Dysiarenone from Marine Sponge Dysidea arenaria Attenuates ROS and Inflammation via Inhibition of 5-LOX/NF-κB/MAPKs and Upregulation of Nrf-2/OH-1 in RAW 264.7 Macrophages

References

• Lv J, Jiang S, Yang Z, et al. PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders. Ageing Res Rev. 2018;44:8–21. doi:10.1016/j.arr.2018.03.004
   PubMed Web of Science ®Google Scholar
• Massaad CA, Pautler RG, Klann E. Mitochondrial superoxide: a key player in Alzheimer’s disease. Aging. 2009;1(9):758–761. doi:10.18632/aging.100088
   PubMedGoogle Scholar
• Matsuzawa-Ishimoto Y, Hwang S, Cadwell K. Autophagy and Inflammation. Annu Rev Immunol. 2018;36(1):73–101. doi:10.1146/annurev-immunol-042617-053253
   PubMed Web of Science ®Google Scholar
• Fullerton JN, Gilroy DW. Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov. 2016;15(8):551–567. doi:10.1038/nrd.2016.39
   PubMed Web of Science ®Google Scholar
• Galkina E, Ley K. Immune and Inflammatory Mechanisms of Atherosclerosis. Annu Rev Immunol. 2009;27:165–197. doi:10.1146/annurev.immunol.021908.132620
   PubMed Web of Science ®Google Scholar
• Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Review Article. Nat Rev Neurosci. 2015;16:358. doi:10.1038/nrn3880
   PubMed Web of Science ®Google Scholar
• Deng T, Lyon CJ, Bergin S, Caligiuri MA, Hsueh WA. Obesity, Inflammation, and Cancer. Annu Rev Pathol. 2016;11:421–449. doi:10.1146/annurev-pathol-012615-044359
   PubMed Web of Science ®Google Scholar
• Ivashkiv LB. Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states. Eur J Immunol. 2011;41(9):2477–2481. doi:10.1002/eji.201141783
   PubMed Web of Science ®Google Scholar
• Molinski TF, Dalisay DS, Lievens SL, Saludes JP. Drug development from marine natural products. Review Article. Nat Rev Drug Discov. 2008;8:69. doi:10.1038/nrd2487
   PubMed Web of Science ®Google Scholar
• Senthilkumar K, Kim S-K. Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases. Evid Based Complementary Altern Med. 2013;2013:572859. doi:10.1155/2013/572859
   PubMed Web of Science ®Google Scholar
• Jiao W-H, Cheng B-H, Chen G-D, et al. Dysiarenone, a Dimeric C 21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria. Org Lett. 2018;20(10):3092–3095. doi:10.1021/acs.orglett.8b01148
   PubMed Web of Science ®Google Scholar
• Jiao W-H, Cheng B-H, Shi G-H, et al. Dysivillosins A–D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa. Sci Rep. 2017;7(1):8947. doi:10.1038/s41598-017-04021-z
   PubMedGoogle Scholar
• Jiao W-H, Huang X-J, Yang J-S, et al. Dysidavarones A–D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara. Org Lett. 2012;14(1):202–205. doi:10.1021/ol202994c
   PubMed Web of Science ®Google Scholar
• Jiao W-H, Shi G-H, Xu -T-T, et al. Dysiherbols A–C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge. J Nat Prod. 2016;79(2):406–411. doi:10.1021/acs.jnatprod.5b01079
   PubMed Web of Science ®Google Scholar
• Jiao W-H, Xu -T-T, Yu H-B, et al. Dysideanones A–C, unusual sesquiterpene quinones from the south china sea sponge Dysidea avara. J Nat Prod. 2014;77(2):346–350. doi:10.1021/np4009392
   PubMed Web of Science ®Google Scholar
• Li KK, Shen SS, Deng X, et al. Dihydrofisetin exerts its anti-inflammatory effects associated with suppressing ERK/p38 MAPK and Heme Oxygenase-1 activation in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced mice paw edema. Int Immunopharmacol. 2018;54:366–374. doi:10.1016/j.intimp.2017.11.034
   PubMed Web of Science ®Google Scholar
• Liu J-Q, Lian C-L, Hu T-Y, et al. Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora. Food Chem. 2018;263:155–162. doi:10.1016/j.foodchem.2018.04.097
   PubMed Web of Science ®Google Scholar
• Ahmed SMU, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: pivotal roles in inflammation. Biochim Biophys Acta Mol Basis Dis. 2017;1863(2):585–597. doi:10.1016/j.bbadis.2016.11.005
   PubMed Web of Science ®Google Scholar
• Kapugi M, Cunningham K. Corticosteroids. Orthop Nurs. 2019;38(5):336–339. doi:10.1097/nor.0000000000000595
   PubMed Web of Science ®Google Scholar
• Yasir M, Goyal A, Bansal P, Sonthalia S. Corticosteroid Adverse Effects. StatPearls. StatPearls Publishing. Copyright © 2020. StatPearls Publishing LLC; 2020.
   Google Scholar
• Kingston DGI. Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation. J Nat Prod. 2011;74(3):496–511. doi:10.1021/np100550t
   PubMed Web of Science ®Google Scholar
• Shady N, El-Hossary E, Fouad M, Gulder T, Kamel M, Abdelmohsen U. Bioactive Natural Products of Marine Sponges from the. Genus Hyrtios Molecules. 2017;22(5):781.
   PubMed Web of Science ®Google Scholar
• Jeon YJ, Han SH, Lee YW, Lee M, Yang KH, Kim HM. Dexamethasone inhibits IL-1β gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-κB/Rel and AP-1 activation. Immunopharmacology. 2000;48(2):173–183. doi:10.1016/S0162-3109(00)00199-5
   PubMedGoogle Scholar
• Copple IM, Dinkova-Kostova AT, Kensler TW, Liby KT, Wigley WC. NRF2 as an Emerging Therapeutic Target. Oxid Med Cell Longev. 2017;2017:8165458. doi:10.1155/2017/8165458
   PubMed Web of Science ®Google Scholar
• Zhang X, Ding M, Zhu P, et al. New Insights into the Nrf-2/HO-1 signaling axis and its application in pediatric respiratory diseases. Oxid Med Cell Longev. 2019;2019:3214196. doi:10.1155/2019/3214196
   PubMed Web of Science ®Google Scholar
• Wojdasiewicz P, Poniatowski LA, Szukiewicz D. The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis. Mediators Inflamm. 2014;2014:561459. 561459. doi:10.1155/2014/561459
   PubMed Web of Science ®Google Scholar
• Rider P, Carmi Y, Cohen I. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. Int J Cell Biol. 2016;11:9259646. doi:10.1155/2016/9259646
   Google Scholar
• Poeckel D, Funk CD. The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease. Cardiovasc Res. 2010;86(2):243–253. doi:10.1093/cvr/cvq016
   PubMed Web of Science ®Google Scholar
• Kim HJ, Hawke N, Baldwin AS. NF-kappaB and IKK as therapeutic targets in cancer. Cell Death Differ. 2006;13(5):738–747. doi:10.1038/sj.cdd.4401877
   PubMed Web of Science ®Google Scholar
• Menghini L, Ferrante C, Leporini L, et al. An hydroalcoholic chamomile extract modulates inflammatory and immune response in HT29 cells and isolated rat colon. Phytother Res. 2016;30(9):1513–1518. doi:10.1002/ptr.5655
   PubMed Web of Science ®Google Scholar
• Locatelli M, Macchione N, Ferrante C, et al. Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS. Molecules. 2018;23(5):1145.
   PubMed Web of Science ®Google Scholar
• Zhou L-T, Wang K-J, Li L, Li H, Geng M. Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway. Eur J Pharmacol. 2015;761:211–216. doi:10.1016/j.ejphar.2015.06.003
   PubMed Web of Science ®Google Scholar
• Thalhamer T, McGrath MA, Harnett MM. MAPKs and their relevance to arthritis and inflammation. Rheumatology. 2008;47(4):409–414. doi:10.1093/rheumatology/kem297
   PubMed Web of Science ®Google Scholar
• Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. doi:10.1186/1476-4598-12-86
   PubMed Web of Science ®Google Scholar
• Deshmukh P, Unni S, Krishnappa G, Padmanabhan B. The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017;9(1):41–56. doi:10.1007/s12551-016-0244-4
   PubMedGoogle Scholar
• Datta PK, Koukouritaki SB, Hopp KA, Lianos EA. Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. J Am Soc Nephrol. 1999;10(12):2540–2550.
   PubMed Web of Science ®Google Scholar