Anti-TWEAK Antibody Alleviates Renal Interstitial Fibrosis by Increasing PGC-1α Expression in Lupus Nephritis

References

• Fornoni A, Merscher S. Lipid metabolism gets in a JAML during kidney disease. Cell Metab. 2020;32(6):903–905. doi:10.1016/j.cmet.2020.11.002
   PubMed Web of Science ®Google Scholar
• Fu Y, Sun Y, Wang M, et al. Elevation of JAML Promotes diabetic kidney disease by modulating podocyte lipid metabolism. Cell Metab. 2020;32(6):1052–1062.e8. doi:10.1016/j.cmet.2020.10.019
   Web of Science ®Google Scholar
• Pei K, Gui T, Li C, et al. Recent progress on lipid intake and chronic kidney disease. Biomed Res Int. 2020;2020:3680397. doi:10.1155/2020/3680397
   PubMed Web of Science ®Google Scholar
• Ke Q, Yuan Q, Qin N, et al. UCP2-induced hypoxia promotes lipid accumulation and tubulointerstitial fibrosis during ischemic kidney injury. Cell Death Dis. 2020;11(1):26. doi:10.1038/s41419-019-2219-4
   PubMed Web of Science ®Google Scholar
• Declèves AE, Zolkipli Z, Satriano J, et al. Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury. Kidney Int. 2014;85(3):611–623. doi:10.1038/ki.2013.462
   PubMed Web of Science ®Google Scholar
• Du XG, Ruan XZ. Lipid metabolism disorder and renal fibrosis. Adv Exp Med Biol. 2019;1165:525–541. doi:10.1007/978-981-13-8871-2_26
   PubMed Web of Science ®Google Scholar
• Kang HM, Ahn SH, Choi P, et al. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med. 2015;21(1):37–46. doi:10.1038/nm.3762
   PubMed Web of Science ®Google Scholar
• Calvo JA, Daniels TG, Wang X, et al. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985). 2008;104(5):1304–1312. doi:10.1152/japplphysiol.01231.2007
   PubMed Web of Science ®Google Scholar
• Chambers JM, Wingert RA. PGC-1α in disease: recent renal insights into a versatile metabolic regulator. Cells. 2020;9:10. doi:10.3390/cells9102234
   Web of Science ®Google Scholar
• Tadaishi M, Miura S, Kai Y, Kano Y, Oishi Y, Ezaki O. Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. PLoS One. 2011;6(12):e28290. doi:10.1371/journal.pone.0028290
   PubMed Web of Science ®Google Scholar
• Feng X, Pan W, Liu L, et al. Prognosis for hospitalized patients with systemic lupus erythematosus in China: 5-year update of the jiangsu cohort. PLoS One. 2016;11(12):e0168619. doi:10.1371/journal.pone.0168619
   PubMed Web of Science ®Google Scholar
• Liu Z, Xue L, Liu Z, et al. Tumor Necrosis factor-like weak inducer of apoptosis accelerates the progression of renal fibrosis in lupus nephritis by activating SMAD and p38 MAPK in TGF-β1 signaling pathway. Mediators Inflamm. 2016;2016:8986451. doi:10.1155/2016/8986451
   PubMed Web of Science ®Google Scholar
• Michaelson JS, Wisniacki N, Burkly LC, Putterman C. Role of TWEAK in lupus nephritis: a bench-to-bedside review. J Autoimmun. 2012;39(3):130–142. doi:10.1016/j.jaut.2012.05.003
   PubMed Web of Science ®Google Scholar
• Zhao Z, Burkly LC, Campbell S, et al. TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol. 2007;179(11):7949–7958. doi:10.4049/jimmunol.179.11.7949
   PubMed Web of Science ®Google Scholar
• Sanz AB, Izquierdo MC, Sanchez-Niño MD, et al. TWEAK and the progression of renal disease: clinical translation. Nephrol Dial Transplant. 2014;29(Suppl 1):i54–54i62. doi:10.1093/ndt/gft342
   Google Scholar
• Xia Y, Herlitz LC, Gindea S, et al. Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis. J Am Soc Nephrol. 2015;26(5):1053–1070. doi:10.1681/ASN.2014030233
   PubMed Web of Science ®Google Scholar
• Xia Y, Campbell SR, Broder A, et al. Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis. Clin Immunol. 2012;145(2):108–121. doi:10.1016/j.clim.2012.08.008
   PubMed Web of Science ®Google Scholar
• Shi J, Jiang B, Qiu Y, et al. PGC1α plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One. 2013;8(1):e54054. doi:10.1371/journal.pone.0054054
   PubMed Web of Science ®Google Scholar
• Hindi SM, Mishra V, Bhatnagar S, et al. Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program. FASEB J. 2014;28(3):1398–1411. doi:10.1096/fj.13-242123
   PubMed Web of Science ®Google Scholar
• Couto M, Cates C. Laboratory guidelines for animal care. Methods Mol Biol. 2019;1920:407–430. doi:10.1007/978-1-4939-9009-2_25
   PubMedGoogle Scholar
• Corna D, Morigi M, Facchinetti D, Bertani T, Zoja C, Remuzzi G. Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Kidney Int. 1997;51(5):1583–1589. doi:10.1038/ki.1997.217
   PubMed Web of Science ®Google Scholar
• Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol. 2006;17(12):3382–3393. doi:10.1681/ASN.2006050520
   PubMed Web of Science ®Google Scholar
• Gu L, Weinreb A, Wang XP, et al. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol. 1998;161(12):6999–7006.
   PubMed Web of Science ®Google Scholar
• Ucero AC, Benito-Martin A, Fuentes-Calvo I, et al. TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast. Biochim Biophys Acta. 2013;1832(10):1744–1755. doi:10.1016/j.bbadis.2013.05.032
   PubMed Web of Science ®Google Scholar
• Gao HX, Campbell SR, Burkly LC, et al. TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells. Cytokine. 2009;46(1):24–35. doi:10.1016/j.cyto.2008.12.001
   PubMed Web of Science ®Google Scholar
• Tian LX, Tang X, Ma W, et al. Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation. FEBS Open Biol. 2020. doi:10.1002/2211-5463.12977
   Google Scholar
• Martínez-Miguel P, Medrano-Andrés D, Griera-Merino M, et al. Tweak up-regulates endothelin-1 system in mouse and human endothelial cells. Cardiovasc Res. 2017;113(2):207–221. doi:10.1093/cvr/cvw239
   PubMed Web of Science ®Google Scholar
• Han SH, Wu MY, Nam BY, et al. PGC-1α protects from notch-induced kidney fibrosis development. J Am Soc Nephrol. 2017;28(11):3312–3322. doi:10.1681/ASN.2017020130
   PubMed Web of Science ®Google Scholar
• Peng H, Wang Q, Lou T, et al. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017;8(1):1493. doi:10.1038/s41467-017-01646-6
   PubMedGoogle Scholar
• Rey E, Meléndez-Rodríguez F, Marañón P, et al. Hypoxia-inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36. Liver Int. 2020;40(10):2553–2567. doi:10.1111/liv.14519
   PubMed Web of Science ®Google Scholar
• Mørkholt AS, Oklinski MK, Larsen A, et al. Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents. PLoS One. 2020;15(6):e0234493. doi:10.1371/journal.pone.0234493
   PubMed Web of Science ®Google Scholar
• Beck ME, Zhang Y, Bharathi SS, et al. The common K333Q polymorphism in long-chain acyl-CoA dehydrogenase (LCAD) reduces enzyme stability and function. Mol Genet Metab. 2020;131(1–2):83–89. doi:10.1016/j.ymgme.2020.04.005
   PubMed Web of Science ®Google Scholar
• Hernández EÁ, Kahl S, Seelig A, et al. Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J Clin Invest. 2017;127(2):695–708. doi:10.1172/JCI89444
   PubMed Web of Science ®Google Scholar
• Sastre C, Fernández-Laso V, Madrigal-Matute J, et al. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. J Cell Mol Med. 2014;18(4):721–734. doi:10.1111/jcmm.12221
   PubMed Web of Science ®Google Scholar
• Tiller G, Fischer-Posovszky P, Laumen H, et al. Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes. Endocrinology. 2009;150(12):5373–5383. doi:10.1210/en.2009-0488
   PubMed Web of Science ®Google Scholar
• Escoté X, Gómez-Zorita S, López-Yoldi M, et al. Role of omentin, vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in obesity and diabetes development. Int J Mol Sci. 2017;18:8. doi:10.3390/ijms18081770
   Web of Science ®Google Scholar
• Sato S, Ogura Y, Mishra V, et al. TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity. Skelet Muscle. 2013;3(1):18. doi:10.1186/2044-5040-3-18
   PubMedGoogle Scholar
• Liu H, Peng H, Xiang H, et al. TWEAK/Fn14 promotes oxidative stress through AMPK/PGC‑1α/MnSOD signaling pathway in endothelial cells. Mol Med Rep. 2018;17(1):1998–2004. doi:10.3892/mmr.2017.8090
   PubMed Web of Science ®Google Scholar
• Ruiz-Andres O, Suarez-Alvarez B, Sánchez-Ramos C, et al. The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury. Kidney Int. 2016;89(2):399–410. doi:10.1038/ki.2015.332
   PubMed Web of Science ®Google Scholar
• Gomez IG, Roach AM, Nakagawa N, et al. TWEAK-Fn14 signaling activates myofibroblasts to drive progression of fibrotic kidney disease. J Am Soc Nephrol. 2016;27(12):3639–3652. doi:10.1681/ASN.2015111227
   PubMed Web of Science ®Google Scholar
• Sanz AB, Justo P, Sanchez-Niño MD, et al. The cytokine TWEAK modulates renal tubulointerstitial inflammation. J Am Soc Nephrol. 2008;19(4):695–703. doi:10.1681/ASN.2007050577
   PubMed Web of Science ®Google Scholar
• Xue L, Liu Z, Hu J, Huang J, Wen J, Liu Z. Estrogen-induced expression of tumor necrosis factor-like weak inducer of apoptosis through ERα accelerates the progression of lupus nephritis. Rheumatology (Oxford). 2016;55(10):1880–1888. doi:10.1093/rheumatology/kew248
   PubMed Web of Science ®Google Scholar