Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study

References

• Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–1330. doi:10.1136/annrheumdis-2013-204763
   PubMed Web of Science ®Google Scholar
• Storheim K, Zwart JA. Musculoskeletal disorders and the Global Burden of Disease study. Ann Rheum Dis. 2014;73(6):949–950. doi:10.1136/annrheumdis-2014-205327
   PubMed Web of Science ®Google Scholar
• Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745–1759. doi:10.1016/S0140-6736(19)30417-9
   PubMed Web of Science ®Google Scholar
• Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheum Dis Clin North Am. 2013;39(1):1–19. doi:10.1016/j.rdc.2012.10.004
   PubMed Web of Science ®Google Scholar
• Huey DJ, Hu JC, Athanasiou KA. Unlike bone, cartilage regeneration remains elusive. Science. 2012;338(6109):917–921. doi:10.1126/science.1222454
   PubMed Web of Science ®Google Scholar
• Djouad F, Bouffi C, Ghannam S, Noel D, Jorgensen C. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol. 2009;5(7):392–399. doi:10.1038/nrrheum.2009.104
   PubMed Web of Science ®Google Scholar
• Johnson K, Zhu S, Tremblay MS, et al. A stem cell-based approach to cartilage repair. Science. 2012;336(6082):717–721. doi:10.1126/science.1215157
   PubMed Web of Science ®Google Scholar
• Gossec L, Paternotte S, Maillefert JF, et al. The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT task force on total joint replacement. Osteoarthritis Cartilage. 2011;19(2):147–154. doi:10.1016/j.joca.2010.10.025
   PubMed Web of Science ®Google Scholar
• Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology. 2005;44(1):7–16. doi:10.1093/rheumatology/keh344
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 2005;52(1):128–135. doi:10.1002/art.20776
   PubMed Web of Science ®Google Scholar
• Santangelo KS, Nuovo GJ, Bertone AL. In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthritis Cartilage. 2012;20(12):1610–1618. doi:10.1016/j.joca.2012.08.011
   PubMed Web of Science ®Google Scholar
• Loeser RF. Molecular mechanisms of cartilage destruction in osteoarthritis. J Musculoskelet Neuronal Interact. 2008;8(4):303–306.
   PubMedGoogle Scholar
• Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23(5):471–478. doi:10.1097/BOR.0b013e328349c2b1
   PubMed Web of Science ®Google Scholar
• Jotanovic Z, Mihelic R, Sestan B, Dembic Z. Role of interleukin-1 inhibitors in osteoarthritis: an evidence-based review. Drugs Aging. 2012;29(5):343–358. doi:10.2165/11599350-000000000-00000
   PubMed Web of Science ®Google Scholar
• Kerkhof HJM, Doherty M, Arden NK, et al. Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. Osteoarthritis Cartilage. 2011;19(3):265–271. doi:10.1016/j.joca.2010.12.003
   PubMed Web of Science ®Google Scholar
• Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-kappaB: its role in health and disease. J Mol Med (Berl). 2004;82(7):434–448. doi:10.1007/s00109-004-0555-y
   PubMed Web of Science ®Google Scholar
• Moynagh PN. The NF-kappaB pathway. J Cell Sci. 2005;118(Pt 20):4589–4592. doi:10.1242/jcs.02579
   PubMedGoogle Scholar
• Zhuang Z, Ye G, Huang B. Kaempferol alleviates the interleukin-1β-induced inflammation in rat osteoarthritis chondrocytes via suppression of NF-κB. Med Sci Monit. 2017;23:3925–3931. doi:10.12659/MSM.902491
   PubMed Web of Science ®Google Scholar
• Qian Y-Q, Feng Z-H, Li X-B, et al. Downregulating PI3K/Akt/NF-κB signaling with allicin for ameliorating the progression of osteoarthritis: in vitro and vivo studies. Food Funct. 2018;9(9):4865–4875. doi:10.1039/C8FO01095A
   PubMed Web of Science ®Google Scholar
• Saha S, Buttari B, Panieri E, Profumo E, Saso L. An overview of Nrf2 signaling pathway and its role in inflammation. Molecules. 2020;25(22):5474.
   PubMed Web of Science ®Google Scholar
• Fang J, Yan Y, Teng X, et al. Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress. Aging (Albany NY). 2018;10(10):2954–2972. doi:10.18632/aging.101602
   PubMedGoogle Scholar
• Tang S, Tang Q, Jin J, et al. Polydatin inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis. Food Funct. 2018;9(3):1701–1712. doi:10.1039/C7FO01555K
   PubMed Web of Science ®Google Scholar
• Kong P, Chen G, Jiang A, et al. Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway. Oncotarget. 2016;7(50):83720–83726. doi:10.18632/oncotarget.13360
   PubMedGoogle Scholar
• Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol. 2011;12(8):715–723. doi:10.1038/ni.2060
   PubMed Web of Science ®Google Scholar
• Na H-K, Surh Y-J. Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1. Free Radic Biol Med. 2014;67:353–365. doi:10.1016/j.freeradbiomed.2013.10.819
   PubMed Web of Science ®Google Scholar
• Shao Z-X, Wang B, Shi F-Y, et al. Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. Osteoarthritis Cartilage. 2021;29(3):413–422.
   PubMed Web of Science ®Google Scholar
• Tang Q, Feng Z-H, Tong M-J, et al. Piceatannol inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2. Food Funct. 2017;8(11):3926–3937. doi:10.1039/C7FO00822H
   PubMed Web of Science ®Google Scholar
• He M, Min JW, Kong WL, He XH, Li JX, Peng BW. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016;115:74–85. doi:10.1016/j.fitote.2016.09.011
   PubMed Web of Science ®Google Scholar
• Liu S, Zhang X, Wang J. Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses. Int Immunopharmacol. 2020;83:106437. doi:10.1016/j.intimp.2020.106437
   PubMed Web of Science ®Google Scholar
• Lin CM, Huang ST, Liang YC, et al. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Planta Med. 2005;71(8):748–753. doi:10.1055/s-2005-871287
   PubMed Web of Science ®Google Scholar
• Lv H, Yu Z, Zheng Y, et al. Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. Int J Biol Sci. 2016;12(1):72–86. doi:10.7150/ijbs.13188
   PubMed Web of Science ®Google Scholar
• Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9):e45–e45. doi:10.1093/nar/29.9.e45
   PubMed Web of Science ®Google Scholar
• Tsou H, MacEwan G, Birnberg G, et al. Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg Med Chem Lett. 2010;20(7):2321–2325. doi:10.1016/j.bmcl.2010.01.135
   PubMed Web of Science ®Google Scholar
• Tu M, Liu H, Zhang R, et al. Analysis and evaluation of the inhibitory mechanism of a novel angiotensin-I-converting enzyme inhibitory peptide derived from casein hydrolysate. J Agric Food Chem. 2018;66(16):4139–4144. doi:10.1021/acs.jafc.8b00732
   PubMed Web of Science ®Google Scholar
• Shao Z, Pan Z, Lin J, et al. S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway. Aging (Albany NY). 2020;12(19):19254–19272. doi:10.18632/aging.103757
   PubMedGoogle Scholar
• Guimarães CC, Oliveira DD, Valdevite M, et al. The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity. Food Chem Toxicol. 2015;86:88–94. doi:10.1016/j.fct.2015.09.002
   PubMed Web of Science ®Google Scholar
• Liu B, Huang B, Hu G, et al. Isovitexin-mediated regulation of microglial polarization in lipopolysaccharide-induced neuroinflammation via activation of the CaMKKβ/AMPK-PGC-1α signaling axis. Front Immunol. 2019;10:2650. doi:10.3389/fimmu.2019.02650
   PubMed Web of Science ®Google Scholar
• Liang X, Xu C, Cao X, Wang W. Isovitexin suppresses cancer stemness property and induces apoptosis of osteosarcoma cells by disruption of the DNMT1/miR-34a/Bcl-2 axis. Cancer Manag Res. 2019;11:8923–8936. doi:10.2147/CMAR.S222708
   PubMed Web of Science ®Google Scholar
• Lv SX, Qiao X. Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. Biochem Biophys Res Commun. 2018;496(4):1047–1054. doi:10.1016/j.bbrc.2018.01.111
   PubMed Web of Science ®Google Scholar
• Qiu Y-B, Cao X-C, Liu L-H, et al. Modulation of MnSOD and FoxM1 is involved in invasion and EMT suppression by isovitexin in hepatocellular carcinoma cells. Cancer Manag Res. 2020;12:5759–5771. doi:10.2147/CMAR.S245283
   PubMed Web of Science ®Google Scholar
• Hu Z-C, Gong L-F, Li X-B, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: in vitro and in vivo studies. J Cell Physiol. 2019;234(5):6940–6950. doi:10.1002/jcp.27437
   PubMed Web of Science ®Google Scholar
• Fu X, Gong L-F, Wu Y-F, et al. Urolithin A targets the PI3K/Akt/NF-κB pathways and prevents IL-1β-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies. Food Funct. 2019;10(9):6135–6146. doi:10.1039/C9FO01332F
   PubMed Web of Science ®Google Scholar
• Zhang C, Shao Z, Hu X, et al. Inhibition of PI3K/Akt/NF-κB signaling by aloin for ameliorating the progression of osteoarthritis: in vitro and in vivo studies. Int Immunopharmacol. 2020;89(PtB):107079. doi:10.1016/j.intimp.2020.107079
   PubMedGoogle Scholar
• Hu JJ, Wang H, Pan CW, Lin MX. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. Microb Pathog. 2018;119:86–92. doi:10.1016/j.micpath.2018.03.053
   PubMed Web of Science ®Google Scholar