Regulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia

References

• Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19(8):312–318. doi:10.1016/0166-2236(96)10049-7
   PubMed Web of Science ®Google Scholar
• Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia. 2007;55(4):412–424. doi:10.1002/glia.20468
   PubMed Web of Science ®Google Scholar
• Thion MS, Ginhoux F, Garel S. Microglia and early brain development: an intimate journey. Science. 2018;362(6411):185–189. doi:10.1126/science.aat0474
   PubMed Web of Science ®Google Scholar
• Butovsky O, Weiner HL. Microglial signatures and their role in health and disease. Nat Rev Neurosci. 2018;19(10):622–635. doi:10.1038/s41583-018-0057-5
   PubMed Web of Science ®Google Scholar
• Colonna M, Butovsky O. Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441–468. doi:10.1146/annurev-immunol-051116-052358
   PubMed Web of Science ®Google Scholar
• Colonna M, Butovsky O. Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol. 2017;35(1):441.
   PubMed Web of Science ®Google Scholar
• Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018;18(4):225–242. doi:10.1038/nri.2017.125
   PubMed Web of Science ®Google Scholar
• Ransohoff RM, Pan F, Ye Z, Cheng L, Liu JO. How neuroinflammation contributes to neurodegeneration. Science. 2016;353(6301):777–783. doi:10.1126/science.aag2590
   PubMed Web of Science ®Google Scholar
• Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 1992;6(9):1783–1798. doi:10.1101/gad.6.9.1783
   PubMed Web of Science ®Google Scholar
• Heidenreich KA, Linseman DA. Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival. Mol Neurobiol. 2004;29(2):155–166. doi:10.1385/MN:29:2:155
   PubMed Web of Science ®Google Scholar
• Yang Q, She H, Gearing M, et al. Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy. Science. 2009;323(5910):124–127. doi:10.1126/science.1166088
   PubMed Web of Science ®Google Scholar
• Savignac M, Mellstrom B, Naranjo JR. Calcium-dependent transcription of cytokine genes in T lymphocytes. Pflugers Arch. 2007;454(4):523–533. doi:10.1007/s00424-007-0238-y
   PubMed Web of Science ®Google Scholar
• Pan F, Ye Z, Cheng L, Liu JO, Factor ME. 2 Mediates Calcium-dependent Transcription of the Interleukin-2 Gene in T Lymphocytes. J Biol Chem. 2004;279(15):14477–14480.
   PubMedGoogle Scholar
• Gao L, She H, Li W, et al. Oxidation of Survival Factor MEF2D in Neuronal Death and Parkinson’s Disease. Antioxid Redox Signal. 2014;20(18):2936–2948. doi:10.1089/ars.2013.5399
   PubMed Web of Science ®Google Scholar
• Chu Y, Mickiewicz AL, Kordower JH. α-synuclein aggregation reduces nigral myocyte enhancer Factor-2D in idiopathic and experimental Parkinson’s disease. Neurobiol Dis. 2011;41(1):71–82. doi:10.1016/j.nbd.2010.08.022
   PubMed Web of Science ®Google Scholar
• Arosio A, Sala G, Rodriguez-Menendez V, et al. MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients. Mol Cell Neurosci. 2016;74:10–17. doi:10.1016/j.mcn.2016.02.002
   PubMed Web of Science ®Google Scholar
• Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature. 1997;386(6622):296–299. doi:10.1038/386296a0
   PubMed Web of Science ®Google Scholar
• Yang S, Gao L, Lu F, et al. Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death. J Neuroinflammation. 2015;12(1):33. doi:10.1186/s12974-015-0258-z
   PubMedGoogle Scholar
• Clark Rebecca I, Tan Sharon WS, Péan Claire B, et al. MEF2 Is an In Vivo Immune-Metabolic Switch. Cell. 2013;155(2):435–447. doi:10.1016/j.cell.2013.09.007
   PubMed Web of Science ®Google Scholar
• Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol. 1990;27(2–3):229–237. doi:10.1016/0165-5728(90)90073-V
   PubMed Web of Science ®Google Scholar
• Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev. 2005;204(1):27–42. doi:10.1111/j.0105-2896.2005.00239.x
   PubMedGoogle Scholar
• Chin AC. Neuroinflammation and the cGAS-STING pathway. J Neurophysiol. 2019;121(4):1087–1091. doi:10.1152/jn.00848.2018
   PubMed Web of Science ®Google Scholar
• Deczkowska A, Baruch K, Schwartz M. Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology. Trends Immunol. 2016;37(3):181–192. doi:10.1016/j.it.2016.01.006
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Takaoka A. The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol. 2002;14(1):111–116. doi:10.1016/S0952-7915(01)00305-3
   PubMed Web of Science ®Google Scholar
• Perry AK, Chen G, Zheng D, Tang H, Cheng G. The host type I interferon response to viral and bacterial infections. Cell Res. 2005;15(6):407–422. doi:10.1038/sj.cr.7290309
   PubMed Web of Science ®Google Scholar
• Thackray LB, Duan E, Lazear HM, et al. Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type I interferon-mediated control of murine norovirus replication. J Virol. 2012;86(24):13515–13523. doi:10.1128/JVI.01824-12
   PubMed Web of Science ®Google Scholar
• Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005;434(7034):772–777. doi:10.1038/nature03464
   PubMed Web of Science ®Google Scholar
• Jang JS, Lee JH, Jung NC, et al. Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway. Cell Death Dis. 2018;9(8):823. doi:10.1038/s41419-018-0889-y
   PubMedGoogle Scholar
• Karthikeyan A, Patnala R, Jadhav SP, Eng-Ang L, Dheen ST. MicroRNAs: key Players in Microglia and Astrocyte Mediated Inflammation in CNS Pathologies. Curr Med Chem. 2016;23(30):3528–3546. doi:10.2174/0929867323666160814001040
   PubMed Web of Science ®Google Scholar
• Kiernan EA, Smith SM, Mitchell GS, Watters JJ. Mechanisms of microglial activation in models of inflammation and hypoxia: implications for chronic intermittent hypoxia. J Physiol. 2016;594(6):1563–1577. doi:10.1113/JP271502
   PubMed Web of Science ®Google Scholar
• Ma XJ, Song TY, Wang WL, Zhang ZW. Effect of microRNA-129-5p targeting high mobility group protein box1 on regulating inflammation in lipopolysaccharide-activated primary spinal microglia cells. J Biol Regul Homeost Agents. 2020;34(4):1423–1430. doi:10.23812/20-133-L
   PubMed Web of Science ®Google Scholar
• Wang X, She H, Mao Z. Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis. J Biol Chem. 2009;284(47):32619–32626. doi:10.1074/jbc.M109.067785
   PubMed Web of Science ®Google Scholar
• She H, Yang Q, Shepherd K, et al. Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients. J Clin Invest. 2011;121(3):930–940. doi:10.1172/JCI43871
   PubMed Web of Science ®Google Scholar
• Chen K, Liu J, Cao X. Regulation of type I interferon signaling in immunity and inflammation: a comprehensive review. J Autoimmun. 2017;83:1–11. doi:10.1016/j.jaut.2017.03.008
   PubMed Web of Science ®Google Scholar
• Nallar SC, Kalvakolanu DV. Interferons, signal transduction pathways, and the central nervous system. J Interferon Cytokine Res. 2014;34(8):559–576. doi:10.1089/jir.2014.0021
   PubMed Web of Science ®Google Scholar
• Reinert LS, Lopusna K, Winther H, et al. Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nat Commun. 2016;7:13348. doi:10.1038/ncomms13348
   PubMed Web of Science ®Google Scholar
• Baruch K, Deczkowska A, David E, et al. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science. 2014;346(6205):89–93. doi:10.1126/science.1252945
   PubMed Web of Science ®Google Scholar
• Nazmi A, Field RH, Griffin EW, et al. Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression. Glia. 2019;67(7):1254–1276. doi:10.1002/glia.23592
   PubMed Web of Science ®Google Scholar
• Taylor JM, Minter MR, Newman AG, Zhang M, Adlard PA, Crack PJ. Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer’s disease. Neurobiol Aging. 2014;35(5):1012–1023. doi:10.1016/j.neurobiolaging.2013.10.089
   PubMed Web of Science ®Google Scholar
• Raftopoulou M. IRF-7 triggers the interferon alarm. Nat Cell Biol. 2005;7(5):459. doi:10.1038/ncb0505-459
   PubMed Web of Science ®Google Scholar
• Bengtsson AA, Ronnblom L. Role of interferons in SLE. Best Pract Res Clin Rheumatol. 2017;31(3):415–428. doi:10.1016/j.berh.2017.10.003
   PubMed Web of Science ®Google Scholar
• Farias FHG, Dahlqvist J, Kozyrev SV, et al. A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts. Eur J Hum Genet. 2019;27(3):432–441. doi:10.1038/s41431-018-0297-x
   PubMed Web of Science ®Google Scholar
• Axtell RC, Type SL. 1 interferons cool the inflamed brain. Immunity. 2008;28(5):600–602. doi:10.1016/j.immuni.2008.04.006
   PubMed Web of Science ®Google Scholar
• Main BS, Zhang M, Brody KM, et al. Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson’s disease. Glia. 2016;64(9):1590–1604. doi:10.1002/glia.23028
   PubMed Web of Science ®Google Scholar