AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling

References

• Saito H. Pathophysiological regulation of renal slc22a organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol Ther. 2010;125(1):79–91. doi:10.1016/j.pharmthera.2009.09.008
   PubMed Web of Science ®Google Scholar
• Iwata K, Watanabe H, Morisaki T, et al. Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure. Pharm Res. 2007;24(4):662–671. doi:10.1007/s11095-006-9183-2
   PubMed Web of Science ®Google Scholar
• Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–1305. doi:10.1056/NEJMoa041031
   PubMed Web of Science ®Google Scholar
• Brunet P, Gondouin B, Duval-Sabatier A, et al. Does uremia cause vascular dysfunction? Kidney Blood Press Res. 2011;34(4):284–290. doi:10.1159/000327131
   PubMed Web of Science ®Google Scholar
• Ologunde R, Zhao H, Lu K, Ma D. Organ cross talk and remote organ damage following acute kidney injury. Int Urol Nephrol. 2014;46(12):2337–2345. doi:10.1007/s11255-014-0766-2
   PubMed Web of Science ®Google Scholar
• Li XHH, Santora R, Rabb H, Rabb H. Organ crosstalk: the role of the kidney. Curr Opin Crit Care. 2009;15(6):481–487. doi:10.1097/MCC.0b013e328332f69e
   PubMed Web of Science ®Google Scholar
• Akcay ANQ, Edelstein CL, Edelstein CL. Mediators of inflammation in acute kidney injury. Mediators Inflamm. 2009;2009:137072. doi:10.1155/2009/137072
   PubMed Web of Science ®Google Scholar
• Hughes SF, Hendricks BD, Edwards DR, Bastawrous SS, Roberts GE, Middleton JF. Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. J Inflamm. 2007;4:12. doi:10.1186/1476-9255-4-12
   Google Scholar
• Manka DR, Wiegman P, Din S, et al. Arterial injury increases expression of inflammatory adhesion molecules in the carotid arteries of apolipoprotein-e-deficient mice. J Vasc Res. 1999;36(5):372–378. doi:10.1159/000025676
   PubMed Web of Science ®Google Scholar
• Roy J, Audette M, Tremblay MJ. Intercellular adhesion molecule-1 (icam-1) gene expression in human t cells is regulated by phosphotyrosyl phosphatase activity. Involvement of nf-kappab, ets, and palindromic interferon-gamma-responsive element-binding sites. J Biol Chem. 2001;276(18):14553–14561. doi:10.1074/jbc.M005067200
   PubMed Web of Science ®Google Scholar
• Kempe S, Kestler H, Lasar A, Wirth T. NF-κB controls the global pro-inflammatory response in endothelial ells: evidence for the regulation of a pro-atherogenic program. Nucleic Acids Res. 2005;33(16):5308–5319. doi:10.1093/nar/gki836
   PubMed Web of Science ®Google Scholar
• Kim SH, Yu MA, Ryu ES, Jang YH, Kang DH. Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease. Lab Invest. 2012;92(4):488–498.
   PubMed Web of Science ®Google Scholar
• Tumur Z, Shimizu H, Enomoto A, Miyazaki H, Niwa T. Indoxyl sulfate upregulates expression of icam-1 and mcp-1 by oxidative stress-induced Nf-kappab activation. Am J Nephrol. 2010;31(5):435–441. doi:10.1159/000299798
   PubMed Web of Science ®Google Scholar
• Zheng L, Hsu SI, Hong Hsu S. In situ glomerular expression of activated nf-kappab in human lupus nephritis and other non-proliferative proteinuric glomerulopathy. Virchows Arch. 2006;448(2):172–183. doi:10.1007/s00428-005-0061-9
   PubMed Web of Science ®Google Scholar
• Ito SOM, Higuchi Y, Nishijima F, Ishii H, Yoshida M, Yoshida M. Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of e-selectin. J Biol Chem. 2010;285(50):38869–38875. doi:10.1074/jbc.M110.166686
   PubMed Web of Science ®Google Scholar
• Sun CY, Hsu HH, Wu MS. P-cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells. Nephrol Dial Transplant. 2013;28(1):70–78. doi:10.1093/ndt/gfs133
   PubMed Web of Science ®Google Scholar
• Mehta RL, Kellum JA, Shah SV, et al. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. doi:10.1186/cc5713
   PubMed Web of Science ®Google Scholar
• Shen WC, Liang CJ, Huang TM, et al. Indoxyl sulfate enhances IL-1beta-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFkappaB/AP-1 pathway. Arch Toxicol. 2016;90(11):2779–2792. doi:10.1007/s00204-015-1652-0
   PubMed Web of Science ®Google Scholar
• Tsai CT, Wang DL, Chen WP, et al. Angiotensin II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes. Circ Res. 2007;100(10):1476–1485. doi:10.1161/01.RES.0000268497.93085.e1
   PubMed Web of Science ®Google Scholar
• Melotti P, Nicolis E, Tamanini A, Rolfini R, Pavirani A, Cabrini G. Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector. Gene Ther. 2001;8(18):1436–1442. doi:10.1038/sj.gt.3301533
   PubMed Web of Science ®Google Scholar
• Shen WC, Chou YH, Huang HP, Sheen JF, Hung SC, Chen HF. Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction. Stem Cell Res Ther. 2018;9(1):344. doi:10.1186/s13287-018-1092-x
   PubMedGoogle Scholar
• Wang X, Shapiro JI. Evolving concepts in the pathogenesis of uraemic cardiomyopathy. Nature Rev Nephrol. 2019;15(3):159–175. doi:10.1038/s41581-018-0101-8
   PubMed Web of Science ®Google Scholar
• Ross R, Epstein FH. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340(2):115–126. doi:10.1056/NEJM199901143400207
   PubMed Web of Science ®Google Scholar
• Malatino LS, Stancanelli B, Cataliotti A, et al. Circulating E-selectin as a risk marker in patients with end-stage renal disease. J Intern Med. 2007;262(4):479–487.
   PubMed Web of Science ®Google Scholar
• Simmons EM, Himmelfarb J, Sezer MT, et al. Plasma cytokine levels predict mortality in patients with acute renal failure. Kidney Int. 2004;65(4):1357–1365.
   PubMed Web of Science ®Google Scholar
• Vanholder R, Schepers E, Pletinck A, Nagler EV, Glorieux G. The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. J Am Soc Nephrol. 2014;25(9):1897–1907. doi:10.1681/ASN.2013101062
   PubMed Web of Science ®Google Scholar
• Barreto FC, Barreto DV, Liabeuf S, et al.; European Uremic Toxin Work Group (EUTox). Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol. 2009;4(10):1551–1558. doi:10.2215/CJN.03980609
   PubMed Web of Science ®Google Scholar
• Suliman ME, Qureshi AR, Heimbürger O, Lindholm B, Stenvinkel P. Soluble adhesion molecules in end-stage renal disease: a predictor of outcome. Nephrol Dial Transplant. 2006;21(6):1603–1610. doi:10.1093/ndt/gfl005
   PubMed Web of Science ®Google Scholar
• Viedt C, Dechend R, Fei J, Hänsch GM, Kreuzer J, Orth SR. MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factoR-κB and activating protein-1. J Am Soc Nephrol. 2002;13(6):1534–1547. doi:10.1097/01
   PubMed Web of Science ®Google Scholar
• Loverre A, Ditonno P, Crovace A, et al. Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: differential modulation by rapamycin. J Am Soc Nephrol. 2004;15:2675–2686. doi:10.1097/01.ASN.0000139932.00971.E4
   PubMed Web of Science ®Google Scholar
• Yingjie K, Haihong Y, Lingwei C, et al. Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)- induce acute kidney injury by suppressing inflammation and apoptosis: the role of AKT/mTOR signaling. Biomed Pharmacother. 2019;112:108681.
   PubMed Web of Science ®Google Scholar
• Yu X, Meng X, Xu M, et al. Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-kappaB and improving mitochondrial function. EBioMedicine. 2018;36:266–280. doi:10.1016/j.ebiom.2018.09.031
   PubMed Web of Science ®Google Scholar
• Sumida M, Doi K, Ogasawara E, et al. Regulation of mitochondrial dynamics by dynamin-related protein-1 in acute cardiorenal syndrome. J Am Soc Nephrol. 2015;26(10):2378–2387. doi:10.1681/ASN.2014080750
   PubMed Web of Science ®Google Scholar
• Han B, Li S, Lv Y, et al. Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Food Funct. 2019;10(9):5555–5565. doi:10.1039/c9fo01152h
   PubMed Web of Science ®Google Scholar
• Zhang Z, Guo C, Jiang H, et al. Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell-cell interactions. Food Funct. 2020;11(10):9252–9262. doi:10.1039/d0fo01223h
   PubMed Web of Science ®Google Scholar
• Li S, Zheng X, Zhang X, et al. Exploring the liver fibrosis induced by deltamethrin exposure in quails and elucidating the protective mechanism of resveratrol. Ecotoxicol Environ Saf. 2021;207:111501. doi:10.1016/j.ecoenv.2020.111501
   PubMed Web of Science ®Google Scholar
• Sato E, Saigusa D, Mishima E, et al. Impact of the oral adsorbent AST-120 on organ-specific accumulation of uremic toxins: lc-ms/ms and ms imaging techniques. Toxins (Basel). 2018;10(1):19. doi:10.3390/toxins10010019
   Web of Science ®Google Scholar
• Sakaguchi Y, Hamano T, Obi Y, et al. A randomized trial of magnesium oxide and oral carbon adsorbent for coronary artery calcification in predialysis CKD. J Am Soc Nephrol. 2019;30(6):1073–1085. doi:10.1681/ASN.2018111150
   PubMed Web of Science ®Google Scholar
• Niwa T. Indoxyl sulfate is a nephro-vascular toxin. J Ren Nutr. 2010;20(5Suppl):S2–S6. doi:10.1053/j.jrn.2010.05.002
   PubMedGoogle Scholar
• Shibahara H, Shibahara N. Cardiorenal protective effect of the oral uremic toxin absorbent AST-120 in chronic heart disease patients with moderate CKD. J Nephrol. 2009;23(5):535–540.
   Web of Science ®Google Scholar
• Fuji H, Nakai K, Fukagawa M. Role of oxidative stress and indoxyl sulfate in progression of cardiovascular disease in chronic kidney disease. Ther Apher Dial. 2011;15(2):125–128. doi:10.1111/j.1744-9987.2010.00883.x
   PubMed Web of Science ®Google Scholar