Hypoglycemic, Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Bersama abyssinica Fresen (Melianthaceae) Leaves’ Solvent Fractions in Normoglycemic and Streptozotocin-Induced Diabetic Mice

References

• Kristova V, Líšková S, Sotnikova R, Vojtko R, Kurtanský A. Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats. Physiological Research. 2008;57:3.
   Web of Science ®Google Scholar
• Li W, Zheng H, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol. 2004;92(1):1–21. doi:10.1016/j.jep.2003.12.031
   PubMed Web of Science ®Google Scholar
• Organization WH. Global Report on Diabetes. World Health Organization; 2016.
   Google Scholar
• Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi:10.1016/j.diabres.2018.02.023
   PubMed Web of Science ®Google Scholar
• García-Risco MR, Mouhid L, Salas-Pérez L, et al. Biological activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts. Plant Foods Human Nutrition. 2017;72(1):96–102. doi:10.1007/s11130-016-0596-8
   PubMed Web of Science ®Google Scholar
• Gupta B, Sharma I, Kohli N, Sharma S, Rathi A, Sharma A. Preliminary clinical assessment and non-toxicity evaluation of an ayurvedic formulation BGR-34 in NIDDM. J Traditional Complementary Med. 2018;8(4):506–514. doi:10.1016/j.jtcme.2017.11.004
   Google Scholar
• Jani DK, Goswami S. Antidiabetic activity of Cassia angustifolia Vahl. and Raphanus sativus Linn. leaf extracts. J Traditional Complementary Medicine. 2020;10(2):124. doi:10.1016/j.jtcme.2019.03.002
   PubMedGoogle Scholar
• Grover J, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81(1):81–100. doi:10.1016/S0378-8741(02)00059-4
   PubMed Web of Science ®Google Scholar
• Prabhakar PK, Doble M. Mechanism of action of natural products used in the treatment of diabetes mellitus. Chin J Integr Med. 2011;17(8):563.
   PubMed Web of Science ®Google Scholar
• Fatima A, Agrawal P, Singh PP. Herbal option for diabetes: an overview. Asian Pacific J Tropical Disease. 2012;2:S536S44. doi:10.1016/S2222-1808(12)60216-3
   Google Scholar
• Hegazy M-E, Ngandeu F, Neguim G, et al. C-Glucoside xanthone from the stem bark extract of Bersama engleriana. Pharmacognosy Res. 2010;2(4):229. doi:10.4103/0974-8490.69110
   Google Scholar
• Mikkelsen K, Seberg O. Morphometric analysis of the Bersama abyssinica Fresen. complex (Melianthaceae) in East Africa. Plant Systematics Evolution. 2001;227(34):157–182. doi:10.1007/s006060170046
   Web of Science ®Google Scholar
• Demissew S, Friis I, Awas T, et al. Four new species of Aloe (Aloaceae) from Ethiopia, with notes on the ethics of describing new taxa from foreign countries. Kew Bulletin. 2011;66(1):111–121. doi:10.1007/s12225-011-9263-2
   Google Scholar
• Vuksan V, Sievenpiper JL. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutrition, Metabolism Cardiovascular Diseases. 2005;15(3):149–160. doi:10.1016/j.numecd.2005.05.001
   Web of Science ®Google Scholar
• Zekeya N, Chacha M, Shahada F, Kidukuli A. Analysis of phytochemical composition of Bersama abyssinica by gas chromatography-mass spectrometry. J Pharmacognosy Phytochemistry. 2014;3(4):246–252.
   Google Scholar
• Mathewos Anza FW, Libsu S, Mamo F. Milkyas endale phytochemical screening and antibacterial activity of leaves extract of bersama abyssinica. J of Advanced Botany Zoology. 2015;3:2.
   Google Scholar
• Amit L, Vikas G, Vaibhav T, Vikash K, Siddhartha G, Lather A. Phytochemistry and pharmacological activities of bersama engleriana guerke-an overview. Sexually Transmitted Diseases. 2010;11:12.
   Google Scholar
• Edeoga H, Okwu D, Mbaebie B. Phytochemical constituents of some Nigerian medicinal plants. African j Biotechnol. 2005;4(7):685–688. doi:10.5897/AJB2005.000-3127
   Web of Science ®Google Scholar
• Birhanu Z, Endale A, Shewamene Z. An ethnomedicinal investigation of plants used by traditional healers of Gondar town, North-Western Ethiopia. J Medicinal Plants Studies. 2015;3(2):36–43.
   Google Scholar
• Bekele G, Reddy PR. Ethnobotanical study of medicinal plants used to treat human ailments by Guji Oromo tribes in Abaya District, Borana, Oromia, Ethiopia. Universal J Plant Sci. 2015;3(1):1–8.
   Google Scholar
• Esubalew ST, Belete A, Lulekal E, Gabriel T, Engidawork E, Asres K. Review of ethnobotanical and ethnopharmacological evidences of some ethiopian medicinal plants traditionally used for the treatment of cancer. Ethiopian J Health Development. 2017;31(3):161–187.
   Web of Science ®Google Scholar
• Schmelzer G, Gurib-Fakim A. Plant Resources of Tropical Africa 11 (1). Medicinal Plants 1. Wageningen/Leiden: PROTA Foundation. Backhuys Publishers; 2008.
   Google Scholar
• Kifle ZD, Enyew EF. Evaluation of in vivo antidiabetic, in vitro α-amylase inhibitory, and in vitro antioxidant activity of leaves crude extract and solvent fractions of bersama abyssinica fresen (melianthaceae). J Evid Based Integr Med. 2020;25:2515690x20935827. doi:10.1177/2515690X20935827
   Web of Science ®Google Scholar
• Satyajit D, Sarker ZL, Alexander I. Gray. Natural Products Isolation-Second Edition. Biotechnology™. United Kingdom: Humana Press Inc; 2006.
   Google Scholar
• Geleta B, Makonnen E, Debella A, Tadele A. In vivo antihypertensive and antihyperlipidemic effects of the crude extracts and fractions of Moringa stenopetala (Baker f.). Cufod Leaves in Rats Frontiers Pharmacol. 2016;7:97.
   PubMed Web of Science ®Google Scholar
• Molla M, Gemeda N, Abay SM. Investigating potential modes of actions of Mimusops kummel fruit extract and solvent fractions for their antidiarrheal activities in mice. Evidence-Based Complementary Alternative Medicine. 2017;2017.
   Web of Science ®Google Scholar
• Kashimawo A, Kolawole J, Ahmadu A. Bioassay Guided Fractionation and Α-Amylase Inhibitory Activity of Lupeol from the Stem Bark of Faidherbia Albida Del. Mimosaceae. International Journal of Pharmaceutical Science Invention. 2017;6(6):29–32.
   Google Scholar
• Care I, Animals U, Resources N. Guide for the care and Use of Laboratory animals. National Academies; 1985.
   Google Scholar
• OCDE O. Acute oral Toxicity: up and Down Procedure. OECD Guideline Testing Chemicals. 2008;425:1–2.
   Google Scholar
• Baquer NZ, Kumar P, Taha A, Kale R, Cowsik S, McLean P. Metabolic and molecular action of Trigonella foenum-graecum (fenugreek) and trace metals in experimental diabetic tissues. J Biosci. 2011;36(2):383–396. doi:10.1007/s12038-011-9042-0
   PubMed Web of Science ®Google Scholar
• Birru EM, Abdelwuhab M, Shewamene Z. Effect of hydroalcoholic leaves extract of Indigofera spicata Forssk. on blood glucose level of normal, glucose loaded and diabetic rodents. BMC Complement Altern Med. 2015;15(1):321.
   Web of Science ®Google Scholar
• Tesfaye A, Makonnen E, Gedamu S. Hypoglycemic and antihyperglycemic activity of aqueous extract of Justicia Schimperiana leaves in normal and streptozotocin-induced diabetic mice. Int J Pharma Sci Res. 2016;7(2):110–113.
   Google Scholar
• Bowe JE, Franklin ZJ, Hauge-Evans AC, et al. Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models. J Endocrinol. 2014;222(3):G13G25. doi:10.1530/JOE-14-0182
   Web of Science ®Google Scholar
• Ayala JE, Samuel VT, Morton GJ, et al. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech. 2010;dmm:006239.
   Google Scholar
• Krishnaveni M, Mirunalini S, Karthishwaran K, Dhamodharan G. Antidiabetic and antihyperlipidemic properties of Phyllanthus emblica Linn. (Euphorbiaceae) on streptozotocin induced diabetic rats. Pak J Nutr. 2010;9(1):43–51. doi:10.3923/pjn.2010.43.51
   Google Scholar
• Graham ML, Janecek JL, Kittredge JA, Hering BJ, Schuurman H-J. The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources. Comp Med. 2011;61(4):356–360.
   PubMed Web of Science ®Google Scholar
• Budin SB, Othman F, Louis S, et al. Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats. Rom J Morphol Embryol. 2009;50(1):23–30.
   Web of Science ®Google Scholar
• Gibbons GF. Hyperlipidaemia of diabetes. Clin Sci. 1986;71(5):477–486. doi:10.1042/cs0710477
   Web of Science ®Google Scholar
• Gebreyohannis T, Shibeshi W, Asres K. Effects of solvent fractions of caylusea abyssinica (fresen.) fisch. and mey. on blood glucose levels of normoglycemic, glucose loaded and streptozotocin-induced diabetic rodents. J Natural Remedies. 2013;14(1):67–75.
   Google Scholar
• Arya A, Nyamathulla S, Noordin MI, Mohd MA. Antioxidant and hypoglycemic activities of leaf extracts of three popular Terminalia species. E-J Chem. 2012;9.
   Google Scholar
• Kifle ZD, Yesuf JS, Atnafie SA. Evaluation of in vitro and in vivo anti-diabetic, anti-hyperlipidemic and anti-oxidant activity of flower crude extract and solvent fractions of hagenia abyssinica (rosaceae). J Exp Pharmacol. 2020;12:151–167. doi:10.2147/JEP.S249964
   PubMedGoogle Scholar
• Alema NM, Periasamy G, Sibhat GG, Tekulu GH, Hiben MG. Antidiabetic activity of extracts of terminalia brownii fresen. stem bark in mice. J Exp Pharmacol. 2020;12:61. doi:10.2147/JEP.S240266
   PubMedGoogle Scholar
• Etuk E. Animals models for studying diabetes mellitus. Agric Biol JN Am. 2010;1(2):130–134.
   Google Scholar
• Beshir K, Shibeshi W, Ejigu A, Engidawork E. In-vivo wound healing activity of 70% ethanol leaf extract of Beciumgrandiflorum Lam. (Lamiaceae) in mice. Ethiopian Pharmarmaceutical J. 2016;32:117–130. doi:10.4314/epj.v32i2.3
   Google Scholar
• Jadhav R, Puchchakayala G. Hypoglycemic and antidiabetic activity of flavonoids: boswellic acid, ellagic acid, quercetin, rutin on streptozotocin-nicotinamide induced type 2 diabetic rats. Group. 2012;1:100g.
   Google Scholar
• Belayneh YM, Birhanu Z, Birru EM, Getenet G. Evaluation of in vivo antidiabetic, antidyslipidemic, and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L. (Solanaceae). J Exp Pharmacol. 2019;11:29. doi:10.2147/JEP.S192264
   PubMedGoogle Scholar
• TOMAI F CREA, Gaspardone F, Versaci A, et al. Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. American Heart Association. 1994;(700–705).
   Google Scholar
• Spinas GA. The dual role of nitric oxide in islet β-cells. Physiology. 1999;14(2):49–54. doi:10.1152/physiologyonline.1999.14.2.49
   Web of Science ®Google Scholar
• Šoltésová D, Herichová I. On the mechanisms of diabetogenic effects of alloxan and streptozotocin. Diabetologie, Metabolismus, Endokrinologie, Výživa. 2011;14:130–138.
   Google Scholar
• Swanston-Flatt S, Day C, Bailey C, Flatt P. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia. 1990;33(8):462–464. doi:10.1007/BF00405106
   PubMed Web of Science ®Google Scholar
• Ravi K, Ramachandran B, Subramanian S. Protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin-induced diabetic rats. Biol Pharm Bull. 2004;27(8):1212–1217. doi:10.1248/bpb.27.1212
   PubMed Web of Science ®Google Scholar
• Pari L, Satheesh MA. Antidiabetic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. J Ethnopharmacol. 2004;91(1):109–113. doi:10.1016/j.jep.2003.12.013
   PubMed Web of Science ®Google Scholar
• Oyedemi S, Bradley G, Afolayan A. Antidiabetic activities of aqueous stem bark extract of Strychnoshenningsii Gilg in streptozotocin-nicotinamide type 2 diabetic rats. IJPR. 2012;11(1):221.
   Google Scholar
• Hammeso WW, Emiru YK, Ayalew Getahun K, Kahaliw W. Antidiabetic and antihyperlipidemic activities of the leaf latex extract of Aloe megalacantha baker (Aloaceae) in streptozotocin-induced diabetic model. Evidence-Based Complementary Alternative Medicine. 2019;2019.
   Web of Science ®Google Scholar
• Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. A potential source of high-value components for functional foods and nutraceuticals-a review. Phytotherapy Research. 2013.
   Google Scholar
• Gao D, Li Q, Li Y, et al. Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait in alloxan‐induced diabetic rats. Phytother Res. 2009;23(9):1257–1262. doi:10.1002/ptr.2603
   PubMed Web of Science ®Google Scholar
• Enkhmaa B, Ozturk Z, Anuurad E, Berglund L. Postprandial lipoproteins and cardiovascular disease risk in diabetes mellitus. Curr Diab Rep. 2010;10(1):61–69. doi:10.1007/s11892-009-0088-4
   PubMed Web of Science ®Google Scholar
• Samatha P, Venkateswarlu M, Siva Prabodh V. Lipid profile levels in type 2 diabetes mellitus from the tribal population of Adilabad in Andhra Pradesh, India. J Clin Diagnostic Res. 2012;6(4):590–592.
   Google Scholar
• Puddu A, Sanguineti R, Mach F, Dallegri F, Viviani GL, Montecucco F. Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. Mediators Inflamm. 2013;2013.
   Web of Science ®Google Scholar
• Jia Q, Liu X, Wu X, et al. Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats. Phytomedicine. 2009;16(8):744–750. doi:10.1016/j.phymed.2008.12.012
   PubMed Web of Science ®Google Scholar
• Jelodar G, Mohsen M, Shahram S. Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. African J Traditional, Complementary Alternative Medicines. 2007;4(3):299–305. doi:10.4314/ajtcam.v4i3.31223
   PubMedGoogle Scholar
• Shiju TM, Pragasam V. Lipoprotein modification: a hallmark in the progression of diabetic nephropathy. Webmedcentral. 2012.
   Google Scholar
• Egga E, Adeyanju O, Agyeno O. Preliminary phytochemical, antimicrobial and proximate analysis of tender leaves of psidium guajava l in jos, plateau state, nigeria. Asian Review of Environmental and Earth Sciences. 2014.
   Google Scholar
• Carlson TJ, King SR. From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia. 1997;40:614–617. doi:10.1007/s001250050724
   PubMed Web of Science ®Google Scholar
• Ragavan B, Krishnakumari S. Antidiabetic effect ofT. arjuna bark extract in alloxan induced diabetic rats. Indian J Clin Biochem. 2006;21(2):123. doi:10.1007/BF02912926
   Google Scholar
• Miura T, Koike T, Ishida T. Antidiabetic activity of green tea (Thea sinensis L.) in genetically type 2 diabetic mice. J Health Science. 2005;51(6):708–710. doi:10.1248/jhs.51.708
   Google Scholar