Fc gamma receptors: glycobiology and therapeutic prospects

References

• AlzariPMLascombeMBPoljakRJThree-dimensional structure of antibodiesAnnu Rev Immunol198865555802454644
   PubMed Web of Science ®Google Scholar
• BurtonDRWoofJMHuman antibody effector functionAdv Immunol1992511841502974
   PubMed Web of Science ®Google Scholar
• EdelmanGMCunninghamBAGallWEGottliebPDRutishauserUWaxdalMJThe covalent structure of an entire gammaG immunoglobulin moleculeProc Natl Acad Sci U S A196963178855257969
   PubMed Web of Science ®Google Scholar
• PorterRRStructural studies of immunoglobulinsScience197318040877137164122075
   PubMed Web of Science ®Google Scholar
• KohlerGMilsteinCContinuous cultures of fused cells secreting antibody of predefined specificityNature197525655174954971172191
   PubMed Web of Science ®Google Scholar
• ChungCHMirakhurBChanECetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactoseN Engl J Med2008358111109111718337601
   PubMed Web of Science ®Google Scholar
• ArnoldJNWormaldMRSimRBRuddPMDwekRAThe impact of glycosylation on the biological function and structure of human immunoglobulinsAnnu Rev Immunol200725215017029568
   PubMed Web of Science ®Google Scholar
• JefferisRGlycosylation as a strategy to improve antibody-based therapeuticsNat Rev Drug Discov20098322623419247305
   PubMed Web of Science ®Google Scholar
• JefferisRLundJGoodallMRecognition sites on human IgG for Fc gamma receptors: the role of glycosylationImmunol Lett1995442–31111177797239
   PubMed Web of Science ®Google Scholar
• ReuschDTejadaMLFc glycans of therapeutic antibodies as critical quality attributesGlycobiology201525121325133426263923
   PubMed Web of Science ®Google Scholar
• KrappSMimuraYJefferisRHuberRSondermannPStructural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrityJ Mol Biol2003325597998912527303
   PubMed Web of Science ®Google Scholar
• KanekoYNimmerjahnFRavetchJVAnti-inflammatory activity of immunoglobulin G resulting from Fc sialylationScience2006313578767067316888140
   PubMed Web of Science ®Google Scholar
• OkazakiAShoji-HosakaENakamuraKFucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIaJ Mol Biol200433651239124915037082
   PubMed Web of Science ®Google Scholar
• IidaSMisakaHInoueMNonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIaClin Cancer Res20061292879288716675584
   PubMed Web of Science ®Google Scholar
• SatohMIidaSShitaraKNon-fucosylated therapeutic antibodies as next-generation therapeutic antibodiesExpert Opin Biol Ther20066111161117317049014
   PubMed Web of Science ®Google Scholar
• ShieldsRLLaiJKeckRLack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicityJ Biol Chem200227730267332674011986321
   PubMed Web of Science ®Google Scholar
• NiwaRNatsumeAUeharaAIgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharidesJ Immunol Methods20053061–215116016219319
   PubMed Web of Science ®Google Scholar
• NatsumeAWakitaniMYamane-OhnukiNFucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded bispecific antibody comprising of two single-chain antibodies linked to the antibody constant regionJ Biochem2006140335936816861252
   PubMed Web of Science ®Google Scholar
• WalshGBiopharmaceutical benchmarks 2014Nat Biotechnol20143210992100025299917
   PubMed Web of Science ®Google Scholar
• EckerDMJonesSDLevineHLThe therapeutic monoclonal antibody marketMAbs20157191425529996
   PubMed Web of Science ®Google Scholar
• SondermannPPinceticAMaamaryJLammensKRavetchJVGeneral mechanism for modulating immunoglobulin effector functionProc Natl Acad Sci U S A2013110249868987223697368
   PubMed Web of Science ®Google Scholar
• CrispinMYuXBowdenTACrystal structure of sialylated IgG Fc: implications for the mechanism of intravenous immunoglobulin therapyProc Natl Acad Sci U S A201311038E3544E354623929778
   PubMed Web of Science ®Google Scholar
• LiuLAntibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteinsJ Pharm Sci201510461866188425872915
   PubMed Web of Science ®Google Scholar
• LiuLGomathinayagamSHamuroLThe impact of glycosylation on the pharmacokinetics of a TNFR2:Fc fusion protein expressed in glycoengineered Pichia pastorisPharm Res201330380381223135825
   PubMed Web of Science ®Google Scholar
• AnthonyRMNimmerjahnFAshlineDJReinholdVNPaulsonJCRavetchJVRecapitulation of IVIG anti-inflammatory activity with a recombinant IgG FcScience2008320587437337618420934
   PubMed Web of Science ®Google Scholar
• KandaYYamadaTMoriKComparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex typesGlycobiology200717110411817012310
   PubMed Web of Science ®Google Scholar
• GoetzeAMLiuYDZhangZHigh-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humansGlycobiology201121794995921421994
   PubMed Web of Science ®Google Scholar
• DaeronMFc receptor biologyAnnu Rev Immunol1997152032349143687
   PubMed Web of Science ®Google Scholar
• BruhnsPIannascoliBEnglandPSpecificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclassesBlood2009113163716372519018092
   PubMed Web of Science ®Google Scholar
• PowellMSHogarthPMFc receptorsAdv Exp Med Biol2008640223419065781
   PubMed Web of Science ®Google Scholar
• RavetchJVBollandSIgG Fc receptorsAnnu Rev Immunol20011927529011244038
   PubMed Web of Science ®Google Scholar
• SondermannPKaiserJJacobUMolecular basis for immune complex recognition: a comparison of Fc-receptor structuresJ Mol Biol2001309373774911397093
   PubMed Web of Science ®Google Scholar
• HulettMDHogarthPMMolecular basis of Fc receptor functionAdv Immunol19945711277872156
   PubMed Web of Science ®Google Scholar
• NimmerjahnFRavetchJVFcgamma receptors as regulators of immune responsesNat Rev Immunol200881344718064051
   PubMed Web of Science ®Google Scholar
• KoeneHRKleijerMAlgraJRoosDvon dem BorneAEde HaasMFc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotypeBlood1997903110911149242542
   PubMed Web of Science ®Google Scholar
• WuJEdbergJCRedechaPBA novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune diseaseJ Clin Invest19971005105910709276722
   PubMed Web of Science ®Google Scholar
• NietoACalizRPascualMMataranLGarciaSMartinJInvolvement of Fcgamma receptor IIIA genotypes in susceptibility to rheumatoid arthritisArthritis Rheum200043473573910765917
   PubMed Web of Science ®Google Scholar
• DuitsAJBootsmaHDerksenRHSkewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patientsArthritis Rheum19953812183218368849356
   PubMed Web of Science ®Google Scholar
• HayesJMCosgraveEFStruweWBGlycosylation and Fc receptorsCurr Top Microbiol Immunol201438216519925116100
   PubMed Web of Science ®Google Scholar
• FerraraCGrauSJagerCUnique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucoseProc Natl Acad Sci U S A201110831126691267421768335
   PubMed Web of Science ®Google Scholar
• FerraraCStuartFSondermannPBrunkerPUmanaPThe carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoformsJ Biol Chem200628185032503616330541
   PubMed Web of Science ®Google Scholar
• Shibata-KoyamaMIidaSOkazakiAThe N-linked oligosaccharide at Fc gamma RIIIa Asn-45: an inhibitory element for high Fc gamma RIIIa binding affinity to IgG glycoforms lacking core fucosylationGlycobiology200919212613418952826
   PubMed Web of Science ®Google Scholar
• HayesJMFrostellACosgraveEFFc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactionsJ Proteome Res201413125471548525345863
   PubMed Web of Science ®Google Scholar
• EdbergJCBarinskyMRedechaPBSalmonJEKimberlyRPFc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cellsJ Immunol199014412472947342141043
   PubMed Web of Science ®Google Scholar
• EdbergJCKimberlyRPCell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand bindingJ Immunol19971598384938579378972
   PubMed Web of Science ®Google Scholar
• KimberlyRPTappeNJMerriamLTCarbohydrates on human Fc gamma receptors. Interdependence of the classical IgG and nonclassical lectin-binding sites on human Fc gamma RIII expressed on neutrophilsJ Immunol198914211392339302523939
   PubMed Web of Science ®Google Scholar
• ZeckAPohlentzGSchlothauerTPeter-KatalinicJRegulaJTCell type-specific and site directed N-glycosylation pattern of FcgammaRIIIaJ Proteome Res20111073031303921561106
   PubMed Web of Science ®Google Scholar
• SondermannPHuberROosthuizenVJacobUThe 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complexNature2000406679326727310917521
   PubMed Web of Science ®Google Scholar
• RadaevSMotykaSFridmanWHSautes-FridmanCSunPDThe structure of a human type III Fcgamma receptor in complex with FcJ Biol Chem200127619164691647711297532
   PubMed Web of Science ®Google Scholar
• CosgraveEFStruweWBHayesJMHarveyDJWormaldMRRuddPMN-linked glycan structures of the human Fcgamma receptors produced in NS0 cellsJ Proteome Res20131283721373723777450
   PubMed Web of Science ®Google Scholar
• SondermannPJacobUKutscherCFreyJCharacterization and crystallization of soluble human Fc gamma receptor II (CD32) isoforms produced in insect cellsBiochemistry199938268469847710387093
   PubMed Web of Science ®Google Scholar
• PowellMSBartonPAEmmanouilidisDBiochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgGImmunol Lett1999681172310397151
   PubMed Web of Science ®Google Scholar
• TakahashiNCohen-SolalJGalinhaAFridmanWHSautes-FridmanCKatoKN-glycosylation profile of recombinant human soluble Fcgamma receptor IIIGlycobiology200212850751512145191
   PubMed Web of Science ®Google Scholar
• TakahashiNYamadaWMasudaKN-glycan structures of a recombinant mouse soluble Fcgamma receptor IIGlycoconj J199815990591410052594
   PubMed Web of Science ®Google Scholar
• GalonJRobertsonMWGalinhaAAffinity of the interaction between Fc gamma receptor type III (Fc gammaRIII) and monomeric human IgG subclasses. Role of Fc gammaRIII glycosylationEur J Immunol1997278192819329295028
   PubMed Web of Science ®Google Scholar
• AllenJMSeedBIsolation and expression of functional high-affinity Fc receptor complementary DNAsScience198924348893783812911749
   PubMed Web of Science ®Google Scholar
• HarrisonPTAllenJMHigh affinity IgG binding by FcgammaRI (CD64) is modulated by two distinct IgSF domains and the transmembrane domain of the receptorProtein Eng19981132252329613847
   PubMedGoogle Scholar
• LuJChuJZouZHamacherNBRixonMWSunPDStructure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG bindingProc Natl Acad Sci U S A2015112383383825561553
   PubMed Web of Science ®Google Scholar
• LuJEllsworthJLHamacherNOakSWSunPDCrystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin bindingJ Biol Chem201128647406084061321965667
   PubMed Web of Science ®Google Scholar
• JungSTReddySTKangTHAglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cellsProc Natl Acad Sci U S A2010107260460920080725
   PubMed Web of Science ®Google Scholar
• KrambeckFJBetenbaughMJA mathematical model of N-linked glycosylationBiotechnol Bioeng200592671172816247773
   PubMed Web of Science ®Google Scholar
• UmanaPBaileyJEA mathematical model of N-linked glycoform biosynthesisBiotechnol Bioeng199755689090818636599
   PubMed Web of Science ®Google Scholar
• McDonaldAGHayesJMBezakTGalactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylationJ Cell Sci2014127pt 235014502625271059
   PubMed Web of Science ®Google Scholar
• McDonaldAGTiptonKFDaveyGPA knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockoutsPLoS Comput Biol2016124e100484427054587
   PubMed Web of Science ®Google Scholar
• McDonaldAGHayesJMDaveyGPMetabolic flux control in glycosylationCurr Opin Struct Biol2016409710327620650
   PubMed Web of Science ®Google Scholar
• WengWKLevyRTwo immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphomaJ Clin Oncol200321213940394712975461
   PubMed Web of Science ®Google Scholar
• CartronGDacheuxLSallesGTherapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa geneBlood200299375475811806974
   PubMed Web of Science ®Google Scholar
• CassardLCohen-SolalJFFournierEMSelective expression of inhibitory Fcgamma receptor by metastatic melanoma impairs tumor susceptibility to IgG-dependent cellular responseInt J Cancer2008123122832283918798552
   PubMed Web of Science ®Google Scholar
• CassardLCohen-SolalJFGalinhaAModulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cellsJ Clin Invest2002110101549155712438452
   PubMed Web of Science ®Google Scholar
• CallananMBLe BacconPMossuzPThe IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphomaProc Natl Acad Sci U S A200097130931410618414
   PubMed Web of Science ®Google Scholar
• Camilleri-BroetSCassardLBroetPFcgammaRIIB is differentially expressed during B cell maturation and in B-cell lymphomasBr J Haematol20041241556214675408
   PubMed Web of Science ®Google Scholar
• TackenbergBJelcicIBaerenwaldtAImpaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathyProc Natl Acad Sci U S A2009106124788479219261857
   PubMed Web of Science ®Google Scholar
• LiYLeePYSobelESIncreased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupusArthritis Res Ther2009111R619144150
   PubMed Web of Science ®Google Scholar
• TillingerWJilchRJilmaBExpression of the high-affinity IgG receptor FcRI (CD64) in patients with inflammatory bowel disease: a new biomarker for gastroenterologic diagnosticsAm J Gastroenterol2009104110210919098857
   PubMed Web of Science ®Google Scholar
• BelostockiKParkMSRedechaPBMasudaESalmonJEPricopLFcgammaRIIa is a target for modulation by TNFalpha in human neutrophilsClin Immunol20051171788616084773
   PubMed Web of Science ®Google Scholar
• LunnonKTeelingJLTuttALCraggMSGlennieMJPerryVHSystemic inflammation modulates Fc receptor expression on microglia during chronic neurodegenerationJ Immunol2011186127215722421572034
   PubMed Web of Science ®Google Scholar
• DugastASTonelliABergerCTDecreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individualsVirology2011415216016721565376
   PubMed Web of Science ®Google Scholar
• CapsoniFMinonzioFOngariAMFc receptors expression and function in mononuclear phagocytes from AIDS patients: modulation by IFN-gammaScand J Immunol199439145508290892
   PubMed Web of Science ®Google Scholar
• de HaasMKleijerMMinchintonRMRoosDvon dem BorneAESoluble Fc gamma RIIIa is present in plasma and is derived from natural killer cellsJ Immunol199415229009078283059
   PubMed Web of Science ®Google Scholar
• WerwitzkeSTrickDSondermannPTreatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32)Ann Rheum Dis200867215416117557887
   PubMed Web of Science ®Google Scholar
• EllsworthJLHamacherNHarderBRecombinant soluble human FcgammaR1A (CD64A) reduces inflammation in murine collagen-induced arthritisJ Immunol2009182117272727919454724
   PubMed Web of Science ®Google Scholar
• EllsworthJLMaurerMHarderBTargeting immune complex-mediated hypersensitivity with recombinant soluble human FcgammaRIA (CD64A)J Immunol2008180158058918097060
   PubMed Web of Science ®Google Scholar
• MagnussonSEAndrenMNilssonKESondermannPJacobUKleinauSAmelioration of collagen-induced arthritis by human recombinant soluble FcgammaRIIbClin Immunol2008127222523318346938
   PubMed Web of Science ®Google Scholar
• IwataHPipiEMockelNRecombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisitaJ Invest Dermatol2015135391691925330298
   PubMed Web of Science ®Google Scholar
• NimmerjahnFTranslating inhibitory Fc receptor biology into novel therapeutic approachesJ Clin Immunol201636suppl 1838726957094
   PubMed Web of Science ®Google Scholar
• CampbellMPRoyleLRadcliffeCMDwekRARuddPMGlycoBase and autoGU: tools for HPLC-based glycan analysisBioinformatics20082491214121618344517
   PubMed Web of Science ®Google Scholar