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Review

Recent advances in the treatment of multiple sclerosis

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Pages 155-161 | Published online: 03 Nov 2010

References

  • SetoSCarreraCJKubotaMWassonDBCarsonDAMechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytesJ Clin Invest19857523773832579098
  • LassmannHLucchinettiCFCortical demyelination in CNS inflammatory demyelinating diseasesNeurology200870533233318227414
  • DaviesGRRamio-TorrentaLHadjiprocopisAEvidence for grey matter MTR abnormality in minimally disabled patients with early relapsing-remitting multiple sclerosisJ Neurol Neurosurg Psychiatry2004757998100215201359
  • SpurgeonSYuMPhillipsJDEpnerEMCladribine: not just another purine analogue?Expert Opin Investig Drugs200918811691181
  • SeronoEClinicalTrials.govCLARITY A phase III, randomized, double-blind, three-arm, placebo-controlled, multi-center study to evaluated the safety and efficacy of oral cladribine in subjects with relapsing-remitting multiple sclerosis2009 Available from: http://clinicaltrials.gov/ct2/show/nct00213135Accessed 2010 Aug 20
  • HavrdovaEGalettaSHutchinsonMEffect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) studyLancet Neurol20098325426019201654
  • GeaGiovannoniSafety and tolerability of cladribine tablets in relapsing-remitting multiple sclerosis during the 96-week, phase III, double-blind, placebo-controlled CLARITY studyPresentation at ECTRIMS 2009Dusseldorf, Germany2009
  • MehlingMBrinkmannVAntelJFTY720 therapy exerts differential effects on T cell subsets in multiple sclerosisNeurology200871161261126718852441
  • BrinkmannVFTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous systemBr J Pharmacol200915851173118219814729
  • BrinkmannVWiltCKristoficCFTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effectsTransplant Proc2001337–83078308011750323
  • PinschewerDDOchsenbeinAFOdermattBBrinkmannVHengartnerHZinkernagelRMFTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memoryJ Immunol2000164115761577010820254
  • MironVELudwinSKDarlingtonPJFingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slicesAm J Pathol201017662682269420413685
  • ColesAJCompstonDASelmajKWAlemtuzumab vs interferon beta-1a in early multiple sclerosisN Engl J Med2008359171786180118946064
  • HauserSLWaubantEArnoldDLB-cell depletion with rituximab in relapsing-remitting multiple sclerosisN Engl J Med2008358767668818272891
  • YangJSXuLYXiaoBGHedlundGLinkHLaquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis ratsJ Neuroimmunol20041561–23915465591
  • ComiGPulizziARovarisMEffect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb studyLancet200837196302085209218572078
  • Teva Pharmaceutical IndustriesA multinational, multicenter, open-label, single-assignment extension of the MS-LAQ-301 Study, to evaluate the long-term safety, tolerability and effect on disease course of daily oral laquinimod 0.6 mg in subjects with relapsing multiple sclerosis NCT00988052
  • de JongRBezemerACZomerdijkTPvan de Pouw-KraanTOttenhoffTHNibberingPHSelective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarateEur J Immunol1996269206720748814248
  • WierinckxABreveJMercierDSchultzbergMDrukarchBvan damAMDetoxication enzyme inducers modify cytokine production in rat mixed glial cellsJ Neuroimmunol20051661–213214315993952
  • SchimrigkSBruneNHellwigKOral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot studyEur J Neurol200613660461016796584
  • BiogenIdecClinicalTrials.govA randomized, multicenter, placebo-controlled and active reference (glatiramer acetate) comparison study to evaluate the efficacy and safety of BG00012 in subjects with relapsing-remitting multiple sclerosis (CONFIRM)2010 Available from: http://clinicaltrials.gov/ct2/show/nct00451451Accessed 2010 Aug 20
  • BiogenIdecClinicalTrials.govA randomized, multicenter, double-blind, placebo-controlled, dose-camparison study to determine the efficacy and safety of BG00012 in subjects with relaping-remitting multiple sclerosis (DEFINE)2010 Available from: http://clinicaltrials.gov/ct2/show/nct00420212Accessed 2010 Aug 20
  • GlaxoSmithKlinehttp://ClinicalTrials.govRandomised, double-blind, placebo-controlled, parallel-group, dose-ranging study to investigate the MRI efficacy and the safety of six months administration of SB-683699 in subjects with relapsing-remitting multiple sclerosis (MS)2008 Available from: http://clinicaltrials.gov/ct2/show/nct00395317Accessed 2010 Aug 20
  • KornTMagnusTToykaKJungSModulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide – mechanisms independent of pyrimidine depletionJ Leukoc Biol200476595096015328336
  • Sanofi-Aventishttp://ClinicalTrials.govLong-term extension of the multinational, double-blind, placebo controlled study EFC6049 (HMR1726D/3001) to document the safety of two doses of teriflunomide (7 and 14 mg) in patients with multiple sclerosis with relapses2010 Available from: http://clinicaltrials.gov/ct2/show/nct00803049Accessed 2010 Aug 20
  • Sanofi-Aventishttp://ClinicalTrials.govA randomized, multinational, double-blind, placebo-controlled, parallel-group design pilot study to estimate the tolerability, safety, pharmacokinetics, and pharmacodynamic effects of teriflunomide for 24 weeks when added to treatment with glatiramer acetate in subjects with multiple sclerosis2009 Available from: http://clinicaltrials.gov/ct2/show/nct00475865Accessed 2010 Aug 20
  • Sanofi-Aventishttp://ClinicalTrials.govA randomized, multinational, double-blind, placebo-controlled, parallel-group design pilot study to estimate the tolerability, safety, pharmacokinetics, and pharmacodynamic effects of teriflunomide for 24 weeks when added to treatment with interferon-beta in subjects with multiple sclerosis2010 Available from: http://clinicaltrials.gov/ct2/show/nct00489489Accessed 2010 Aug 20
  • Sanofi-Aventishttp://ClinicalTrials.govAn international, multi-center, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of two year treatment with teriflunomide 7 mg once daily and 14 mg once daily versus placebo in patients with a first clinical episode suggestive of multiple sclerosis2010 Available from: http://clinicaltrials.gov/ct2/show/nct00622700Accessed 2010 Aug 20
  • Genzyme/Bayerhttp://ClinicalTrials.govComparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study One (CARE-MS I)2010 Available from: http://clinicaltrials.gov/ct2/show/nct00530348Accessed 2010 Aug 20
  • Genzyme/Bayerhttp://ClinicalTrials.govComparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study Two (CARE-MS II)2010 Available from: http://clinicaltrials.gov/ct2/show/nct00548405Accessed 2010 Aug 20
  • HawkerKO’ConnorPFreedmanMSRituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trialAnn Neurol200966446047119847908
  • Genentech H-LRhttp://ClinicalTrials.govA study of the efficacy and safety of ocrelizumab in patients with relapsing-remitting multiple sclerosis2010 Available from: http://clinicaltrials.gov/ct2/show/nct00676715Accessed 2010 Aug 20
  • BielekovaBCatalfamoMReichert-ScrivnerSRegulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosisProc Natl Acad Sci U S A2006103155941594616585503
  • BielekovaBRichertNHowardTHumanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon betaProc Natl Acad Sci U S A2004101238705870815161974
  • BielekovaBHowardTPackerANEffect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosisArch Neurol200966448348919364933
  • VigliettaVBourcierKBuckleGJCTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trialNeurology2008711291792418794494
  • AxtellRCde JongBABonifaceKT helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitisNat Med201016440641220348925