Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

References

• Zychlinsky A, Prevost MC, Sansonetti PJ. Shigella flexneri induces apoptosis in infected macrophages. Nature. 1992;358(6382):167–169. doi:10.1038/358167a0
   PubMed Web of Science ®Google Scholar
• Cookson BT, Brennan MA. Pro-inflammatory programmed cell death. Trends Microbiol. 2001;9(3):113–114. doi:10.1016/S0966-842X(00)01936-3
   PubMed Web of Science ®Google Scholar
• Zeng C, Wang R, Tan H. Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications. Int J Biol Sci. 2019;15(7):1345–1357.
   PubMed Web of Science ®Google Scholar
• Jia C, Chen H, Zhang J, et al. Role of pyroptosis in cardiovascular diseases. Int Immunopharmacol. 2019;67:311–318. doi:10.1016/j.intimp.2018.12.028
   PubMed Web of Science ®Google Scholar
• Zhaolin Z, Guohua L, Shiyuan W, Zuo W. Role of pyroptosis in cardiovascular disease. Cell Prolif. 2019;52(2):e12563. doi:10.1111/cpr.12563
   PubMed Web of Science ®Google Scholar
• Sl F, Bt C. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun. 2005;73(4):1907–1916.
   PubMed Web of Science ®Google Scholar
• Sl F, Bt C. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006;8(11):1812–1825. doi:10.1111/j.1462-5822.2006.00751.x
   PubMed Web of Science ®Google Scholar
• Li Z, Tian X, Ji X. ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle. PLoS Biol. 2020;18(6):e3000288. doi:10.1371/journal.pbio.3000288
   PubMed Web of Science ®Google Scholar
• Suzuki H, Osawa T, Fujioka Y, Noda NN. Structural biology of the core autophagy machinery. Curr Opin Struct Biol. 2017;43:10–17. doi:10.1016/j.sbi.2016.09.010
   PubMed Web of Science ®Google Scholar
• Tixeira R, Shi B, Parkes M, et al. Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes. Front Immunol. 2018;9:2842. doi:10.3389/fimmu.2018.02842
   PubMed Web of Science ®Google Scholar
• Chaudhary G, Yadav P, Yadav A, et al. Necrosis and necroptosis in germ cell depletion from mammalian ovary. J Cell Physiol. 2019;234(6):8019–8027. doi:10.1002/jcp.27562
   PubMed Web of Science ®Google Scholar
• Kishino A, Hayashi K, Maeda M, et al. Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells. Int J Mol Sci. 2019;20:23. doi:10.3390/ijms20235896
   Web of Science ®Google Scholar
• Wang M, Wan H, Wang S, et al. RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells. J Anat. 2020;237(1):29–47. doi:10.1111/joa.13185
   PubMed Web of Science ®Google Scholar
• Wang S. The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy. Cell Biol Toxicol. 2020.
   Web of Science ®Google Scholar
• Liu Z, Wang C, Yang J, et al. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. 2020;53(1):106–114.e105. doi:10.1016/j.immuni.2020.06.007
   PubMed Web of Science ®Google Scholar
• Muendlein H, Jetton D, Connolly W, et al. cFLIP protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science. 2020;367(6484):1379–1384. doi:10.1126/science.aay3878
   PubMed Web of Science ®Google Scholar
• Shi J, Zhao Y, Wang Y, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514(7521):187–192. doi:10.1038/nature13683
   PubMed Web of Science ®Google Scholar
• Xia X, Wang X, Zheng Y, Jiang J, Hu J. What role does pyroptosis play in microbial infection? J Cell Physiol. 2019;234(6):7885–7892. doi:10.1002/jcp.27909
   PubMed Web of Science ®Google Scholar
• Wandel M, Kim B, Park E, et al. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nat Immunol. 2020;21(8):880–891. doi:10.1038/s41590-020-0697-2
   PubMed Web of Science ®Google Scholar
• Wang K, Sun Q, Zhong X, et al. Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020;180(5):941–955.e920. doi:10.1016/j.cell.2020.02.002
   PubMed Web of Science ®Google Scholar
• Zhou B, Zhang J, Liu X, et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28(12):1171–1185. doi:10.1038/s41422-018-0090-y
   PubMed Web of Science ®Google Scholar
• Zheng X, Zhong T, Ma Y, et al. Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME. Life Sci. 2020;242:117186. doi:10.1016/j.lfs.2019.117186
   PubMed Web of Science ®Google Scholar
• Zhang C, Li C, Wang Y, et al. Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation. Apoptosis. 2019;24(3–4):312–325. doi:10.1007/s10495-019-01515-1
   PubMed Web of Science ®Google Scholar
• Wang Y, Gao W, Shi X, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017;547(7661):99–103. doi:10.1038/nature22393
   PubMed Web of Science ®Google Scholar
• Wang S. ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury. Oxid Med Cell Longev. 2016;2016:2183026.
   PubMed Web of Science ®Google Scholar
• Long Y, Liu X, Tan X-Z. ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells. Ecotoxicol Environ Saf. 2020;189:109937. doi:10.1016/j.ecoenv.2019.109937
   PubMed Web of Science ®Google Scholar
• Tang Y-S, Zhao Y-H, Zhong Y. Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway. Inflammation Res. 2019;68(9):727–738. doi:10.1007/s00011-019-01256-6
   PubMed Web of Science ®Google Scholar
• Tavakoli Dargani Z, Singla R, Johnson T, Kukreja R, Singla DK. Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells. Can J Physiol Pharmacol. 2018;96(3):304–307. doi:10.1139/cjpp-2017-0340
   PubMed Web of Science ®Google Scholar
• Zeng C, Wang R, Tan H. Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications. Int J Biol Sci. 2019;15(7):1345–1357. doi:10.7150/ijbs.33568
   PubMed Web of Science ®Google Scholar
• Que Y, Zhu T, Zhang F, Peng J. Neuroprotective effect of DUSP14 overexpression against isoflurane-induced inflammatory response, pyroptosis and cognitive impairment in aged rats through inhibiting the NLRP3 inflammasome. Eur Rev Med Pharmacol Sci. 2020;24(12):7101–7113. doi:10.26355/eurrev_202006_21704
   PubMed Web of Science ®Google Scholar
• Morimoto N, Okamura Y, Maekawa S, et al. ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka, Oryzias latipes. Fish Shellfish Immunol. 2020;105:427–437. doi:10.1016/j.fsi.2020.07.027
   PubMed Web of Science ®Google Scholar
• Dang E, McDonald J, Russell D, Cyster J. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017;171(5):1057–1071.e1011. doi:10.1016/j.cell.2017.09.029
   PubMed Web of Science ®Google Scholar
• Westerterp M, Gautier E, Ganda A, et al. Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity. Cell Metab. 2017;25(6):1294–1304.e1296. doi:10.1016/j.cmet.2017.04.005
   PubMed Web of Science ®Google Scholar
• Niyonzima N, Bakke S, Gregersen I, et al. Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. EBioMedicine. 2020;60:102985. doi:10.1016/j.ebiom.2020.102985
   PubMed Web of Science ®Google Scholar
• Silva G, Gierman L, Rakner J, et al. Cholesterol Crystals and NLRP3 Mediated Inflammation in the Uterine Wall Decidua in Normal and Preeclamptic Pregnancies. Front Immunol. 2020;11:564712. doi:10.3389/fimmu.2020.564712
   PubMed Web of Science ®Google Scholar
• Hedbrant A, Andersson L, Bryngelsson I, et al. Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers. Mediators Inflamm. 2020;2020:8490908. doi:10.1155/2020/8490908
   PubMed Web of Science ®Google Scholar
• Liu G, Gu C, Liu M, et al. Protective role of p120-catenin on mitochondria by inhibiting NLRP3 in ventilator-induced lung injury. J Cell Mol Med. 2019;23(11):7360–7371. doi:10.1111/jcmm.14595
   PubMed Web of Science ®Google Scholar
• Yang S, Han Y, He J, et al. Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway. Biomed Pharmacother. 2020;130:110521. doi:10.1016/j.biopha.2020.110521
   PubMed Web of Science ®Google Scholar
• An Z, Su J. Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264.7 macrophages. Microbes Infection. 2019;21(3–4):143–153. doi:10.1016/j.micinf.2018.10.005
   PubMed Web of Science ®Google Scholar
• Campden R, Zhang Y. The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation. Arch Biochem Biophys. 2019;670:32–42. doi:10.1016/j.abb.2019.02.015
   PubMed Web of Science ®Google Scholar
• Nagoor Meeran M, Azimullah S, Laham F, et al. α-Bisabolol protects against β-adrenergic agonist-induced myocardial infarction in rats by attenuating inflammation, lysosomal dysfunction, NLRP3 inflammasome activation and modulating autophagic flux. Food Funct. 2020;11(1):965–976. doi:10.1039/C9FO00530G
   PubMed Web of Science ®Google Scholar
• Liu D, Zeng X, Li X, Mehta J, Wang X. Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol. 2018;113(1):5. doi:10.1007/s00395-017-0663-9
   PubMed Web of Science ®Google Scholar
• Karki R, Lee E, Sharma B, Banoth B, Kanneganti T. IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death. J Immunol. 2020;204(9):2514–2522. doi:10.4049/jimmunol.1901508
   PubMed Web of Science ®Google Scholar
• Choudhury S, Ma X, Abdullah S, Zheng H. Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses. J Inflamm Res. 2021;14:1145–1163. doi:10.2147/JIR.S295706
   PubMed Web of Science ®Google Scholar
• Ge X, Li W, Huang S, et al. The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury. Brain Res. 2018;1697:10–20. doi:10.1016/j.brainres.2018.06.008
   PubMed Web of Science ®Google Scholar
• Romacho T, Valencia I, Ramos-González M, et al. Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome. Sci Rep. 2020;10(1):5386. doi:10.1038/s41598-020-62190-w
   PubMed Web of Science ®Google Scholar
• Wang W, Wu Q, Sui Y, Wang Y, Qiu X. Rutin protects endothelial dysfunction by disturbing Nox4 and ROS-sensitive NLRP3 inflammasome. Biomed Pharmacother. 2017;86:32–40. doi:10.1016/j.biopha.2016.11.134
   PubMed Web of Science ®Google Scholar
• Wu Q, He X, Wu L, et al. MLKL Aggravates Ox-LDL-Induced Cell Pyroptosis via Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells. Inflammation. 2020;43(6):2222–2231. doi:10.1007/s10753-020-01289-8
   PubMed Web of Science ®Google Scholar
• Jin H, Ko Y, Park S, Kim H. P2YR activation by ATP induces oxLDL-mediated inflammasome activation through modulation of mitochondrial damage in human endothelial cells. Free Radic Biol Med. 2019;136:109–117. doi:10.1016/j.freeradbiomed.2019.04.004
   PubMed Web of Science ®Google Scholar
• Jia C, Zhang J, Chen H, et al. Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation. Cell Death Dis. 2019;10(10):778. doi:10.1038/s41419-019-2021-3
   PubMedGoogle Scholar
• Wu X, Zhang H, Qi W. Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 2018;9(2):171. doi:10.1038/s41419-017-0257-3
   PubMed Web of Science ®Google Scholar
• Yang F, Qin Y, Lv J, et al. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy. Cell Death Dis. 2018;9(10):1000. doi:10.1038/s41419-018-1029-4
   PubMedGoogle Scholar
• Rashidi M, Wicks I, Vince J. Inflammasomes and Cell Death: common Pathways in Microparticle Diseases. Trends Mol Med. 2020;26(11):1003–1020. doi:10.1016/j.molmed.2020.06.005
   PubMed Web of Science ®Google Scholar
• Han Y, Qiu H, Pei X, Fan Y, Tian H, Geng J. Low-dose Sinapic Acid Abates the Pyroptosis of Macrophages by Downregulation of lncRNA-MALAT1 in Rats With Diabetic Atherosclerosis. J Cardiovasc Pharmacol. 2018;71(2):104–112. doi:10.1097/FJC.0000000000000550
   PubMed Web of Science ®Google Scholar
• Tumurkhuu G, Dagvadorj J, Porritt RA. Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018;28(3):432–448.e434. doi:10.1016/j.cmet.2018.05.027
   PubMed Web of Science ®Google Scholar
• Cosmai L, Gallieni M, Liguigli W, Porta C. Renal toxicity of anticancer agents targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). J Nephrol. 2017;30(2):171–180. doi:10.1007/s40620-016-0311-8
   PubMed Web of Science ®Google Scholar
• Ie S, Sa K. Vasculitis is an antiangiogenic state. J Am Soc Nephrology. 2012;23(1):8–10. doi:10.1681/ASN.2011111116
   PubMed Web of Science ®Google Scholar
• Jin F, Hagemann N, Brockmeier U, Schäfer ST, Zechariah A, Hermann DM. LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking. Angiogenesis. 2013;16(3):625–637. doi:10.1007/s10456-013-9340-2
   PubMed Web of Science ®Google Scholar
• L-p J, Lm F, Yf L, et al. Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis: a NOVEL THERAPEUTIC POTENTIAL FOR ISCHEMIA. J Biol Chem. 2015;290(28):17485–17494. doi:10.1074/jbc.M115.641191
   PubMed Web of Science ®Google Scholar
• Mena HA, Carestia A, Scotti L, Parborell F, Schattner M, Negrotto S. Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells. J Thrombosis Haemostasis. 2016;14(2):397–410. doi:10.1111/jth.13223
   PubMed Web of Science ®Google Scholar
• Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15(7):387–407.
   PubMed Web of Science ®Google Scholar
• Hou J, Kang Y. Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets. Pharmacol Ther. 2012;135(3):337–354.
   PubMed Web of Science ®Google Scholar
• Tham Y, Bernardo B, Ooi J, Weeks K, McMullen J. Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015;89(9):1401–1438.
   PubMed Web of Science ®Google Scholar
• Peng X, Chen H, Li Y, Huang D, Huang B, Sun D. Effects of NIX-mediated mitophagy on ox-LDL-induced macrophage pyroptosis in atherosclerosis. Cell Biol Int. 2020;44(7):1481–1490. doi:10.1002/cbin.11343
   PubMed Web of Science ®Google Scholar
• Heger J, Schulz R, Euler G. Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure. Br J Pharmacol. 2016;173(1):3–14. doi:10.1111/bph.13344
   PubMed Web of Science ®Google Scholar
• Man S, Karki R, Kanneganti T. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev. 2017;277(1):61–75. doi:10.1111/imr.12534
   PubMed Web of Science ®Google Scholar
• Bai Y, Sun X, Chu Q, et al. Caspase-1 regulate AngII-induced cardiomyocyte hypertrophy via upregulation of IL-1β. Biosci Rep. 2018;38(2). doi:10.1042/BSR20171438
   Google Scholar
• Li X, Du N, Zhang Q, et al. MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy. Cell Death Dis. 2014;5(10):e1479. doi:10.1038/cddis.2014.430
   PubMedGoogle Scholar
• Turner N. Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs). J Mol Cell Cardiol. 2016;94:189–200. doi:10.1016/j.yjmcc.2015.11.002
   PubMed Web of Science ®Google Scholar
• Junttila M, Holmström L, Pylkäs K, et al. Primary Myocardial Fibrosis as an Alternative Phenotype Pathway of Inherited Cardiac Structural Disorders. Circulation. 2018;137(25):2716–2726. doi:10.1161/CIRCULATIONAHA.117.032175
   PubMed Web of Science ®Google Scholar
• González A, Schelbert E, Díez J, Butler J. Myocardial Interstitial Fibrosis in Heart Failure: biological and Translational Perspectives. J Am Coll Cardiol. 2018;71(15):1696–1706. doi:10.1016/j.jacc.2018.02.021
   PubMed Web of Science ®Google Scholar
• Liu C, Heckbert S, Lai S, et al. Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Coll Cardiol. 2017;70(25):3102–3109. doi:10.1016/j.jacc.2017.10.044
   PubMed Web of Science ®Google Scholar
• Senra T, Ianni B, Costa A, et al. Long-Term Prognostic Value of Myocardial Fibrosis in Patients With Chagas Cardiomyopathy. J Am Coll Cardiol. 2018;72(21):2577–2587. doi:10.1016/j.jacc.2018.08.2195
   PubMed Web of Science ®Google Scholar
• Henri O, Pouehe C, Houssari M, et al. Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction. Circulation. 2016;133(15):1484–1497. doi:10.1161/CIRCULATIONAHA.115.020143
   PubMed Web of Science ®Google Scholar
• Ferreira V, Marcelino M, Piechnik S, et al. Pheochromocytoma Is Characterized by Catecholamine-Mediated Myocarditis, Focal and Diffuse Myocardial Fibrosis, and Myocardial Dysfunction. J Am Coll Cardiol. 2016;67(20):2364–2374. doi:10.1016/j.jacc.2016.03.543
   PubMed Web of Science ®Google Scholar
• Farris S, Don C, Helterline D, et al. Cell-Specific Pathways Supporting Persistent Fibrosis in Heart Failure. J Am Coll Cardiol. 2017;70(3):344–354. doi:10.1016/j.jacc.2017.05.040
   PubMed Web of Science ®Google Scholar
• Yu Y, Sun J, Wang R, Liu J, Wang P, Wang C. Curcumin Management of Myocardial Fibrosis and its Mechanisms of Action: a Review. Am J Chin Med. 2019;47(8):1675–1710. doi:10.1142/S0192415X19500861
   PubMed Web of Science ®Google Scholar
• Dreyer RP, Zheng X, Xu X. Sex differences in health outcomes at one year following acute myocardial infarction: a report from the China Patient-Centered Evaluative Assessment of Cardiac Events prospective acute myocardial infarction study. Eur Heart j Acute Cardiovascular Care. 2019;8(3):273–282. doi:10.1177/2048872618803726
   PubMed Web of Science ®Google Scholar
• Mao Q, Liang X-L, Zhang C-L, Pang Y-H, Lu Y-X. LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis. Stem Cell Res Ther. 2019;10(1):393. doi:10.1186/s13287-019-1522-4
   PubMed Web of Science ®Google Scholar
• Rauf A, Shah M, Yellon DM, Davidson SM. Role of Caspase 1 in Ischemia/Reperfusion Injury of the Myocardium. J Cardiovasc Pharmacol. 2019;74(3):194–200. doi:10.1097/FJC.0000000000000694
   PubMed Web of Science ®Google Scholar
• Pang H, Wang N, Chai J. Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury. Eur J Med Chem. 2020;197:112314. doi:10.1016/j.ejmech.2020.112314
   PubMed Web of Science ®Google Scholar
• Zhang T, Yang W, Wang Y, et al. Electroacupuncture preconditioning attenuates acute myocardial ischemia injury through inhibiting NLRP3 inflammasome activation in mice. Life Sci. 2020;248:117451. doi:10.1016/j.lfs.2020.117451
   PubMed Web of Science ®Google Scholar
• Wang F, Gao Q, Yang J, et al. Artemisinin suppresses myocardial ischemia-reperfusion injury via NLRP3 inflammasome mechanism. Mol Cell Biochem. 2020;474:171–180. doi:10.1007/s11010-020-03842-3
   PubMed Web of Science ®Google Scholar
• Xiao H, Lu M, Lin T, et al. Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation. 2013;128(6):632–642. doi:10.1161/CIRCULATIONAHA.113.002714
   PubMed Web of Science ®Google Scholar
• Zhuang T, Liu J, Chen X, et al. Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation. Circ Res. 2019;125(6):590–605. doi:10.1161/CIRCRESAHA.118.314402
   PubMed Web of Science ®Google Scholar
• Tumurkhuu G, Shimada K, Dagvadorj J, et al. Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res. 2016;119(6):e76–90. doi:10.1161/CIRCRESAHA.116.308362
   PubMed Web of Science ®Google Scholar
• Peng X, Chen H, Li Y, Huang D, Huang B, Sun D. Effects of NIX-mediated mitophagy on ox-LDL-induced macrophage pyroptosis in atherosclerosis. Cell Biol Int. 2020;44(7):1481–1490.
   PubMed Web of Science ®Google Scholar
• Yan J, Li M, Wang X, Lu Z, Ni X. Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE) mice through reducing inflammation via the suppression of NLRP3 signaling pathway. Biomed Pharmacother. 2018;105:862–869. doi:10.1016/j.biopha.2018.04.140
   PubMed Web of Science ®Google Scholar
• Parsamanesh N, Moossavi M, Bahrami A, Fereidouni M, Barreto G, Sahebkar A. NLRP3 inflammasome as a treatment target in atherosclerosis: a focus on statin therapy. Int Immunopharmacol. 2019;73:146–155. doi:10.1016/j.intimp.2019.05.006
   PubMed Web of Science ®Google Scholar
• Fink S, Cookson B. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun. 2005;73(4):1907–1916.
   PubMed Web of Science ®Google Scholar
• Yang F, Qin Y, Wang Y, et al. LncRNA KCNQ1OT1 Mediates Pyroptosis in Diabetic Cardiomyopathy. Cell Physiol Biochem. 2018;50(4):1230–1244. doi:10.1159/000494576
   PubMedGoogle Scholar
• Li X, Du N, Zhang Q. MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy. Cell Death Dis. 2014;5(10):e1479.
   PubMedGoogle Scholar
• Xie Y, Huang Y, Ling X, Qin H, Wang M, Luo B. Chemerin/CMKLR1 Axis Promotes Inflammation and Pyroptosis by Activating NLRP3 Inflammasome in Diabetic Cardiomyopathy Rat. Front Physiol. 2020;11:381. doi:10.3389/fphys.2020.00381
   PubMed Web of Science ®Google Scholar
• Chen H, Tran D, Yang H, Nylander S, Birnbaum Y, Ye Y. Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK-mTOR Interplay. Cardiovasc Drugs Therapy. 2020;34(4):443–461. doi:10.1007/s10557-020-06978-y
   PubMed Web of Science ®Google Scholar
• Dalamaga M, Karampela I, Mantzoros C. Commentary: could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens? Metabolism. 2020;108:154260. doi:10.1016/j.metabol.2020.154260
   PubMed Web of Science ®Google Scholar
• Klimke A, Hefner G, Will B, Voss U. Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection. Med Hypotheses. 2020;142:109783. doi:10.1016/j.mehy.2020.109783
   PubMed Web of Science ®Google Scholar
• Liu J, Cao R, Xu M, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery. 2020;6(1):16. doi:10.1038/s41421-020-0156-0
   PubMed Web of Science ®Google Scholar
• Jean S, Lee P, Hsueh P. Treatment options for COVID-19: the reality and challenges. J Microbiol Immunol Infect. 2020;53(3):436–443. doi:10.1016/j.jmii.2020.03.034
   PubMedGoogle Scholar
• Maldonado V, Loza-Mejía M, Chávez-Alderete J. Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19. Med Hypotheses. 2020;144:109988. doi:10.1016/j.mehy.2020.109988
   PubMed Web of Science ®Google Scholar
• Moccia F, Gerbino A, Lionetti V, et al. COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. GeroScience. 2020;42(4):1021–1049. doi:10.1007/s11357-020-00198-w
   PubMed Web of Science ®Google Scholar
• Wang S. Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits. J Cardiovasc Transl Res. 2020.
   Web of Science ®Google Scholar
• Chen G, Chelu MG, Dobrev D, Li N. Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: mechanisms and Potential Therapeutic Implications. Front Physiol. 2018;9:1115. doi:10.3389/fphys.2018.01115
   PubMed Web of Science ®Google Scholar
• Wan Y, Xu L, Wang Y, Tuerdi N, Ye M, Qi R. Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome. Eur J Pharmacol. 2018;833:545–554. doi:10.1016/j.ejphar.2018.06.016
   PubMed Web of Science ®Google Scholar
• Yue L, Xie J, Nattel S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011;89(4):744–753. doi:10.1093/cvr/cvq329
   PubMed Web of Science ®Google Scholar
• Chen G, Chelu M, Dobrev D, Li N. Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: mechanisms and Potential Therapeutic Implications. Front Physiol. 2018;9:1115.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Usui-Kawanishi F, Karasawa T, et al. The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. PLoS One. 2017;12(5):e0176676. doi:10.1371/journal.pone.0176676
   PubMed Web of Science ®Google Scholar
• Cheng J, Akkerhuis K, Battes L, et al. Biomarkers of heart failure with normal ejection fraction: a systematic review. Eur J Heart Fail. 2013;15(12):1350–1362. doi:10.1093/eurjhf/hft106
   PubMed Web of Science ®Google Scholar
• Amit U, Kain D, Wagner A, et al. New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure. J Am Heart Assoc. 2017;6(5):5. doi:10.1161/JAHA.116.005108
   Web of Science ®Google Scholar
• Maruyama S, Nakamura K, Papanicolaou K, et al. Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture. EMBO Mol Med. 2016;8(8):949–966. doi:10.15252/emmm.201506151
   PubMed Web of Science ®Google Scholar
• Shibata R, Izumiya Y, Sato K, et al. Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J Mol Cell Cardiol. 2007;42(6):1065–1074. doi:10.1016/j.yjmcc.2007.03.808
   PubMed Web of Science ®Google Scholar
• Shibata R, Ouchi N, Ito M, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med. 2004;10(12):1384–1389. doi:10.1038/nm1137
   PubMed Web of Science ®Google Scholar
• Ørn S, Ueland T, Manhenke C, et al. Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention. J Intern Med. 2012;272(3):267–276. doi:10.1111/j.1365-2796.2012.02517.x
   PubMed Web of Science ®Google Scholar
• Sano S, Oshima K, Wang Y, et al. Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome. J Am Coll Cardiol. 2018;71(8):875–886. doi:10.1016/j.jacc.2017.12.037
   PubMed Web of Science ®Google Scholar
• Monnerat G, Alarcón M, Vasconcellos L, et al. Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice. Nat Commun. 2016;7(1):13344. doi:10.1038/ncomms13344
   PubMedGoogle Scholar
• Long V, Bonilla I, Vargas-Pinto P, et al. Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling. Life Sci. 2015;123:61–71. doi:10.1016/j.lfs.2014.12.024
   PubMed Web of Science ®Google Scholar
• El Khoury N, Mathieu S, Fiset C. Interleukin-1β reduces L-type Ca2+ current through protein kinase C activation in mouse heart. J Biol Chem. 2014;289(32):21896–21908. doi:10.1074/jbc.M114.549642
   PubMed Web of Science ®Google Scholar
• Westermann D, Lindner D, Kasner M, et al. Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction. Circ Heart Fail. 2011;4(1):44–52. doi:10.1161/CIRCHEARTFAILURE.109.931451
   PubMed Web of Science ®Google Scholar
• Nguyen K, Chau V, Mauro A, et al. Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction. J Cardiovasc Pharmacol Ther. 2020;25(5):472–483. doi:10.1177/1074248420923542
   PubMed Web of Science ®Google Scholar
• Sun H, Ren X, Xiong X, et al. NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension. Cell Death Dis. 2017;8(10):e3074. doi:10.1038/cddis.2017.470
   PubMedGoogle Scholar
• Qi J, Yu X, Shi X, et al. NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1. Cardiovasc Toxicol. 2016;16(4):345–354. doi:10.1007/s12012-015-9344-9
   PubMed Web of Science ®Google Scholar
• Zheng F, Gong Z, Xing S, Xing Q. Overexpression of caspase-1 in aorta of patients with coronary atherosclerosis. Heart Lung Circ. 2014;23(11):1070–1074. doi:10.1016/j.hlc.2014.04.256
   PubMed Web of Science ®Google Scholar
• Doi T, Doi S, Nakashima A, et al. Mizoribine ameliorates renal injury and hypertension along with the attenuation of renal caspase-1 expression in aldosterone-salt-treated rats. PLoS One. 2014;9(4):e93513. doi:10.1371/journal.pone.0093513
   PubMed Web of Science ®Google Scholar
• Krishnan S, Dowling J, Ling Y, et al. Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice. Br J Pharmacol. 2016;173(4):752–765. doi:10.1111/bph.13230
   PubMed Web of Science ®Google Scholar
• Krishnan S, Ling Y, Huuskes B, et al. Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. Cardiovasc Res. 2019;115(4):776–787. doi:10.1093/cvr/cvy252
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang Y, Zhang L, et al. Reduced Platelet miR-223 Induction in Kawasaki Disease Leads To Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis. Circ Res. 2020.
   Web of Science ®Google Scholar
• Lee P, Day-Lewis M, Henderson L, et al. Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020;130(11):5942–5950. doi:10.1172/JCI141113
   PubMed Web of Science ®Google Scholar
• Pouletty M, Borocco C, Ouldali N, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort. Ann Rheum Dis. 2020;79(8):999–1006. doi:10.1136/annrheumdis-2020-217960
   PubMed Web of Science ®Google Scholar
• Noval Rivas M, Arditi M. Kawasaki disease: pathophysiology and insights from mouse models. Nat Rev Rheumatol. 2020;16(7):391–405. doi:10.1038/s41584-020-0426-0
   PubMed Web of Science ®Google Scholar
• Liu L, Yuan Y, He X, et al. [Expression of Nod-like receptor protein 3 inflammasome in peripheral blood mononuclear cells of children with Kawasaki disease in the acute stage]. Zhongguo dang Dai Er Ke Za Zhi. 2019;21(10):992–997.
   PubMedGoogle Scholar
• Anzai F, Watanabe S, Kimura H, et al. Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease. J Mol Cell Cardiol. 2020;138:185–196. doi:10.1016/j.yjmcc.2019.11.158
   PubMed Web of Science ®Google Scholar
• Lee Y, Schulte D, Shimada K, et al. Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation. 2012;125(12):1542–1550. doi:10.1161/CIRCULATIONAHA.111.072769
   PubMed Web of Science ®Google Scholar