Upregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion

References

• Chen Z, Zhong D, Li G. The role of microglia in viral encephalitis: a review. J Neuroinflammation. 2019;16(1):76. doi:10.1186/s12974-019-1443-2
   PubMedGoogle Scholar
• Zhao SC, Ma LS, Chu ZH, et al. Regulation of microglial activation in stroke. Acta Pharmacol Sin. 2017;38:445–458. doi:10.1038/aps.2016.162
   PubMed Web of Science ®Google Scholar
• Harry GJ. Microglia during development and aging. Pharmacol Ther. 2013;139(3):313–326. doi:10.1016/j.pharmthera.2013.04.013
   PubMed Web of Science ®Google Scholar
• Kabba JA, Xu Y, Christian H, et al. Microglia: housekeeper of the Central Nervous System. Cell Mol Neurobiol. 2018;38(1):53–71. doi:10.1007/s10571-017-0504-2
   PubMed Web of Science ®Google Scholar
• Amani H, Shahbazi MA, D’Amico C, et al. Microneedles for painless transdermal immunotherapeutic applications. J of Con Rel. 2021;330.
   Google Scholar
• Valles SL, Iradi A, Aldasoro M, et al. Function of Glia in Aging and the Brain Diseases. Int J Med Sci. 2019;16(11):1473–1479. doi:10.7150/ijms.37769
   PubMed Web of Science ®Google Scholar
• Liu X, Liu J, Zhao S, et al. Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia. Stroke. 2016;47(2):498–504. doi:10.1161/STROKEAHA.115.012079
   PubMed Web of Science ®Google Scholar
• Ganbold T, Bao Q, Zandan J, et al. Modulation of Microglia Polarization through Silencing of NF-kappaB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi. ACS Appl Mater Interfaces. 2020;12:11363–11374. doi:10.1021/acsami.9b23004
   PubMed Web of Science ®Google Scholar
• Hopp SC. Targeting microglia L‐type voltage‐dependent calcium channels for the treatment of central nervous system disorders. J Neurosci Res. 2020;99(1):141–162. doi:10.1002/jnr.24585
   PubMed Web of Science ®Google Scholar
• Liu W, Jiang L, Bian C, et al. Role of CX3CL1 in Diseases. Arch Immunol Ther Exp (Warsz). 2016;64(5):371–383. doi:10.1007/s00005-016-0395-9
   PubMed Web of Science ®Google Scholar
• Fumagalli S, Perego C, Ortolano F, et al. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia. 2013;61(6):827–842. doi:10.1002/glia.22474
   PubMed Web of Science ®Google Scholar
• Camargos QM, Silva BC, Silva DG, et al. Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke. Brain Res Bull. 2020;155:1–10. doi:10.1016/j.brainresbull.2019.11.009
   PubMed Web of Science ®Google Scholar
• Lauro C, Chece G, Monaco L, et al. Fractalkine Modulates Microglia Metabolism in Brain Ischemia. Front Cell Neurosci. 2019;13:414. doi:10.3389/fncel.2019.00414
   PubMed Web of Science ®Google Scholar
• Luo P, Chu SF, Zhang Z, et al. Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases. Brain Res Bull. 2019;146:12–21. doi:10.1016/j.brainresbull.2018.11.017
   PubMed Web of Science ®Google Scholar
• Ahn J, Kim D, Park J, et al. Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia. Int J Mol Med. 2019. doi:10.3892/ijmm.2019.4273
   Web of Science ®Google Scholar
• Sheridan GK, Murphy KJ. Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biol. 2013;3:130181. doi:10.1098/rsob.130181
   PubMed Web of Science ®Google Scholar
• Morrison HW, Filosa JA. A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion. J Neuroinflammation. 2013;10(1):4. doi:10.1186/1742-2094-10-4
   PubMedGoogle Scholar
• Taylor RA, Sansing LH. Microglial responses after ischemic stroke and intracerebral hemorrhage. Clin Dev Immunol. 2013;2013:746068. doi:10.1155/2013/746068
   PubMedGoogle Scholar
• Ma DC, Zhang NN, Zhang YN, et al. Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia. Exp Neurol. 2020;332:113399. doi:10.1016/j.expneurol.2020.113399
   PubMed Web of Science ®Google Scholar
• Denes A, Vidyasagar R, Feng J, et al. Proliferating resident microglia after focal cerebral ischaemia in mice. J Cereb Blood Flow Metab. 2007;27(12):1941–1953. doi:10.1038/sj.jcbfm.9600495
   PubMed Web of Science ®Google Scholar
• Heideker J, Wertz IE. DUBs, the regulation of cell identity and disease. Biochem J. 2015;467(1):191. doi:10.1042/bj4670191
   PubMedGoogle Scholar
• Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132:344–362. doi:10.1016/j.cell.2008.01.020
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Kumar R, Tsakem Lenou E, et al. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nat Immunol. 2020;21(6):626–635. doi:10.1038/s41590-020-0681-x
   PubMed Web of Science ®Google Scholar
• Hellerbrand C, Massoumi R. Cylindromatosis–A Protective Molecule against Liver Diseases. Med Res Rev. 2016;36:342–359. doi:10.1002/med.21381
   PubMed Web of Science ®Google Scholar
• Nikolaou K, Tsagaratou A, Eftychi C, et al. Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. Cancer Cell. 2012;21(6):738–750. doi:10.1016/j.ccr.2012.04.026
   PubMed Web of Science ®Google Scholar
• Ganjam GK, Terpolilli NA, Diemert S, et al. Cylindromatosis mediates neuronal cell death in vitro and in vivo. Cell Death Differ. 2018;25(8):1394–1407. doi:10.1038/s41418-017-0046-7
   PubMed Web of Science ®Google Scholar
• Jiang J, Luo Y, Qin W, et al. Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats. Front Mol Neurosci. 2017;10:10. doi:10.3389/fnmol.2017.00363
   PubMed Web of Science ®Google Scholar
• Chi L, Du K, Liu D, et al. Electroacupuncture brain protection during ischemic stroke: a role for the parasympathetic nervous system. J Cereb Blood Flow Metab. 2018;38(3):479–491. doi:10.1177/0271678X17697988
   PubMed Web of Science ®Google Scholar
• Zhu Y, Deng L, Tang H, et al. Electroacupuncture improves neurobehavioral function and brain injury in rat model of intracerebral hemorrhage. Brain Res Bull. 2017;131:123–132. doi:10.1016/j.brainresbull.2017.04.003
   PubMed Web of Science ®Google Scholar
• Zhu XL, Chen X, Wang W, et al. Electroacupuncture pretreatment attenuates spinal cord ischemia-reperfusion injury via inhibition of high-mobility group box 1 production in a LXA4 receptor-dependent manner. Brain Res. 2017;1659:113–120. doi:10.1016/j.brainres.2017.01.008
   PubMed Web of Science ®Google Scholar
• Qin WY, Luo Y, Chen L, et al. Electroacupuncture Could Regulate the NF-kappaB Signaling Pathway to Ameliorate the Inflammatory Injury in Focal Cerebral Ischemia/Reperfusion Model Rats. Evid Based Complement Alternat Med. 2013;2013:924541. doi:10.1155/2013/924541
   PubMed Web of Science ®Google Scholar
• Zhan J, Qin W, Zhang Y, et al. Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats. J Neuroinflammation. 2016;13:258. doi:10.1186/s12974-016-0731-3
   PubMed Web of Science ®Google Scholar
• Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84–91. doi:10.1161/01.STR.20.1.84
   PubMed Web of Science ®Google Scholar
• Bederson JB, Pitts LH, Tsuji M, et al. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17:472–476. doi:10.1161/01.STR.17.3.472
   PubMed Web of Science ®Google Scholar
• Garcia JH, Wagner S, Liu KF, et al. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26:627–634. doi:10.1161/01.STR.26.4.627
   PubMed Web of Science ®Google Scholar
• Ren J, Meng S, Yan B, et al. Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-kappaB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation. Mol Med Rep. 2016;13:3627–3638. doi:10.3892/mmr.2016.4980
   PubMed Web of Science ®Google Scholar
• Massoumi R. CYLD: a deubiquitination enzyme with multiple roles in cancer. Future Oncol. 2011;7(2):285–297. doi:10.2217/fon.10.187
   PubMed Web of Science ®Google Scholar
• Courtois G. Tumor suppressor CYLD: negative regulation of NF-kappaB signaling and more. Cell Mol Life Sci. 2008;65:1123–1132. doi:10.1007/s00018-007-7465-4
   PubMed Web of Science ®Google Scholar
• Sun SC. CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2010;17:25–34. doi:10.1038/cdd.2009.43
   PubMed Web of Science ®Google Scholar
• Jayaraj RL, Azimullah S, Beiram R, et al. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16:142.
   PubMed Web of Science ®Google Scholar
• Okada T, Suzuki H. Mechanisms of neuroinflammation and inflammatory mediators involved in brain injury following subarachnoid hemorrhage. Histol Histopathol. 2020;18208.
   Web of Science ®Google Scholar
• Le Thuc O, Blondeau N, Nahon J-L, et al. The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects. Ann N Y Acad Sci. 2015;1351(1):127–140. doi:10.1111/nyas.12855
   PubMedGoogle Scholar
• Mo Y, Sun YY, Liu KY. Autophagy and inflammation in ischemic stroke. Neural Regen Res. 2020;15:1388–1396. doi:10.4103/1673-5374.274331
   PubMed Web of Science ®Google Scholar
• Zhang W, Tian T, Gong SX, et al. Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke. Neural Regen Res. 2021;16:6–11. doi:10.4103/1673-5374.286954
   PubMed Web of Science ®Google Scholar
• Collmann FM, Pijnenburg R, Hamzei-Taj S, et al. Individual in vivo profiles of microglia polarization after stroke, represented by the genes iNOS and Ym1. Front Immunol. 2019;10:1236. doi:10.3389/fimmu.2019.01236
   PubMed Web of Science ®Google Scholar
• Ye SY, Apple JE, Ren X, et al. Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex. J Neuroinflammation. 2019;16:235. doi:10.1186/s12974-019-1633-y
   PubMed Web of Science ®Google Scholar
• Hongxia L, Yuxiao T, Zhilei S, et al. Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells. J Affect Disord. 2019;249:136–142. doi:10.1016/j.jad.2019.02.041
   PubMed Web of Science ®Google Scholar
• Xiang J, Zhang X, Fu J, et al. USP18 overexpression protects against focal cerebral ischemia injury in mice by suppressing microglial activation. Neuroscience. 2019;419:121–128. doi:10.1016/j.neuroscience.2019.09.001
   PubMed Web of Science ®Google Scholar
• Jiang X, Yu M, Ou Y, et al. Downregulation of USP4 promotes activation of microglia and subsequent neuronal inflammation in rat spinal cord after injury. Neurochem Res. 2017;42(11):3245–3253. doi:10.1007/s11064-017-2361-2
   PubMed Web of Science ®Google Scholar
• Slusarczyk J, Trojan E, Wydra K, et al. Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: possible role of NLRP3 inflammasome pathway. Biochem Pharmacol. 2016;113:45–56. doi:10.1016/j.bcp.2016.05.008
   PubMed Web of Science ®Google Scholar
• Cunha C, Gomes C, Vaz AR, et al. Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators Inflamm. 2016;2016:1–17. doi:10.1155/2016/6986175
   Web of Science ®Google Scholar
• Qin Y, Qiu J, Wang P, et al. Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease. Brain Behav Immun. 2021;91:324–338. doi:10.1016/j.bbi.2020.10.010
   PubMed Web of Science ®Google Scholar
• Du X, Xu Y, Chen S, et al. Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway. Neural Plast. 2020;2020:8825954. doi:10.1155/2020/8825954
   PubMed Web of Science ®Google Scholar
• Yang XD, Li W, Zhang S, et al. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020;39:e102201. doi:10.15252/embj.2019102201
   PubMed Web of Science ®Google Scholar
• Schlicher L, Brauns-Schubert P, Schubert F, et al. SPATA2: more than a missing link. Cell Death Differ. 2017;24(7):1142–1147. doi:10.1038/cdd.2017.26
   PubMed Web of Science ®Google Scholar
• Schlicher L, Wissler M, Preiss F, et al. SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death. EMBO Rep. 2016;17:1485–1497. doi:10.15252/embr.201642592
   PubMed Web of Science ®Google Scholar
• Kupka S, De Miguel D, Draber P, et al. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016;16(9):2271–2280. doi:10.1016/j.celrep.2016.07.086
   PubMed Web of Science ®Google Scholar
• Li L, Li L, Zhang J, et al. Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease. Neural Plast. 2020;2020:8836173. doi:10.1155/2020/8836173
   PubMed Web of Science ®Google Scholar
• Li Y, Jiang J, Tang Q, et al. Microglia TREM2: a Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model. Neural Plast. 2020;2020:8867547. doi:10.1155/2020/8867547
   PubMed Web of Science ®Google Scholar
• Liu R, Xu NG, Yi W, et al. Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF-kappaB-Mediated Activation of Microglia. Evid Based Complement Alternat Med. 2020;2020:8163052.
   PubMed Web of Science ®Google Scholar
• He HY, Ren L, Guo T, et al. Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke. Neural Regen Res. 2019;14:280–288. doi:10.4103/1673-5374.244793
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu XM, Luo QQ, et al. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. J Cereb Blood Flow Metab. 2015;35:1623–1631. doi:10.1038/jcbfm.2015.97
   PubMed Web of Science ®Google Scholar
• Joanna S, Ewa T, Karolina W, et al. Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: possible role of NLRP3 inflammasome pathway. Biochem Pharmacol. 2016;113:45–56.
   PubMed Web of Science ®Google Scholar
• He HY, Ren L, Guo T, et al. Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke. Neural Regen Res. 2019;14(2):280–288.
   PubMed Web of Science ®Google Scholar
• Wang J, Gan Y, Han P, et al. Ischemia-induced neuronal cell death is mediated by chemokine receptor CX3CR1. Sci Rep. 2018;8(1):556. doi:10.1038/s41598-017-18774-0
   PubMedGoogle Scholar
• Freria CM, Hall JC, Wei P, et al. Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice. J Neurosci. 2017;37:3568–3587. doi:10.1523/JNEUROSCI.2841-16.2017
   PubMed Web of Science ®Google Scholar
• Beth K, Luke AJ. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25(7):771–784. doi:10.1038/cr.2015.68
   PubMed Web of Science ®Google Scholar