95
Views
34
CrossRef citations to date
0
Altmetric
Review

The androgen receptor as an emerging target in hepatocellular carcinoma

&
Pages 91-99 | Published online: 26 Jun 2015

References

  • YamashitaYIYoshidaYKuriharaTSurgical results for recurrent hepatocellular carcinoma after curative hepatectomy: repeat hepatectomy vs salvage living donor liver transplantationLiver Transpl2015
  • LlovetJMRicciSMazzaferroVSHARP Investigators Study GroupSorafenib in advanced hepatocellular carcinomaN Engl J Med2008359437839018650514
  • FuruseJIshiiHNakachiKSuzukiEShimizuSNakajimaKPhase I study of sorafenib in Japanese patients with hepatocellular carcinomaCancer Sci200899115916517953709
  • ShiinaSTateishiRAranoTRadiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factorsAm J Gastroenterol2012107456957722158026
  • El-SeragHBHepatocellular carcinomaN Engl J Med2011365121118112721992124
  • ShiratoriYShiinaSImamuraMCharacteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in JapanHepatology1995224 pt 1102710337557847
  • TateishiROkanoueTFujiwaraNClinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort studyJ Gastroenterol201550335036024929638
  • NauglerWESakuraiTKimSGender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 productionScience2007317583412112417615358
  • ZhaoYLiZInterplay of estrogen receptors and FOXA factors in the liver cancerMol Cell Endocrinol2015
  • ChiuCMYehSHChenPJHepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen levelProc Natl Acad Sci U S A200710482571257817259306
  • ZhengYChenWLMaWLChangCOuJHEnhancement of gene transactivation activity of androgen receptor by hepatitis B virus X proteinVirology2007363245446117335866
  • KandaTSteeleRRayRRayRBHepatitis C virus core protein augments androgen receptor-mediated signalingJ Virol20088222110661107218768969
  • IqbalMJWilkinsonMLJohnsonPJWilliamsRSex steroid receptor proteins in foetal, adult and malignant human liver tissueBr J Cancer19834867917966317004
  • WongLYChanSHOonCJRauffAImmunocytochemical localization of testosterone in human hepatocellular carcinomaHistochem J19841666876926330003
  • NagasueNYukayaHChangYCOgawaYKohnoHItoAActive uptake of testosterone by androgen receptors of hepatocellular carcinoma in humansCancer19865711216221673008976
  • NagasueNItoAYukayaHOgawaYAndrogen receptors in hepatocellular carcinoma and surrounding parenchymaGastroenterology19858936436472991072
  • WilkinsonMLIqbalMJWilliamsRCharacterisation of high affinity binding sites of androgens in primary hepatocellular carcinomaClin Chim Acta19851521–21051132414040
  • OhnishiSMurakamiTMoriyamaTMitamuraKImawariMAndrogen and estrogen receptors in hepatocellular carcinoma and in the surrounding noncancerous liver tissueHepatology1986634404433011631
  • BannisterPMeystreCMLosowskyMSAndrogen receptor concentrations in needle biopsy specimens of human liverLiver19888128313367706
  • NagasueNKohnoHChangYCAndrogen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in womenCancer19896311121162535950
  • NagasueNChangYCHayashiTAndrogen receptor in hepatocellular carcinoma as a prognostic factor after hepatic resectionAnn Surg198920944244272539062
  • NagasueNKohnoHChangYHayashiTNakamuraTSpecificity of androgen receptors of hepatocellular carcinoma and liver in humansHepatogastroenterology19903754744792174826
  • NagasueNKohnoHYamanoiAKimotoTChangYCNakamuraTProgesterone receptor in hepatocellular carcinoma. Correlation with androgen and estrogen receptorsCancer19916710250125051849788
  • EagonPKFrancavillaADiLeoAQuantitation of estrogen and androgen receptors in hepatocellular carcinoma and adjacent normal human liverDig Dis Sci1991369130313081654243
  • NagasueNYamanoiAKohnoHAndrogen receptor in cirrhotic liver, adenomatous hyperplastic nodule and hepatocellular carcinoma in the humanHepatogastroenterology19923954554601334038
  • BoixLBruixJCastellsASex hormone receptors in hepatocellular carcinoma. Is there a rationale for hormonal treatment?J Hepatol19931721871918383159
  • NegroFPapottiMPacchioniDGalimiFBoninoFBussolatiGDetection of human androgen receptor mRNA in hepatocellular carcinoma by in situ hybridisationLiver19941442132197968281
  • BoixLCastellsABruixJAndrogen receptors in hepatocellular carcinoma and surrounding liver: relationship with tumor size and recurrence rate after surgical resectionJ Hepatol19952266166227560855
  • TavianDDe PetroGPitozziAPortolaniNGiuliniSMBarlatiSAndrogen receptor mRNA under-expression in poorly differentiated human hepatocellular carcinomaHistol Histopathol20021741113111912371139
  • VizosoFJRodriguezMAltadillALiver expression of steroid hormones and apolipoprotein D receptors in hepatocellular carcinomaWorld J Gastroenterol200713233221322717589901
  • ZhangYShenYCaoBYanAJiHElevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and stagingExp Ther Med20159390590825667651
  • HughesIADaviesJDBunchTIPasterskiVMastroyannopoulouKMacDougallJAndrogen insensitivity syndromeLancet201238098511419142822698698
  • GelmannEPMolecular biology of the androgen receptorJ Clin Oncol200220133001301512089231
  • ShafiAAYenAEWeigelNLAndrogen receptors in hormone-dependent and castration-resistant prostate cancerPharmacol Ther2013140322323823859952
  • UedaTMawjiNRBruchovskyNSadarMDLigand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cellsJ Biol Chem200227741380873809412163482
  • CuligZHobischACronauerMVAndrogen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factorCancer Res19945420547454787522959
  • OkitsuKKandaTImazekiFInvolvement of interleukin-6 and androgen receptor signaling in pancreatic cancerGenes Cancer20101885986721779469
  • KandaTYokosukaOOmataMAndrogen receptor and hepatocellular carcinomaJ Gastroint Dig Syst2013S12
  • KandaTJiangXYokosukaOAndrogen receptor signaling in hepatocellular carcinoma and pancreatic cancersWorld J Gastroenterol201420289229923625071315
  • WuSKandaTImazekiFNakamotoSShirasawaHYokosukaONuclear receptor mRNA expression by HBV in human hepatoblastoma cell linesCancer Lett20113121334221903321
  • TanakaSMohrLSchmidtEVSugimachiKWandsJRBiological effects of human insulin receptor substrate-1 overexpression in hepatocytesHepatology19972635986049303488
  • ItoYSasakiYHorimotoMActivation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinomaHepatology19982749519589537433
  • SuzukiAHayashidaMKawanoHSugimotoKNakanoTShirakiKHepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppressionHepatology2000324 pt 179680211003625
  • FujimakiSMatsudaYWakaiTBlockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signalingCancer Lett201231919810822265862
  • SatoMMatsudaYWakaiTP21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migrationJ Gastroenterol Hepatol20132861047105523425030
  • MatsudaYWakaiTKubotaMValproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinomaInt J Clin Exp Pathol2014741299131324817927
  • YoshikawaHMatsubaraKQianGSSOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activityNat Genet2001281293511326271
  • KandaTImazekiFKanaiFTadaMYokosukaOOmataMSignaling pathways involved in molecular carcinogenesis of HCCQiaoLYanXLiYGeorgeYMolecular Aspect of Hepatocellular CarcinomaSharjahBentham Science Publishers20123955
  • BoltonECSoAYChaivorapolCHaqqCMLiHYamamotoKRCell- and gene-specific regulation of primary target genes by the androgen receptorGenes Dev200721162005201717699749
  • DePrimoSEDiehnMNelsonJBTranscriptional programs activated by exposure of human prostate cancer cells to androgenGenome Biol200237RESEARCH003212184806
  • NelsonPSCleggNArnoldHThe program of androgen-responsive genes in neoplastic prostate epitheliumProc Natl Acad Sci U S A20029918118901189512185249
  • GetzenbergRHPientaKJWardWSCoffeyDSNuclear structure and the three-dimensional organization of DNAJ Cell Biochem19914742892991795013
  • RippleMOHenryWFSchwarzeSRWildingGWeindruchREffect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cellsJ Natl Cancer Inst199991141227123210413424
  • ShetMSMcPhaulMFisherCWStallingsNREstabrookRWMetabolism of the antiandrogenic drug (Flutamide) by human CYP1A2Drug Metab Dispos19972511129813039351907
  • GehlhausMSchmittNVolkBMeyerRPAntiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathwayJ Pharmacol Exp Ther2007322255055917505019
  • EagonPKElmMSTadicSDNanjiAADownregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injuryAm J Physiol Gastrointest Liver Physiol20012812G342G43911447013
  • SongCSJungMHKimSCHassanTRoyAKChatterjeeBTissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoterJ Biol Chem19982733421856218669705324
  • ItoNKawataSTamuraSElevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinomaCancer Res19915115408040831649698
  • NagaharaHEzhevskySAVocero-AkbaniAMKaldisPSolomonMJDowdySFTransforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activityProc Natl Acad Sci U S A19999626149611496610611320
  • RobertsABSpornMBAssoianRKTransforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroProc Natl Acad Sci U S A19868312416741712424019
  • TsukamotoHMatsuokaMFrenchSWExperimental models of hepatic fibrosis: a reviewSemin Liver Dis199010156652110685
  • YagerJDZurloJNiNSex hormones and tumor promotion in liverProc Soc Exp Biol Med199119826676741924403
  • LinJKChouCKIn vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1Cancer Res19925223853881309441
  • FaustoNMeadJEBraunLProto-oncogene expression and growth factors during liver regenerationSymp Fundam Cancer Res19863969863321311
  • BraunLMeadJEPanzicaMMikumoRBellGIFaustoNTransforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulationProc Natl Acad Sci U S A1988855153915433422749
  • YoonGKimJYChoiYKWonYSLimIKDirect activation of TGF-beta1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude miceJ Cell Biochem200697239341116187311
  • RobinsDMAndrogen receptor and molecular mechanisms of male-specific gene expressionNovartis Found Symp2005268425216206874
  • Movérare-SkrticSVenkenKAnderssonNDihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized miceObesity (Silver Spring)200614466267216741268
  • LinHYYuICWangRSIncreased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptorHepatology20084761924193518449947
  • NorlinMPetterssonHTangWWikvallKAndrogen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathwayArch Biochem Biophys2011506223624121134350
  • KrycerJRBrownAJCross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasisJ Biol Chem201128623206372064721489984
  • SchöffskiPDumezHClementPEmerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a reviewAnn Oncol20061781185119616418310
  • KudoMUeshimaKPositioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in JapanOncology201078Suppl 115416620616599
  • TakedaHNishikawaHOsakiYJapanese Red Cross Liver Study GroupClinical features associated with radiological response to sorafenib in unresectable hepatocellular carcinoma: a large multicenter study in JapanLiver Int20153551581158924836552
  • FengHChengASTsangDPCell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesisJ Clin Invest201112183159317521747169
  • KrügerTLongMBonefeld-JørgensenECPlastic components affect the activation of the aryl hydrocarbon and the androgen receptorToxicology20082462–311212318294747
  • WuYBaumgartenSCZhouPStoccoCTestosterone-dependent interaction between androgen receptor and aryl hydrocarbon receptor induces liver receptor homolog 1 expression in rat granulosa cellsMol Cell Biol201333152817282823689136
  • LiZTutejaGSchugJKaestnerKHFoxa1 and Foxa2 are essential for sexual dimorphism in liver cancerCell20121481–2728322265403
  • ShenFYanCLiuMFengYChenYRACK1 promotes prostate cancer cell proliferation, invasion and metastasisMol Med Rep201384999100423912224
  • MaWLHsuCLYehCCHepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikisHepatology201256117618522318717
  • AoJMengJZhuLActivation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasionMol Oncol20126550751522819717
  • HuangCKLeeSOLaiKPTargeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosisHepatology20135741550156323150236
  • NieHCaoQZhuLGongYGuJHeZAcetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinomaPLoS One201384e6167823620780
  • MaWLLaiHCYehSCaiXChangCAndrogen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitisEndocr Relat Cancer2014213R165R18224424503
  • MaWLJengLBLaiHCLiaoPYChangCAndrogen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cellsCancer Lett20143511647124944078
  • DaiRYanDLiJActivation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cellsJ Cell Biochem201211351800180822228470
  • ShudaMKondohNImazekiNActivation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisJ Hepatol200338560561412713871
  • TanSSAhmadIBennettHLGRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancerJ Pathol20112231818721125667
  • BennettHLFlemingJTO’PreyJRyanKMLeungHYAndrogens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cellsCell Death Dis20101e7221364676
  • KimSSChoHJKangJYKangHKYooTKInhibition of androgen receptor expression with small interfering RNA enhances cancer cell apoptosis by suppressing survival factors in androgen insensitive, late stage LNCaP cellsScientific World Journal2013201351939723476140
  • YangYCFuHCHsiaoBLAndrogen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cellsCell Death Dis20134e60723618905
  • JiangXKandaTNakamotoSMiyamuraTWuSYokosukaOInvolvement of androgen receptor and glucose-regulated protein 78 kDa in human hepatocarcinogenesisExp Cell Res2014323232633624583399
  • ButtsCLJonesYLLimJKSalterCEBelyavskayaESternbergEMTissue expression of steroid hormone receptors is associated with differ ential immune responsivenessBrain Behav Immun20112551000100721074604
  • JiangXKandaTTanakaTLipopolysaccharide blocks induction of unfolded protein response in human hepatoma cell linesImmunol Lett2013152181523578665
  • Sánchez-HernándezMChaves-PozoECabasIMuleroVGarcía-AyalaAGarcía-AlcázarATestosterone implants modify the steroid hormone balance and the gonadal physiology of gilthead seabream (Sparus aurata L) malesJ Steroid Biochem Mol Biol201313818319423743364
  • PeekEMSongWZhangHHuangJChinAILoss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytesProstate201575546347325597486
  • HuynhHNgoVCKoongHNSorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinomaJ Cell Mol Med2009138B2673268319220580
  • HuynhHNgoVCFargnoliJBrivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinomaClin Cancer Res200814196146615318829493
  • HuynhHChowKHSooKCRAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinomaJ Cell Mol Med20091371371138018466352
  • PengLMalloyPJWangJFeldmanDGrowth inhibitory concentrations of androgens up-regulate insulin-like growth factor binding protein-3 expression via an androgen response element in LNCaP human prostate cancer cellsEndocrinology20061474599460716825320
  • PandiniGMineoRFrascaFAndrogens up-regulate the insulin-like growth factor-I receptor in prostate cancer cellsCancer Res2005651849185715753383
  • TsueiDJLeePHPengHYMale germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancerPLoS One2011611e2694822073224
  • RosiniPBonaccorsiLBaldiEAndrogen receptor expression induces FGF2, FGF-binding protein production, and FGF2 release in prostate carcinoma cells: role of FGF2 in growth, survival, and androgen receptor down-modulationProstate200253431032112430142
  • WuYChhipaRRChengJZhangHMohlerJLIpCAndrogen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survivalAnticancer Res201030103895390121036700
  • WangSHYehSHChenPJThe driving circuit of HBx and androgen receptor in HBV-related hepatocarcinogenesisGut201463111688168924598130
  • WangSHChenPJYehSHGender disparity in chronic hepatitis B: mechanisms of sex hormonesJ Gastroenterol Hepatol2015
  • YehSHChenPJGender disparity of hepatocellular carcinoma: the roles of sex hormonesOncology201078Suppl 117217920616601
  • Groupe d’Etude et de Traitement du Carcinome HépatocellulaireRandomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifenHepatology20044061361136915565568
  • ChaoYChanWKHuangYSPhase II study of flutamide in the treatment of hepatocellular carcinomaCancer19967746356398616754
  • GrimaldiCBleibergHGayFEvaluation of antiandrogen therapy in unresectable hepatocellular carcinoma: results of a European Organization for Research and Treatment of Cancer multicentric double-blind trialJ Clin Oncol19981624114179469323
  • ForbesAWilkinsonMLIqbalMJJohnsonPJWilliamsRResponse to cyproterone acetate treatment in primary hepatocellular carcinoma is related to fall in free 5 alpha-dihydrotestosteroneEur J Cancer Clin Oncol19872311165916642828073
  • GuptaSKorulaJFailure of ketoconazole as anti-androgen therapy in nonresectable primary hepatocellular carcinomaJ Clin Gastroenterol19881066516542466073
  • GuéchotJPeigneyNBalletFVaubourdolleMGiboudeauJPouponREffect of D-tryptophan-6-luteinizing hormone-releasing hormone on the tumoral growth and plasma sex steroid levels in cirrhotic patients with hepatocellular carcinomaHepatology19891033463482547704
  • ManesisEKGiannoulisGZoumboulisPVafiadouIHadziyannisSJTreatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: a randomized, controlled trialHepatology1995216153515427768497
  • FalksonGAnsellSPhase II trial of buserelin in hepatocellular carcinomaEur J Cancer Clin Oncol1989259133913402553420
  • YuMWChengSWLinMWAndrogen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinomaJ Natl Cancer Inst200092242023202811121465
  • YuMWYangYCYangSYHormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among menJ Natl Cancer Inst200193211644165111698569
  • YuMWYangYCYangSYAndrogen receptor exon 1 CAG repeat length and risk of hepatocellular carcinoma in womenHepatology200236115616312085360
  • YehSHChangCFShauWYDominance of functional androgen receptor allele with longer CAG repeat in hepatitis B virus-related female hepatocarcinogenesisCancer Res200262154346435112154039
  • YehSHChiuCMChenCLSomatic mutations at the tri-nucleotide repeats of androgen receptor gene in male hepatocellular carcinomaInt J Cancer200712081610161717230529
  • ZhuRZhangJSZhuYZHBx-induced androgen receptor expression in HBV-associated hepatocarcinoma is independent of the methylation status of its promoterHistol Histopathol201126233521117024
  • LiuBWenXHuangCWeiYUnraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 yearsInt J Biochem Cell Biol2013451987199623819994
  • YangWJChangCJYehSHHepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathwaysHepatology20094951515152419205031
  • WangSHYehSHLinWHWangHYChenDSChenPJIdentification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis BHepatology20095051392140219670412
  • WuMHMaWLHsuCLAndrogen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcriptionSci Transl Med201023232ra35
  • TianYKuoCFChenWLOuJHEnhancement of hepatitis B virus replication by androgen and its receptor in miceJ Virol20128641904191022156518
  • YuZGaoYQFengHCell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesisGut201463111793180424440987
  • HoggKWoodCMcNeillyASDuncanWCThe in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheepPLoS One201169e2487721935484
  • ZhangHLiuYWangLDifferential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male ratJ Lipid Res201354234535723175777
  • KellyDMNettleshipJEAkhtarSTestosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient miceLife Sci201410929510324953607