Orexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways

References

• Zhang M, Xu L, Yang H. Schisandra chinensis fructus and its active ingredients as promising resources for the treatment of neurological diseases. Int J Mol Sci. 2018;19(7).
   Web of Science ®Google Scholar
• Ye J, Yao J-P, Wang XU, et al. Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury. Mol Med Rep. 2016;13(4):3083–3091. doi:10.3892/mmr.2016.4914
   PubMed Web of Science ®Google Scholar
• Huang Y, Wan C, Wu G. Acute kidney injury after a stroke: a PRISMA-compliant meta-analysis. Brain Behav. 2020;10(9):e01722. doi:10.1002/brb3.1722
   PubMed Web of Science ®Google Scholar
• Liao LY, Lau B-M, Sánchez-Vidaña D, et al. Exogenous neural stem cell transplantation for cerebral ischemia. Neural Regen Res. 2019;14(7):1129–1137. doi:10.4103/1673-5374.251188
   PubMed Web of Science ®Google Scholar
• Haghi M, Masoudi R, Najibi SM. Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy. Ups J Med Sci. 2020;125(4):265–273. doi:10.1080/03009734.2020.1785063
   PubMed Web of Science ®Google Scholar
• Tejeda GS, Esteban‐Ortega GM, San Antonio E, et al. Prevention of excitotoxicity-induced processing of BDNF receptor TrkB-FL leads to stroke neuroprotection. EMBO Mol Med. 2019;11(7):e9950. doi:10.15252/emmm.201809950
   PubMed Web of Science ®Google Scholar
• Birbeck GL, Meyer AC, Ogunniyi A. Nervous system disorders across the life course in resource-limited settings. Nature. 2015;527(7578):S167–71. doi:10.1038/nature16031
   PubMed Web of Science ®Google Scholar
• Platschek S, Cuntz H, Vuksic M, et al. A general homeostatic principle following lesion induced dendritic remodeling. Acta Neuropathol Commun. 2016;4:19. doi:10.1186/s40478-016-0285-8
   PubMed Web of Science ®Google Scholar
• Feng Y, Jiang C, Yang F, et al. Apocynum venetum leaf extract protects against H(2)O(2)-induced oxidative stress by increasing autophagy in PC12 cells. Biomed Rep. 2020;13(2):6. doi:10.3892/br.2020.1313
   PubMed Web of Science ®Google Scholar
• Tang Y, Dong X, Chen G, et al. Vagus nerve stimulation attenuates early traumatic brain injury by regulating the NF-κB/NLRP3 signaling pathway. Neurorehabil Neural Repair. 2020;34(9):831–843. doi:10.1177/1545968320948065
   PubMed Web of Science ®Google Scholar
• Zamboni M, Llorens-Bobadilla E, Magnusson JP, et al. A widespread neurogenic potential of neocortical astrocytes is induced by injury. Cell Stem Cell. 2020;27(4):605–617.e5. doi:10.1016/j.stem.2020.07.006
   PubMed Web of Science ®Google Scholar
• Griffin TA, Anderson HC, Wolfe JH. Ex vivo gene therapy using patient iPSC-derived NSCs reverses pathology in the brain of a homologous mouse model. Stem Cell Rep. 2015;4(5):835–846. doi:10.1016/j.stemcr.2015.02.022
   PubMed Web of Science ®Google Scholar
• Robinson AP, Foraker JE, Ylostalo J, et al. Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling. Stem Cells Dev. 2011;20(2):289–300. doi:10.1089/scd.2009.0444
   PubMed Web of Science ®Google Scholar
• Di Lorenzo F, Pither MD, Martufi M, et al. Pairing bacteroides vulgatus LPS structure with its immunomodulatory effects on human cellular models. ACS Cent Sci. 2020;6(9):1602–1616. doi:10.1021/acscentsci.0c00791
   PubMed Web of Science ®Google Scholar
• Zhu W, Li J, Liu Y, et al. Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways. Immunopharmacol Immunotoxicol. 2016;38(3):205–213. doi:10.3109/08923973.2016.1168433
   PubMed Web of Science ®Google Scholar
• Ni J, Zhao Y, Su J, et al. Toddalolactone protects lipopolysaccharide-induced sepsis and attenuates lipopolysaccharide-induced inflammatory response by modulating HMGB1-NF-κB translocation. Front Pharmacol. 2020;11:109. doi:10.3389/fphar.2020.00109
   PubMed Web of Science ®Google Scholar
• He P, Gelissen IC, Ammit AJ. Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease. Respir Res. 2020;21(1):250. doi:10.1186/s12931-020-01515-9
   PubMed Web of Science ®Google Scholar
• Zheng C, Yin Q, Wu H. Structural studies of NF-κB signaling. Cell Res. 2011;21(1):183–195. doi:10.1038/cr.2010.171
   PubMed Web of Science ®Google Scholar
• Tang X, Huang B, Lin S, et al. CgMyD88s serves as an innate immune system plug during ostreid herpesvirus 1 infection in the Pacific Oyster (Crassostrea gigas). Front Immunol. 2020;11:1247. doi:10.3389/fimmu.2020.01247
   PubMed Web of Science ®Google Scholar
• Georg I, Díaz-Barreiro A, Morell M, et al. BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells. Cell Mol Immunol. 2020;17(9):954–965. doi:10.1038/s41423-019-0254-9
   PubMed Web of Science ®Google Scholar
• Malireddi RKS, Gurung P, Kesavardhana S, et al. Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. J Exp Med. 2020;217(3). doi:10.1084/jem.20191644.
   PubMed Web of Science ®Google Scholar
• Tsujino N, Sakurai T. Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci. 2013;7:28. doi:10.3389/fnbeh.2013.00028
   PubMed Web of Science ®Google Scholar
• Zordan MA, Sandrelli F. Circadian clock dysfunction and psychiatric disease: could fruit flies have a say? Front Neurol. 2015;6:80. doi:10.3389/fneur.2015.00080
   PubMed Web of Science ®Google Scholar
• Janockova J, Dolezal R, Nepovimova E, et al. Investigation of new orexin 2 receptor modulators using in silico and in vitro methods. Molecules. 2018;23(11). doi:10.3390/molecules23112926.
   PubMed Web of Science ®Google Scholar
• Dong X, Feng Z. Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex. Neural Regener Res. 2018;13(2):244–251. doi:10.4103/1673-5374.226395
   PubMed Web of Science ®Google Scholar
• Schlett K, Madarász E. Retinoic acid induced neural differentiation in a neuroectodermal cell line immortalized by p53 deficiency. J Neurosci Res. 1997;47(4):405–415. doi:10.1002/(SICI)1097-4547(19970215)47:4<405::AID-JNR6>3.0.CO;2-I
   PubMed Web of Science ®Google Scholar
• Gao M, Dong Q, Zhang H, et al. Syringe needle skull penetration reduces brain injuries and secondary inflammation following intracerebral neural stem cell transplantation. Exp Ther Med. 2017;13(3):885–890. doi:10.3892/etm.2017.4054
   PubMed Web of Science ®Google Scholar
• Yoon Y, Kim HS, Jeon I, et al. Implantation of the clinical-grade human neural stem cell line, CTX0E03 rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington’s disease. Stem Cells. 2020;38(8):936–947. doi:10.1002/stem.3191
   PubMed Web of Science ®Google Scholar
• Messal N, Fernandez N, Dayot S, et al. Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. Biochimica Et Biophysica Acta Mol Basis Dis. 2018;1864(11):3618–3628. doi:10.1016/j.bbadis.2018.08.023
   PubMed Web of Science ®Google Scholar
• Suo L, Chang X, Zhao Y. The Orexin-A-regulated Akt/mTOR pathway promotes cell proliferation through inhibiting apoptosis in pancreatic cancer cells. Front Endocrinol (Lausanne). 2018;9:647. doi:10.3389/fendo.2018.00647
   PubMed Web of Science ®Google Scholar
• Ito N, Yabe T, Gamo Y, et al. I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation. Neuroscience. 2008;157(4):720–732. doi:10.1016/j.neuroscience.2008.09.042
   PubMed Web of Science ®Google Scholar
• Han X, Zhou J, Peng W. Orexins facilitates osteogenic differentiation of MC3T3-E1 cells. IUBMB Life. 2018;70(7):633–641. doi:10.1002/iub.1757
   PubMed Web of Science ®Google Scholar
• Zhang C, Sun C, Wang B, et al. Orexin-A stimulates the expression of GLUT4 in a glucose dependent manner in the liver of orange-spotted grouper (Epinephelus coioides). Comp Biochem Physiol Mol Integr Physiol. 2016;199:95–104. doi:10.1016/j.cbpa.2016.05.027
   PubMed Web of Science ®Google Scholar
• Xu D, Kong T, Zhang S, et al. Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway. Cell Signal. 2021;79:109839. doi:10.1016/j.cellsig.2020.109839
   PubMed Web of Science ®Google Scholar