References
- YamashitaYIYoshidaYKuriharaTSurgical results for recurrent hepatocellular carcinoma after curative hepatectomy: repeat hepatectomy vs salvage living donor liver transplantationLiver Transpl2015
- LlovetJMRicciSMazzaferroVSHARP Investigators Study GroupSorafenib in advanced hepatocellular carcinomaN Engl J Med2008359437839018650514
- FuruseJIshiiHNakachiKSuzukiEShimizuSNakajimaKPhase I study of sorafenib in Japanese patients with hepatocellular carcinomaCancer Sci200899115916517953709
- ShiinaSTateishiRAranoTRadiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factorsAm J Gastroenterol2012107456957722158026
- El-SeragHBHepatocellular carcinomaN Engl J Med2011365121118112721992124
- ShiratoriYShiinaSImamuraMCharacteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in JapanHepatology1995224 pt 1102710337557847
- TateishiROkanoueTFujiwaraNClinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort studyJ Gastroenterol201550335036024929638
- NauglerWESakuraiTKimSGender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 productionScience2007317583412112417615358
- ZhaoYLiZInterplay of estrogen receptors and FOXA factors in the liver cancerMol Cell Endocrinol2015
- ChiuCMYehSHChenPJHepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen levelProc Natl Acad Sci U S A200710482571257817259306
- ZhengYChenWLMaWLChangCOuJHEnhancement of gene transactivation activity of androgen receptor by hepatitis B virus X proteinVirology2007363245446117335866
- KandaTSteeleRRayRRayRBHepatitis C virus core protein augments androgen receptor-mediated signalingJ Virol20088222110661107218768969
- IqbalMJWilkinsonMLJohnsonPJWilliamsRSex steroid receptor proteins in foetal, adult and malignant human liver tissueBr J Cancer19834867917966317004
- WongLYChanSHOonCJRauffAImmunocytochemical localization of testosterone in human hepatocellular carcinomaHistochem J19841666876926330003
- NagasueNYukayaHChangYCOgawaYKohnoHItoAActive uptake of testosterone by androgen receptors of hepatocellular carcinoma in humansCancer19865711216221673008976
- NagasueNItoAYukayaHOgawaYAndrogen receptors in hepatocellular carcinoma and surrounding parenchymaGastroenterology19858936436472991072
- WilkinsonMLIqbalMJWilliamsRCharacterisation of high affinity binding sites of androgens in primary hepatocellular carcinomaClin Chim Acta19851521–21051132414040
- OhnishiSMurakamiTMoriyamaTMitamuraKImawariMAndrogen and estrogen receptors in hepatocellular carcinoma and in the surrounding noncancerous liver tissueHepatology1986634404433011631
- BannisterPMeystreCMLosowskyMSAndrogen receptor concentrations in needle biopsy specimens of human liverLiver19888128313367706
- NagasueNKohnoHChangYCAndrogen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in womenCancer19896311121162535950
- NagasueNChangYCHayashiTAndrogen receptor in hepatocellular carcinoma as a prognostic factor after hepatic resectionAnn Surg198920944244272539062
- NagasueNKohnoHChangYHayashiTNakamuraTSpecificity of androgen receptors of hepatocellular carcinoma and liver in humansHepatogastroenterology19903754744792174826
- NagasueNKohnoHYamanoiAKimotoTChangYCNakamuraTProgesterone receptor in hepatocellular carcinoma. Correlation with androgen and estrogen receptorsCancer19916710250125051849788
- EagonPKFrancavillaADiLeoAQuantitation of estrogen and androgen receptors in hepatocellular carcinoma and adjacent normal human liverDig Dis Sci1991369130313081654243
- NagasueNYamanoiAKohnoHAndrogen receptor in cirrhotic liver, adenomatous hyperplastic nodule and hepatocellular carcinoma in the humanHepatogastroenterology19923954554601334038
- BoixLBruixJCastellsASex hormone receptors in hepatocellular carcinoma. Is there a rationale for hormonal treatment?J Hepatol19931721871918383159
- NegroFPapottiMPacchioniDGalimiFBoninoFBussolatiGDetection of human androgen receptor mRNA in hepatocellular carcinoma by in situ hybridisationLiver19941442132197968281
- BoixLCastellsABruixJAndrogen receptors in hepatocellular carcinoma and surrounding liver: relationship with tumor size and recurrence rate after surgical resectionJ Hepatol19952266166227560855
- TavianDDe PetroGPitozziAPortolaniNGiuliniSMBarlatiSAndrogen receptor mRNA under-expression in poorly differentiated human hepatocellular carcinomaHistol Histopathol20021741113111912371139
- VizosoFJRodriguezMAltadillALiver expression of steroid hormones and apolipoprotein D receptors in hepatocellular carcinomaWorld J Gastroenterol200713233221322717589901
- ZhangYShenYCaoBYanAJiHElevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and stagingExp Ther Med20159390590825667651
- HughesIADaviesJDBunchTIPasterskiVMastroyannopoulouKMacDougallJAndrogen insensitivity syndromeLancet201238098511419142822698698
- GelmannEPMolecular biology of the androgen receptorJ Clin Oncol200220133001301512089231
- ShafiAAYenAEWeigelNLAndrogen receptors in hormone-dependent and castration-resistant prostate cancerPharmacol Ther2013140322323823859952
- UedaTMawjiNRBruchovskyNSadarMDLigand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cellsJ Biol Chem200227741380873809412163482
- CuligZHobischACronauerMVAndrogen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factorCancer Res19945420547454787522959
- OkitsuKKandaTImazekiFInvolvement of interleukin-6 and androgen receptor signaling in pancreatic cancerGenes Cancer20101885986721779469
- KandaTYokosukaOOmataMAndrogen receptor and hepatocellular carcinomaJ Gastroint Dig Syst2013S12
- KandaTJiangXYokosukaOAndrogen receptor signaling in hepatocellular carcinoma and pancreatic cancersWorld J Gastroenterol201420289229923625071315
- WuSKandaTImazekiFNakamotoSShirasawaHYokosukaONuclear receptor mRNA expression by HBV in human hepatoblastoma cell linesCancer Lett20113121334221903321
- TanakaSMohrLSchmidtEVSugimachiKWandsJRBiological effects of human insulin receptor substrate-1 overexpression in hepatocytesHepatology19972635986049303488
- ItoYSasakiYHorimotoMActivation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinomaHepatology19982749519589537433
- SuzukiAHayashidaMKawanoHSugimotoKNakanoTShirakiKHepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppressionHepatology2000324 pt 179680211003625
- FujimakiSMatsudaYWakaiTBlockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signalingCancer Lett201231919810822265862
- SatoMMatsudaYWakaiTP21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migrationJ Gastroenterol Hepatol20132861047105523425030
- MatsudaYWakaiTKubotaMValproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinomaInt J Clin Exp Pathol2014741299131324817927
- YoshikawaHMatsubaraKQianGSSOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activityNat Genet2001281293511326271
- KandaTImazekiFKanaiFTadaMYokosukaOOmataMSignaling pathways involved in molecular carcinogenesis of HCCQiaoLYanXLiYGeorgeYMolecular Aspect of Hepatocellular CarcinomaSharjahBentham Science Publishers20123955
- BoltonECSoAYChaivorapolCHaqqCMLiHYamamotoKRCell- and gene-specific regulation of primary target genes by the androgen receptorGenes Dev200721162005201717699749
- DePrimoSEDiehnMNelsonJBTranscriptional programs activated by exposure of human prostate cancer cells to androgenGenome Biol200237RESEARCH003212184806
- NelsonPSCleggNArnoldHThe program of androgen-responsive genes in neoplastic prostate epitheliumProc Natl Acad Sci U S A20029918118901189512185249
- GetzenbergRHPientaKJWardWSCoffeyDSNuclear structure and the three-dimensional organization of DNAJ Cell Biochem19914742892991795013
- RippleMOHenryWFSchwarzeSRWildingGWeindruchREffect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cellsJ Natl Cancer Inst199991141227123210413424
- ShetMSMcPhaulMFisherCWStallingsNREstabrookRWMetabolism of the antiandrogenic drug (Flutamide) by human CYP1A2Drug Metab Dispos19972511129813039351907
- GehlhausMSchmittNVolkBMeyerRPAntiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathwayJ Pharmacol Exp Ther2007322255055917505019
- EagonPKElmMSTadicSDNanjiAADownregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injuryAm J Physiol Gastrointest Liver Physiol20012812G342G43911447013
- SongCSJungMHKimSCHassanTRoyAKChatterjeeBTissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoterJ Biol Chem19982733421856218669705324
- ItoNKawataSTamuraSElevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinomaCancer Res19915115408040831649698
- NagaharaHEzhevskySAVocero-AkbaniAMKaldisPSolomonMJDowdySFTransforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activityProc Natl Acad Sci U S A19999626149611496610611320
- RobertsABSpornMBAssoianRKTransforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroProc Natl Acad Sci U S A19868312416741712424019
- TsukamotoHMatsuokaMFrenchSWExperimental models of hepatic fibrosis: a reviewSemin Liver Dis199010156652110685
- YagerJDZurloJNiNSex hormones and tumor promotion in liverProc Soc Exp Biol Med199119826676741924403
- LinJKChouCKIn vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1Cancer Res19925223853881309441
- FaustoNMeadJEBraunLProto-oncogene expression and growth factors during liver regenerationSymp Fundam Cancer Res19863969863321311
- BraunLMeadJEPanzicaMMikumoRBellGIFaustoNTransforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulationProc Natl Acad Sci U S A1988855153915433422749
- YoonGKimJYChoiYKWonYSLimIKDirect activation of TGF-beta1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude miceJ Cell Biochem200697239341116187311
- RobinsDMAndrogen receptor and molecular mechanisms of male-specific gene expressionNovartis Found Symp2005268425216206874
- Movérare-SkrticSVenkenKAnderssonNDihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized miceObesity (Silver Spring)200614466267216741268
- LinHYYuICWangRSIncreased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptorHepatology20084761924193518449947
- NorlinMPetterssonHTangWWikvallKAndrogen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathwayArch Biochem Biophys2011506223624121134350
- KrycerJRBrownAJCross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasisJ Biol Chem201128623206372064721489984
- SchöffskiPDumezHClementPEmerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a reviewAnn Oncol20061781185119616418310
- KudoMUeshimaKPositioning of a molecular-targeted agent, sorafenib, in the treatment algorithm for hepatocellular carcinoma and implication of many complete remission cases in JapanOncology201078Suppl 115416620616599
- TakedaHNishikawaHOsakiYJapanese Red Cross Liver Study GroupClinical features associated with radiological response to sorafenib in unresectable hepatocellular carcinoma: a large multicenter study in JapanLiver Int20153551581158924836552
- FengHChengASTsangDPCell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesisJ Clin Invest201112183159317521747169
- KrügerTLongMBonefeld-JørgensenECPlastic components affect the activation of the aryl hydrocarbon and the androgen receptorToxicology20082462–311212318294747
- WuYBaumgartenSCZhouPStoccoCTestosterone-dependent interaction between androgen receptor and aryl hydrocarbon receptor induces liver receptor homolog 1 expression in rat granulosa cellsMol Cell Biol201333152817282823689136
- LiZTutejaGSchugJKaestnerKHFoxa1 and Foxa2 are essential for sexual dimorphism in liver cancerCell20121481–2728322265403
- ShenFYanCLiuMFengYChenYRACK1 promotes prostate cancer cell proliferation, invasion and metastasisMol Med Rep201384999100423912224
- MaWLHsuCLYehCCHepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikisHepatology201256117618522318717
- AoJMengJZhuLActivation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasionMol Oncol20126550751522819717
- HuangCKLeeSOLaiKPTargeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosisHepatology20135741550156323150236
- NieHCaoQZhuLGongYGuJHeZAcetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinomaPLoS One201384e6167823620780
- MaWLLaiHCYehSCaiXChangCAndrogen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitisEndocr Relat Cancer2014213R165R18224424503
- MaWLJengLBLaiHCLiaoPYChangCAndrogen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cellsCancer Lett20143511647124944078
- DaiRYanDLiJActivation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cellsJ Cell Biochem201211351800180822228470
- ShudaMKondohNImazekiNActivation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisJ Hepatol200338560561412713871
- TanSSAhmadIBennettHLGRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancerJ Pathol20112231818721125667
- BennettHLFlemingJTO’PreyJRyanKMLeungHYAndrogens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cellsCell Death Dis20101e7221364676
- KimSSChoHJKangJYKangHKYooTKInhibition of androgen receptor expression with small interfering RNA enhances cancer cell apoptosis by suppressing survival factors in androgen insensitive, late stage LNCaP cellsScientific World Journal2013201351939723476140
- YangYCFuHCHsiaoBLAndrogen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cellsCell Death Dis20134e60723618905
- JiangXKandaTNakamotoSMiyamuraTWuSYokosukaOInvolvement of androgen receptor and glucose-regulated protein 78 kDa in human hepatocarcinogenesisExp Cell Res2014323232633624583399
- ButtsCLJonesYLLimJKSalterCEBelyavskayaESternbergEMTissue expression of steroid hormone receptors is associated with differ ential immune responsivenessBrain Behav Immun20112551000100721074604
- JiangXKandaTTanakaTLipopolysaccharide blocks induction of unfolded protein response in human hepatoma cell linesImmunol Lett2013152181523578665
- Sánchez-HernándezMChaves-PozoECabasIMuleroVGarcía-AyalaAGarcía-AlcázarATestosterone implants modify the steroid hormone balance and the gonadal physiology of gilthead seabream (Sparus aurata L) malesJ Steroid Biochem Mol Biol201313818319423743364
- PeekEMSongWZhangHHuangJChinAILoss of MyD88 leads to more aggressive TRAMP prostate cancer and influences tumor infiltrating lymphocytesProstate201575546347325597486
- HuynhHNgoVCKoongHNSorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinomaJ Cell Mol Med2009138B2673268319220580
- HuynhHNgoVCFargnoliJBrivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinomaClin Cancer Res200814196146615318829493
- HuynhHChowKHSooKCRAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinomaJ Cell Mol Med20091371371138018466352
- PengLMalloyPJWangJFeldmanDGrowth inhibitory concentrations of androgens up-regulate insulin-like growth factor binding protein-3 expression via an androgen response element in LNCaP human prostate cancer cellsEndocrinology20061474599460716825320
- PandiniGMineoRFrascaFAndrogens up-regulate the insulin-like growth factor-I receptor in prostate cancer cellsCancer Res2005651849185715753383
- TsueiDJLeePHPengHYMale germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancerPLoS One2011611e2694822073224
- RosiniPBonaccorsiLBaldiEAndrogen receptor expression induces FGF2, FGF-binding protein production, and FGF2 release in prostate carcinoma cells: role of FGF2 in growth, survival, and androgen receptor down-modulationProstate200253431032112430142
- WuYChhipaRRChengJZhangHMohlerJLIpCAndrogen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survivalAnticancer Res201030103895390121036700
- WangSHYehSHChenPJThe driving circuit of HBx and androgen receptor in HBV-related hepatocarcinogenesisGut201463111688168924598130
- WangSHChenPJYehSHGender disparity in chronic hepatitis B: mechanisms of sex hormonesJ Gastroenterol Hepatol2015
- YehSHChenPJGender disparity of hepatocellular carcinoma: the roles of sex hormonesOncology201078Suppl 117217920616601
- Groupe d’Etude et de Traitement du Carcinome HépatocellulaireRandomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifenHepatology20044061361136915565568
- ChaoYChanWKHuangYSPhase II study of flutamide in the treatment of hepatocellular carcinomaCancer19967746356398616754
- GrimaldiCBleibergHGayFEvaluation of antiandrogen therapy in unresectable hepatocellular carcinoma: results of a European Organization for Research and Treatment of Cancer multicentric double-blind trialJ Clin Oncol19981624114179469323
- ForbesAWilkinsonMLIqbalMJJohnsonPJWilliamsRResponse to cyproterone acetate treatment in primary hepatocellular carcinoma is related to fall in free 5 alpha-dihydrotestosteroneEur J Cancer Clin Oncol19872311165916642828073
- GuptaSKorulaJFailure of ketoconazole as anti-androgen therapy in nonresectable primary hepatocellular carcinomaJ Clin Gastroenterol19881066516542466073
- GuéchotJPeigneyNBalletFVaubourdolleMGiboudeauJPouponREffect of D-tryptophan-6-luteinizing hormone-releasing hormone on the tumoral growth and plasma sex steroid levels in cirrhotic patients with hepatocellular carcinomaHepatology19891033463482547704
- ManesisEKGiannoulisGZoumboulisPVafiadouIHadziyannisSJTreatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: a randomized, controlled trialHepatology1995216153515427768497
- FalksonGAnsellSPhase II trial of buserelin in hepatocellular carcinomaEur J Cancer Clin Oncol1989259133913402553420
- YuMWChengSWLinMWAndrogen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinomaJ Natl Cancer Inst200092242023202811121465
- YuMWYangYCYangSYHormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among menJ Natl Cancer Inst200193211644165111698569
- YuMWYangYCYangSYAndrogen receptor exon 1 CAG repeat length and risk of hepatocellular carcinoma in womenHepatology200236115616312085360
- YehSHChangCFShauWYDominance of functional androgen receptor allele with longer CAG repeat in hepatitis B virus-related female hepatocarcinogenesisCancer Res200262154346435112154039
- YehSHChiuCMChenCLSomatic mutations at the tri-nucleotide repeats of androgen receptor gene in male hepatocellular carcinomaInt J Cancer200712081610161717230529
- ZhuRZhangJSZhuYZHBx-induced androgen receptor expression in HBV-associated hepatocarcinoma is independent of the methylation status of its promoterHistol Histopathol201126233521117024
- LiuBWenXHuangCWeiYUnraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 yearsInt J Biochem Cell Biol2013451987199623819994
- YangWJChangCJYehSHHepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathwaysHepatology20094951515152419205031
- WangSHYehSHLinWHWangHYChenDSChenPJIdentification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis BHepatology20095051392140219670412
- WuMHMaWLHsuCLAndrogen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcriptionSci Transl Med201023232ra35
- TianYKuoCFChenWLOuJHEnhancement of hepatitis B virus replication by androgen and its receptor in miceJ Virol20128641904191022156518
- YuZGaoYQFengHCell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesisGut201463111793180424440987
- HoggKWoodCMcNeillyASDuncanWCThe in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheepPLoS One201169e2487721935484
- ZhangHLiuYWangLDifferential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male ratJ Lipid Res201354234535723175777
- KellyDMNettleshipJEAkhtarSTestosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient miceLife Sci201410929510324953607