87
Views
4
CrossRef citations to date
0
Altmetric
Original Research

The Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study

ORCID Icon, ORCID Icon, , , , , , ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 995-1005 | Published online: 22 Mar 2021

References

  • Mills LA, Aitken SA, Simpson A. The risk of non-union per fracture: current myths and revised figures from a population of over 4 million adults. Acta Orthop. 2017;88(4):434–439. doi:10.1080/17453674.2017.1321351
  • Amin S, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd. Trends in fracture incidence: a population-based study over 20 years. J Bone Miner Res. 2014;29(3):581–589. doi:10.1002/jbmr.2072
  • Giannoudis PV, Harwood PJ, Tosounidis T, Kanakaris NK. Restoration of long bone defects treated with the induced membrane technique: protocol and outcomes. Injury. 2016;47(Suppl 6):S53–S61. doi:10.1016/S0020-1383(16)30840-3
  • Helbig L, Bechberger M, Aldeeri R, et al. Initial peri- and postoperative antibiotic treatment of infected nonunions: results from 212 consecutive patients after mean follow-up of 34 months. Ther Clin Risk Manag. 2018;14:59–67. doi:10.2147/TCRM.S152008
  • Moghaddam A, Thaler B, Bruckner T, Tanner M, Schmidmaier G. Treatment of atrophic femoral non-unions according to the diamond concept: results of one- and two-step surgical procedure. J Orthop. 2017;14(1):123–133. doi:10.1016/j.jor.2016.10.003
  • Moghaddam A, Zietzschmann S, Bruckner T, Schmidmaier G. Treatment of atrophic tibia non-unions according to ‘diamond concept’: results of one- and two-step treatment. Injury. 2015;46(Suppl 4):S39–50. doi:10.1016/S0020-1383(15)30017-6
  • Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007;38(Suppl 4):S3–6. doi:10.1016/S0020-1383(08)70003-2
  • Hannouche D, Petite H, Sedel L. Current trends in the enhancement of fracture healing. J Bone Joint Surg Br. 2001;83(2):157–164. doi:10.1302/0301-620X.83B2.0830157
  • Schmidmaier G, Moghaddam A. Long bone nonunion. Z Orthop Unfall. 2015;153(6):659–674. (). doi:10.1055/s-0035-1558259
  • Haubruck P, Ober J, Heller R, Miska M, Schmidmaier G, Tanner MC. Complications and risk management in the use of the reaming-irrigator-aspirator (RIA) system: RIA is a safe and reliable method in harvesting autologous bone graft. PLoS One. 2018;13(4):e0196051. doi:10.1371/journal.pone.0196051
  • Mills L, Tsang J, Hopper G, Keenan G, Simpson AH. The multifactorial aetiology of fracture nonunion and the importance of searching for latent infection. Bone Joint Res. 2016;5(10):512–519. doi:10.1302/2046-3758.510.BJR-2016-0138
  • Fischer C, Preuss EM, Tanner M, et al. Dynamic contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging for preoperative diagnosis of infected nonunions. J Ultrasound Med. 2016;35(5):933–942. doi:10.7863/ultra.15.06107
  • Haubruck P, Heller R, Tanner MC, et al. A preliminary study of contrast-enhanced ultrasound (CEUS) and cytokine expression analysis (CEA) as early predictors for the outcome of tibial non-union therapy. Diagnostics (Basel). 2018;8(3). doi:10.3390/diagnostics8030055.
  • Giannoudis PV, Einhorn TA, Schmidmaier G, Marsh D. The diamond concept–open questions. Injury. 2008;39(Suppl 2):S5–8. doi:10.1016/S0020-1383(08)70010-X
  • Masquelet AC, Begue T. The concept of induced membrane for reconstruction of long bone defects. Orthop Clin North Am. 2010;41(1):27–37. doi:10.1016/j.ocl.2009.07.011
  • Tanner M, Vlachopoulos W, Findeisen S, et al. Does age influence the outcome of lower limb non-union treatment? A matched pair analysis. J Clin Med. 2019;8(9):9. doi:10.3390/jcm8091276
  • Calori GM, Giannoudis PV. Enhancement of fracture healing with the diamond concept: the role of the biological chamber. Injury. 2011;42(11):1191–1193. doi:10.1016/j.injury.2011.04.016
  • Giannoudis PV, Faour O, Goff T, Kanakaris N, Dimitriou R. Masquelet technique for the treatment of bone defects: tips-tricks and future directions. Injury. 2011;42(6):591–598. doi:10.1016/j.injury.2011.03.036
  • Gugala Z, Gogolewski S. Healing of critical-size segmental bone defects in the sheep tibiae using bioresorbable polylactide membranes. Injury. 2002;33:71–76. doi:10.1016/S0020-1383(02)00135-3
  • Pelissier P, Masquelet AC, Bareille R, Pelissier SM, Amedee J. Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res. 2004;22(1):73–79. doi:10.1016/S0736-0266(03)00165-7
  • Raven TF, Moghaddam A, Ermisch C, et al. Use of Masquelet technique in treatment of septic and atrophic fracture nonunion. Injury. 2019;50:40–54. doi:10.1016/j.injury.2019.06.018
  • Dapunt U, Spranger O, Gantz S, et al. Are atrophic long-bone nonunions associated with low-grade infections? Ther Clin Risk Manag. 2015;11:1843–1852. doi:10.2147/TCRM.S91532
  • Team RDC, Liverani S, Richardson S. R: a language and environment for statistical computing. R Found Stat Comput. 2015;25(5):1. doi:10.1007/s11222-014-9471-3
  • Wickham H, Wickham MH. Package ‘tidyr’. Easily Tidy Data with’spread’and’gather ()’Functions. 2017.
  • Wickham H, Francois R, Henry L, Müller K. dplyr: a grammar of data manipulation. R Package Version. 2015;3.
  • Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform. 2011;12(1):77. doi:10.1186/1471-2105-12-77
  • Wickham H. Ggplot2: Elegant Graphics for Data Analysis. R Package Version 2.1.0. New York: Springer-Verlag; 2009.
  • Moghaddam A, Heller R, Daniel V, et al. Exploratory study to suggest the possibility of MMP-8 and MMP-9 serum levels as early markers for remission after traumatic spinal cord injury. Spinal Cord. 2016.
  • Moghaddam A, Sperl A, Heller R, et al. Elevated serum insulin-like growth factor 1 levels in patients with neurological remission after traumatic spinal cord injury. PLoS One. 2016;11(7):e0159764. doi:10.1371/journal.pone.0159764
  • Boschloo RD. Raised conditional level of significance for the 2 × 2-table when testing the equality of two probabilities. Statistica Neerlandica. 1970;24(1):1–9. doi:10.1111/j.1467-9574.1970.tb00104.x
  • Ripley B, Venebles B, Bates D, Hornik K, Gebhardt A, Firth D. Package ‘MASS’. Support Functions and Datasets for Venables and Ripley’s MASS Web site. 2013.
  • Lumley T. Regression Subset Selection. Fortran code by Alan Miller Web site. 2013.
  • DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837–845. doi:10.2307/2531595
  • Takamoto M, Takechi M, Ohta K, et al. Risk of bacterial contamination of bone harvesting devices used for autogenous bone graft in implant surgery. Head Face Med. 2013;9(1):3. doi:10.1186/1746-160X-9-3
  • Lee FH, Shen PC, Jou IM, Li CY, Hsieh JL. A population-based 16-year study on the risk factors of surgical site infection in patients after bone grafting: a cross-sectional study in Taiwan. Medicine (Baltimore). 2015;94(47):e2034. doi:10.1097/MD.0000000000002034
  • Flierl MA, Smith WR, Mauffrey C, et al. Outcomes and complication rates of different bone grafting modalities in long bone fracture nonunions: a retrospective cohort study in 182 patients. J Orthop Surg Res. 2013;8:33. doi:10.1186/1749-799X-8-33
  • Moghaddam A, Ermisch C, Fischer C, Zietzschmann S, Schmidmaier G. Tibiadefekt- und Infektpseudarthrosen. Der Orthopäde. 2017;46(3):263–274. doi:10.1007/s00132-016-3305-2
  • Kanakaris NK, Tosounidis TH, Giannoudis PV. Surgical management of infected non-unions: an update. Injury. 2015;46(Suppl 5):S25–32. doi:10.1016/j.injury.2015.08.009
  • Giannoudis PV, Gudipati S, Harwood P, Kanakaris NK. Long bone non-unions treated with the diamond concept: a case series of 64 patients. Injury. 2015;46(Suppl 8):S48–54. doi:10.1016/S0020-1383(15)30055-3
  • Giannoudis PV, Kanakaris NK, Dimitriou R, Gill I, Kolimarala V, Montgomery RJ. The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions. Clin Orthop Relat Res. 2009;467(12):3239–3248. doi:10.1007/s11999-009-0846-2
  • Gardner ID. The effect of aging on susceptibility to infection. Rev Infect Dis. 1980;2(5):801–810. doi:10.1093/clinids/2.5.801
  • Dobner J, Kaser S. Body mass index and the risk of infection - from underweight to obesity. Clin Microbiol Infect. 2018;24(1):24–28. doi:10.1016/j.cmi.2017.02.013
  • Hodgson K, Morris J, Bridson T, Govan B, Rush C, Ketheesan N. Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections. Immunology. 2015;144(2):171–185. doi:10.1111/imm.12394
  • Bariteau JT, Waryasz GR, McDonnell M, Fischer SA, Hayda RA, Born CT. Fungal osteomyelitis and septic arthritis. J Am Acad Orthop Surg. 2014;22(6):390–401. doi:10.5435/JAAOS-22-06-390
  • Corr PD. Musculoskeletal fungal infections. Semin Musculoskelet Radiol. 2011;15(5):506–510. doi:10.1055/s-0031-1293496
  • Fiebig L, Hauer B, Brodhun B, Altmann D, Haas W. Tuberculosis in Germany: a declining trend coming to an end? Eur Respir J. 2016;47(2):667–670. doi:10.1183/13993003.01410-2015