Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles

References

• Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med. 2011;17(3–4):293–307. doi:10.2119/molmed.2010.0013821046059
   PubMed Web of Science ®Google Scholar
• Ganz T, Selsted ME, Szklarek D, et al. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest. 1985;76(4):1427–1435. doi:10.1172/JCI1121202997278
   PubMed Web of Science ®Google Scholar
• Porro GA, Lee JH, de Azavedo J, et al. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. Am J Physiol Lung Cell Mol Physiol. 2001;281(5):L1240–L1247. doi:10.1152/ajplung.2001.281.5.L124011597916
   PubMed Web of Science ®Google Scholar
• Zhang XL, Selsted ME, Pardi A. NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry. 1992;31(46):11348–11356. doi:10.1021/bi00161a0121445872
   PubMed Web of Science ®Google Scholar
• Ganz T, Lehrer RI. Defensins. Curr Opin Immunol. 1994;6(4):584–589. doi:10.1016/0952-7915(94)90145-77946046
   PubMed Web of Science ®Google Scholar
• Ashitani J, Mukae H, Ihiboshi H, et al. [Defensin in plasma and in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome]. Nihon Kyobu Shikkan Gakkai Zasshi. 1996;34(12):1349–1353.9022318
   PubMedGoogle Scholar
• Merkel D, Rist W, Seither P, Weith A, Lenter MC. Proteomic study of human bronchoalveolar lavage fluids from smokers with chronic obstructive pulmonary disease by combining surface-enhanced laser desorption/ionization-mass spectrometry profiling with mass spectrometric protein identification. Proteomics. 2005;5(11):2972–2980. doi:10.1002/pmic.20040118016075419
   PubMed Web of Science ®Google Scholar
• Reilly C, Cervenka T, Hertz MI, Becker T, Wendt CH. Human neutrophil peptide in lung chronic allograft dysfunction. Biomarkers. 2011;16(8):663–669. doi:10.3109/1354750X.2011.62378921988113
   PubMed Web of Science ®Google Scholar
• Soong LB, Ganz T, Ellison A, Caughey GH. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res. 1997;46(3):98–102. doi:10.1007/s0001100501149098722
   PubMed Web of Science ®Google Scholar
• Ihi T, Nakazato M, Mukae H, Matsukura S. Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections. Clin Infect Dis. 1997;25(5):1134–1140. doi:10.1086/5160759402371
   PubMed Web of Science ®Google Scholar
• Ashitani J, Mukae H, Arimura Y, Sano A, Tokojima M, Nakazato M. High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Life Sci. 2004;75(9):1123–1134. doi:10.1016/j.lfs.2004.01.02815207659
   PubMed Web of Science ®Google Scholar
• Khine AA, Del Sorbo L, Vaschetto R, et al. Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. Blood. 2006;107(7):2936–2942. doi:10.1182/blood-2005-06-231416322472
   PubMed Web of Science ®Google Scholar
• Wu J, Han B, Fanelli V, et al. Distinctive roles and mechanisms of human neutrophil peptides in experimental sepsis and acute respiratory distress syndrome. Crit Care Med. 2018;46(9):e921–e927. doi:10.1097/CCM.000000000000326529979223
   PubMed Web of Science ®Google Scholar
• Zheng J, Huang Y, Islam D, et al. Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury. Respir Res. 2018;19(1):190. doi:10.1186/s12931-018-0869-x30268129
   PubMed Web of Science ®Google Scholar
• Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol Ther. 2012;20(1):14–20. doi:10.1038/mt.2011.21122008910
   PubMed Web of Science ®Google Scholar
• Islam D, Huang Y, Fanelli V, et al. Identification and modulation of microenvironment is crucial for effective MSC therapy in acute lung injury. Am J Respir Crit Care Med. 2018. doi:10.1164/rccm.201802-0356OC
   Web of Science ®Google Scholar
• de Almeida PE, van Rappard JR, Wu JC. In vivo bioluminescence for tracking cell fate and function. Am J Physiol Heart Circ Physiol. 2011;301(3):H663–H671. doi:10.1152/ajpheart.00337.201121666118
   PubMed Web of Science ®Google Scholar
• Eggenhofer E, Benseler V, Kroemer A, et al. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front Immunol. 2012;3:297. doi:10.3389/fimmu.2012.0029723056000
   PubMed Web of Science ®Google Scholar
• Sun Z, Gong X, Zhu H, et al. Inhibition of Wnt/beta-catenin signaling promotes engraftment of mesenchymal stem cells to repair lung injury. J Cell Physiol. 2014;229(2):213–224. doi:10.1002/jcp.2443623881674
   PubMed Web of Science ®Google Scholar
• Nystedt J, Anderson H, Tikkanen J, et al. Cell surface structures influence lung clearance rate of systemically infused mesenchymal stromal cells. Stem Cells. 2013;31(2):317–326. doi:10.1002/stem.127123132820
   PubMed Web of Science ®Google Scholar
• Studies of Blood DNA in Patients With Severe Infection DYNAMICS. https://clinicaltrials.gov/ct2/show/NCT01355042 Accessed 123, 2019.
   Google Scholar
• Harwig SS, Ganz T, Lehrer RI. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol. 1994;236:160–172. doi:10.1016/0076-6879(94)36015-47968608
   PubMed Web of Science ®Google Scholar
• Meng X, Cheng K, Krohkin O, et al. Evidence for the presence of a low-mass beta1 integrin on the cell surface. J Cell Sci. 2005;118(Pt17):4009–4016. doi:10.1242/jcs.0252016105875
   PubMed Web of Science ®Google Scholar
• Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med. 1993;122(2):202–207.8340706
   PubMed Web of Science ®Google Scholar
• Ashitani J, Mukae H, Nakazato M, et al. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J. 1998;11(1):104–111. doi:10.1183/09031936.98.110101049543278
   PubMed Web of Science ®Google Scholar
• Hiemstra PS, van Wetering S, Stolk J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur Respir J. 1998;12(5):1200–1208. doi:10.1183/09031936.98.120512009864022
   PubMed Web of Science ®Google Scholar
• Matsushita I, Hasegawa K, Nakata K, Yasuda K, Tokunaga K, Keicho N. Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease. Biochem Biophys Res Commun. 2002;291(1):17–22. doi:10.1006/bbrc.2002.639511829455
   PubMed Web of Science ®Google Scholar
• Herr C, Shaykhiev R, Bals R. The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther. 2007;7(9):1449–1461. doi:10.1517/14712598.7.9.144917727333
   PubMed Web of Science ®Google Scholar
• Berkestedt I, Herwald H, Ljunggren L, Nelson A, Bodelsson M. Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsis. J Innate Immun. 2010;2(5):478–482. doi:10.1159/00031703620571257
   PubMed Web of Science ®Google Scholar
• Saini D, Angaswamy N, Tiriveedhi V, et al. Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantation. J Heart Lung Transplant. 2010;29(12):1330–1336. doi:10.1016/j.healun.2010.05.03620691611
   PubMed Web of Science ®Google Scholar
• Thomas NJ, Carcillo JA, Doughty LA, Sasser H, Heine RP. Plasma concentrations of defensins and lactoferrin in children with severe sepsis. Pediatr Infect Dis J. 2002;21(1):34–38. doi:10.1097/00006454-200201000-0000811791096
   PubMed Web of Science ®Google Scholar
• White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol. 1995;5(4):521–527. doi:10.1016/0959-440X(95)80038-78528769
   PubMed Web of Science ®Google Scholar
• Quinn K, Henriques M, Parker T, Slutsky AS, Zhang H. Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2008;295(5):H1817–H1824. doi:10.1152/ajpheart.00472.200818805897
   PubMed Web of Science ®Google Scholar
• Semon JA, Nagy LH, Llamas CB, Tucker HA, Lee RH, Prockop DJ. Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels. Cell Tissue Res. 2010;341(1):147–158. doi:10.1007/s00441-010-0994-420563599
   PubMed Web of Science ®Google Scholar
• Veevers-Lowe J, Ball SG, Shuttleworth A, Kielty CM. Mesenchymal stem cell migration is regulated by fibronectin through alpha5beta1-integrin-mediated activation of PDGFR-beta and potentiation of growth factor signals. J Cell Sci. 2011;124(Pt8):1288–1300. doi:10.1242/jcs.07693521429937
   PubMed Web of Science ®Google Scholar
• Amable PR, Teixeira MV, Carias RB, Granjeiro JM, Borojevic R. Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly. Stem Cell Res Ther. 2014;5(2):53. doi:10.1186/scrt44224739658
   PubMed Web of Science ®Google Scholar
• Liang X, Ding Y, Zhang Y, Tse HF, Lian Q. Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives. Cell Transplant. 2014;23(9):1045–1059. doi:10.3727/096368913X66770923676629
   PubMed Web of Science ®Google Scholar
• Lee CG, Hartl D, Matsuura H, et al. Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. Am J Respir Cell Mol Biol. 2008;39(6):739–746. doi:10.1165/rcmb.2008-0053OC18617680
   PubMed Web of Science ®Google Scholar
• Schafer S, Viswanathan S, Widjaja AA, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552(7683):110–115. doi:10.1038/nature2467629160304
   PubMed Web of Science ®Google Scholar
• Tang W, Geba GP, Zheng T, et al. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest. 1996;98(12):2845–2853. doi:10.1172/JCI1191138981933
   PubMed Web of Science ®Google Scholar
• Agassandian M, Shurin GV, Ma Y, Shurin MR. C-reactive protein and lung diseases. Int J Biochem Cell Biol. 2014;53:77–88. doi:10.1016/j.biocel.2014.05.01624853773
   PubMed Web of Science ®Google Scholar
• Kapur R, Kim M, Rondina MT, Porcelijn L, Semple JW. Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury. Oncotarget. 2016;7(47):78048–78054. doi:10.18632/oncotarget.1287227793007
   PubMedGoogle Scholar
• Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Med. 2008;121(3):219–225. doi:10.1016/j.amjmed.2007.10.03318328306
   PubMed Web of Science ®Google Scholar
• Neff TA, Guo RF, Neff SB, et al. Relationship of acute lung inflammatory injury to Fas/FasL system. Am J Pathol. 2005;166(3):685–694. doi:10.1016/S0002-9440(10)62290-015743781
   PubMed Web of Science ®Google Scholar
• Perl M, Chung CS, Perl U, et al. Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury. Am J Respir Crit Care Med. 2007;176(6):591–601. doi:10.1164/rccm.200611-1743OC17600273
   PubMed Web of Science ®Google Scholar
• McKinley D, Wu Q, Yang-Feng T, Yang YC. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics. 1992;13(3):814–819. doi:10.1016/0888-7543(92)90158-O1386338
   PubMed Web of Science ®Google Scholar
• Nakchbandi IA, Mitnick MA, Masiukiewicz US, Sun BH, Insogna KL. IL-6 negatively regulates IL-11 production in vitro and in vivo. Endocrinology. 2001;142(9):3850–3856. doi:10.1210/endo.142.9.836811517162
   PubMed Web of Science ®Google Scholar
• Syeda F, Tullis E, Slutsky AS, Zhang H. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. Am J Physiol Heart Circ Physiol. 2008;294(6):H2769–H2774. doi:10.1152/ajpheart.00211.200818441204
   PubMed Web of Science ®Google Scholar
• Jin HJ, Lee HJ, Heo J, et al. Senescence-associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells. Antioxid Redox Signal. 2016;24(9):471–485. doi:10.1089/ars.2015.635926573462
   PubMed Web of Science ®Google Scholar
• Foronjy RF, Dabo AJ, Cummins N, Geraghty P. Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection. BMC Immunol. 2014;15:41. doi:10.1186/s12865-014-0041-425277705
   PubMed Web of Science ®Google Scholar
• Quinton LJ, Mizgerd JP, Hilliard KL, Jones MR, Kwon CY, Allen E. Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol. 2012;188(12):6300–6308. doi:10.4049/jimmunol.120025622581855
   PubMed Web of Science ®Google Scholar
• Banner LR, Patterson PH, Allchorne A, Poole S, Woolf CJ. Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine. J Neurosci. 1998;18(14):5456–5462. doi:10.1523/JNEUROSCI.18-14-05456.19989651226
   PubMed Web of Science ®Google Scholar