A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction

References

• Fairweather D. Sex differences in inflammation during atherosclerosis. Clin Med Insights Cardiol. 2015;8:49–59. doi:10.4137/CMC.S17068
   PubMedGoogle Scholar
• Koellhoffer EC, McCullough LD. The effects of estrogen in ischemic stroke. Transl Stroke Res. 2013;4(4):390–401. doi:10.1007/s12975-012-0230-5
   PubMed Web of Science ®Google Scholar
• Stubbins RE, Najjar K, Holcomb VB, Hong J, Núñez NP. Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab. 2012;14(1):58–66. doi:10.1111/j.1463-1326.2011.01488.x
   PubMed Web of Science ®Google Scholar
• Maggioli ES, McArthur S, Mauro C, et al. Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Brain Behav Immun. 2016;51:212–222. doi:10.1016/j.bbi.2015.08.020
   PubMed Web of Science ®Google Scholar
• Everhardt Queen A, Moerdyk-Schauwecker M, McKee LM, Leamy LJ, Huet YM. Differential expression of inflammatory cytokines in male and female mice in response to a lipopolysaccharide challenge. PLoS One. 2016;11(4):e0152289. doi:10.1371/journal.pone.0152289
   PubMed Web of Science ®Google Scholar
• Bábíčková J, Tóthová L, Lengyelová E, et al. Sex differences in experimentally induced colitis in mice: a role for estrogens. Inflammation. 2015;38(5):1996–2006. doi:10.1007/s10753-015-0180-7
   PubMed Web of Science ®Google Scholar
• Bosch FX, Ribes J, Díaz M, Cléries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127(5 Suppl 1):S5–S16. doi:10.1053/j.gastro.2004.09.011
   PubMed Web of Science ®Google Scholar
• Morale MC, Serra PA, L’episcopo F, et al. Estrogen, neuroinflammation and neuroprotection in Parkinson’s disease: glia dictates resistance versus vulnerability to neurodegeneration. Neuroscience. 2006;138(3):869–878. doi:10.1016/j.neuroscience.2005.07.060
   PubMed Web of Science ®Google Scholar
• Arnal JF, Douin-Echinard V, Brouchet L, et al. Understanding the oestrogen action in experimental and clinical atherosclerosis. Fundam Clin Pharmacol. 2006;20(6):539–548. doi:10.1111/j.1472-8206.2006.00445.x
   PubMed Web of Science ®Google Scholar
• Choudhry MA, Bland KI, Chaudry IH. Gender and susceptibility to sepsis following trauma. Endocr Metab Immune Disord Drug Targets. 2006;6(2):127–135. doi:10.2174/187153006777442422
   PubMedGoogle Scholar
• Stein B, Yang MX. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol. 1995;15(9):4971–4979. doi:10.1128/MCB.15.9.4971
   PubMed Web of Science ®Google Scholar
• Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317(5834):121–124. doi:10.1126/science.1140485
   PubMed Web of Science ®Google Scholar
• Medzhitov R, Preston-Hurlburt P, Kopp E, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell. 1998;2:253–258. doi:10.1016/S1097-2765(00)80136-7
   PubMed Web of Science ®Google Scholar
• Le Romancer M, Treilleux I, Leconte N, et al. Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol Cell. 2008;31(2):212–221. doi:10.1016/j.molcel.2008.05.025
   PubMed Web of Science ®Google Scholar
• Poulard C, Treilleux I, Lavergne E, et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012;4(11):1200–1213. doi:10.1002/emmm.201201615
   PubMed Web of Science ®Google Scholar
• Darimont BD, Wagner RL, Apriletti JW, et al. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 1998;12(21):3343–3356. doi:10.1101/gad.12.21.3343
   PubMed Web of Science ®Google Scholar
• Söderberg O, Gullberg M, Jarvius M, et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods. 2006;3(12):9951000. doi:10.1038/nmeth947
   Web of Science ®Google Scholar
• Cutolo M, Villaggio B, Bisso A, Sulli A, Coviello D, Dayer JM. Presence of estrogen receptors in human myeloid monocytic cells (THP-1 cell line). Eur Cytokine Netw. 2001;12(2):368–372.
   PubMed Web of Science ®Google Scholar
• Ojaniemi M, Glumoff V, Harju K, Liljeroos M, Vuori K, Hallman M. Phosphatidylinositol 3-kinase is involved in toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol. 2003;33:597–605. doi:10.1002/eji.200323376
   PubMed Web of Science ®Google Scholar
• Wei H, Mundade R, Lange KC, Lu T. Protein arginine methylation of non-histone proteins and its role in diseases. Cell Cycle. 2014;13(1):32–41. doi:10.4161/cc.27353
   PubMed Web of Science ®Google Scholar
• Moreno R, Sobotzik JM, Schultz C, Schmitz ML. Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon. Nucleic Acids Res. 2010;38(18):6029–6044. doi:10.1093/nar/gkq439
   PubMed Web of Science ®Google Scholar
• Song WC, Qian Y, Sun X, Negishi M. Cellular localization and regulation of expression of testicular estrogen sulfotransferase. Endocrinology. 1997;138(11):5006–5012. doi:10.1210/endo.138.11.5512
   PubMed Web of Science ®Google Scholar
• Judd HL, Judd GE, Lucas WE, Yen SS. Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab. 1974;39(6):1020–1024. doi:10.1210/jcem-39-6-1020
   PubMed Web of Science ®Google Scholar
• Simon V. Wanted: women in clinical trials. Science. 2005;308(5728):1517. doi:10.1126/science.1115616
   PubMed Web of Science ®Google Scholar
• Boyce BF, Xing L, Franzoso G, Siebenlist U. Required and nonessential functions of nuclear factor-kappa B in bone cells. Bone. 1999;25(1):137–139. doi:10.1016/S8756-3282(99)00105-2
   PubMed Web of Science ®Google Scholar
• Kiziltas S. Toll-like receptors in pathophysiology of liver diseases. World J Hepatol. 2016;8(32):1354–1369. doi:10.4254/wjh.v8.i32.1354
   PubMedGoogle Scholar
• Coulter KR, Wewers MD, Lowe MP, Knoell LD. Extracellular regulation of interleukin (IL)-1beta through lung epithelial cells and defective IL-1 type II receptor expression. Am J Respir Cell Mol Biol. 1999;20(5):964–975. doi:10.1165/ajrcmb.20.5.3458
   PubMed Web of Science ®Google Scholar
• Diemer T, Hales DB, Weidner W. Immune-endocrine interactions and leydig cell function: the role of cytokines. Andrologia. 2003;35(1):55–63. doi:10.1046/j.1439-0272.2003.00537.x
   PubMed Web of Science ®Google Scholar