentiation of neural progenitor cells by high-epitope density nanofibersScience200430356621352135514739465
   PubMed Web of Science ®Google Scholar
• LiuLi XJoseyXBShort laminin peptide for improved neural stem cell growthStem Cells Transl Med20143566267024692587
   PubMed Web of Science ®Google Scholar
• AdamsDNKaoEYHypoliteCLDistefanoMDHuWSLetourneauPCGrowth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptideJ Neurobiol200562113414715452851
   PubMed Web of Science ®Google Scholar
• FawcettJWThe extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative diseaseProg Brain Res201521821322625890139
   PubMed Web of Science ®Google Scholar
• Smith CallahanLAThe concentration game: differential effects of bioactive signaling in 2D and 3D cultureNeural Regen Res2016111666826981082
   PubMed Web of Science ®Google Scholar
• LimHJMosleyMCKurosuYSmith CallahanLAConcentration dependent survival and neural differentiation of murine embryonic stem cells cultured on polyethylene glycol dimethacrylate hydrogels possessing a continuous concentration gradient of n-cadherin derived peptide His-Ala-Val-Asp-LleActa Biomater20175615316027915022
   PubMed Web of Science ®Google Scholar
• LimHJKhanZWilemsTSHuman induced pluripotent stem cell derived neural stem cell survival and neural differentiation on polyethylene glycol dimethacrylate hydrogels containing a continuous concentration gradient of N-Cadherin derived peptide His-Ala-Val-Asp-IleACS Biomater Sci Eng201735776781
   Web of Science ®Google Scholar
• YangYHKhanZMaCLimHJSmith CallahanLAOptimization of adhesive conditions for neural differentiation of murine embryonic stem cells using hydrogels functionalized with continuous Ile-Lys-Val-Ala-Val concentration gradientsActa Biomater201521556225931018
   PubMed Web of Science ®Google Scholar
• MosleyMCLimHJChenJNeurite extension and neuronal differentiation of human induced pluripotent stem cell derived neural stem cells on polyethylene glycol hydrogels containing a continuous Young’s Modulus gradientJ Biomed Mater Res A2017105382483327798956
   PubMed Web of Science ®Google Scholar
• OzawaHMatsumotoTOhashiTSatoMKokubunSComparison of spinal cord gray matter and white matter softness: measurement by pipette aspiration methodJ Neurosurg2001952 Suppl22122411599840
   PubMed Web of Science ®Google Scholar
• RussellLNLampeKJOligodendrocyte precursor cell viability, proliferation, and morphology is dependent on mesh size and storage modulus in 3D Poly(ethylene glycol)-based hydrogelsACS Biomater Sci Eng201731234593468
   Web of Science ®Google Scholar
• YanYLiYSongLZengCPluripotent stem cell expansion and neural differentiation in 3-D scaffolds of tunable Poisson’s ratioActa Biomater20174919220327845272
   PubMed Web of Science ®Google Scholar
• RammenseeSKangMSGeorgiouKKumarSSchafferDVDynamics of mechanosensitive neural stem cell differentiationStem Cells201735249750627573749
   PubMed Web of Science ®Google Scholar
• LourencoTPaes de FariaJBippesCAModulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cuesSci Rep201662156326879561
   PubMed Web of Science ®Google Scholar
• RussellLNLampeKJEngineering biomaterials to influence oligodendroglial growth, maturation, and myelin productionCells Tissues Organs20162021–28510127701172
   PubMed Web of Science ®Google Scholar
• HappelRDSmithKPNaren BanikLJames PowersMHoganELDouglas BalentineJCa2+-accumulation in experimental spinal cord traumaBrain Research198121124764797237138
   PubMed Web of Science ®Google Scholar
• HuffTBShiYSunWWuWShiRChengJXReal-time CARS imaging reveals a calpain-dependent pathway for paranodal myelin retraction during high-frequency stimulationPLoS One201163e1717621390223
   PubMed Web of Science ®Google Scholar
• NehrtAHamannKOuyangHShiRPolyethylene glycol enhances axolemmal resealing following transection in cultured cells and in ex vivo spinal cordJ Neurotrauma201027115116119691421
   PubMed Web of Science ®Google Scholar
• WangAZhangGXiaochenWZhangCTaoSHuoXCombination of applied electric field and polyethylene glycol effectively enhance functional recovery in acute spinal cord injury of ratsPaper presented at: 2016 Asia-Pacific International Symposium on Electromagnetic Compatibility (APEMC)17–21 May 20162016
   Google Scholar
• Carballo-MolinaOAVelascoIHydrogels as scaffolds and delivery systems to enhance axonal regeneration after injuriesFront Cell Neurosci2015913
   PubMed Web of Science ®Google Scholar
• CensiRDi MartinoPVermondenTHenninkWEHydrogels for protein delivery in tissue engineeringJ Control Release2012161268069222421425
   PubMed Web of Science ®Google Scholar
• TrimailleTPerticiVGigmesDRecent advances in synthetic polymer based hydrogels for spinal cord repairComptes Rendus Chimie2016191157166
   Web of Science ®Google Scholar
• LuoJBorgensRShiRPolyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injuryJ Neurochem200283247148012423257
   PubMed Web of Science ®Google Scholar
• ShiRPolyethylene glycol repairs membrane damage and enhances functional recovery: a tissue engineering approach to spinal cord injuryNeurosci Bull201329446046623893430
   PubMed Web of Science ®Google Scholar
• RenSLiuZ-HWuQPolyethylene glycol-induced motor recovery after total spinal transection in ratsCNS Neurosci Ther201723868068528612398
   PubMed Web of Science ®Google Scholar
• LiuZRenSFuKRestoration of motor function after operative reconstruction of the acutely transected spinal cord in the canine modelSurgery2018163597698329223327
   PubMed Web of Science ®Google Scholar
• AndersonMABurdaJERenYAstrocyte scar formation aids central nervous system axon regenerationNature2016532759819520027027288
   PubMed Web of Science ®Google Scholar
• KimCYPEG-assisted reconstruction of the cervical spinal cord in rats: effects on motor conduction at 1hSpinal Cord20165491091227215738
   PubMed Web of Science ®Google Scholar
• EstradaVBrazdaNSchmitzCLong-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantationNeurobiol Dis20146716517924713436
   PubMed Web of Science ®Google Scholar
• MacayaDSpectorMInjectable hydrogel materials for spinal cord regeneration: a reviewBiomed Mater201271012001
   Web of Science ®Google Scholar
• OdaYTaniKIsozakiAEffects of polyethylene glycol administration and bone marrow stromal cell transplantation therapy in spinal cord injury miceJ Vet Med Sci201476341542124270802
   PubMed Web of Science ®Google Scholar
• HuangZFilipovicZMpNAC105 Increases extracellular magnesium delivery and reduces excitotoxic glutamate exposure within injured spinal cords in ratsJ Neurotrauma201634368569427503053
   PubMed Web of Science ®Google Scholar
• AgnesEHInesM-LMartinOBiomaterials for revascularization and immunomodulation after spinal cord injuryBiomed Mater201813404410529359704
   PubMed Web of Science ®Google Scholar
• JainAKimYTMcKeonRJBellamkondaRVIn situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injuryBiomaterials200627349750416099038
   PubMed Web of Science ®Google Scholar
• ComolliNNeuhuberBFischerILowmanAIn vitro analysis of PNIPAAm-PEG, a novel, injectable scaffold for spinal cord repairActa Biomater2009541046105519054721
   PubMed Web of Science ®Google Scholar
• CaiLDewiREHeilshornSCInjectable hydrogels with in situ double network formation enhance retention of transplanted stem cellsAdv Funct Mater20152591344135126273242
   PubMed Web of Science ®Google Scholar
• TylerJYXuXMChengJXNanomedicine for treating spinal cord injuryNanoscale20135198821883623945984
   PubMed Web of Science ®Google Scholar
• KimYTCaldwellJMBellamkondaRVNanoparticle-mediated local delivery of methylprednisolone after spinal cord injuryBiomaterials200930132582259019185913
   PubMed Web of Science ®Google Scholar
• KangCEBaumannMDTatorCHShoichetMSLocalized and sustained delivery of fibroblast growth factor-2 from a nanoparticle-hydrogel composite for treatment of spinal cord injuryCells Tissues Organs20131971556322796886
   PubMed Web of Science ®Google Scholar
• HottaRChengLGrahamHKDelivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivoBiomaterials20168811126922325
   PubMed Web of Science ®Google Scholar
• VeroneseFMMeroAThe impact of PEGylation on biological therapiesBioDrugs200822531532918778113
   PubMed Web of Science ®Google Scholar
• GefenTVayaJKhatibSThe impact of PEGylation on protein immunogenicityInt Immunopharmacol201315225425923306102
   PubMed Web of Science ®Google Scholar
• YanKu SWangFSunYYangYYeNLThe blood-brain barrier penetration and distribution of PEGylated fluorescein-doped magnetic silica nanoparticles in rat brainBiochem Biophys Res Commun2010394487187620206605
   PubMed Web of Science ®Google Scholar
• RichterAWAkerblomEAntibodies against polyethylene glycol produced in animals by immunization with monomethoxy polyethylene glycol modified proteinsInt Arch Allergy Appl Immunol19837021241316401699
   PubMedGoogle Scholar
• WunderlichDAMacdougallMMierzDVGeneration and characterization of a monoclonal IgG antibody to polyethylene glycolHybridoma (Larchmt)200726316817217600499
   PubMedGoogle Scholar
• ShimizuTIchiharaMYoshiokaYIshidaTNakagawaSKiwadaHIntravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M responseBiol Pharm Bull20123581336134222863934
   PubMed Web of Science ®Google Scholar
• SwartzlanderMDBarnesCABlakneyAKKaarJLKyriakidesTRBryantSJLinking the foreign body response and protein adsorption to PEG-based hydrogels using proteomicsBiomaterials201541263625522962
   PubMed Web of Science ®Google Scholar
• LynnADBlakneyAKKyriakidesTRBryantSJTemporal progression of the host response to implanted poly(ethylene glycol)-based hydrogelsJ Biomed Mater Res A201196462163121268236
   PubMed Web of Science ®Google Scholar
• GarayRPEl-GewelyRArmstrongJKGarrattyGRichettePAntibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agentsExpert Opin Drug Deliv20129111319132322931049
   PubMed Web of Science ®Google Scholar
• MimaYHashimotoYShimizuTKiwadaHIshidaTAnti-PEG IgM Is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated proteinMolecular Pharmaceutics20151272429243526070445
   PubMed Web of Science ®Google Scholar
• YangQLaiSKAnti-PEG immunity: emergence, characteristics, and unaddressed questionsWiley Interdiscip Rev Nanomed Nanobiotechnol20157565567725707913
   PubMed Web of Science ®Google Scholar
• IshidaTWangXShimizuTNawataKKiwadaHPEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent mannerJ Control Release2007122334935517610982
   PubMed Web of Science ®Google Scholar
• ShimizuTMimaYHashimotoYAnti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cellsImmunobiology2015220101151116026095176
   PubMed Web of Science ®Google Scholar
• VosQLeesAWuZQSnapperCMMondJJB-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganismsImmunological Reviews20031761154170
   Google Scholar
• VerhoefJJCarpenterJFAnchordoquyTJSchellekensHPotential induction of anti-PEG antibodies and complement activation toward PEGylated therapeuticsDrug Discov Today201419121945195225205349
   PubMed Web of Science ®Google Scholar
• PapastefanakiFJakovcevskiIPouliaNIntraspinal delivery of polyethylene glycol-coated gold nanoparticles promotes functional recovery after spinal cord injuryMol Ther2015236993100225807288
   PubMed Web of Science ®Google Scholar
• PapaSFerrariRDe PaolaMPolymeric nanoparticle system to target activated microglia/macrophages in spinal cord injuryJ Control Release2014174152624225226
   PubMed Web of Science ®Google Scholar
• JenkinsSIWeinbergDal-ShakliAF“Stealth” nanoparticles evade neural immune cells but also evade major brain cell populations: implications for PEG-based neurotherapeuticsJ Control Release201622413614526780172
   PubMed Web of Science ®Google Scholar
• DengLi JYuanJJZonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injuryInt J Nanomedicine2017122443245628408816
   PubMed Web of Science ®Google Scholar
• JiangWu JBiHQApamin-mediated actively targeted drug delivery for treatment of spinal cord injury: more than just a conceptMol Pharm20141193210322225098949
   PubMed Web of Science ®Google Scholar
• LiJMooneyDJDesigning hydrogels for controlled drug deliveryNat Rev Mater20161121607129657852
   PubMed Web of Science ®Google Scholar
• LeeKSilvaEAMooneyDJGrowth factor delivery-based tissue engineering: general approaches and a review of recent developmentsJ R Soc Interface201185515317020719768
   PubMed Web of Science ®Google Scholar
• BurdickJAWardMLiangEYoungMJLangerRStimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogelsBiomaterials200627345245916115674
   PubMed Web of Science ®Google Scholar
• KongLAskesSHCBonnetSKrosACampbellFTemporal control of membrane fusion through photolabile PEGylation of liposome membranesAngew Chem Int Ed Engl20165541396140026661729
   PubMed Web of Science ®Google Scholar
• LampeKJKernDSMahoneyMJBjugstadKBThe administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: protein distribution and the glial responseJ Biomed Mater Res A201196A3595607
   Web of Science ®Google Scholar
• LynamDAShahriariDWolfKJBrain derived neurotrophic factor release from layer-by-layer coated agarose nerve guidance scaffoldsActa Biomater20151812813125712385
   PubMed Web of Science ®Google Scholar
• Elliott DonaghueIShoichetMSControlled release of bioactive PDGF-AA from a hydrogel/nanoparticle compositeActa Biomater201525354226257128
   PubMed Web of Science ®Google Scholar
• GarbayoEAnsorenaELanciegoJLAymerichMSBlanco-PrietoMJSustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheresEur J Pharm Biopharm200869384485118417331
   PubMed Web of Science ®Google Scholar
• StanwickJCBaumannMDShoichetMSEnhanced neurotrophin-3 bioactivity and release from a nanoparticle-loaded composite hydrogelJ Control Release2012160366667522510446
   PubMed Web of Science ®Google Scholar
• HammerNBrandlFPKirchhofSMessmannVGoepferichAMProtein compatibility of selected cross-linking reactions for hydrogelsMacromol Biosci201515340541325399803
   PubMed Web of Science ®Google Scholar
• van de WeteringPMettersATSchoenmakersRGHubbellJAPoly(ethylene glycol) hydrogels formed by conjugate addition with controllable swelling, degradation, and release of pharmaceutically active proteinsJ Control Release2005102361962715681084
   PubMed Web of Science ®Google Scholar
• LinC-CMettersATEnhanced Protein Delivery from Photopolymerized Hydrogels Using a Pseudospecific Metal Chelating LigandPharm Res200623361416397740
   PubMed Web of Science ®Google Scholar
• CensiRVermondenTvan SteenbergenMJPhotopolymerized thermosensitive hydrogels for tailorable diffusion-controlled protein deliveryJ Control Release2009140323023619527757
   PubMed Web of Science ®Google Scholar
• LangerRTirrellDADesigning materials for biology and medicineNature2004428698248749215057821
   PubMed Web of Science ®Google Scholar
• HongLTAKimYMParkHHAn injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodelingNat Commun20178153328912446
   PubMed Web of Science ®Google Scholar
• HejclALesnyPPradnyMBiocompatible hydrogels in spinal cord injury repairPhysiol Res200857Suppl 3S12113218481908
   PubMed Web of Science ®Google Scholar
• LiuCHuangYPangMTissue-engineered regeneration of completely transected spinal cord using induced neural stem cells and gelatin-electrospun poly (Lactide-Co-Glycolide)/Polyethylene glycol scaffoldsPLoS One2015103e011770925803031
   PubMed Web of Science ®Google Scholar
• ChenBKMadiganNNHakimJSGDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in ratsJ Tissue Eng Regen Med2018121e398e40728296347
   PubMed Web of Science ®Google Scholar
• CaronIRossiFPapaSA new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injuryBiomaterials20167513514726497428
   PubMed Web of Science ®Google Scholar
• HakimJSEsmaeili RadMGrahnPJPositively charged oligo[Poly(Ethylene Glycol) Fumarate] scaffold implantation results in a permissive lesion environment after spinal cord injury in ratTissue Engineering Part A20152113–142099211425891264
   PubMed Web of Science ®Google Scholar