Antidiabetic Activity of Hydromethanolic Extract of Crude Dorstenia barnimiana Root: Validation of In Vitro and In Vivo Antidiabetic and Antidyslipidemic Activity

References

• Punthakee Z, Goldenberg R, Katz P. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Can J Diabetes. 2018;42:S10–5. doi:10.1016/j.jcjd.2017.10.003
   PubMed Web of Science ®Google Scholar
• Fattaheian-Dehkordi S, Hojjatifard R, Saeedi M, Khanavi M, Mancianti F. A review on antidiabetic activity of Centaurea spp.: a new approach for developing herbal remedies. Evid Based Complement Altern Med. 2021;2021:1–23. doi:10.1155/2021/5587938
   Web of Science ®Google Scholar
• Siddiqui AA, Siddiqui SSA, Ahmad S, et al. Diabetes: mechanism, pathophysiology and management-A review. Int J Drug Dev Res. 2013;5(2):1–23.
   Google Scholar
• Baynest HW. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J Diabetes Metab. 2015;06(05). doi:10.4172/2155-6156.1000541
   Google Scholar
• Skyler JS, Bakris GL, Bonifacio E, et al. Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes. 2017;66(2):241–255. doi:10.2337/db17-ti02
   PubMed Web of Science ®Google Scholar
• Olukayode Ajayi G, Mary Edamisan O, Titilayo Obayemi P, Namesegua Elegbeleye E, Uchechukwu Obi E. Phytoconstituents and antidiabetic activity of Vernonia amygdalina (Asteraceae) in streptozotocin-induced diabetic rats. Int J Biochem Bioinforma Biotechnol Stud. 2021;6(1):1–16.
   Google Scholar
• Aynalem SB, Zeleke AJ. Prevalence of diabetes mellitus and its risk factors among individuals aged 15 years and above in Mizan-Aman Town, Southwest Ethiopia, 2016: a cross sectional study. Int J Endocrinol. 2018;2018:1–7. doi:10.1155/2018/9317987
   Web of Science ®Google Scholar
• Alqathama A, Alluhiabi G, Baghdadi H, et al. Herbal medicine from the perspective of type II diabetic patients and physicians: what is the relationship? BMC Complement Med Ther. 2020;20(1):65. doi:10.1186/s12906-020-2854-4
   PubMedGoogle Scholar
• Tafesse TB, Hymete A, Mekonnen Y, Tadesse M. Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice. BMC Complement Altern Med. 2017;17(1):1–9. doi:10.1186/s12906-017-1757-5
   PubMed Web of Science ®Google Scholar
• Saraei P, Asadi I, Kakar MA, Moradi-Kor N. The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances. Cancer Manag Res. 2019;11:3295–3313. doi:10.2147/CMAR.S200059
   PubMed Web of Science ®Google Scholar
• Govindappa M. A review on role of plant (s) extracts and its phytochemicals for the management of diabetes. J Diabetes Metab. 2015;6(7):1–38. doi:10.4172/2155-6156.1000565
   Web of Science ®Google Scholar
• Rupeshkumar M, Kavitha K, Haldar PK. Role of herbal plants in the diabetes mellitus therapy: an overview. Int J Appl Pharm. 2014;6(3):1–3.
   Google Scholar
• Arika WM, Abdirahman YA, Mawia MA, et al. In vivo antidiabetic activity of the aqueous leaf extract of Croton macrostachyus in alloxan induced diabetic mice. Pharm Anal Acta. 2015;6(11):1–5. doi:10.4172/2153-2435.1000447
   Google Scholar
• Wakene W, Asmamaw S, Kahaliw W. Evaluation of antidiabetic and antioxidant activity of leaf extract and solvent fractions of hypoestes forskaolii (Val) (Acanthaceae) in mice. J Exp Pharmacol. 2021;13:859–872. doi:10.2147/JEP.S318696
   PubMedGoogle Scholar
• Taye GM, Bule M, Gadisa DA, Teka F, Abula T. In vivo antidiabetic activity evaluation of aqueous and 80% methanolic extracts of leaves of thymus schimperi (Lamiaceae) in alloxan-induced diabetic mice. Diabetes Metab Syndr Obes Targets Ther. 2020;13:3205–3212. doi:10.2147/DMSO.S268689
   PubMed Web of Science ®Google Scholar
• Ayele AG, Kumar P, Engidawork E. Antihyperglycemic and hypoglycemic activities of the aqueous leaf extract of Rubus Erlangeri Engl (Rosacea) in mice. Metab Open. 2021;11:100118. doi:10.1016/j.metop.2021.100118
   PubMedGoogle Scholar
• Kifle ZD, Enyew EF. Evaluation of in vivo antidiabetic, in vitro α-amylase inhibitory, and in vitro antioxidant activity of leaves crude extract and solvent fractions of Bersama abyssinica Fresen (Melianthaceae). J Evid Based Integr Med. 2020;25:2515690X2093582. doi:10.1177/2515690X20935827
   Web of Science ®Google Scholar
• Belayneh YM, Birru EM. Antidiabetic activities of hydromethanolic leaf extract of Calpurnia aurea (Ait.) Benth. Subspecies aurea (Fabaceae) in mice. Evid Based Complement Altern Med. 2018;2018:1–9. doi:10.1155/2018/3509073
   Web of Science ®Google Scholar
• Shewamene Z, Abdelwuhab M, Birhanu Z. Methanolic leaf extract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents. BMC Complement Altern Med. 2015;15(1):1–7. doi:10.1186/s12906-015-0535-5
   PubMed Web of Science ®Google Scholar
• Derebe D, Wubetu M, Alamirew A. Hypoglycemic and antihyperglycemic activities of 80% methanol root extract of acanthus polystachyus delile (Acanthaceae) in type 2 diabetic rats. Clin Pharmacol Adv Appl. 2020;12:149–157. doi:10.2147/CPAA.S273501
   PubMed Web of Science ®Google Scholar
• Melaku BC, Amare GG. Evaluation of antidiabetic and antioxidant potential of hydromethanolic seed extract of datura stramonium Linn (Solanaceae). J Exp Pharmacol. 2020;12:181–189. doi:10.2147/JEP.S258522
   PubMedGoogle Scholar
• Mekuria AB, Geta M, Birru EM, Gelayee DA. antimalarial activity of seed extracts of Schinus molle against Plasmodium berghei in mice. J Evid Based Integr Med. 2021;26:2515690X2098428. doi:10.1177/2515690X20984287
   Web of Science ®Google Scholar
• Kifle ZD, Yesuf JS, Atnafie SA. Evaluation of in vitro and in vivo anti-diabetic, anti-hyperlipidemic and anti-oxidant activity of flower crude extract and solvent fractions of hagenia abyssinica (Rosaceae). J Exp Pharmacol. 2020;12:151–167. doi:10.2147/JEP.S249964
   PubMedGoogle Scholar
• Alema NM, Periasamy G, Sibhat GG, Tekulu GH, Hiben MG. Antidiabetic activity of extracts of Terminalia brownii fresen. Stem bark in mice. J Exp Pharmacol. 2020;12:61–71. doi:10.2147/JEP.S240266
   PubMedGoogle Scholar
• Wang L, Wu H, Deng Y, et al. FTZ ameliorates diabetic cardiomyopathy by inhibiting inflammation and cardiac fibrosis in the streptozotocin-induced model. Evid Based Complement Altern Med. 2021;2021:1–16. doi:10.1155/2021/5582567
   Web of Science ®Google Scholar
• Chen Y, Lin X, Zheng Y, Yu W, Lin F, Zhang J. Dendrobium mixture ameliorates diabetic nephropathy in db/db mice by regulating the TGF- β 1/smads signaling pathway. Evid Based Complement Altern Med. 2021;2021:1–11. doi:10.1155/2021/9931983
   Web of Science ®Google Scholar
• Yineger H, Kelbessa E, Bekele T. A study of ethno botany of medicinal plants and floristic composition of the dry Afromontane forest at Bale Mountains National Park. SINET Ethiop J Sci. 2008;31(2):103–120.
   Google Scholar
• Bishai D. Review of ethnobotanical and ethnopharmacological evidences of some Ethiopian medicinal plants traditionally used for the treatment of cancer. Ethiop J Health Dev. 2017;31(3):161–187. doi:10.4314/ejhd.v31i3
   Web of Science ®Google Scholar
• Teklehaymanot T. An ethnobotanical survey of medicinal and edible plants of Yalo Woreda in Afar regional state, Ethiopia. J Ethnobiol Ethnomed. 2017;13(1). doi:10.1186/s13002-017-0166-7
   PubMed Web of Science ®Google Scholar
• Negesse GS, Lulekal E. Use and conservation of traditional medicinal plants in Alelitu Woreda North Shewa, Oromia Region Ethiopia. 2019.
   Google Scholar
• Derebe D, Wubetu M, Alamirew A. Evaluation of antimalarial activity of 80% methanolic root extract of dorstenia barnimiana against plasmodium berghei–infected mice. Clin Pharmacol Adv Appl. 2021;13:157–167. doi:10.2147/CPAA.S313847
   PubMed Web of Science ®Google Scholar
• Aphrodite C, Johanns M, Beaufay C, et al. Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia. Biochem J. 2019;476(24):3687–3704. doi:10.1042/BCJ20190326
   PubMed Web of Science ®Google Scholar
• Franke K, Porzel A, Masaoud M, Nter Adam G, Rgen Schmidt J. Furanocoumarins from Dorstenia gigas. Phytochemistry. 2001;56:611–621. doi:10.1016/S0031-9422(00)00419-2
   PubMed Web of Science ®Google Scholar
• Abegaz BM, Ngadjui BT, Dongo E, Bezabih MT. Chemistry of the genus Dorstenia. Curr Org Chem. 2000;4:1079–1090. doi:10.2174/1385272003375905
   Web of Science ®Google Scholar
• Belayneh YM, Birhanu Z, Birru EM, Getenet G. Evaluation of in vivo antidiabetic, antidyslipidemic, and in vitro antioxidant activities of hydromethanolic root extract of datura stramonium L. (Solanaceae). J Exp Pharmacol. 2019;11:29–38. doi:10.2147/JEP.S192264
   PubMedGoogle Scholar
• Shetty SB, Mahin-Syed-Ismail P, Varghese S, et al. Antimicrobial effects of Citrus sinensis peel extracts against dental caries bacteria: an in vitro study. J Clin Exp Dent. 2016;8:70–77.
   Google Scholar
• Alhadi EA, Khalid HS, Alhassan MS, Kabbashi AS, Noo MO. Antimicrobial and phytochemical screening of Cordia africana in Sudan. World J Pharm Res. 2015;4:257–269.
   Google Scholar
• OECD. Organization for Economic Cooperation and Development Guideline Test No. 425: Acute Oral Toxicity: Up-And-Down Procedure(UDP). Paris, France: OECD Publishing; 2008:1–21.
   Google Scholar
• Furman BL. Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol. 2015;70(1):5.47.1–5.47.20. doi:10.1002/0471141755.ph0547s70
   PubMedGoogle Scholar
• Deeds MC, Anderson JM, Armstrong AS, et al. Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Lab Anim. 2011;45(3):131–140. doi:10.1258/la.2010.010090
   PubMed Web of Science ®Google Scholar
• Tamiru W, Engidawork E, Asres K. Evaluation of the effects of 80% methanolic leaf extract of Caylusea abyssinica (fresen.) fisch. & Mey. on glucose handling in normal, glucose loaded and diabetic rodents. BMC Complement Altern Med. 2012;12:1–7. doi:10.1186/1472-6882-12-151
   Web of Science ®Google Scholar
• Demoz MS, Gachoki KP, Mungai KJ, Negusse BG. Evaluation of the anti-diabetic potential of the methanol extracts of aloe camperi, meriandra dianthera and a polyherb. J Diabetes Mellit. 2015;05(04):267–276. doi:10.4236/jdm.2015.54033
   Google Scholar
• Vogel HG. Drug Discovery and Evaluation: Pharmacological Assays. Springer Science & Business Media; 2002.
   Google Scholar
• Jayaraju KJ, Ishaq BM. Evaluation of antidiabetic activity of a novel polyherbal preparation against streptozotocin induced diabetes rat model. J Pharm Res Int. 2021;42–54. doi:10.9734/jpri/2021/v33i26a31470
   Web of Science ®Google Scholar
• Tijjani H, Imam SA. Inhibition of haemoglobin glycosylation, glucose uptake and in vitro antidiabetic activities of solvent fractions from Daucus carota seed. Ann Sci Technol. 2021. doi:10.2478/ast-2021-0004
   Google Scholar
• Nagoor Gunny AA, Qing LZ, Che Mat MH. In-vitro antioxidant and antidiabetic activity of curcuma xanthorrhiza. In: AIP Conference Proceedings. American Institute of Physics Inc.; 2021. doi:10.1063/5.0044369.
   Google Scholar
• Tsofack N, Théophile D, Djomeni D, Désiré P. Antidiabetic activities of methanol-derived extract of Dorstenia picta twigs in normal and streptozotocin-induced diabetic rats. Asian J Tradit Med. 2007;2(4):140–148.
   Google Scholar
• Kyerematen G, Medina E, Saavedra D, Sandberg F. Antidiarrhoeal properties of Dorstenia drakena L. Acta Pharm Suec. 1985;22(1):31–36.
   PubMedGoogle Scholar
• Alene M, Abdelwuhab M, Belay A, Yazie TS. Evaluation of antidiabetic activity of Ajuga integrifolia (Lamiaceae) root extract and solvent fractions in mice. Evid Based Complement Altern Med. 2020;2020:1–11. doi:10.1155/2020/6642588
   Web of Science ®Google Scholar
• Rashid U, Khan MR. Phytochemicals of Periploca aphylla Dcne. ameliorated streptozotocin-induced diabetes in rat. Environ Health Prev Med. 2021;26. doi:10.1186/s12199-021-00962-0
   PubMed Web of Science ®Google Scholar
• King AJF. The use of animal models in diabetes research. Br J Pharmacol. 2012;166(3):877–894. doi:10.1111/j.1476-5381.2012.01911.x
   PubMed Web of Science ®Google Scholar
• Ansari MN, Saeedan AS, Bajaj S, Singh L. Evaluation of antidiabetic and hypolipidemic activity of Barleria cristata Linn. leaves in alloxan-induced diabetic rats. 3 Biotech. 2021;11(4). doi:10.1007/s13205-021-02728-5
   Google Scholar
• Sharma A, Kaur R, Kaur J, Garg S, Bhatti R, Kaur A. An endophytic Schizophyllum commune Fr. exhibits in-vitro and in-vivo antidiabetic activity in streptozotocin induced diabetic rats. AMB Express. 2021;11(1). doi:10.1186/s13568-021-01219-3
   Web of Science ®Google Scholar
• Pérez Gutiérrez RM, Muñiz-Ramirez A, Garcia-Campoy AH, Mota Flores JM. Evaluation of the antidiabetic potential of extracts of Urtica dioica, Apium graveolens, and Zingiber officinale in mice, zebrafish, and pancreatic β-cell. Plants. 2021;10(7). doi:10.3390/plants10071438
   Web of Science ®Google Scholar
• Yazid F, Salim SO, Rahmadika FD, et al. Antidiabetic effects of Tithonia diversifolia and Malus domestica leaf extracts in alloxan-induced Sprague Dawley rats. Syst Rev Pharm. 2021;12(1):1630–1638.
   Google Scholar
• Wasana KGP, Attanayake AP, Jayatilaka KA, Weerarathna TP. Antidiabetic activity of widely used medicinal plants in the Sri Lankan traditional healthcare system: new insight to medicinal flora in Sri Lanka. Evid Based Complement Altern Med. 2021;2021:1–12. doi:10.1155/2021/6644004
   Web of Science ®Google Scholar
• Kennedy MS, Masharani U. Pancreatic hormones & antidiabetic drugs. In: Katzung BG, editor. Basic & Clinical Pharmacology. 14th ed. McGraw-Hill; 2018:762–833.
   Google Scholar
• Agem KF, Teke GN, Bathelemy N, Charles F, Jean-paul DLK. In vitro antifungal activity of Dorstenia mannii leaf extracts (Moraceae). Afri J Biotechnol. 2015;14(46):3164–3169.
   Google Scholar
• Sadasivan Nair AN, Raveendran Nair RV, Rajendran Nair AP, et al. Antidiabetes constituents, cycloartenol and 24-methylenecycloartanol, from ficus krishnae. PLoS One. 2020;15(6):1–21. doi:10.1371/journal.pone.0235221
   Web of Science ®Google Scholar
• Prabhakar PK, Doble M. Mechanism of action of natural products used in the treatment of diabetes mellitus. Chin J Integr Med. 2011;17(8):563–574. doi:10.1007/s11655-011-0810-3
   PubMed Web of Science ®Google Scholar
• Chao J, Cheng HY, Chang ML, et al. Gallic acid ameliorated impaired lipid homeostasis in a mouse model of high-fat diet—and streptozotocin-induced NAFLD and diabetes through improvement of β-oxidation and ketogenesis. Front Pharmacol. 2021;11:1–14. doi:10.3389/fphar.2020.606759
   Web of Science ®Google Scholar
• Woldekidan S, Mulu A, Ergetie W, et al. Evaluation of antihyperglycemic effect of extract of moringa stenopetala (Baker f.) aqueous leaves on alloxan-induced diabetic rats. Diabetes Metab Syndr Obes Targets Ther. 2021;14:185–192. doi:10.2147/DMSO.S266794
   PubMed Web of Science ®Google Scholar
• Eleazu CO, Iroaganachi M, Okafor PN, Ijeh II, Eleazu KC. Ameliorative potentials of ginger (Z. officinale Roscoe) on relative organ weights in streptozotocin induced diabetic rats. Int J Biomed Sci. 2013;9(2):82–90.
   PubMedGoogle Scholar
• Lavle N, Shukla P, Panchal A. Role of flavonoids and saponins in the treatment of diabetes mellitus. J Pharm Sci Biosci Res. 2016;6(4):535–541.
   Google Scholar
• Dufall KG, Ngadjui BT, Simeon KF, Abegaz BM, Croft KD. Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii. J Ethnopharmacol. 2003;87(1):67–72. doi:10.1016/S0378-8741(03)00108-9
   PubMed Web of Science ®Google Scholar
• Peniche-Pavía HA, Vera-Ku M, Peraza-Sánchez SR. Phytochemical and pharmacological studies on species of dorstenia genus (2000–2016). J Mex Chem Soc. 2018;62(3):9–23. doi:10.29356/jmcs.v62i3.381
   Web of Science ®Google Scholar
• Basel Declaration Society. Research at a Crossroads. Basel Declaration A: a call for more trust, transparency and communication on animal research; Basel connference; Basel. 2010:1–2.
   Google Scholar
• International Council for Laboratory Animal Science. ICLAS ethical guideline for researchers. 2015:5–6.
   Google Scholar
• European Union. Legislation for the protection of animals used for scientific purposes. Commission E, editor. 2010:1–12.
   Google Scholar