C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study

References

• Guglielmi V, Sbraccia P. Obesity phenotypes: depot-differences in adipose tissue and their clinical implications. Eat Weight Disord. 2018;23:3–14. doi:10.1007/s40519-017-0467-9
   PubMed Web of Science ®Google Scholar
• Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378:815–825. doi:10.1016/S0140-6736(11)60814-3
   PubMed Web of Science ®Google Scholar
• Dwivedi AK, Dubey P, Cistola DP, Reddy SY. Association between obesity and cardiovascular outcomes: updated evidence from meta-analysis studies. Curr Cardiol Rep. 2020;22:25. doi:10.1007/s11886-020-1273-y
   PubMed Web of Science ®Google Scholar
• World Health Organization. http://www.who.int/mediacentre/factsheets/fs311/en/.
   Google Scholar
• Liu X, Wu W, Mao Z, et al. Prevalence and influencing factors of overweight and obesity in a Chinese rural population: the Henan Rural Cohort Study. Sci Rep. 2018;8:13101. doi:10.1038/s41598-018-31336-2
   PubMed Web of Science ®Google Scholar
• Keaver L, Webber L, Dee A, Shiely F, Marsh T, Balanda K. Application of the UK foresight obesity model in Ireland: the health and economic consequences of projected obesity trends in Ireland. PLoS One. 2013;8:e79827. doi:10.1371/journal.pone.0079827
   PubMed Web of Science ®Google Scholar
• Federation ID: The IDF consensus worldwide definition of the metabolic syndrome. 2006.
   Google Scholar
• Srinivasan SR, Wang R, Chen W, Wei CY, Xu J, Berenson GS. Utility of waist-to-height ratio in detecting central obesity and related adverse cardiovascular risk profile among normal weight younger adults (from the Bogalusa Heart Study). Am J Cardiol. 2009;104:721–724. doi:10.1016/j.amjcard.2009.04.037
   PubMed Web of Science ®Google Scholar
• Chen C, Lu FC. Department of Disease Control Ministry of Health PRC: the guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2004;17:Suppl:1–36.
   Google Scholar
• Organization WH. Waist Circumference and Waist-Hip Ratio Report of a WHO Expert Consultation. Geneva; 2008.
   Google Scholar
• Fu W, Cao S, Liu B, et al. Association of general and central adiposity with blood pressure among Chinese adults: results from the China National Stroke Prevention Project. J Hypertens. 2018;36:2406–2413. doi:10.1097/HJH.0000000000001852
   PubMed Web of Science ®Google Scholar
• Bragg F, Tang K, Guo Y, et al. Associations of general and central adiposity with incident diabetes in Chinese men and women. Diabetes Care. 2018;41:494–502. doi:10.2337/dc17-1852
   PubMed Web of Science ®Google Scholar
• Dale CE, Fatemifar G, Palmer TM, et al. Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes, and Type 2 diabetes mellitus: a mendelian randomization analysis. Circulation. 2017;135(24):2373–2388. doi:10.1161/CIRCULATIONAHA.116.026560
   PubMed Web of Science ®Google Scholar
• Campbell SE, Febbraio MA. Effects of ovarian hormones on exercise metabolism. Curr Opin Clin Nutr Metab Care. 2001;4:515–520. doi:10.1097/00075197-200111000-00009
   PubMed Web of Science ®Google Scholar
• Mayes JS, Watson GH. Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev. 2004;5(4):197–216. doi:10.1111/j.1467-789X.2004.00152.x
   PubMedGoogle Scholar
• Gray JM, George WN. Cytoplasmic progestin binding in rat adipose tissues. Endocrinology. 1979;104(5):1377–1382. doi:10.1210/endo-104-5-1377
   PubMed Web of Science ®Google Scholar
• Esfahlan RJ, Zarghami N, Esfahlan AJ, Mollazadeh M, Nejati K, Nasiri M. The possible impact of obesity on androgen, progesterone and estrogen receptors (ERalpha and ERbeta) gene expression in breast cancer patients. Breast Cancer (Auckl). 2011;5:227–237. doi:10.4137/BCBCR.S7707
   PubMedGoogle Scholar
• Clark MK, Dillon JS, Sowers M, Nichols S. Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception. Int J Obes (Lond). 2005;29:1252–1258. doi:10.1038/sj.ijo.0803023
   PubMed Web of Science ®Google Scholar
• Blanchette S, Marceau P, Biron S, Brochu G, Tchernof A. Circulating progesterone and obesity in men. Horm Metab Res. 2006;38:330–335. doi:10.1055/s-2006-925392
   PubMed Web of Science ®Google Scholar
• Goh JY, He S, Allen JC, Malhotra R, Tan TC. Maternal obesity is associated with a low serum progesterone level in early pregnancy. Horm Mol Biol Clin Investig. 2016;27:97–100. doi:10.1515/hmbci-2015-0030
   PubMed Web of Science ®Google Scholar
• Moutachakkir M, Lamrani Hanchi A, Baraou A, Boukhira A, Chellak S. Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein. Ann Biol Clin (Paris). 2017;75:225–229. doi:10.1684/abc.2017.1232
   PubMed Web of Science ®Google Scholar
• Gaskins AJ, Wilchesky M, Mumford SL, et al. Endogenous reproductive hormones and C-reactive protein across the menstrual cycle: the BioCycle Study. Am J Epidemiol. 2012;175:423–431. doi:10.1093/aje/kwr343
   PubMed Web of Science ®Google Scholar
• Reuben DB, Palla SL, Hu P, et al. Progestins affect mechanism of estrogen-induced C-reactive protein stimulation. Am J Med. 2006;119:167 e161–168. doi:10.1016/j.amjmed.2005.08.012
   Google Scholar
• Black S, Kushner I, Samols D. C-reactive Protein. J Biol Chem. 2004;279:48487–48490. doi:10.1074/jbc.R400025200
   PubMed Web of Science ®Google Scholar
• Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96:939–949. doi:10.1161/01.RES.0000163635.62927.34
   PubMed Web of Science ®Google Scholar
• Fearnley GR, Chakrabarti R, Avis PRD. Blood fibrinolytic activity in diabetes mellitus and its bearing on ischaemic heart disease and obesity. Br Med J. 1963;1:921–923. doi:10.1136/bmj.1.5335.921
   PubMedGoogle Scholar
• Liu X, Mao Z, Li Y, et al. Cohort Profile: the Henan Rural Cohort: a prospective study of chronic non-communicable diseases. Int J Epidemiol. 2019;48:1756–1756j. doi:10.1093/ije/dyz039
   PubMed Web of Science ®Google Scholar
• Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511. doi:10.1161/01.CIR.0000052939.59093.45
   PubMed Web of Science ®Google Scholar
• Society CN. The Dietary Guidelines for Chinese Residents. The Tibet People’s Publishing House. Lhasa; 2011.
   Google Scholar
• China WGoOi. Guidelines for prevention and control of overweight and obesity in chinese adults. Acta Nutrimenta Sinica. 2004;26.
   Google Scholar
• Glisic M, Shahzad S, Tsoli S, et al. Association between progestin-only contraceptive use and cardiometabolic outcomes: a systematic review and meta-analysis. Eur J Prev Cardiol. 2018;25:1042–1052. doi:10.1177/2047487318774847
   PubMed Web of Science ®Google Scholar
• Vanderweele TJ, Vansteelandt S. Odds ratios for mediation analysis for a dichotomous outcome. Am J Epidemiol. 2010;172:1339–1348. doi:10.1093/aje/kwq332
   PubMed Web of Science ®Google Scholar
• Genazzani AR, Petraglia F, Bernardi F, et al. Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences. J Clin Endocrinol Metab. 1998;83:2099–2103. doi:10.1210/jcem.83.6.4905
   PubMed Web of Science ®Google Scholar
• Wu Y, Potempa LA, El Kebir D, Filep JG. C-reactive protein and inflammation: conformational changes affect function. Biol Chem. 2015;396:1181–1197.
   PubMed Web of Science ®Google Scholar
• Sudhakar M, Silambanan S, Chandran AS, Prabhakaran AA, Ramakrishnan R. C-Reactive Protein (CRP) and leptin receptor in obesity: binding of monomeric crp to leptin receptor. Front Immunol. 2018;9:1167. doi:10.3389/fimmu.2018.01167
   PubMed Web of Science ®Google Scholar
• Freeman DJ, Norrie J, Caslake MJ, et al. West of Scotland Coronary Prevention S: c-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes. 2002;51:1596–1600. doi:10.2337/diabetes.51.5.1596
   PubMed Web of Science ®Google Scholar
• Meisel P, Eremenko M, Holtfreter B, Volzke H, Kocher T. The sex paradox in the interplay between periodontitis, obesity, and serum C-reactive protein: data from a general population. J Periodontol. 2019;90:1365–1373. doi:10.1002/JPER.18-0733
   PubMed Web of Science ®Google Scholar
• Ebrahimi M, Heidari-Bakavoli AR, Shoeibi S, et al. Association of Serum hs-CRP levels with the presence of obesity, diabetes mellitus, and other cardiovascular risk factors. J Clin Lab Anal. 2016;30(5):672–676. doi:10.1002/jcla.21920
   PubMed Web of Science ®Google Scholar
• Bochud M, Marquant F, Marques-Vidal PM, et al. Association between C-reactive protein and adiposity in women. J Clin Endocrinol Metab. 2009;94:3969–3977. doi:10.1210/jc.2008-2428
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord. 2003;27(Suppl 3):S53–55. doi:10.1038/sj.ijo.0802502
   PubMed Web of Science ®Google Scholar
• Nieto-Vazquez I, Fernandez-Veledo S, Kramer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo M. Insulin resistance associated to obesity: the link TNF-alpha. Arch Physiol Biochem. 2008;114(3):183–194. doi:10.1080/13813450802181047
   PubMedGoogle Scholar
• Kovacs A, Green F, Hansson LO, et al. A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. Atherosclerosis. 2005;178:193–198. doi:10.1016/j.atherosclerosis.2004.08.018
   PubMed Web of Science ®Google Scholar
• Kim KA. Recent progress in research on beta-cell apoptosis by cytokines. Front Biosci (Landmark Ed). 2009;14:657–664. doi:10.2741/3271
   PubMed Web of Science ®Google Scholar
• Novotny GW, Lundh M, Backe MB, et al. Transcriptional and translational regulation of cytokine signaling in inflammatory beta-cell dysfunction and apoptosis. Arch Biochem Biophys. 2012;528:171–184. doi:10.1016/j.abb.2012.09.014
   PubMed Web of Science ®Google Scholar
• Ndumele CE, Pradhan AD, Ridker PM. Interrelationships between inflammation, C-reactive protein, and insulin resistance. J Cardiometab Syndr. 2006;1:190–196. doi:10.1111/j.1559-4564.2006.05538.x
   PubMedGoogle Scholar
• Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286:327–334. doi:10.1001/jama.286.3.327
   PubMed Web of Science ®Google Scholar
• Barazzoni R, Gortan Cappellari G, Ragni M, Nisoli E. Insulin resistance in obesity: an overview of fundamental alterations. Eat Weight Disord. 2018;23:149–157. doi:10.1007/s40519-018-0481-6
   PubMed Web of Science ®Google Scholar
• Brismar K, Nilsson SE. Interrelations and associations of serum levels of steroids and pituitary hormones with markers of insulin resistance, inflammatory activity, and renal function in men and women aged >70 years in an 8-year longitudinal study of opposite-sex twins.. Gend Med. 2009;6(Suppl 1):123–136. doi:10.1016/j.genm.2009.01.001
   PubMedGoogle Scholar
• Wander K, Brindle E, O’Connor KA. C-reactive protein across the menstrual cycle. Am J Phys Anthropol. 2008;136:138–146. doi:10.1002/ajpa.20785
   PubMed Web of Science ®Google Scholar
• Walsh BW, Paul S, Wild RA, Dean RA, Tracy RP, Cox DA. The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: a randomized, controlled trial. J Clin Endocrinol Metab. 2000;85:214–218. doi:10.1210/jcem.85.1.6326
   PubMed Web of Science ®Google Scholar
• Bouman A, Heineman MJ, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update. 2005;11:411–423. doi:10.1093/humupd/dmi008
   PubMed Web of Science ®Google Scholar
• Bain BJ, England JM. Variations in leucocyte count during menstrual cycle. Br Med J. 1975;2:473–475. doi:10.1136/bmj.2.5969.473
   PubMedGoogle Scholar
• Molloy EJ, O’Neill AJ, Grantham JJ, Sheridan-Pereira M, Fitzpatrick JM, Webb DW. Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone. Blood. 2003;102:2653–2659. doi:10.1182/blood-2003-02-0649
   PubMed Web of Science ®Google Scholar
• Manson JE, Hsia J, Johnson KC, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349:523–534. doi:10.1056/NEJMoa030808
   PubMed Web of Science ®Google Scholar
• Ishii S, Karlamangla AS, Bote M, Irwin MR, Jacobs DRJr, Cho HJ. Gender, obesity and repeated elevation of C-reactive protein: data from the CARDIA cohort. PLoS One. 2012;7:e36062. doi:10.1371/journal.pone.0036062
   PubMed Web of Science ®Google Scholar
• Nilsson SE, Fransson E, Brismar K. Relationship between serum progesterone concentrations and cardiovascular disease, diabetes, and mortality in elderly Swedish men and women: an 8-year prospective study. Gend Med. 2009;6:433–443. doi:10.1016/j.genm.2009.09.011
   PubMedGoogle Scholar