Aryl Hydrocarbon Receptor is Essential in the Control of Lung Club Cell Homeostasis

References

• Xiao C, Puddicombe SM, Field S, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol. 2011;128(3):e541–512. doi:10.1016/j.jaci.2011.05.038
   Web of Science ®Google Scholar
• Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med. 2012;18(5):684–692. doi:10.1038/nm.2737
   PubMed Web of Science ®Google Scholar
• Whitsett JA, Alenghat T. Respiratory epithelial cells orchestrate pulmonary innate immunity. Nat Immunol. 2015;16(1):27–35. doi:10.1038/ni.3045
   PubMed Web of Science ®Google Scholar
• Lloyd CM, Marsland BJ. Lung homeostasis: influence of age, microbes, and the immune system. Immunity. 2017;46(4):549–561. doi:10.1016/j.immuni.2017.04.005
   PubMed Web of Science ®Google Scholar
• Franks TJ, Colby TV, Travis WD, et al. Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc. 2008;5(7):763–766. doi:10.1513/pats.200803-025HR
   PubMedGoogle Scholar
• Rokicki W, Rokicki M, Wojtacha J, Dzeljijli A. The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases. Kardiochir Torakochirurgia Pol. 2016;13:26–30. doi:10.5114/kitp.2016.58961
   PubMedGoogle Scholar
• Mackay R-MA, Grainge CL, Lau LC, et al. Airway Surfactant Protein D deficiency in adults with severe asthma. Chest. 2016;149(5):1165–1172. doi:10.1016/j.chest.2015.11.012
   Google Scholar
• Chen LC, Zhang Z, Myers AC, Huang SK. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein. J Immunol. 2001;167(6):3025–3028. doi:10.4049/jimmunol.167.6.3025
   Google Scholar
• Fakih D, Akiki Z, Junker K, et al. Surfactant protein D multimerization and gene polymorphism in COPD and asthma. Respirology. 2018;23(3):298–305. doi:10.1111/resp.13193
   Google Scholar
• Morimoto M, Nishinakamura R, Saga Y, Kopan R. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development. 2012;139(23):4365–4373. doi:10.1242/dev.083840
   PubMed Web of Science ®Google Scholar
• Huang MT, Chiu CJ, Chiang BL. Multi-faceted notch in allergic airway inflammation. Int J Mol Sci. 2019;20(14):3508. doi:10.3390/ijms20143508
   PubMed Web of Science ®Google Scholar
• Kim D, Chen Z, Zhou LF, Huang SX. Air pollutants and early origins of respiratory diseases. Chronic Dis Transl Med. 2018;4(2):75–94. doi:10.1016/j.cdtm.2018.03.003
   PubMedGoogle Scholar
• Beamer CA, Shepherd DM. Role of the aryl hydrocarbon receptor (AhR) in lung inflammation. Semin Immunopathol. 2013;35(6):693–704. doi:10.1007/s00281-013-0391-7
   PubMed Web of Science ®Google Scholar
• Chang H, Chang LW, Cheng Y-H, et al. Preferential induction of CYP1A1 and CYP1B1 in CCSP-positive cells. Toxicol Sci. 2006;89(1):205–213. doi:10.1093/toxsci/kfj025
   PubMed Web of Science ®Google Scholar
• Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol. 2003;43:309–334. doi:10.1146/annurev.pharmtox.43.100901.135828
   PubMed Web of Science ®Google Scholar
• Schmidt JV, Bradfield CA. Ah receptor signaling pathways. Annu Rev Cell Dev Biol. 1996;12(1):55–89. doi:10.1146/annurev.cellbio.12.1.55
   PubMedGoogle Scholar
• Walisser JA, Glover E, Pande K, Liss AL, Bradfield CA. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A. 2005;102(49):17858–17863. doi:10.1073/pnas.0504757102
   PubMed Web of Science ®Google Scholar
• Xing Y, Li A, Borok Z, Li C, Minoo P. NOTCH1 is required for regeneration of Clara cells during repair of airway injury. Stem Cells. 2012;30(5):946–955. doi:10.1002/stem.1059
   PubMed Web of Science ®Google Scholar
• Wong T-H, Lee C-L, Su -H-H, et al. A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. Sci Rep. 2018;8(1):5198. doi:10.1038/s41598-018-23542-9
   PubMedGoogle Scholar
• Huang B, Butler R, Miao Y, et al. Dysregulation of Notch and ERα signaling in AhR−/−male mice. Proc Natl Acad Sci U S A. 2016;113:11883–11888. doi:10.1073/pnas.1613269113
   PubMed Web of Science ®Google Scholar
• Xia M, Viera-Hutchins L, Garcia-Lloret M, et al. Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. J Allergy Clin Immunol. 2015;136(2):441–453. doi:10.1016/j.jaci.2015.02.014
   PubMed Web of Science ®Google Scholar
• Xia M, Harb H, Saffari A, Sioutas C, Chatila TA, Jagged A. 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles. J Allergy Clin Immunol. 2018;142(1243–1256):e1217. doi:10.1016/j.jaci.2018.03.009
   Google Scholar
• Stripp BR, Maxson K, Mera R, Singh G. Plasticity of airway cell proliferation and gene expression after acute naphthalene injury.. Am J Physiol. 1995;269(6 Pt 1):L791–799. doi:10.1152/ajplung.1995.269.6.L791
   PubMedGoogle Scholar
• Hiemstra PS, Bourdin A. Club cells, CC10 and self-control at the epithelial surface. Eur Respir J. 2014;44(4):831–832. doi:10.1183/09031936.00089214
   PubMed Web of Science ®Google Scholar
• Shijubo N, Itoh Y, Yamaguchi T, et al. Clara cell protein-positive epithelial cells are reduced in small airways of asthmatics. Am J Respir Crit Care Med. 1999;160(3):930–933. doi:10.1164/ajrccm.160.3.9803113
   PubMed Web of Science ®Google Scholar
• Hung C-H, Chen L-C, Zhang Z, et al. Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol. 2004;114(3):664–670. doi:10.1016/j.jaci.2004.05.042
   PubMed Web of Science ®Google Scholar
• Xu Y-D, Cui J-M, Wang Y, et al. Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset. Evid Based Complement Alternat Med. 2012;2012:850512. doi:10.1155/2012/850512
   PubMed Web of Science ®Google Scholar
• Zhao G, Lin X, Zhou M, Zhao J. Association between CC10 +38A/G polymorphism and asthma risk: a meta-analysis. Pak J Med Sci. 2013;29(6):1439–1443. doi:10.12669/pjms.296.3724
   PubMed Web of Science ®Google Scholar
• Haczku A, Cao Y, Vass G, et al. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol. 2006;176(6):3557–3565. doi:10.4049/jimmunol.176.6.3557
   PubMed Web of Science ®Google Scholar
• Brandt EB, Mingler MK, Stevenson MD, et al. Surfactant protein D alters allergic lung responses in mice and human subjects. J Allergy Clin Immunol. 2008;121(5):e1142. doi:10.1016/j.jaci.2008.02.011
   Web of Science ®Google Scholar
• Li C, Hu L, Xiao J, et al. Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol. 2005;287(1):86–97. doi:10.1016/j.ydbio.2005.08.035
   PubMed Web of Science ®Google Scholar
• Wang L-T, Chiou -S-S, Chai C-Y, et al. Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma. Oncotarget. 2017;8(5):7489–7501. doi:10.18632/oncotarget.9841
   PubMedGoogle Scholar
• van Rijt LS, Kuipers H, Vos N, et al. A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma. J Immunol Methods. 2004;288(1–2):111–121. doi:10.1016/j.jim.2004.03.004
   PubMed Web of Science ®Google Scholar
• Kujur W, Gurram RK, Haleem N, Maurya SK, Agrewala JN. Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma. Sci Rep. 2015;5(1):15396. doi:10.1038/srep15396
   PubMedGoogle Scholar