Adenosine A_2A Receptor Agonist Polydeoxyribonucleotide Alleviates Interstitial Cystitis-Induced Voiding Dysfunction by Suppressing Inflammation and Apoptosis in Rats

References

• Ahn ST, Jeong HG, Park TY, et al. Differences in urodynamic para-meters according to the presence of a Hunner lesion in women with interstitial cystitis/bladder pain syndrome. Int Neurourol J. 2018;22:S55–61. doi:10.5213/inj.1835044.522
   Google Scholar
• Akiyama Y, Luo Y, Hanno PM, et al. Interstitial cystitis/bladder pain syndrome: the evolving landscape, animal models and future perspectives. Int J Urol. 2020;27(6):491–503. doi:10.1111/iju.14229
   PubMed Web of Science ®Google Scholar
• Schrepf A, O’Donnell M, Luo Y, et al. Multidisciplinary approach to the study of chronic pelvic pain (MAPP) research network. Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: associations with painful symptoms. Pain. 2014;155(9):1755–1761. doi:10.1016/j.pain.2014.05.029
   PubMed Web of Science ®Google Scholar
• Di Capua-Sacoto C, Sanchez-Llopis A, Oconnor JE, et al. Apoptotic effect as biomarker of disease, severity and follow-up in interstitial cystitis. Actas Urol Esp. 2018;42(4):262–266. doi:10.1016/j.acuro.2017.09.007
   PubMed Web of Science ®Google Scholar
• Jiang YH, Peng CH, Liu HT, et al. Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis/bladder pain syndrome. PLoS One. 2013;8(10):e76779. doi:10.1371/journal.pone.0076779
   PubMed Web of Science ®Google Scholar
• Shahid M, Lee MY, Yeon A, et al. Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis. Sci Rep. 2018;8(1):10859. doi:10.1038/s41598-018-29085-3
   PubMedGoogle Scholar
• Luo J, Yang C, Luo X, et al. Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis. Life Sci. 2020;254:117590. doi:10.1016/j.lfs.2020.117590
   PubMed Web of Science ®Google Scholar
• Cuschieri J, Maier RV. Mitogen-activated protein kinase (MAPK). Crit Care Med. 2005;33:S417–S419. doi:10.1097/01.CCM.0000191714.39495.A6
   PubMed Web of Science ®Google Scholar
• Bradley MS, Burke EE, Grenier C, et al. A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome. Neurourol Urodyn. 2018;37(4):1485–1493. doi:10.1002/nau.23489
   PubMed Web of Science ®Google Scholar
• Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298(5600):1911–1912. doi:10.1126/science.1072682
   PubMed Web of Science ®Google Scholar
• Gantke T, Sriskantharajah S, Sadowski M, et al. IκB kinase regulation of the TPL-2/ERK MAPK pathway. Immunol Rev. 2012;246(1):168–182. doi:10.1111/j.1600-065X.2012.01104.x
   PubMedGoogle Scholar
• Marentette JO, Hauser PJ, Hurst RE, et al. Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase. PLoS One. 2013;8(7):e69948. doi:10.1371/journal.pone.0069948
   PubMed Web of Science ®Google Scholar
• Shie J-H, Liu H-T, Wang Y-S, et al. Immunohistochemical evidence suggests repeated intravesical application of botulinum toxin A injections may improve treatment efficacy of interstitial cystitis/bladder pain syndrome. BJU International. 2013;111(4):638–646. doi:10.1111/j.1464-410X.2012.11466.x
   PubMed Web of Science ®Google Scholar
• Abdel-Mageed AB, Bajwa A, Shenassa BB, et al. NF-κB-dependent gene expression of proinflammatory cytokines in T24 cells: possible role in interstitial cystitis. Urol Res. 2003;31(5):300–305. doi:10.1007/s00240-003-0339-9
   PubMedGoogle Scholar
• Zhao J, Wang L, Dong X, et al. The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis. Sci Rep. 2016;6:19670. doi:10.1038/srep19670
   PubMed Web of Science ®Google Scholar
• Shie JH, Liu HT, Kuo HC. Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome. Urology. 2012;79(2):484.e7–13. doi:10.1016/j.urology.2011.09.049
   PubMed Web of Science ®Google Scholar
• Yu W, Zacharia LC, Jackson EK, et al. Adenosine receptor expression and function in bladder uroepithelium. Am J Physiol Cell Physiol. 2006;291(2):C254–265. doi:10.1152/ajpcell.00025.2006
   PubMed Web of Science ®Google Scholar
• Guerrero A. A2A adenosine receptor agonists and their potential therapeutic applications. An update. Curr Med Chem. 2018;25(30):3597–3612. doi:10.2174/0929867325666180313110254
   PubMed Web of Science ®Google Scholar
• Sawynok J. Adenosine receptor targets for pain. Neuroscience. 2016;338:1–18. doi:10.1016/j.neuroscience.2015.10.031
   PubMed Web of Science ®Google Scholar
• Ko IG, Kim SE, Jin JJ, et al. Combination therapy with polydeoxyribonucleotide and proton pump inhibitor enhances therapeutic effectiveness for gastric ulcer in rats. Life Sci. 2018;203:12–19. doi:10.1016/j.lfs.2018.04.009
   PubMed Web of Science ®Google Scholar
• Ko I-G, Hwang JJ, Chang BS, et al. Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced acute lung injury via modulation of the MAPK/NF-κB signaling pathway in rats. Int Immunopharmacol. 2020;83:106444. doi:10.1016/j.intimp.2020.106444
   PubMed Web of Science ®Google Scholar
• Kim SE, Ko IG, Jin JJ, et al. Polydeoxyribonucleotide exerts therapeutic effect by increasing VEGF and inhibiting inflammatory cytokines in ischemic colitis rats. Biomed Res Int. 2020;21:2169083. doi:10.1155/2020/2169083
   Google Scholar
• Ko IG, Moon BM, Kim SE, et al. Effects of combination treatment of α1-adrenergic receptor antagonists on voiding dysfunction: study on target organs in overactive bladder rats. Int Neurourol J. 2016;20:S150–S158. doi:10.5213/inj.1632768.384
   PubMed Web of Science ®Google Scholar
• Park JS, Jung HD, Cho YS, et al. Neonatal bladder irritation is associated with vanilloid receptor TRPV1 expression in adult rats. Int Neurourol J. 2018;22(3):169‐176. doi:10.5213/inj.1836020.101
   Web of Science ®Google Scholar
• Li M, Han T, Zhang W, et al. Simulated altitude exercise training damages small intestinal mucosa barrier in the rats. J Exerc Rehabil. 2018;14(3):341–348. doi:10.12965/jer.1835128.064
   PubMed Web of Science ®Google Scholar
• Starkman JS, Martinez-Ferrer M, Iturregui JM, et al. Nicotinic signaling ameliorates acute bladder inflammation induced by protamine sulfate or cyclophosphamide. J Urol. 2008;179(6):2440. doi:10.1016/j.juro.2008.01.082
   PubMed Web of Science ®Google Scholar
• Cheng SF, Jiang YH, Kuo HC. Urothelial dysfunction and chronic inflammation are associated with increased bladder sensation in patients with chronic renal insufficiency. Int Neurourol J. 2018;22:S46–S54. doi:10.5213/inj.1832814.407
   PubMed Web of Science ®Google Scholar
• Song SH, Jee YS, Ko IG, et al. Treadmill exercise and wheel exercise improve motor function by suppressing apoptotic neuronal cell death in brain inflammation rats. J Exerc Rehabil. 2018;14(6):911–919. doi:10.12965/jer.1836508.254
   PubMed Web of Science ®Google Scholar
• Birder L, Andersson K-E. Animal modelling of interstitial cystitis/bladder pain syndrome. Int Neurourol J. 2018;22(Suppl 1):S3–S9. doi:10.5213/inj.1835062.531
   PubMed Web of Science ®Google Scholar
• Song PH, Chun SY, Chung JW, et al. Comparison of 5 different rat models to establish a standard animal model for research into interstitial cystitis. Int Neurourol J. 2017;21(3):163–170. doi:10.5213/inj.1734898.449
   PubMed Web of Science ®Google Scholar
• Gomez G, Sitkovsky MV. Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo. Int J Biochem Cell Biol. 2003;35(4):410–414. doi:10.1016/s1357-2725(02)00177-2
   PubMed Web of Science ®Google Scholar
• Khoa ND, Montesinos MC, Williams AJ, et al. Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. J Immunol. 2003;171(8):3991–3998. doi:10.4049/jimmunol.171.8.3991
   PubMed Web of Science ®Google Scholar
• Song J, Liu L, Li L, et al. Protective effects of lipoic acid and mesna on cyclophosphamide-induced haemorrhagic cystitis in mice. Cell Biochem Funct. 2014;32(2):125–132. doi:10.1002/cbf.2978
   PubMed Web of Science ®Google Scholar
• Li D, Zhang X, Chen B. SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells. BMC Immunol. 2015;16:73. doi:10.1186/s12865-015-0137-5
   PubMed Web of Science ®Google Scholar
• Corrow KA, Vizzard MA. Phosphorylation of extracellular signal-regulated kinases in bladder afferent pathways with cyclophosphamide-induced cystitis. Neuroscience. 2009;163(4):1353–1362. doi:10.1016/j.neuroscience.2009.07.044
   PubMed Web of Science ®Google Scholar
• Scheidereit C. IκB kinase complexes: gateways to NF-κB activation and transcription. Oncogene. 2006;25(51):6685–6705. doi:10.1038/sj.onc.1209934
   PubMed Web of Science ®Google Scholar
• Verhelst K, Carpentier I, Beyaert R. Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events. Cytokine Growth Factor Rev. 2011;22(5–6):277–286. doi:10.1016/j.cytogfr.2011.11.002
   PubMed Web of Science ®Google Scholar
• Giambelluca MS, Pouliot M. Early tyrosine phosphorylation events following adenosine A2A receptor in human neutrophils: identification of regulated pathways. J Leukoc Biol. 2017;102(3):829–836. doi:10.1189/jlb.2VMA1216-517R
   PubMed Web of Science ®Google Scholar
• Haskó G, Linden J, Cronstein B, et al. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov. 2008;7(9):759–770. doi:10.1038/nrd2638
   PubMed Web of Science ®Google Scholar
• Chera S, Ghila L, Wenger Y, Galliot B. Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration. Dev Growth Differ. 2011;53:186–201. doi:10.1111/j.1440-169X.2011.01250.x
   PubMed Web of Science ®Google Scholar
• Saban MR, O’Donnell MA, Hurst RE, et al. Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-α. BMC Immunol. 2008;9:4. doi:10.1186/1471-2172-9-4
   PubMed Web of Science ®Google Scholar