Association of a High Neutrophil-to-Lymphocyte Ratio with Hyperdense Artery Sign and Unfavorable Short-Term Outcomes in Patients with Acute Ischemic Stroke

References

• Sato S, Toyoda K, Uehara T, et al. Baseline NIH stroke scale score predicting outcome in anterior and posterior circulation strokes. Neurology. 2008;70(Issue 24, Part 2):2371–2377. doi:10.1212/01.wnl.0000304346.14354.0b
   PubMed Web of Science ®Google Scholar
• Rost NS, Bottle A, Lee JM, et al. Stroke severity is a crucial predictor of outcome: an international prospective validation study. J Am Heart Assoc. 2016;5(1):e002433. doi:10.1161/JAHA.115.002433
   PubMed Web of Science ®Google Scholar
• Barlas RS, Honney K, Loke YK, et al. Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review, and meta-analysis. J Am Heart Assoc. 2016;5(8):e003019. doi:10.1161/JAHA.115.003019
   PubMed Web of Science ®Google Scholar
• Schrock JW, Glasenapp M, Drogell K. Elevated blood urea nitrogen/creatinine ratio is associated with poor outcome in patients with ischemic stroke. Clin Neurol Neurosurg. 2012;114(7):881–884. doi:10.1016/j.clineuro.2012.01.031
   PubMed Web of Science ®Google Scholar
• Su YC, Huang KF, Yang FY, et al. Elevation of troponin I in acute ischemic stroke. PEERJ. 2016;4:e1866. doi:10.7717/peerj.1866
   PubMed Web of Science ®Google Scholar
• Massiot N, Lareyre F, Voury-Pons A, et al. High neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with symptomatic internal carotid artery stenosis. J Stroke Cerebrovas Dis. 2019;28(1):76–83. doi:10.1016/j.jstrokecerebrovasdis.2018.09.001
   PubMed Web of Science ®Google Scholar
• Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med. 2011;17(7):796–808. doi:10.1038/nm.2399
   PubMed Web of Science ®Google Scholar
• Opal SM, Esmon CT. Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis. Crit Care. 2002;7(1):23–38. doi:10.1186/cc1854.
   PubMed Web of Science ®Google Scholar
• Van der Willik KD, Fani L, Rizopoulos D, et al. Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study. J Neuroinflamm. 2019;16(1):68. doi:10.1186/s12974-019-1454-z
   PubMedGoogle Scholar
• Fang YN, Tong MS, Sung PH, et al. Higher neutrophil counts and neutrophil-to-lymphocyte ratio predict prognostic outcomes in patients after non-atrial fibrillation-caused ischemic stroke. Biomed J. 2017;40(3):154–162. doi:10.1016/j.bj.2017.03.002
   PubMed Web of Science ®Google Scholar
• Lim HH, Jeong IH, An GD, et al. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019;33(3):e22714. doi:10.1002/jcla.22714
   PubMed Web of Science ®Google Scholar
• Hirahara T, Arigami T, Yanagita S, et al. Combined neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with advanced gastric cancer. BMC Cancer. 2019;19(1):672. doi:10.1186/s12885-019-5903-y
   PubMed Web of Science ®Google Scholar
• Huszno J, Kolosza Z. Prognostic value of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratio in breast cancer patients. Oncol Lett. 2019;18(6):6275–6283. doi:10.3892/ol.2019.10966
   PubMed Web of Science ®Google Scholar
• Haridy J, Churilov L, Mitchell P, Dowling R, Yan B. Is there association between hyperdense middle cerebral artery sign on CT scan and time from stroke onset within the first 24-hours? BMC Neurol. 2015;15(1):101. doi:10.1186/s12883-015-0358-5
   PubMedGoogle Scholar
• Li Q, Davis S, Mitchell P, Dowling R, Yan B. Proximal hyperdense middle cerebral artery sign predicts poor response to thrombolysis. PLoS One. 2014;9(5):e96123. doi:10.1371/journal.pone.0096123
   PubMed Web of Science ®Google Scholar
• Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke. 1993;24(1):35–41. doi:10.1161/01.str.24.1.35
   PubMed Web of Science ®Google Scholar
• Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12(3):204–212. doi:10.1038/ni.2001
   PubMed Web of Science ®Google Scholar
• Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10(5):471–480. doi:10.1016/S1474-4422(11)70066-7
   PubMed Web of Science ®Google Scholar
• Zhang R, Wu X, Hu W, et al. Neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: a meta-analysis. Brain Behav. 2019;9(9):e01382. doi:10.1002/brb3.1382
   PubMed Web of Science ®Google Scholar
• Gökhan S, Özhasenekler A, Mansur Durgun H, et al. Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack. Eur Rev Med Pharmacol Sci. 2013;17(5):653–657.
   PubMed Web of Science ®Google Scholar
• Alshoabi SA, Alsultan KD. Hyperdense artery sign on computed tomography is extremely valuable marker of middle cerebral artery occlusion in early hemiparesis. Am J Diagn Imaging. 2020;6(1):15–17. doi:10.5455/ajdi.20190824024709
   Google Scholar
• Koo CK, Teasdale E, Muir KW. What constitutes a true hyperdense middle cerebral artery sign? Cerebrovasc Dis. 2000;10(6):419–423. doi:10.1159/000016101
   PubMed Web of Science ®Google Scholar
• Chieng JSL, Singh DR, Chawla A, Peh WCG. The hyperdense vessel sign in cerebral computed tomography: pearls and pitfalls. Singapore Med J. 2020;61(5):230–237. doi:10.11622/smedj.2020074
   PubMed Web of Science ®Google Scholar
• Liebeskind DS, Sanossian N, Yong WH, et al. CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke. 2011;42(5):1237–1243. doi:10.1161/STROKEAHA.110.605576
   PubMed Web of Science ®Google Scholar
• Froehler M, Tateshima S, Duckwiler G, et al. The hyperdense vessel sign on CT predicts successful recanalization with the merci device in acute ischemic stroke. J NeuroInterv Surg. 2013;5(4):289–293. doi:10.1136/neurintsurg-2012-010313
   PubMed Web of Science ®Google Scholar
• Jodaitis L, Ligot N, Chapusette R, Bonnet T, Gaspard N, Naeije G. The hyperdense middle cerebral artery sign in drip-and-ship models of acute stroke management. Cerebrovasc Dis Extra. 2020;10(1):36–43. doi:10.1159/000506971
   PubMed Web of Science ®Google Scholar
• Lim J, Magarik JA, Froehler MT. The CT-defined hyperdense arterial sign as a marker for acute intracerebral large vessel occlusion. J Neuroimaging. 2018;28(2):212–216. doi:10.1111/jon.12484
   PubMed Web of Science ®Google Scholar
• Zaorsky NG, Zhang Y, Tchelebi LT, et al. Stroke among cancer patients. Nat Commun. 2019;10(1):5172. doi:10.1038/s41467-019-13120-6
   PubMedGoogle Scholar
• Shi J, Peng H, You S, et al. Increase in neutrophils after recombinant tissue plasminogen activator thrombolysis predicts poor functional outcome of ischemic stroke: a longitudinal study. Eur J Neurol. 2018;25(4):687–745. doi:10.1111/ene.13575
   PubMed Web of Science ®Google Scholar